Basiru O Ajiboye, Oluwafemi A Ojo, Oluwatosin Adeyonu, Oluwatosin D Imiere, Adewale O Fadaka, Adetutu O Osukoya
{"title":"Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats.","authors":"Basiru O Ajiboye, Oluwafemi A Ojo, Oluwatosin Adeyonu, Oluwatosin D Imiere, Adewale O Fadaka, Adetutu O Osukoya","doi":"10.1177/2156587216685510","DOIUrl":"https://doi.org/10.1177/2156587216685510","url":null,"abstract":"<p><p>This study sought to investigate the ameliorative effects of ethanol extract Artocarpus heterophyllus (EAH) in alloxan-induced diabetic rats. The rats were divided into 6 groups, with groups 1 and 2 serving as nondiabetic and diabetic control, respectively; group 3 serving as diabetic rats treated with 5 mg/kg glibenclamide; and groups 4 to 6 were diabetic rats treated with 50, 100, and 150 mg/kg of EAH, respectively. Assays determined were serum insulin, lipid peroxidation, and antioxidant enzyme activities. EAH stem bark reduced fasting blood glucose and lipid peroxidation levels and increased serum insulin levels and activities of antioxidant enzymes. Data obtained demonstrated the ability of EAH stem bark to ameliorate pancreatic β-cell dysfunction in alloxan-induced diabetic rats.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"538-543"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587216685510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35689479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypnotherapy to Reduce Hot Flashes: Examination of Response Expectancies as a Mediator of Outcomes.","authors":"Jim R Sliwinski, Gary R Elkins","doi":"10.1177/2156587217708523","DOIUrl":"10.1177/2156587217708523","url":null,"abstract":"<p><p>The mechanism of action responsible for hypnotherapy's effect in reducing hot flashes is not yet known. The purpose of this study was to examine the role of response expectancies as a potential mediator. Hypnotizability was also tested as an effect moderator. Data were collected from a sample of 172 postmenopausal women, who had been randomized to receive either a 5-week hypnosis intervention or structured attention counseling. Measures of response expectancies were analyzed to determine if the relationship between group assignment and hot flashes frequency was mediated by expectancies for treatment efficacy. A series of simple mediation and conditional process analyses did not support mediation of the relationship between treatment condition and hot flash frequency through response expectancy. The effect of hypnotherapy in reducing hot flashes does not appear to be due to placebo effects as determined by response expectancies. Implications for clinical practice and future research are discussed.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"652-659"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/a1/10.1177_2156587217708523.PMC5871284.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35014012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Duan, Xiao-Lu Wu, Fei Zhao, Rong Zeng, Ke-Hu Yang
{"title":"Induction Effect to Apoptosis by Maitake Polysaccharide: Synergistic Effect of Its Combination With Vitamin C in Neuroglioma Cell.","authors":"Lei Duan, Xiao-Lu Wu, Fei Zhao, Rong Zeng, Ke-Hu Yang","doi":"10.1177/2156587217708524","DOIUrl":"https://doi.org/10.1177/2156587217708524","url":null,"abstract":"<p><p>Polysaccharide extracted from the Maitake mushroom (MP) is considered as a potential anticancer agent. The present study was performed to investigate the cytotoxic effects of MP and vitamin C (VC) alone and in combination on the viability of human neuroglioma M059 K cells in vitro. A combination of MP (1.0 mg/mL) and VC (0.4 mmol/L) led to a 53.10% reduction in cell viability and this treatment induced cell cycle arrest at the G2/M phase, and apoptosis occurred in 38.54% of the cells. Results of Hoechst 33258 staining and Western blot showed apoptotic cells appeared and changes in the expression of apoptosis-related proteins (upregulation of Bax and caspase-3, downregulation of Bcl-2, and activation of poly-(ADP-ribose)-polymerase). Moreover, the activities of caspase-3, caspase-8, and caspase-9 were enhanced in M059 K cells. The inhibiting effect of combined treatment with MP and VC on M059 K cells indicates the mechanism of anticancer activity involved induction of cell apoptosis.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"667-674"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217708524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35014013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Rashidian, Fatemeh Kazemi, Saeed Mehrzadi, Ahmad Reza Dehpour, Shahram Ejtemai Mehr, Seyed Mahdi Rezayat
