Journal of Experimental Nanoscience最新文献_第3页

Influence of fuel-to-oxidizer ratio, potential of hydrogen and annealing temperature on the structural and optical properties of nanocrystalline MgO powders synthesized by the hydrothermal method 燃料-氧化剂比、氢电位和退火温度对水热法制备纳米晶MgO粉体结构和光学性能的影响

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-11-03 DOI: 10.1080/17458080.2023.2276278

Bruska Azhdar

{"title":"Influence of fuel-to-oxidizer ratio, potential of hydrogen and annealing temperature on the structural and optical properties of nanocrystalline MgO powders synthesized by the hydrothermal method","authors":"Bruska Azhdar","doi":"10.1080/17458080.2023.2276278","DOIUrl":"https://doi.org/10.1080/17458080.2023.2276278","url":null,"abstract":"Nanocrystalline magnesium oxide powders (MgO) were prepared using a hydrothermal method. In various fuel-to-oxidizer ratios (F/O) and precursor solutions with pH levels from 8 to 12, magnesium nitrate hexahydrate Mg(NO3)2 was utilized as an oxidizer and polyvinyl alcohol (PVA) as a fuel. To improve crystallinity and phase purity, these materials were annealed for two hours at varied temperatures. XRD, FTIR, EDS, FESEM and DRS were used to study the MgO nanopowders’ structure, vibration, elemental and optical properties. The fuel-to-oxidizer ratios, annealing temperatures and pH values greatly affected the samples’ properties. The synthesized powders had a particle size distribution in the range of 18–49 nm. The XRD results showed that the crystallite percent of the MgO phase grew with an increase in the F/O from 0.5 to 0.75, and then, it decreased at F/O = 1. The maximum percent of crystallites was observed at pH = 8. By increasing the annealing temperatures, the crystallite size of the samples increased from 22.82 nm to 49.06 nm, while the specific surface area and dislocation density decreased from 20.59 m2/g to 7.83 m2/g and 0.0006 nm−2 to 0.0001 nm−2, respectively. FTIR spectra results indicated that the MgO band peaking at (418–688 cm−1) was high at pH value 8, then it reduced at pH 10 and finally, this peak had the smallest size at pH = 12. Further confirmation of MgO presence and its homogeneity in the final product was approved through EDS measurements. DRS spectra were used to obtain energy gap using Kubelka–Munk relation and noticed in the range of 5.72–5.89 eV for MgO NPs.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"37 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135820049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-synthesis of silver nanoparticles from Plumeria pudica leaf extract and its application in anti-cancerous activity 鸡蛋花叶提取物合成纳米银及其抗癌活性研究

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-10-26 DOI: 10.1080/17458080.2023.2267183

Sumit K. Shrivastava, Asita Kulshreshtha, Rajesh K. Gangwar, Shikha Srivastava, Abhishek P. Tiwari, Santpal Singh, Saurabh Kumar, Shama Parveen, Monisha Banerjee, Dhirendra K. Chaudhary

{"title":"Phyto-synthesis of silver nanoparticles from Plumeria pudica leaf extract and its application in anti-cancerous activity","authors":"Sumit K. Shrivastava, Asita Kulshreshtha, Rajesh K. Gangwar, Shikha Srivastava, Abhishek P. Tiwari, Santpal Singh, Saurabh Kumar, Shama Parveen, Monisha Banerjee, Dhirendra K. Chaudhary","doi":"10.1080/17458080.2023.2267183","DOIUrl":"https://doi.org/10.1080/17458080.2023.2267183","url":null,"abstract":"In this study, we have developed an environment friendly and novel approach for the synthesis of silver nanoparticles utilising plumeria pudica leaf extract. In this technique, the leaf extract was employed as both a reducing agent for the reduction of a silver nitrate (AgNO3) solution and a capping agent, leading to the synthesis of silver nanoparticles (Ag NPs). The outcomes of these analyses revealed an average particle size of ∼19 nm as determined by SEM, while XRD measurements indicated a crystalline domain size of ∼12 nm and a lattice parameter of approximately 4.087467 Å. Furthermore, the anti-cancer potential of the synthesised silver nanoparticles was evaluated, unveiling an IC50 value of around 28 µM. This suggests that the introduced silver nanoparticles may have triggered apoptosis, consequently inducing cell death. These findings underscore the potential of utilising environmentally benign silver nanoparticles in lung cancer chemotherapy.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization, and analysis of zinc oxide nanoparticles using varying pulsed laser ablation energies in liquid 利用不同脉冲激光烧蚀能量在液体中合成、表征和分析氧化锌纳米颗粒

