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C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?最新文献

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Novel Multiplexed Plasma Biomarkers and Clinical Factors Augment Risk Assessment for Indeterminate Pulmonary Nodules in Former Smokers 新的多路血浆生物标志物和临床因素增加了前吸烟者不确定肺结节的风险评估
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7452
A. Fish, A. Vachani, P. Massion, S. Antic, N. Trivedi, J. K. Brown, T. Rubenstein, A. D. Rostykus, M. Beggs, Hongfeng Yu, L. Carbonell, M. Arjomandi
{"title":"Novel Multiplexed Plasma Biomarkers and Clinical Factors Augment Risk Assessment for Indeterminate Pulmonary Nodules in Former Smokers","authors":"A. Fish, A. Vachani, P. Massion, S. Antic, N. Trivedi, J. K. Brown, T. Rubenstein, A. D. Rostykus, M. Beggs, Hongfeng Yu, L. Carbonell, M. Arjomandi","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7452","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7452","url":null,"abstract":"METHODS: Plasma protein assays for the MagArray immunoassay platform were developed for biomarkers likely to provide discrimination between benign and malignant pulmonary nodules found on CT scan in former smokers. Retrospective plasma samples from a cohort of 217 subjects at high risk of lung cancer, collected at three medical centers across the US, were randomly assigned to a training set (n=73) and a testing set (n=144) for generalized linear modeling. The minimum set of protein biomarkers and clinical factors that provided the highest accuracy in classifying benign and malignant subjects were identified. Model performance was further evaluated by its ability to assign the correct risk classification for subjects with an intermediate risk nodule based on the Mayo Pre-Test Probability of Malignancy Model. RESULTS: A biomarker and clinical factor model consisting of TIMP1, ProSB, EGFR, CEA, and NAP2 protein biomarker levels, along with subject age, sex, nodule size, and nodule spiculated appearance provided an accuracy of 73% in the 144 testing subjects with a sensitivity of 76% and a specificity of 82%. The ROC curve AUC was 0.86 compared to the Mayo model AUC of 0.79 (Figure 1A). Within the 93 test subjects falling into the Mayo model intermediate risk range (0.05 to 0.65), the algorithm showed a ROC curve AUC of 0.82 compared to the Mayo model AUC of 0.64 (Figure 1B). Of those 93 subjects falling within the intermediate risk range, the algorithm correctly classified 70 of 93 samples (75%) as either benign or malignant.","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123438849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of the ABCG2 C421A Polymorphism on Plasma Concentration of Gefitinib ABCG2 C421A多态性对吉非替尼血药浓度的影响
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5821
Sho Sakamoto, Kazuhiro Sato, Y. Okuda, Y. Izumiya, Naho Kumagai, Kazuhisa Sudo, Mariko Asano, M. Takeda, M. Sano, K. Nakayama
{"title":"Effect of the ABCG2 C421A Polymorphism on Plasma Concentration of Gefitinib","authors":"Sho Sakamoto, Kazuhiro Sato, Y. Okuda, Y. Izumiya, Naho Kumagai, Kazuhisa Sudo, Mariko Asano, M. Takeda, M. Sano, K. Nakayama","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5821","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5821","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124579056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOP2A and HER2neu Evaluation in Malignant Pleural Mesothelioma 恶性胸膜间皮瘤的TOP2A和HER2neu评价
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5824
F. Abou El-Kasem, M. Rahouma, Iman Loay, O. Badawi, Mohamed S. Kamel, Dina A. Ibrahim, G. Ghaly, M. Amin, A. Abdelrahman
{"title":"TOP2A and HER2neu Evaluation in Malignant Pleural Mesothelioma","authors":"F. Abou El-Kasem, M. Rahouma, Iman Loay, O. Badawi, Mohamed S. Kamel, Dina A. Ibrahim, G. Ghaly, M. Amin, A. Abdelrahman","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5824","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5824","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130947417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plasma CK-19 Expressions Can Differentiate High Risk COPD from Lung Cancer 血浆CK-19表达可区分高风险COPD与肺癌
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5818
S. Umekawa, K. Almodovar, S. Tonthat, S. Lee, M. Lee, S. Khanolkar, D. Upadhyay
