Journal of gastrointestinal oncology最新文献

{"title":"Barcelona Clinic Liver Cancer strategy adherence in hepatocellular carcinoma and its influence on long-term outcomes.","authors":"Niklas Sarelin, Valtteri Kairaluoma, Minna Nortunen, Marjo Koskela, Juha Saarnio, Joonas H Kauppila, Olli Helminen, Heikki Huhta","doi":"10.21037/jgo-2025-639","DOIUrl":"https://doi.org/10.21037/jgo-2025-639","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) survival rates remain poor. This retrospective study evaluated the adherence to the Barcelona Clinic Liver Cancer (BCLC) treatment strategy for HCC in a real-world setting and the effect of deviation from the strategy on long-term outcomes.</p><p><strong>Methods: </strong>We retrospectively analysed all histologically confirmed HCC cases that received invasive treatment at Oulu University Hospital 1986-2022 and Central Finland Central Hospital 1997-2022. Adherence to the BCLC strategy was re-evaluated according to: (I) tumor burden, (II) liver function, (III) patient profile, and (IV) surgical technique. Patients were re-evaluated according to the BCLC strategy of the year of treatment.</p><p><strong>Results: </strong>Among 208 total patients, 93 received surgical treatment, 29 underwent local ablative treatment, and 86 received transarterial treatment. Altogether, 145 (69.7%) patients were treated according to the BCLC strategy. Patients who received surgical treatment according to the BCLC strategy (n=76) had superior survival outcomes than those treated surgically outside the strategy (n=17), with 1-, 3-, and 5-year survival rates of 92.1%, 84.2%, and 78.9%, compared to 82.4%, 41.2%, and 23.5%, respectively (P<0.001).</p><p><strong>Conclusions: </strong>Our findings suggest that adherence to the BCLC strategy is associated with improved survival outcomes in a real-world setting. Patients treated outside the strategy should be carefully selected.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"21"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond LEAP-015: the ongoing challenge of vascular endothelial growth factor inhibition in gastric cancer.","authors":"Oluseyi Abidoye, Mohamad Bassam Sonbol","doi":"10.21037/jgo-2025-aw-824","DOIUrl":"https://doi.org/10.21037/jgo-2025-aw-824","url":null,"abstract":"","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"34"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biology before stage in advanced gastric cancer: converting to cure in biomarker-selected patients.","authors":"Yassine Alami Idrissi, Alina Zatsepina, Anwaar Saeed","doi":"10.21037/jgo-2025-757","DOIUrl":"https://doi.org/10.21037/jgo-2025-757","url":null,"abstract":"","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"43"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hedyotis diffusa Willd suppresses hepatocellular carcinoma tumor-stromal interactions by inactivating cancer-associated hepatic stellate cells.","authors":"Jing Chen, Tongnin Zhong, Xuemei Li, Yuxi Han, Jinglin Lai, Defeng Lei, Qirui Lin, Minghua Li, Zilong Yan","doi":"10.21037/jgo-2025-753","DOIUrl":"https://doi.org/10.21037/jgo-2025-753","url":null,"abstract":"<p><strong>Background: </strong>Hedyotis diffusa Willd (HDW) has the effects of clearing the heat, removing the toxins, restoring the circulation, eliminating the stasis and promoting the process of diuresis. Variety formulations of HDW various formulas involving HDW show remarkable clinical effects and have become second-lines anticancer drugs in China. However, its underlying mechanism against hepatocellular carcinoma (HCC) remains unclear. The objective of this study is to investigate the functional effect of HDW in the treatment of HCC, and to clarify the mechanism of HDW in suppression of tumor-stromal interaction.</p><p><strong>Methods: </strong>Therapeutic effects of HDW on HCC cells and cancer-associated hepatic stellate cells (HSCs) were investigated in vitro and in vivo. Potential targets of HDW were predicted and signaling pathway analyses were conducted using network pharmacology. The HDW-target gene set (HDW-TGS) was systematically screened to investigate the mechanisms by which HDW influences tumor-stromal interactions and to identify target genes with significant clinical value.