{"title":"Small Cell Neuroendocrine Cervical Carcinoma: A Case Report.","authors":"Malihe Hasanzadeh, Nooshin Babapour, Marjaneh Farazestanian, Farzaneh Hashem Niay Torshizi","doi":"10.18502/jfrh.v14i4.5212","DOIUrl":"https://doi.org/10.18502/jfrh.v14i4.5212","url":null,"abstract":"<p><p><b>Objective:</b> Small cell neuroendocrine cervical carcinoma is a neuroendocrine tumor with the great aggravation that comprises 0.5 to 3 percent of cervical tumors and progresses rapidly with early lymphogenous and hematogenous metastases. <b>Case report:</b> We reported a 40 years old woman with cervical cancer in stage IB2 that had radical hysterectomy with mistaken diagnosis of squamous cervical cancer. The disease has progressed after 50 days of surgery with a 6 cm tumor in vaginal cuff; review of pathology demonstrated small cell neuroendocrine cervical carcinoma. <b>Conclusion:</b> Recognition of this separate histopathological entity with IHC analysis is important. Chemoradiotherapy and multimodality therapeutic approaches could improve the survival rates.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":"14 4","pages":"273-275"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/fe/JFRH-14-273.PMC8144480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sakthi Arasu, Geethu Maria Joseph, Lijiya Mathew, Josephine S Antoniammal, Rajitha K Manolas, Avita Rose Johnson
{"title":"Development of a Comprehensive Antenatal Risk Assessment Tool to Predict Adverse Maternal and Perinatal Outcomes in Rural Areas: An Exploratory Study.","authors":"Sakthi Arasu, Geethu Maria Joseph, Lijiya Mathew, Josephine S Antoniammal, Rajitha K Manolas, Avita Rose Johnson","doi":"10.18502/jfrh.v14i4.5208","DOIUrl":"https://doi.org/10.18502/jfrh.v14i4.5208","url":null,"abstract":"<p><p><b>Objective:</b> To develop a comprehensive antenatal risk assessment tool to predict adverse maternal and early perinatal outcomes in a rural setting. <b>Materials and methods:</b> Cross-sectional study among women admitted for delivery in a rural maternity hospital, south India. Risk factors from Rotterdam Reproductive Risk Reduction (R4U) scorecard and social factors relevant to Indian rural context were included in questionnaire. Maternal and perinatal outcomes were obtained from in-patient records. Logistic regression of risk factors associated with adverse outcomes and weighted scores assigned using beta-coefficients. Cut-off score to predict adverse outcome was derived using Receiver Operator Characteristic Curve (ROC Curve) and Likelihood ratios. <b>Results:</b> Adjusted odds for adverse outcome highest for small for gestational age by ultrasound scan [OR=7.4 (1.4-36.5)], tobacco chewing [OR=5.6 (1.8-28.5)] and hypertensive disorders of pregnancy [OR=3.5 (1.9-9.6)]. After assigning weighted scores, the 74-item antenatal risk assessment tool had a maximum possible score of 86. Risk score was calculated for all subjects. Cut-off score to predict adverse outcome was 4, using ROC curve, with a sensitivity of 98%, a specificity of 21% and positive likelihood ratio of 1.23 (1.10-1.37). <b>Conclusion:</b> This comprehensive antenatal risk assessment tool is easy to administer, specific to rural areas and can help community-level workers to screen, monitor, and refer high risk pregnancies for further management to prevent adverse maternal and perinatal outcomes. This may be considered a prototype towards developing more robust antenatal risk screening and outcome prediction in rural settings.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":"14 4","pages":"242-251"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/69/JFRH-14-242.PMC8144483.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39033966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahra Kasheh Farahani, Mahnaz Taherianfard, Mohammad Mehdi Naderi, Hortensia Ferrero
{"title":"Assessing Pain Behavioral Responses and Neurotrophic Factors in the Dorsal Root Ganglion, Serum and Peritoneal Fluid in Rat Models of Endometriosis.","authors":"Zahra Kasheh Farahani, Mahnaz Taherianfard, Mohammad Mehdi Naderi, Hortensia Ferrero","doi":"10.18502/jfrh.v14i4.5210","DOIUrl":"https://doi.org/10.18502/jfrh.v14i4.5210","url":null,"abstract":"<p><p><b>Objective:</b> Pain is the most frequently reported symptom involving in endometriosis. The alterations of neurotrophic factors and certain neuropeptides in the dorsal root ganglion (DRG), as well as serum and peritoneal fluid (PF), were evaluated in rat models of endometriosis. <b>Materials and methods:</b> Twenty-four Sprague Dawley female rats were selected and maintained in a standard condition with 12 hours' dark-light cycles. All the rats were randomly assigned to 3 groups: Control (intact rats); Sham (the operation was conducted without endometriosis induction); and Endometriosis (endometriosis induction was performed). The formalin test was performed for all groups on the first and the 21<sup>st</sup> day of the study. The assessments of Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), Calcitonin