{"title":"Anticonvulsant Effects of Aerial Parts of Verbena officinalis Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors.","authors":"Amir Rashidian, Fatemeh Kazemi, Saeed Mehrzadi, Ahmad Reza Dehpour, Shahram Ejtemai Mehr, Seyed Mahdi Rezayat","doi":"10.1177/2156587217709930","DOIUrl":"https://doi.org/10.1177/2156587217709930","url":null,"abstract":"<p><p>To evaluate the anticonvulsant activity of the aerial parts of Verbena officinalis used traditionally by local Iranians for the treatment of convulsion. The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizures in mice. Diazepam was used as reference drug. In addition, for investigating the mechanism of V officinalis in PTZ model, flumazenil and naloxone were injected before V officinalis. The extract showed no toxicity and significantly increased the period taken before the onset and decreased the duration of the seizures induced by PTZ. In the MES test, V officinalis displayed significant reduction in hind limb tonic extension duration in a dose-dependent manner. The results propose that V officinalis ethanolic extract has anticonvulsant activity against seizure. It seems that these effects may be related to potentiating of GABAergic system. Moreover, this study supports the use of this plant by local Iranians in order to treat convulsion.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"632-636"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217709930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Postoperative Sore Throat With the Aid of the Homeopathic Remedy Arnica montana: A Report of Two Cases.","authors":"Dionysis Tsintzas, George Vithoulkas","doi":"10.1177/2156587217735986","DOIUrl":"https://doi.org/10.1177/2156587217735986","url":null,"abstract":"<p><p>We present 2 cases of severe postoperative sore throat, hoarseness, aphonia, and dysphagia, after a laryngeal mask insertion, who were treated successfully with the homeopathic remedy Arnica montana. Three doses of Arnica montana 200CH were given to the patients over 36 hours. Although the symptoms were very intense, the remedy was very effective and cleared most of the symptoms in 48 hours.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"926-928"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217735986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35243335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens.","authors":"Mohammadmehdi Fani, Jamshid Kohanteb","doi":"10.1177/2156587217700772","DOIUrl":"https://doi.org/10.1177/2156587217700772","url":null,"abstract":"<p><p>The objective of present investigation was to determine antimicrobial activity of Thymus vulgaris oil on some oral pathogens. Thymus vulgaris oil was prepared by hydrodistillation and tested against 30 clinical isolates of each of Streptococcus pyogenes, Streptococcus mutans, Candida albicans, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans, prepared from related oral infections using agar disk diffusion and broth microdilution methods. Thymus vulgaris oil at concentrations of 16 to 256 μg/mL exhibited strong inhibitory activity on all clinical isolates producing inhibition zones of 7.5 to 42 mm as measured by agar disk diffusion method. Streptococcus pyogenes and Streptococcus mutans were the most sensitive isolates with minimum inhibitory concentrations of 1.9 and 3.6 μg/mL, respectively. The minimum inhibitory concentration values for C albicans, A actinomycetemcomitans, and P gingivalis were 16.3, 32, and 32 μg/mL, respectively.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"660-666"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217700772","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34902516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Mahjoub, Roshanak Salari, Mohammad Reza Noras, Mahdi Yousefi
{"title":"Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.","authors":"Fatemeh Mahjoub, Roshanak Salari, Mohammad Reza Noras, Mahdi Yousefi","doi":"10.1177/2156587217712763","DOIUrl":"https://doi.org/10.1177/2156587217712763","url":null,"abstract":"<p><p>Fibromyalgia and chronic fatigue syndrome are disorders that often occur simultaneously and are characterized by widespread pain and persistent fatigue. The patients are associated with disability and impairment social and physical functions. There are many remedies in traditional Persian medicine suggested for management of the disease complaints. The aim of this study was to investigate the clinical presentations and pathophysiology of disorders with the basic and principal textbook of traditional Persian medicine written by Avicenna ( Canon of Medicine). According to Persian medicine, the term E'aya can be matched by mentioned disorders. Avicenna believed that strenuous activities play an important role in the beginning of some types of fatigue. He classified fatigue into 4 groups, and in each type the clinical symptoms varied. The multifaceted entity of fibromyalgia and chronic fatigue syndrome in Persian medicine and conventional medicine suggests multidisciplinary therapies in management of these disabling disorders.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"1011-1016"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217712763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35074221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tapas K Kundu, Pradip B Barde, Ghanshyam D Jindal, Farooq F Motiwala
