Journal of gastrointestinal oncology最新文献

{"title":"Impact of new onset diabetes on pancreatic cancer outcomes.","authors":"Casey P Borowsky, Peter J Hosein","doi":"10.21037/jgo-2025-217","DOIUrl":"10.21037/jgo-2025-217","url":null,"abstract":"","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1782-1784"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poorer prognosis of early gastric cardia cancer compared to early gastric non-cardia cancer: evidence from SEER database analysis.","authors":"Shuang Ma, Liuqing Yao, Bo Yang, Zhuo Huang, Chenfei Shao, Lanping Zhu, Xin Chen","doi":"10.21037/jgo-2025-107","DOIUrl":"10.21037/jgo-2025-107","url":null,"abstract":"<p><strong>Background: </strong>Limited evidence and contradictory results exist regarding lymph node metastasis (LNM) and prognosis in early gastric cardia cancer (EGCC) and early gastric non-cardia cancer (EGNCC). This study aims to compare the clinicopathological features, LNM patterns, and survival outcomes between EGCC and EGNCC using a large population-based dataset.</p><p><strong>Methods: </strong>This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) population and employed multivariate analysis, Kaplan-Meier method, propensity score matching (PSM), and nomogram analysis to achieve comprehensive insights.</p><p><strong>Results: </strong>EGCC tended to be younger in age, intestinal type, smaller tumor size, and well-differentiated type (P<0.05). No positive association was found between LNM and tumor location after adjusting for other risk factors [odds ratio (OR): 0.87; 95% confidence interval (CI): 0.60-1.25; P=0.44]. Moreover, patients with EGNCC showed a better prognosis compared with EGCC patients [5-year disease-specific survival (DSS): 87.3% <i>vs.</i> 80.3%, P<0.001 for log-rank test]. Patients with early gastric cancer (EGC) were further divided by invasion depth. When EGC patients were limited to the mucosa, EGCC patients had a similar overall survival (OS) to EGNCC patients (P=0.26). As the depth of infiltration reached the submucosa, EGCC had a significantly worse DSS compared to EGNCC (5-year DSS: 73.9% <i>vs.</i> 85.7%, P<0.001 for log-rank test). PSM further proved that our analysis was credible and reliable.</p><p><strong>Conclusions: </strong>The risk of LNM in EGCC is comparable to that in EGNCC. However, EGCC exhibits poorer survival outcomes compared to EGNCC. This discovery underscores the importance of enhanced monitoring and individualized treatment approaches for patients with EGCC to improve their prognosis and survival.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1380-1392"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal <i>vs.</i> distal colon cancer location: a subset analysis of the Minnesota colon cancer control study.","authors":"Alexander Troester, Claire Sokas, Jack M Wolf, Kyle Rudser, Timothy R Church, Aasma Shaukat, Paolo Goffredo","doi":"10.21037/jgo-2025-85","DOIUrl":"10.21037/jgo-2025-85","url":null,"abstract":"<p><strong>Background: </strong>Several patient and tumor characteristics impact the prognosis of non-metastatic colon cancer. Among those, tumor location is believed to be a significant factor, as proximal lesions are associated with lower overall survival (OS) in modern cohorts. We aimed to validate these findings in a cohort of patients from the Minnesota Colon Cancer Control Study who underwent curative colectomy.</p><p><strong>Methods: </strong>From 1976 to 1992, 46,551 patients aged 50-80 years were randomized to usual care, annual, or biennial screening with fecal occult blood testing (FOBT). Positive FOBT was followed by colonoscopy. We analyzed participants whose colonoscopy revealed colon adenocarcinoma to estimate the impact of tumor laterality on survival after adjustment for demographic and clinicopathologic characteristics. Proximal tumors were defined as those between the cecum and the splenic flexure.</p><p><strong>Results: </strong>Of 1,486 patients, 796 met inclusion criteria; 57% had proximal cancers. After adjustment, there was no significant difference between proximal and distal tumors in disease-specific mortality [subdistribution hazard ratio (SHR) =0.94, 95% confidence interval (CI): 0.70-1.3], but proximal tumors had lower rates of death from any cause [hazard ratio (HR) =0.9, 95% CI: 0.77-1.00].