{"title":"Plasma CK-19 Expressions Can Differentiate High Risk COPD from Lung Cancer","authors":"S. Umekawa, K. Almodovar, S. Tonthat, S. Lee, M. Lee, S. Khanolkar, D. Upadhyay","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5818","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5818","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125488463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Density of PD-1 Positive T-Cells from Resected Tumor Specimens Analyzed by Multiplex Immunohistochemistry Can Predict Recurrence in Lung Adenocarcinoma 多重免疫组化分析切除肿瘤标本PD-1阳性t细胞密度可预测肺腺癌复发
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5828
T. Atwater, P. Massion
{"title":"Density of PD-1 Positive T-Cells from Resected Tumor Specimens Analyzed by Multiplex Immunohistochemistry Can Predict Recurrence in Lung Adenocarcinoma","authors":"T. Atwater, P. Massion","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5828","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5828","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121871849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Significance of APOBEC-Mediated RNA Editing in Lung Cancer Tumors apobecc介导的RNA编辑在肺癌肿瘤中的流行及意义
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5811
Frank Zhang, S. Yendamuri, S. Patnaik
{"title":"Prevalence and Significance of APOBEC-Mediated RNA Editing in Lung Cancer Tumors","authors":"Frank Zhang, S. Yendamuri, S. Patnaik","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5811","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5811","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133043590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability of PD-L1 Assays Using Small Tissue Samples Compared with Surgical Specimens 与手术标本相比，小组织样本PD-L1检测的可靠性
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5814
M.K. Lee, J. Eom
{"title":"Reliability of PD-L1 Assays Using Small Tissue Samples Compared with Surgical Specimens","authors":"M.K. Lee, J. Eom","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5814","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5814","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128677471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Utility of Liquid Based Biopsy Using Next Generation Sequencing Technology at the Time of Tissue Collection by Bronchoscopy for Suspected Lung Cancer 使用新一代测序技术的液体活检在支气管镜收集疑似肺癌组织时的应用
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5810
S. Ghadermarzi, P. Chandrika, S. Cowles, J. Denis, M. Bowling
{"title":"The Utility of Liquid Based Biopsy Using Next Generation Sequencing Technology at the Time of Tissue Collection by Bronchoscopy for Suspected Lung Cancer","authors":"S. Ghadermarzi, P. Chandrika, S. Cowles, J. Denis, M. Bowling","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5810","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5810","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121977934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhaled Small, Polar, Energetics-Related Metabolites by GC-MS for Lung Cancer Risk Assessment 气相色谱-质谱分析肺癌风险评估呼气小、极性、能量相关代谢物
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5816
S. Spivack, M. Shi, D. Patel, A. Desai, J. Dobkin, C. Shah, D. Hosgood, K. Ye, Y. Qiu, I. Kurland
{"title":"Exhaled Small, Polar, Energetics-Related Metabolites by GC-MS for Lung Cancer Risk Assessment","authors":"S. Spivack, M. Shi, D. Patel, A. Desai, J. Dobkin, C. Shah, D. Hosgood, K. Ye, Y. Qiu, I. Kurland","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5816","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5816","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122207662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Impact of a Bronchial Genomic Classifier in Patients Evaluated for Peripheral Pulmonary Nodules with Electromagnetic Navigational Bronchoscopy 支气管基因组分类器在电磁导航支气管镜评估周围性肺结节患者中的影响
C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK? Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5825
S. Awadallah, H. Sarwar, M. Bowling
{"title":"The Impact of a Bronchial Genomic Classifier in Patients Evaluated for Peripheral Pulmonary Nodules with Electromagnetic Navigational Bronchoscopy","authors":"S. Awadallah, H. Sarwar, M. Bowling","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5825","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5825","url":null,"abstract":"","PeriodicalId":158441,"journal":{"name":"C110. THE FUTURE OF LUNG CANCER BIOMARKERS: WHERE SHOULD WE LOOK?","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133095739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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