{"title":"An Exploratory Study of Autonomic Function Investigations in Hemophiliacs on Homoeopathy Medications Using Impedance Plethysmography.","authors":"Tapas K Kundu, Pradip B Barde, Ghanshyam D Jindal, Farooq F Motiwala","doi":"10.1177/2156587217718750","DOIUrl":"https://doi.org/10.1177/2156587217718750","url":null,"abstract":"<p><strong>Background: </strong>Status of autonomic homoeostasis in hemostasic disturbances due to hemophilia needs to be studied.</p><p><strong>Objectives: </strong>To compare autonomic nervous system markers measured by heart rate variability (HRV) and blood flow variability (BFV) in hemophiliacs and healthy age-matched control population using medical analyzer system.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Settings: </strong>Motiwala Homoeopathy Medical College, and Hemophilia Clinics, Nashik.</p><p><strong>Subjects: </strong>Eighty subjects.</p><p><strong>Interventions: </strong>Nil.</p><p><strong>Outcome measures: </strong>Autonomic function markers for HRV and BFV.</p><p><strong>Results: </strong>Among 80 subjects, BFV time domain measure, root mean square of successive NN (normal-to-normal) interval differences (RMSSD), was significantly higher among hemophiliacs than nonhemophiliacs. Frequency domain analysis parameter, low frequency for both HRV and BFV was significantly higher among hemophiliacs as compared with nonhemophiliacs.</p><p><strong>Conclusions: </strong>Hemophiliacs were shown to have higher autonomic activity as compared with healthy controls. Homoeopathic medicines used as an adjunct was associated with decrease in parasympathetic modulations.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"760-764"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217718750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35180455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christine Tara Peterson, Sarah M Bauer, Deepak Chopra, Paul J Mills, Raj K Maturi
{"title":"Effects of Shambhavi Mahamudra Kriya, a Multicomponent Breath-Based Yogic Practice ( Pranayama), on Perceived Stress and General Well-Being.","authors":"Christine Tara Peterson, Sarah M Bauer, Deepak Chopra, Paul J Mills, Raj K Maturi","doi":"10.1177/2156587217730934","DOIUrl":"https://doi.org/10.1177/2156587217730934","url":null,"abstract":"<p><p>Stress-induced disorders such as anxiety represent the leading causes of adult disability worldwide. Previous studies indicate that yoga and other contemplative practices such as pranayama, or controlled yogic breathing techniques, may be effective in the treatment of mood disorders and stress. In this study, 142 individuals (mean age = 43 years; SD = 13.90) participated in a 3-day retreat program during which they learned Shambhavi Mahamudra kriya, which is a yogic practice that includes both deep breathing and meditation techniques. Participants were instructed to practice the kriya each day for 21 minutes. After 6 weeks of daily practice, participants reported subjectively lower levels of perceived stress (Perceived Stress Scale) and higher levels of general well-being (General Well-Being Scale) compared to baseline. These results support the notion that Shambhavi Mahamudra kriya may represent a natural treatment for stress reduction.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"788-797"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217730934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35331866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Battle of Worldviews: A Case Study of Liver Fluke Infection in Khon Kaen, Thailand.","authors":"Sara Samiphak, S Leonard Syme","doi":"10.1177/2156587217723497","DOIUrl":"https://doi.org/10.1177/2156587217723497","url":null,"abstract":"<p><p>Control efforts to reduce infection from the parasitic flatworm Opisthorchis viverrini have progressed through understanding the epidemiology of Opisthorchis viverrini, antiparasitic drug developments, technological innovations, health education promoting cooking of fish, and improved hygienic defecation. Yet the problem persists. The case study method was used to examine the fundamental cause of the liver fluke infection problem. Evidence shows that the liver fluke-infected population does not care about living a long life. For them, suffering and death are simply a part of life, and expected. Thus, the cause(s) leading to death is not important. They believe morally bad actions, and predetermined fate associated with kamma in Buddhism, play a big role whether or not one is infected with the liver fluke. Health interventions may be made more effective if they take into account the liver fluke-infected population's worldviews about ethics, morality, life, and death. We researchers should not feel concerned only about medically determined causes of death.</p>","PeriodicalId":15804,"journal":{"name":"Journal of Evidence-Based Complementary & Alternative Medicine","volume":"22 4","pages":"902-908"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2156587217723497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}