</p><p><strong>Results: </strong>HDW induced HCC cells apoptosis via reactive oxygen species (ROS) induction. HDW-TGS significantly correlated to prognosis in The Cancer Genome Atlas (TCGA) HCC samples. HDW suppressed activated-HSC migration and invasion by regulating expression of fibrosis markers α-SMA and p-ERK1/2. In an HCC cell and HSC splenic co-transplanted xenograft mouse model, HDW suppressed liver tumor formation by downregulating fibrosis, indicating that HDW inhibited tumor-stromal interactions in vivo. Finally, we revealed a potential downstream target of HDW in HCC. We proposed that HDW might interrupt tumor-stromal interaction via ADH4.</p><p><strong>Conclusions: </strong>This study provides a new perspective for the treatment of HCC with HDW, demonstrating the feasibility of ADH4 as an HCC treatment target.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"23"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and internal validation of a predictive nomogram for early postoperative bacterial infections following liver transplantation in patients with hepatocellular carcinoma.","authors":"Peng-Fei Cheng, Li He, Bin-Wei Duan, Gong-Ming Zhang, Feng Wu, Jin-Xi Wang, Guang-Ming Li","doi":"10.21037/jgo-2025-786","DOIUrl":"https://doi.org/10.21037/jgo-2025-786","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Early postoperative bacterial infections (EPBIs) represent a significant complication following liver transplantation (LT) in individuals with hepatocellular carcinoma (HCC). However, existing predictive tools derived from general LT populations fail to account for HCC-specific risk factors, including cirrhosis-associated immune dysfunction compounded by tumor-induced immunosuppression, frequent healthcare exposures from bridging therapies, and surgical complexities unique to HCC patients. This study aimed to develop and internally validate HCC-specific predictive models for EPBI risk stratification.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted on 549 consecutive HCC patients undergoing LT between 2015 and 2025. EPBI was defined as any bacterial infection occurring within 30 days postoperatively. Consecutive patients who met the inclusion criteria were enrolled. Data collectors responsible for assessing preoperative and intraoperative predictors were blinded to postoperative infection outcomes to minimize ascertainment bias, particularly for outcomes that require clinical judgment such as infection classification. Three predictive models were constructed: a conventional logistic regression model (Model 1), a stepwise regression model optimized using the Akaike information criterion (AIC; Model 2), and a least absolute shrinkage and selection operator (LASSO)-Ridge regression model (Model 3). Model performance was evaluated based on discrimination [area under the curve (AUC)], calibration, clinical utility, and internal validation using 10-fold cross-validation and bootstrapping.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The cohort had a median age of 55 years [interquartile range (IQR), 49-60 years], with 85.1% male patients. EPBI occurred in 250 patients (45.5%), mainly pulmonary (51.2%) and intra-abdominal (43.3%). Among 468 isolates, Gram-negative (51.7%) and Gram-positive (48.3%) bacteria were similarly distributed. Multivariate analysis identified Child-Pugh class B, prolonged operative time, extended intensive care unit (ICU) stay, and decreased postoperative estimated glomerular filtration rate (eGFR) as independent predictors. Model 2 showed fair-to-good discrimination [AUC 0.784, 95% confidence interval (CI): 0.746-0.822]. At the optimal cutoff, sensitivity was 72.4% (95% CI: 68.2-76.6%), specificity 71.2% (95% CI: 67.1-75.3%), positive predictive value (PPV) 69.8% (95% CI: 65.4-74.2%), and negative predictive value (NPV) 73.1% (95% CI: 69.0-77.2%). Decision curve analysis (DCA) demonstrated greater net benefit than treat-all or treat-none strategies at a 6.3% risk threshold.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study developed and internally validated a nomogram for EPBI in HCC patients undergoing LT. The model demonstrates fair discriminative ability and potential clinical utility, supporting its potential for early risk stratification and targeted prevention strategies in clinica","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"27"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world comparative effectiveness of FOLFIRINOX versus gemcitabine/nab-paclitaxel in metastatic pancreatic cancer: prognostic impact of metastatic site and burden in a Middle Eastern cohort.","authors":"Wesal M Eldehna, Fawzy Elbarbry, Rafat Abu Shakra, Shaimaa A Elrasad, Zeinab A Morsi, Shamel M Soaida, Wael M Wagdy, Abrar I Aljohani, Ramy M Abbas","doi":"10.21037/jgo-2025-aw-913","DOIUrl":"https://doi.org/10.21037/jgo-2025-aw-913","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer (PC) is one of the most aggressive cancers, with low survival rates. Although FOLFIRINOX (FFX) and gemcitabine plus nab-paclitaxel (GnP) are standard first-line treatments, there is a lack of comparative real-world data from Middle Eastern populations, as well as the prognostic significance of metastatic patterns. The study aims to examine the efficacy and toxicity of FFX and GnP in advanced and metastatic PC, as well as assess how the site and number of metastases affect survival outcomes.