</p><p><strong>Conclusions: </strong>Although lacking granular data, these findings from the pre-modern chemotherapy era raise questions about the generalizability of the association between side of origin and prognosis identified in contemporary, treatment-based trials.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1498-1502"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-informed circulating tumor DNA assay for surveillance post-liver transplantation in patients with hepatocellular and cholangiocarcinoma.","authors":"Maen Abdelrahim, Ashton A Connor, Abdullah Esmail, Ahmed Elaileh, Souha Farhat, Sudha Kodali, David W Victor, Elizabeth W Brombosz, Ashish Saharia, Linda W Moore, R Mark Ghobrial","doi":"10.21037/jgo-24-791","DOIUrl":"10.21037/jgo-24-791","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation (LT) for primary liver cancers achieves excellent patient outcomes, but a minority recur with poor prognosis. Survival may be improved by earlier recurrence detection. This study aims to evaluate the feasibility and performance of a personalized tumor-informed assay utilizing circulating tumor DNA (ctDNA) from peripheral blood for surveillance after LT in patients with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCA).</p><p><strong>Methods: </strong>Here, we test whether a personalized tumor-informed assay utilizing ctDNA from peripheral blood informs post-LT surveillance. Personalized ctDNA assays were employed for surveillance in 38 LT recipients, alongside standard-of-care imaging and peripheral tumor biomarkers [alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9)].</p><p><strong>Results: </strong>Recurrence was detected radiologically in 6 patients, with positive ctDNA assays in 3 and negative/insufficient to process (ITP) in 3. Nine ITP ctDNA assays were due to insufficient primary tumor tissue. In 31 patients without ITP ctDNA tests, the sensitivity and specificity of ctDNA were 75% [95% confidence interval (CI): 19-99%] and 100% (95% CI: 87-100%). Standard-of-care tumor biomarkers had sensitivity and specificity of 75% (95% CI: 19-99%) and 93% (95% CI: 76-99%), respectively (P>0.99 and P=0.16; McNemar χ²). Only 1 patient had ctDNA positive prior to imaging-based diagnosis.</p><p><strong>Conclusions: </strong>This study corroborates the feasibility of ctDNA assays for recurrence surveillance in LT recipients. The results imply that ctDNA assays show promise in confirming recurrence and minimizing the need for invasive biopsy. However, additional prospective studies are needed to confirm ctDNA test utility in surveillance protocols.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1573-1585"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival of hepatectomy in colorectal cancer patients with ten or more liver metastases: a retrospective cohort study of multidisciplinary treatment.","authors":"Ping Lu, Yaqi Li, Zhiyu Chen, Jianling Zou, Junjie Peng","doi":"10.21037/jgo-2025-221","DOIUrl":"10.21037/jgo-2025-221","url":null,"abstract":"<p><strong>Background: </strong>Palliative chemotherapy is the standard first treatment for patients with ≥10 liver metastases, irrespective of resectability. This study aimed to assess the clinical benefits of hepatic resection and identify optimal treatments for colorectal cancer patients with ≥10 liver-limited metastases (LLMs).</p><p><strong>Methods: </strong>A retrospective study of 373 patients with unresectable colorectal cancer and ≥10 liver metastases. Patients were grouped into hepatic surgery ± radiofrequency ablation (RFA) + systemic therapy, RFA + systemic therapy, and systemic therapy alone. Kaplan-Meier and Cox proportional hazards methods were used to analyze overall survival (OS) and progression-free survival (PFS). A nomogram was developed and validated.</p><p><strong>Results: </strong>Three-year survival rates were 39.2%, 18.6%, and 8.2% for surgery ± RFA + systemic, RFA + systemic, and systemic only groups, respectively. Significant survival differences were noted in both <i>KRAS/NRAS/BRAF</i> wildtype and mutated cohorts. For wildtype LLMs, OS and PFS were 39.3 and 13.8 months for surgery ± RFA + systemic, compared to 23.9 and 9.9 months for RFA + systemic. The nomogram (C-index =0.709) identified independent prognostic factors for OS.