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-10-17 DOI: 10.1080/17458080.2023.2175817

Tahani H. Flemban

引用次数: 0

Machine learning aided evaluation and design based on polymer membrane materials 基于高分子膜材料的机器学习辅助评估与设计

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-10-17 DOI: 10.1080/17458080.2023.2170356

Jianfeng Liao

{"title":"Machine learning aided evaluation and design based on polymer membrane materials","authors":"Jianfeng Liao","doi":"10.1080/17458080.2023.2170356","DOIUrl":"https://doi.org/10.1080/17458080.2023.2170356","url":null,"abstract":"With the acceleration of the global modern industrialisation process and the increasingly serious environmental problems, the development of low energy consumption, high efficiency electrochemical energy conversion equipment and separation system has become a research hotspot in the scientific and industrial circles. At present, machine learning has become an important research method to explore and expand two-dimensional material family. Traditional experimental and computational methods have low fault tolerance when studying two-dimensional materials, which requires a lot of time and research and development costs. Machine learning, due to its powerful data processing capability and flexible algorithm model, can help reduce the time and cost of discovering and understanding two-dimensional materials, and can effectively predict and expand two-dimensional material systems based on data and explore their potential for experimental synthesis and application. This paper will focus on the methods of machine learning, the exploration of machine learning in 2D material design and synthesis, and the exploration of machine learning in 2D material properties and applications. Finally, this paper uses ML algorithm to test the synthesised polymer. The experimental data points and prediction data points have relatively good consistency with each other, which indicates that ML model can be used as a prediction tool to identify the undeveloped polymer for gas separation.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136037761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular docking and molecular dynamics simulations reveal the clinical resistance of the gatekeeper mutation V564F of FGFR2 against Infigratinib 分子对接和分子动力学模拟揭示了FGFR2的看门人突变V564F对Infigratinib的临床耐药性

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-10-05 DOI: 10.1080/17458080.2023.2264521

Guodong Zheng, Wuxia Liu, Qian Zhang, Tuo Shen, Jingfeng Zhang, Lei Jiang, Wenqi Liang, Bin Zhou, Ling Liu, Shenqian Xu, Minyu Li

{"title":"Molecular docking and molecular dynamics simulations reveal the clinical resistance of the gatekeeper mutation V564F of FGFR2 against Infigratinib","authors":"Guodong Zheng, Wuxia Liu, Qian Zhang, Tuo Shen, Jingfeng Zhang, Lei Jiang, Wenqi Liang, Bin Zhou, Ling Liu, Shenqian Xu, Minyu Li","doi":"10.1080/17458080.2023.2264521","DOIUrl":"https://doi.org/10.1080/17458080.2023.2264521","url":null,"abstract":"Fibroblast growth factor receptor 2 (FGFR2), as a transmembrane receptor tyrosine kinase, is implicated in a plethora of human cancers, including intrahepatic cholangiocarcinomas, breast cancers, and non-small cell lung cancer. The clinically relevant V564F gatekeeper mutation conferred resistance to current FGFR2 drug − Infigratinib. In this study, the protein − ligand interactions between FGFR2 kinase domain (wild-type and V564F) and Infigratinib were compared through an integrated computational method. The multiple, large-scale molecular dynamics (MD) simulations, together with dynamic cross-correlation analysis and binding free energy calculations suggested that the resistant mutation may not trigger the conformational changes of the FGFR2 kinase domain. The simulation results also indicated that the driving force to decrease the binding affinity of Infigratinib to the FGFR2 V564F variant derived from the difference in the protein − ligand hydrogen bonding interactions. Moreover, the per-residue free energy decomposition analysis revealed that the reduced contributions from several residues in the ATP-binding site of FGFR2, especially Glu565 and Ala567 located at the kinase hinge domain, were the key residues responsible for the loss of binding affinity of Infigratinib to the V564F variant. This study may offer useful information for the design of novel selective kinase inhibitors targeting FGFR2.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"301 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise construction of Regorafenib-loaded gold nanoparticles: investigation of antiproliferative activity and apoptosis induction in liver cancer cells 瑞非尼负载金纳米颗粒的精确构建:肝癌细胞的抗增殖活性和诱导凋亡的研究