</p><p><strong>Methods: </strong>This retrospective cohort analysis comprised 60 patients with advanced or metastatic PC treated at a tertiary center from 2019 to 2024. Patients were given either FFX (n=36) or GnP (n=24). The baseline clinicopathologic data, treatment response, toxicity, and survival outcomes were evaluated with SPSS v29. Survival was assessed using Kaplan-Meier and compared using the log-rank test. Variables with P<0.10 in univariate analysis were added to multivariable Cox regression models.</p><p><strong>Results: </strong>The demographic and clinical characteristics of patients treated with FFX and GnP were generally comparable between the two groups. In comparison to patients on GnP, those who received FFX had a slightly longer treatment duration and a substantially higher number of treatment cycles. Patients who received GnP experienced significantly more hematologic adverse events than those who received FFX. In terms of treatment response, FFX demonstrated a higher objective response rate (ORR) and disease control rate (DCR) than GnP. The metastatic site significantly influenced both overall survival (OS) and progression-free survival (PFS) survival outcomes. Kaplan-Meier curves indicate that patients with hepatic involvement experience disease progression and mortality at an earlier stage than those with nodal or other metastatic site. The number of metastatic sites did not exhibit a significant correlation with OS and PFS. In general, lung metastasis consistently demonstrated a favorable prognosis.</p><p><strong>Conclusions: </strong>In this real-world Middle Eastern group, survival outcomes were comparable between FEX and GnP. The metastatic site, particularly lung involvement, emerged as a critical prognostic predictor, implying biological heterogeneity among metastatic PC subtypes and underlining the importance of metastatic pattern in clinical prognosis.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"29"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fruit and vegetable consumption with colorectal adenoma among adults in Korea: a cross-sectional study.","authors":"Akinkunmi Paul Okekunle, Jiyoung Youn, Ji Hyun Song, Young Sun Kim, Sun Young Yang, Jung Eun Lee","doi":"10.21037/jgo-2025-456","DOIUrl":"https://doi.org/10.21037/jgo-2025-456","url":null,"abstract":"<p><strong>Background: </strong>Colorectal adenomas (CRA) are critical target precursors in the carcinogenesis of colorectal cancer (CRC), and the association of dietary factors, including fruits and vegetables, with CRA is yet to be clearly understood, especially in Asian populations. It is necessary to study the association of fruit and vegetable consumption with CRA to guide interventions for the primary prevention of CRA in the general population. Therefore, this study examined the relationship of fruit and vegetable consumption with CRA among asymptomatic adults in Korea.</p><p><strong>Methods: </strong>We identified 1,658 (61.2%, men) adults without a history of CRC who underwent colonoscopy as part of routine health screening at the Seoul National University Hospital Healthcare System Gangnam Centre from May to December 2011. Trained gastroenterologists diagnosed low- and high-risk CRA, and dietary information was assessed by trained nutritionists using a validated food frequency questionnaire (FFQ). Fruit and vegetable consumption was estimated in g/day per 1,000 kcal and stratified into quartiles. Multivariable-adjusted polytomous regression models were used to estimate the odds ratio (OR) and 95% confidence interval (CI) of CRA by quartiles of fruits and vegetable consumption at a two-sided P<0.05.