Journal of Data Mining in Genomics & Proteomics最新文献

{"title":"Proteomics Study of the Effect Left Atrial Appendage Resection on theEnergy Metabolism of Atrial Muscle in Beagle Dogs with Rapid Atrial Pacing","authors":"Chang Jing, Xing Yue, Na Lin, Cui Wenjing, Yu Ting, Xue Xin","doi":"10.35248/2153-0602.21.S7.003","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S7.003","url":null,"abstract":"Aims: The myocardial energy metabolism during Atrial Fibrillation (AF) a research hotspot. Proteomics provides a new method for the study of atrial fibrillation; however, there are no related studies of the effect of the Left Atrial Appendage (LAA) on the energy metabolism of the atrial muscle. We use proteomics to analyze the effect of resection of the LAA on the energy metabolism of the left atrial myocardial cells in beagle dogs with rapid atrial pacing. \u0000 \u0000Methods: Nine beagle dogs were divided into three groups: the model group (rapid atrial pacing/LAA resection), the positive control group (rapid atrial pacing/LAA preservation), and the negative control group (sinus rhythm). Twelve weeks later, the atrial tissues were resected for proteomics study. Parallel Reaction Monitoring (PRM) was used for the validation of the targeted proteomics. \u0000 \u0000Results: 55 proteins were up regulated and 68 proteins were down regulated in the experimental vs. the positive control group. Proteins related to glucose and lipid metabolism were mainly down regulated, and mitochondria- related proteins were mainly down regulated during rapid atrial pacing compared with sinus rhythm. After resection of the LAA, glucose-metabolism-related proteins showed a significant up regulation trend, lipid metabolism-related proteins were further down regulated, whereas mitochondria-related proteins were up regulated compared with rapid atrial pacing with LAA preservation. PRM confirmed the reliability of the proteomics results. \u0000 \u0000Conclusion: In the setting of AF, the resection of the LAA had a relatively large effect on the energy metabolism structure by affecting the quantity and functions of mitochondria.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"14 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86727969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effect Analysis of Tuina Manipulations in the Treatment of Insomnia and Itraq Quantitative Proteome Analysis","authors":"Jingjie Zhou, B. Cao, Meng-Jiun Wei, Yuanfeng Xiong, Wan-gang Liu, Li Zhu, Yan Zhao","doi":"10.35248/2153-0602.21.S7.001","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S7.001","url":null,"abstract":"Introduction: Insomnia, one of the most common mental disorders, not only affects the quality of life, but also damages physical and mental health. Therefore, it is very necessary to explore the molecular mechanism of insomnia and find some suitable treatments. At present, methods of using drugs to treat insomnia are not satisfactory due to lack of evidences and side effects. Hence, development of non-drug treatments is particularly important. Tuina manipulations, a Chinese massage method, has achieved certain therapeutic effects on injuries, rheumatism, neurological diseases and other types of diseases. We have treated patient with insomnia by Tuina manipulations, and obtained therapeutic effects indeed. Methods: In the current study, assessments were performed using the Pittsburgh Sleep Quality Index (PSQI) and the insomnia severity index (ISI). iTRAQ (isobaric Tags for Relative and Absolute Quantitation) quantitative proteomics was used to analyze plasma samples taken from the Healthy Control (HC) group, insomnia patients group (before Tuina treatment, BTT) and insomnia-therapy group (after Tuina treatment, ATT) to identify the molecular correlation of insomnia. Results: The results showed that the PSQI score and ISI score of the ATT group were significantly lower than those of BTT, and the difference was statistically significant. In addition, the proteomics results show that in BTT vs. HC, the expression of many immune-related and stress-related proteins is out of control, the expression of many immune-related and stress-related proteins were out of control, and it revealed that Tuina manipulations had the capacities to regulate expression of immune-related and stress-related proteins in ATT vs. BTT, suggesting that Tuina manipulations may improve insomnia by regulating immune-related and stress-related proteins. The proteomics verification results had been verified by commercial ELISA (Enzyme Linked Immunosorbent Assay. Conclusion: All in all, our study not only found a good way to treat insomnia, but also provided a research foundation for improving insomnia.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"55 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86837719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Changes in Microbiome Composition and Genomic Functional Potentials in Bovine Mastitis","authors":"M. N. Hoque, M. Sultana, M. Hossain","doi":"10.35248/2153-0602.21.12.232","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.232","url":null,"abstract":"We provide a mini review on the previously published study entitled “Microbiome Dynamics of Bovine Mastitis Progression and Genomic Determinants”, where we reported the possible dynamic changes in microbiome compositions favored by their genomic functional potentials in different pathophysiological states of bovine mastitis. Using the cutting-edge whole metagenome sequencing (WMS) approach, we reported distinct variation in microbiome composition and abundances across the clinical mastitis (CM), recurrent clinical mastitis (RCM), subclinical mastitis (SCM) and healthy (H) milk metagenomes (CM>H>RCM>SCM). Bacteria were the predominating microbial domain (>99.0% relative abundance) followed by archaea and viruses. Dynamic changes in bacteriome composition across the four metagenomes were numerically dominated by 67.19% inclusion of previously unreported opportunistic strains in mastitis metagenomes. This study also reported the unique and shared distribution of microbiomes across these metagenomes. In addition to microbiome composition and diversity, the study reported the association of several virulence factors-associated genes (VFGs), and antibiotic resistant genes (AGRs) in CM, RCM, SCM, and H-microbiomes. Functional annotation detected several metabolic pathways related to different episodes of mastitis. Therefore, the published data