4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-09-11 DOI: 10.1080/17458080.2023.2254006

Meng Yue, Rui Yang, Yakun Jiang, Xiuhua Yang

{"title":"Precise construction of Regorafenib-loaded gold nanoparticles: investigation of antiproliferative activity and apoptosis induction in liver cancer cells","authors":"Meng Yue, Rui Yang, Yakun Jiang, Xiuhua Yang","doi":"10.1080/17458080.2023.2254006","DOIUrl":"https://doi.org/10.1080/17458080.2023.2254006","url":null,"abstract":"Regorafenib (Reg) inhibits the growth of liver cancer cells in vitro and animal model. However, due to its poor bioavailability, its potential as a chemopreventive or therapeutic drug is severely restricted. In this work, we developed two environmentally friendly delivery systems by synthesizing Regorafenib-gold nanoparticles conjugates Reg@GNPs1 and Reg@GNPs2, employing a dual role of Reg to reduce Au3+ and stabilize the synthesized GNPs. UV-Vis’s spectroscopy, Fourier transform infrared spectroscopy, and Powder-XRD verified the fabrication of Reg@GNPs. Reg@GNPs1 and Reg@GNPs2 were both found to be spherical and uniform in size (10 ± 2 and 2 ± 33 nm, respectively) using transmission electron microscopy. Similar negative zeta potential (−35.0 ± 2.5 and −37.0 ± 1.6 mV) was observed by dynamic light scattering analysis, even though the hydrodynamic diameter of the nanoconjugates ranged from 65.0 ± 1.7 to 153.0 ± 2.2 nm. Reg@GNPs1 and Reg@GNPs2 were calculated to have a Reg loading of 46% and 48%, respectively. Selectivity towards the non-cancerous cell line (L929) cells, whereas the MTT assay in vitro showed the antiproliferative effects of Reg@GNPs on three liver carcinoma (Hep3B, BEL7402, and HepG2) cell lines. Several fluorescent staining techniques were used to examine liver cancer cell morphology. Flow cytometric analysis confirmed that the effects of the superior Reg@GNPs nanoconjugate on cell proliferation than free Reg. In conclusion, the acquired results show that the novel synthesized GNPs loaded with Reg are stable as an anticancer agent, with minimal toxicity against non-cancerous cells, as determined by cytotoxicity and IC50 evaluations.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135980848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dillenia indica bark extract mediated bio-fabrication of copper nanoparticles: characterisation, antioxidant and anticancer activity in vitro 洋地黄皮提取物介导的纳米铜的生物制备：表征、抗氧化和抗癌活性

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-08-26 DOI: 10.1080/17458080.2023.2249241

Larica Mohanta, B. S. Jena

引用次数: 0

Sustainable mechanical properties evaluation for graphene reinforced Epoxy/Kevlar fiber using MD simulations 基于MD模拟的石墨烯增强环氧树脂/凯夫拉纤维可持续力学性能评价

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-08-25 DOI: 10.1080/17458080.2023.2246662

N. Chaudhary, Mithilesh K. Dikshit, C. L. Kumar, Pankaj Sonia, V. Pathak, K. K. Saxena, S. S. Hamid, N. U. Salmaan

引用次数: 1

One-pot construction of gemcitabine loaded zeolitic imidazole framework for the treatment of lung cancer and its apoptosis induction 吉西他滨负载沸石咪唑治疗肺癌的单点构建及其诱导细胞凋亡

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-08-12 DOI: 10.1080/17458080.2023.2241997

Zhan Li, Tiantian Du, Wen Yang, S. Yi, Na Zhang

引用次数: 0

Facile engineering of chitosan-coated aminopterin loaded zeolitic imidazolate framework: promising drug delivery system for breast cancer 壳聚糖-氨基蝶呤负载沸石-咪唑酸盐框架的简易工程化：乳腺癌症有前途的药物递送系统

IF 2.8 4区材料科学

Journal of Experimental Nanoscience Pub Date : 2023-08-08 DOI: 10.1080/17458080.2023.2238129

Limin Zhu, Shuangyan Wang

引用次数: 0