</p><p><strong>Results: </strong>Overall, 536 (32.3%) presented with CRA. The multivariable-adjusted OR (95% CI) for odds of CRA by quartiles of total fruits and vegetable consumption were 1.00, 1.19 (0.85, 1.67), 1.23 (0.88, 1.72), and 1.02 (0.71, 1.46) (P for trend =0.87) for low-risk CRA and 1.00, 1.32 (0.81, 2.13), 0.76 (0.44, 1.31), and 0.58 (0.31, 1.06) (P for trend =0.02) for high-risk CRA. Similar but statistically insignificant trends were observed for vegetables or fruits individually.</p><p><strong>Conclusions: </strong>Higher fruit and vegetable consumption is modestly associated with a lower odds of high-risk CRA, but longitudinal studies are necessary to validate these findings.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"15"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The <i>EZH2-NEAT1</i> epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer.","authors":"Ruibing Li, Qiang Tao, Xijie Chen, Chuanyuan Liu, Huanmiao Zhan, Chong Wang, Xinyou Wang, Yijia Lin","doi":"10.21037/jgo-2025-1-1058","DOIUrl":"https://doi.org/10.21037/jgo-2025-1-1058","url":null,"abstract":"<p><strong>Background: </strong>Cuproptosis represents a promising therapeutic strategy for colorectal cancer (CRC), yet the epigenetic mechanisms governing cuproptosis sensitivity remain largely unexplored. Enhancer of zeste homolog 2 (<i>EZH2</i>), a key epigenetic regulator frequently overexpressed in CRC, may play a critical role in modulating copper-induced cell death. This study aimed to investigate the role of <i>EZH2</i> and its downstream effectors in regulating cuproptosis sensitivity in CRC cells.</p><p><strong>Methods: </strong>Using elesclomol-copper complex treatment, a cuproptosis model in HCT116 and RKO CRC cell lines was established. <i>EZH2</i> expression changes during cuproptosis were examined, and functional studies were performed using <i>EZH2</i> knockdown and overexpression approaches. The mechanistic link between <i>EZH2</i> and the long non-coding RNA (lncRNA) <i>NEAT1</i> was investigated by chromatin immunoprecipitation and transcriptional analysis. Rescue experiments were conducted to validate the <i>EZH2-NEAT1</i> axis in cuproptosis regulation. Additionally, the effects of this pathway on CRC cell migration in macrophage co-culture systems were examined.</p><p><strong>Results: </strong>The elesclomol-copper treatment induced dose-dependent cell death characterized by <i>HSP70</i> upregulation and dihydrolipoamide S-acetyltransferase (DLAT) protein aggregation. Both <i>EZH2</i> and <i>NEAT1</i> were significantly upregulated during copper-induced cell death. <i>EZH2</i> knockdown protected cells from cuproptosis by reducing <i>DLAT</i> aggregation and proteotoxic stress, while <i>EZH2</i> overexpression enhanced copper-induced death. Mechanistically, <i>EZH2</i> transcriptionally activates <i>NEAT1</i> by maintaining <i>H3K27</i> acetylation at its promoter. Rescue experiments confirmed that <i>NEAT1</i> overexpression restored cuproptosis sensitivity in the <i>EZH2</i> knockdown cells, while <i>NEAT1</i> depletion prevented <i>EZH2</i>-mediated death promotion. The <i>EZH2-NEAT1</i> axis modulated lipoylated <i>DLAT</i> levels and proteotoxic stress without affecting <i>FDX1</i> transcription. Further, this axis regulated the extracellular <i>NEAT1</i> levels and influenced CRC cell migration in the macrophage co-culture systems, revealing effects beyond cell-autonomous death sensitivity.</p><p><strong>Conclusions: </strong>The <i>EZH2-NEAT1</i> axis functions as a pro-death pathway in cuproptosis execution machinery rather than a protective response. Tumors with elevated <i>EZH2-NEAT1</i> expression may be particularly sensitive to copper-based therapies. This study establishes <i>EZH2-NEAT1</i> expression as a potential biomarker for patient selection in cuproptosis-based cancer treatment, though the concurrent effects on tumor migration highlight complex therapeutic considerations for combination treatment strategies.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"18"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of mitochondrial-related subtypes and development of a prognostic model for pancreatic ductal adenocarcinoma.","authors":"Fen Zhang, Zijian Jiang, Yuan Gao, Desheng Wang, Shuqiang Yue","doi":"10.21037/jgo-2025-613","DOIUrl":"https://doi.org/10.21037/jgo-2025-613","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a poor prognosis. Mitochondrial dysfunction, including alterations in metabolism, dynamics, and DNA, is increasingly recognized as a critical factor in the initiation and progression of pancreatic cancer. This study aimed to systematically investigate the role of mitochondrial dysfunction in PDAC to identify mitochondria-related genes (MitoRGs) of prognostic significance, explore associated molecular subtypes, and examine their effects on the tumor immune microenvironment.