</p><p><strong>Conclusions: </strong>Hepatectomy, with or without RFA, is associated with significantly improved survival in selected patients with ≥10 liver metastases. Further prospective studies are needed to confirm these findings.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1586-1596"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of endoscopic ultrasound versus indocyanine green fluorescence imaging for sentinel and lymph node metastasis in patients with colorectal cancer.","authors":"Guocong Wu, Yu Huang, Meifeng He, Chenggang Ren, Zhuo Wang, Yangyang Liu, Yao Zhang, Jianyong He, Shaoshuai Liu, Zhengeng Jia","doi":"10.21037/jgo-2024-917","DOIUrl":"10.21037/jgo-2024-917","url":null,"abstract":"<p><strong>Background: </strong>Sentinel lymph nodes and lymph node metastases in patients with colorectal cancer (CRC) seriously affect prognosis. In order to improve the accuracy of lymph node assessment during surgery, it is crucial to explore advanced imaging techniques. This study aimed to evaluate the diagnostic value of endoscopic ultrasound (EUS) versus indocyanine green (ICG) fluorescence imaging for sentinel lymph node metastasis (SLNM) and lymph node metastasis (LNM) in patients with CRC.</p><p><strong>Methods: </strong>A total of 120 patients with CRC admitted to our hospital from March 2022 to December 2023 were included in this retrospective study and, according to the detection method, they were divided into ICG group (ICG fluorescence imaging group, n=50) and control group (EUS group, n=70). The general data of patients, sensitivity, specificity, and accuracy of ICG imaging for the diagnosis of SLNM and LNM in patients with CRC were statistically compared between the two groups using gold standard postoperative pathology reports. Area under receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of ICG fluorescence imaging for SLNM and LNM in patients with CRC.</p><p><strong>Results: </strong>For diagnosing SLNM in CRC patients, ICG fluorescence imaging achieved sensitivities, specificities, and accuracies of 94.44%, 93.75%, and 94.00%, respectively, significantly outperforming EUS, which achieved sensitivities, specificities, and accuracies of 40.74%, 69.77%, and 58.58% respectively. For LNM diagnosis, ICG fluorescence imaging showed sensitivities, specificities, and accuracies of 80.00%, 92.5%, and 90.00%, compared to 28.57%, 71.43%, and 62.86% for EUS. The area under curve (AUC) of ICG for LNM in patients with CRC was 0.932 with an optimal cut-off value of 0.77, achieving sensitivities and specificities of 95.45% and 81.82%.</p><p><strong>Conclusions: </strong>In the assessment of SLNM and LNM in patients with CRC, ICG fluorescence imaging is proven to be more valuable than EUS.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1474-1482"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of gastric cancer attributed to high-salt diets: spatiotemporal trends and socio-demographic inequalities from 1990 to 2021.","authors":"Wei Liu, Yang Liu, Hua-Wan Chen, Zhen-Zhen Peng, Kui Liao","doi":"10.21037/jgo-2025-200","DOIUrl":"10.21037/jgo-2025-200","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) remains a major global health burden. High-salt diets are a key modifiable risk factor, promoting mucosal damage, chronic inflammation, and increased susceptibility to Helicobacter pylori infection. This study aimed to quantify the global, regional, and national GC burden attributable to high-salt diets and assess spatiotemporal trends and socio-demographic disparities from 1990 to 2021.</p><p><strong>Methods: </strong>This study used data from the Global Burden of Disease (GBD) 2021 to assess the burden of GC attributable to high sodium intake. Mortality and disability-adjusted life years (DALYs) were estimated across 204 countries and territories from 1990 to 2021. Age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) were stratified by Socio-demographic Index (SDI) quintile and GBD region. Temporal trends were assessed using estimated annual percentage change (EAPC). Decomposition and inequality analyses were conducted to explore drivers of DALY changes and disparities across SDI levels.