Gene-Related Peptide (CGRP), and Substance P levels were carried out by enzyme-linked immunosorbent assay (Elisa). The data were analyzed by One-Way ANOVA. The Tukey's test was used as post-hoc. <b>Results:</b> Endometriosis induction significantly increased the mean pain scores in the endometriosis group in all three phases of the formalin test. The concentrations of DRG-CGRP (p=0.035), BDNF (p<0.001), and NGF (p=0.006) in the endometriosis group were significantly higher than that of the other groups while serum-BDNF (p<0.001), Substance P (p=0.009), and NGF (p=0.015) were significantly lower in endometriosis group compared to other groups. The concentrations of PF-BDNF (p=0.025) and Substance P (p=0.009) were significantly lower than those of other groups. <b>Conclusion:</b> The present results delineate that endometriosis induction could lead to hyperalgesia. This may be related to the significant increases in the BDNF, NGF, and CGRP in DRG.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":"14 4","pages":"259-268"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/96/JFRH-14-259.PMC8144485.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nguyen Thi Hai Yen, Pataporn Sukontamarn, Truc Ngoc Hoang Dang
{"title":"Sex-Composition of Living Children and Women's Fertility Desire in Vietnam.","authors":"Nguyen Thi Hai Yen, Pataporn Sukontamarn, Truc Ngoc Hoang Dang","doi":"10.18502/jfrh.v14i4.5204","DOIUrl":"https://doi.org/10.18502/jfrh.v14i4.5204","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the relationship between sex-composition of children and women's fertility desire in Vietnam. <b>Materials and methods:</b> Using data from the 2014 Vietnam Multiple Indicator Cluster Survey (MICS), we investigate the association between sex composition of children and desire for additional children among women in reproductive age (15 to 49 years) across Vietnam (N=5,605). <b>Results:</b> Multivariate logistic regression models showed statistically significant association between sex composition of children and women's fertility desire, after controlling for social norms of fertility preference, demographic and socioeconomic factors. For each group of women (those with one child, two children, and three or more children) women with no sons are more likely to have higher fertility desire compared to women with at least one son. However, women with both son (s) and daughter (s) tend to have lower fertility desire compared to those who have all sons. <b>Conclusion:</b> Vietnam's traditional cultural norm of son preference has a strong influence on fertility desire. Besides, mix-gender preference is also documented. The government should enforce the law more strictly regarding the prohibition of ultrasounds to detect fetal sex to reduce the feasibility of sex selection abortion. In addition, the government should improve the social ideology of the role of women in the family and society through mass media.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":"14 4","pages":"234-241"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/ad/JFRH-14-234.PMC8144484.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39033965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alireza Mirahmadizadeh, Ali Semati, Babak Eshrati, Fariba Moradi, Nasrin Asadi
{"title":"Root-Cause Analysis of Maternal Mortality in Fars Province, Southern Iran 2014: Negligence Is the Prime Suspect.","authors":"Alireza Mirahmadizadeh, Ali Semati, Babak Eshrati, Fariba Moradi, Nasrin Asadi","doi":"10.18502/jfrh.v14i3.4669","DOIUrl":"https://doi.org/10.18502/jfrh.v14i3.4669","url":null,"abstract":"Objective: we aimed to carry out an applied methodological tool, using Root-Cause Analysis (RCA), to determine the main causes of maternal mortality in Fars province, south of Iran, in 2014. Materials and methods: This is a case-series study and was conducted based on a careful examination of records and verbal autopsy with the family of the deceased person and their medical care team. Using RCA, quantitative dynamic modeling was done to display the overall impacts of different causes on maternal mortality. Finally, sensitivity analysis was done to determine the magnitude of contribution of each root-cause of maternal mortality. Results: Totally, all 10 maternal deaths with Maternal Mortality Rate (MMR) of 13.4 per 100.000 births, were recorded in the maternal surveillance system during 2014. The RCA results revealed that the root-causes of maternal mortality were ignorance and negligence (50%), delay in diagnosis (30%), delay in service provision in the first 24 hours after delivery (10%), and undesirable health care (10%). The results of sensitivity analysis in different scenarios revealed that medical negligence had the highest contribution to maternal mortality. Conclusion: Although maternal surveillance system stated some causes such as hemorrhage to be responsible for maternal deaths, the RCA showed that root-causes such as medical neglects had a fundamental role. Therefore, maternal mortality can be prevented by reforming the health care system and training all service providers, especially for high-risk mothers.","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"166-172"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/43/JFRH-14-166.PMC7868652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michela Cirillo, Maria Elisabetta Coccia, Cinzia Fatini