revealed that changes in microbiome composition in different types of mastitis, concurrent assessment of VFGS, ARGs, and genomic functional potentials can contribute to develop microbiome-based diagnostics, and therapeutics for mastitis, and carries significant implications on curtailing the economic fallout from this disease","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"70 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83872477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Health and Education to Improve the Human Capital Index in Indonesia","authors":"Frans Salesman","doi":"10.35248/2153-0602.21.S6.003","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S6.003","url":null,"abstract":"Objectives: To analyze the position Indonesia's HCI compared to ASEAN countries in terms of the quality of health and education Study design: Analyzing secondary data published by the World Bank on the calculation HCI in 2018, Basic Health Research Report 2018 from the Indonesian Ministry of Health, Publication the Central Bureau of Statistics, various international research reports. The validity of interpreting numbers through deducto verificato which has scientific truth because it passes through the stages of scientific methodology that are generally accepted in the world of science. Principal findings: Acquisition of HCI in 2018; Singapore 0.90, Vietnam 0.67, Malaysia 0.65, Thailand 0.61, Philippines 0.58, Indonesia 0.55, Camboja 0.49, Myanmar 0.49, Timor Leste 0.47, and Laos 0.46. Indonesia's position is in 6th place among ASEAN Countries, above Cambodia, Myanmar, Timor Leste, and Laos. This means that children born in Singpura have the opportunity to utilize their abilities to generate an income of 0.90, while every child born in Indonesia only has 55% of the resources to manage available opportunities. The remaining 0.45% is used as idle capacity. The remaining capacity is probably due to low supply of nutrition, growth and development constraints, low Quality Adjusted Life Year due to various diseases, low access to modern health services, low quality of classroom learning, and low purchasing power which is robbing the poor. Conclusion: Increasing HCI in Indonesia needs to be a serious concern of the Government, religious and social institutions, international agencies, communities, and families so that Indonesian people can compete in the 4.0 era.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"29 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90059693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression and Its Mechanism","authors":"Corder Christine","doi":"10.35248/2153-0602.21.S7.E003","DOIUrl":"https://doi.org/10.35248/2153-0602.21.S7.E003","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"1 1","pages":"0-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89774874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scope and Fundamentals of Data Mining","authors":"James Lyons Weiler","doi":"10.35248/2153-0602.21.12.235","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.235","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"19 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89232898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA polymerase an enzyme responsible for copying DNA sequence","authors":"Rishika Meadwle","doi":"10.35248/2153-0602.21.12.E131","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.E131","url":null,"abstract":"A record factor and its related record middle person complex should be joined to a DNA restricting site called an advertiser locale before RNAP can start the DNA loosening up at that position. RNAP not just starts RNA record, it additionally controls the nucleotides into position, encourages connection and stretching, has inherent editing and substitution capacities, and end acknowledgment ability. In eukaryotes, RNAP can fabricate chains as long as 2.4 million nucleotides.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"61 1","pages":"0-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85136653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial on Bioinformatics Tools and Techniques for Data Mining","authors":"M. Simonian","doi":"10.35248/2153-0602.21.12.E130","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.E130","url":null,"abstract":"Journal of Data Mining in Genomics and Proteomics (JDMGP) gives quick publication of articles in all interdisciplinary fields of science, identified with genomics and proteomics, data mining applications in genomics and proteomics, genomic data warehousing, data algorithms, computational drug design, genome mapping, proteogenomics, metagenomics, Annotation of genomics, proteomics modeling, bioinformatics.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"3 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73908643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disconnected Limitation Catalysts are Utilized to Control DNA for Various Logical Applications","authors":"Peter B. Stoekweil","doi":"10.35248/2153-0602.21.12.242","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.242","url":null,"abstract":"","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"34 4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77514642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of NUP62 in the Development of Ovarian Cancer","authors":"C. Yong, Chen Hongyu, Hua Shirong, Fang Xiangqun","doi":"10.35248/2153-0602.21.12.240","DOIUrl":"https://doi.org/10.35248/2153-0602.21.12.240","url":null,"abstract":"Objective: This study aims at exploring the relationship between the universal differentially expressed genes and the development of ovarian cancer, and then we established a biological molecular model for the further biological study. Methods: We selected the universal different expression gene, which have not yet been studied and with more than 60% coverage based on the 69 pairs of matched ovarian cancer and normal expression profiles samples with the directed network, and then analyzing the multidimensional data of NUP62 and miRNA-495. Results: We found that mir-495, which target NUP62, was lower in patients with ovarian cancer. Conclusion: The universal different expression of NUP62 is relevant to proliferation and apoptosis in ovarian cancer.","PeriodicalId":15630,"journal":{"name":"Journal of Data Mining in Genomics & Proteomics","volume":"3 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73878069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}