</p><p><strong>Results: </strong>The global ASMR and ASDR for GC due to high salt intake decreased by 48.9% and 53.3%, respectively, from 1990 to 2021. In high-SDI regions, the ASMR decreased from 1.24 to 0.54 per 100,000 [EAPC =-2.72, 95% confidence interval (CI): -2.75, -2.70]. In contrast, in low-SDI regions, the ASMR and ASDR decreased by only 29.4% and 34.6%, respectively, with EAPCs of -1.14 (95% CI: -1.20, -1.08) and -1.41 (95% CI: -1.47, -1.36). East Asia showed the most notable decline, with the ASMR decreasing from 3.77 to 1.76 per 100,000 (EAPC =-2.54, 95% CI: -2.75, -2.33), and the ASDR dropping from 96.58 to 41.09 per 100,000 (EAPC =-2.88, 95% CI: -3.07, -2.69). while Sub-Saharan Africa exhibited limited progress.</p><p><strong>Conclusions: </strong>While global efforts to reduce salt intake have yielded positive results, significant disparities were observed across regions, with high-SDI countries experiencing greater reductions compared to low-SDI regions. Therefore, future interventions should focus on salt reduction policies, improved dietary patterns, and enhanced screening programs, particularly in resource-limited settings.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1403-1419"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A germline variant of ring finger protein 43 in an early onset, treatment-resistant metastatic gastric cancer: a case report.","authors":"Benjamín García-Bloj, Santiago Farah Celis, Natalia Eva Orellana, Tomás de Mayo Glasser, Mauricio A Sáez, Ignacio N Retamal, Matías Muñoz-Medel, Carolina Sánchez, Felipe Pinto, Paola Aravena, Cristopher San Martín, Andrea C Sabioncello H, Marcelo Garrido Villanueva, Fernando Sigler Chávez, Juvenal A Ríos Leal, Patricio A Manque, José M Erpel, Juan A Godoy, Marcelo Garrido","doi":"10.21037/jgo-2025-77","DOIUrl":"10.21037/jgo-2025-77","url":null,"abstract":"<p><strong>Background: </strong>Ring finger protein 43 (RNF43) is an E3 ubiquitin-protein ligase that functions as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis, and subsequent degradation of Frizzled receptors within the Wnt receptor complex. It exerts its effects on both canonical and non-canonical Wnt signaling pathways.</p><p><strong>Case description: </strong>This case report describes a 49-year-old female patient with a significant family history of cancer and parental consanguinity who was diagnosed with treatment-resistant stage IV gastric adenocarcinoma. Genomic profiling conducted via liquid biopsy identified a missense variant in RNF43 exon 9 (NM_017763.6, c.1948C>T; Arg650Ter) with a high variant allele frequency (VAF) of 49.5%. Confirmation of the R650* variant at the germline level underscores its clinical significance in early onset gastric cancer (GC) pathogenesis.</p><p><strong>Conclusions: </strong>While interpretations of its pathogenicity vary in the ClinVar database, the application of the American College of Medical Genetics (ACMG) criteria suggests its potential involvement in cancer pathogenesis. This report highlights the necessity for further research to elucidate the role and impact of RNF43 in GC progression and develop specific preventive measures for affected families as genetic testing and counseling in high-risk families.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1749-1755"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The surgical perspective on CAIRO5 and beyond: all patients with colorectal liver metastases should be evaluated by a liver surgeon, but what defines resectability?","authors":"Victoria S Wu, Lee M Ocuin","doi":"10.21037/jgo-2025-291","DOIUrl":"10.21037/jgo-2025-291","url":null,"abstract":"","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1768-1772"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Activation of RhoA/ROCK2 signaling by hypoxia-inducible factor 1α in promoting tumor growth and metastasis in human colon cancer.","authors":"","doi":"10.21037/jgo-2025b-04","DOIUrl":"10.21037/jgo-2025b-04","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/jgo-23-844.].</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"16 4","pages":"1789-1790"},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}