{"title":"Lifestyle and Comorbidities: Do We Take Enough Care of Preconception Health in Assisted Reproduction?","authors":"Michela Cirillo, Maria Elisabetta Coccia, Cinzia Fatini","doi":"10.18502/jfrh.v14i3.4667","DOIUrl":"10.18502/jfrh.v14i3.4667","url":null,"abstract":"<p><p><b>Objective:</b> The preconception period is largely neglected, whereas it represents an opportunity to identify and modify clinical and behavioral risks, particularly in infertile women characterized by an unfavorable vascular burden. The present study was performed to strengthen previous findings and to increase the awareness of clinicians who should envision a broader preconception approach in infertile women, beyond their reproductive health. <b>Materials and methods:</b> In this cross-sectional study, we investigated 1003 Caucasian women, referred to the Internal Medicine Clinic at the Assisted Reproductive Technologies Center, Florence. <b>Results:</b> A high prevalence of dyslipidemia (57.4%), overweight/obesity (29.1%) and, smoking habit (26.6%) were found. We provided evidence of unhealthy lifestyle habits, represented by a closer adherence to the Mediterranean diet in the 9.5% only and by a sedentary behavior in 73%. A significant correlation between the Mediterranean Diet score and both anthropometric and metabolic parameters was found. We also observed a lower score adherence with both metabolic syndrome and diabetes (for both p=0.02), but not with hypertension. <b>Conclusion:</b> Before infertility treatment, the correction and the management of modifiable and non-modifiable cardiovascular risk factors are mandatory and represent the main goal for a safe pregnancy, and lifetime women's health.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"150-157"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/c8/JFRH-14-150.PMC7868650.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25387644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing the Effectiveness of Doing Intra-uterine Insemination 36 and 42 Hours After Human Chorionic Gonadotropin (HCG) Injection on Pregnancy Rate: A Randomized Clinical Trial.","authors":"Mahboubeh Firouz, Narjes Noori, Marzieh Ghasemi, Alireza Dashipour, Narjes Keikha","doi":"10.18502/jfrh.v14i3.4670","DOIUrl":"https://doi.org/10.18502/jfrh.v14i3.4670","url":null,"abstract":"<p><p><b>Objective:</b> Intrauterine insemination (IUI) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. Hence, we compared the results of doing intra-uterine insemination 36 and 42 hours after human chorionic gonadotropin (hCG) hormone injection to achieve clinical and chemical pregnancy rates. <b>Materials and methods:</b> One hundred and sixty infertile women with unexplained infertility participated in this clinical trial. They were divided into two groups: those who underwent IUI 36 hours after hCG injection (control group), and those who underwent IUI 42 hours after hCG injection (case group). Statistical analyses were done using IBM-SPSS 25.0. and Chi-square test were used for data analysis. <b>Results:</b> The percentages of clinical and chemical pregnancies were significantly higher in the 42h group compared to the other group (P = 0.038 vs. P = 0.009, respectively). There was no significant difference regarding frequency of abortion, twin and ectopic pregnancies between the two groups (P > 0.05). <b>Conclusion:</b> Doing IUI 42 hours after hCG injection can significantly increase chances of fertility compared to doing it 36 hours after hCG injection.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"173-179"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/53/JFRH-14-173.PMC7868649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complementary and Alternative Medicine Usage and Its Determinant Factors Among Infertile Men in Iran.","authors":"Fatemeh Ghaedi Heidari, Mahlagha Dehghan, Sima Mokhtarabadi","doi":"10.18502/jfrh.v14i3.4671","DOIUrl":"https://doi.org/10.18502/jfrh.v14i3.4671","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to assess the use of some Complementary and Alternative Medicine (CAM) techniques in infertile men. <b>Materials and methods:</b> This cross-sectional study was conducted on 102 infertile men referred to the only center of infertility in Kerman, Iran using convenience sampling. Data were collected using a two-part researcher-made questionnaire and analyzed using descriptive and analytical statistics (chi-square test and logistic regression) with SPSS 16. <b>Results:</b> According to the present study, 72.5% of subjects used at least one of the CAM methods in the past year. Among them 28.4% of the subjects have used one CAM technique, 13.7% have used two techniques, 8.8% have used three techniques, 9.8% have used four techniques, and 11.8% have used more than four techniques since the last year. None of the socio-demographic characteristics had significant association with being the user of complementary and alternative medicines. <b>Conclusion:</b> The results showed that almost three quarters of the infertile men used CAM indicating a high prevalence of CAM usage among them.