</p><p><strong>Methods: </strong>We integrated transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to identify a set of MitoRGs with significant prognostic value for PDAC. Their expression was further validated in PDAC cells and using single-cell RNA-sequencing data. Unsupervised clustering was employed to classify PDAC patients into distinct subtypes based on MitoRG expression patterns. A robust prognostic model was subsequently constructed using least absolute shrinkage and selection operator-Cox regression analysis. The predictive accuracy of the model for 1-, 3-, and 5-year overall survival (OS) was assessed. The immune cell infiltration and genomic features of the risk groups defined by the model were also analyzed. Finally, a clinically applicable nomogram was developed to facilitate prognostic prediction.</p><p><strong>Results: </strong>Based on MitoRG expression, PDAC patients were classified into two distinct subtypes (clusters A and B). Patients in cluster A exhibited significantly better OS than those in cluster B. A prognostic model based on a seven-MitoRG signature was established, which demonstrated high predictive accuracy. The high-risk group, as defined by the model, was characterized by an immunosuppressive tumor microenvironment, featuring reduced cytotoxic T-cell activity and increased stromal components. This group also showed significant enrichment of driver mutations such as <i>KRAS</i> and <i>TP53</i>.</p><p><strong>Conclusions: </strong>This study established a significant link between mitochondrial dysfunction and PDAC molecular subtypes, immune microenvironment remodeling, and clinical prognosis. The developed seven-MitoRG signature and nomogram could serve as reliable prognostic tools. These findings provide insights into the role of mitochondria in the pathogenesis of PDAC and offer potential targets for developing personalized therapeutic strategies.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"28"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends and foci of ablation therapies for liver tumours: a scientometric study.","authors":"Shu Dong, Chien-Shan Cheng, Lin Xie, Weijun Fan, Ping Liang, Zhiqiang Meng","doi":"10.21037/jgo-2025-750","DOIUrl":"https://doi.org/10.21037/jgo-2025-750","url":null,"abstract":"<p><strong>Background: </strong>Ablation therapies have attracted sustained research interest in the management of liver tumours. This study aimed to systematically map global research trends, collaboration patterns, and the evolution of themes in liver tumour ablation using a scientometric approach.</p><p><strong>Methods: </strong>Publications related to liver tumour ablation were retrieved from the Web of Science Core Collection. Scientometric analyses, including network construction, co-authorship analysis, and keyword co-occurrence and burst detection, were conducted using VOSviewer and Citespace.</p><p><strong>Results: </strong>A total of 5,970 research articles between 1991 and 2022 were included. Publication output demonstrated continuous growth over the past three decades. The USA, China, Germany, Japan, and Italy were the most productive countries, with major contributions from institutions such as Sun Yat-sen University and Memorial Sloan Kettering Cancer Center. Authors and journal analyses revealed concentrated collaboration networks and diverse publication venues. Keyword analysis identified \"hepatocellular carcinoma\" and \"radiofrequency ablation\" as central research themes. In contrast, more recent research attention has shifted toward outcome-related and integrative topics, including overall survival, irreversible electroporation, and immunotherapy.</p><p><strong>Conclusions: </strong>This scientometric study provides a data-driven overview of the global research landscape in liver tumour ablation, highlighting growth in publications, collaborative structures, and evolving research themes. The findings delineate emerging areas of scholarly attention and offer a structured foundation for future bibliometric investigations into research priorities and thematic development in this field.</p>","PeriodicalId":15841,"journal":{"name":"Journal of gastrointestinal oncology","volume":"17 1","pages":"25"},"PeriodicalIF":2.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}