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"180-185"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/2f/JFRH-14-180.PMC7868654.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molar Changes With a Normal Viable Fetus: A Case Report.","authors":"Marjaneh Farazestanian, Asieh Maleki, Somayeh Bolandi, Zohreh Yousefi, Malihe Hasanzadeh, Laya Shirinzadeh, Sara Kamandi","doi":"10.18502/jfrh.v14i3.4675","DOIUrl":"https://doi.org/10.18502/jfrh.v14i3.4675","url":null,"abstract":"<p><p><b>Objective:</b> The presence of a normal fetus with normal karyotype accompanied by molar changes in the placenta is a rare condition, which carries a significant risk to the mother and fetus. There is a controversy regarding the proper management of this condition. Here, we present the case of a singleton pregnancy that showed molar changes in the pathological study of the placenta, but ended up with a normal viable neonate. <b>Case Report:</b> A 23-year-old primigravida woman, with a 3-year history of infertility, presented with vaginal bleeding and spotting. Her ß-human chorionic gonadotropin (HCG) at 13<sup>th</sup> week was 36500 mIU/ml. Serial sonography assessments were suggestive for molar changes and a normal fetus with growth retardation but normal Doppler assessment. The patient underwent elective Cesarean section at 37 weeks gestation and a healthy female neonate with an Apgar score of 9-10, weighing 2270 g was born. Pathological assessment of the placenta confirmed the diagnosis of incomplete hydatidiform mole. After two months, the mother had no complications, her ß-HCG level was untraceable, and the infant was in good condition. <b>Conclusion:</b> Despite being a rare condition, partial moles can be accompanied by delivery of a normal fetus. The management of this condition still remains challenging and should be done under close monitoring with extreme caution.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"205-208"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/82/JFRH-14-205.PMC7868656.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Efficacy of Zolpidem and Nigella Sativa in Treatment of Sleep Disorder and Vasomotor Symptoms in Menopausal Women of Women's General Hospital.","authors":"Mojgan Asadi, Fatemeh Molavi, Mostafa Qorbani, Fatemeh Davari Tanha","doi":"10.18502/jfrh.v14i3.4672","DOIUrl":"https://doi.org/10.18502/jfrh.v14i3.4672","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the efficacy of Zolpidem and Nigella sativa compared to placebo in treatment of sleep disturbance in healthy postmenopausal women. Menopause is a period that diagnosed after 12 months of amenorrhea and is characterized by a group of symptoms that include irregular menses; vasomotor and urogenital symptoms. The effects of non-hormonal therapies are being widely researched on menopause symptoms. There has been no study to compare Zolpidem and Nigella sativa versus placebo. <b>Materials and methods:</b> In this double-blind, placebo controlled trial, we compared the effect of Zolpidem with Nigella sativa and placebo in reducing sleep quality in 60 menopausal women. The prior and the later results were compared. We divided the patients into three groups after history taking and physical examination and filling the Pittsburgh questionnaire. Each group received their medication as the following order: Group A: Zolpidem, Group B: Nigella sativa, Group C: placebo. The first group received Zolpidem with the dose of 5 mg for 8 weeks. The second group received Nigella sativa with the dose of 600 mg for 8 weeks. The third group received placebo for 8 weeks. After two months, the Pittsburg questionnaire was filled again. <b>Results:</b> In the nigella sativa group, we had not significant improvement in sleep quality (p =0.07), hot flashes (p =0.15), palpitation (p =0.56) and night sweets (p =0.08). In zolpidem group, we have seen lack of improvement of hot flashes (p =0.73), and palpitation (p =0.36), which are nonsignificant statistically according to p values, but in zolpidem group, we had significant improvement in sleep quality (p =0.01), and night sweats (p =0.049). <b>Conclusion:</b> It seems that zolpidem has some effect on improving the quality of sleep in postmenopausal women. zolpidem also is good for night sweats. Nigella sativa was not effective in vasomotor symptoms and sleep quality.</p>","PeriodicalId":15845,"journal":{"name":"Journal of Family and Reproductive Health","volume":" ","pages":"186-191"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/ac/JFRH-14-186.PMC7868655.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}