Journal of electrocardiology最新文献

{"title":"Predictive value of standard electrocardiographic parameters for major adverse cardiovascular events in patients with coronary heart disease: A retrospective cohort study","authors":"Man Yang ,&nbsp;Huan Zhao ,&nbsp;Yajuan Yin ,&nbsp;Xuekun Li ,&nbsp;Yinge Zhan","doi":"10.1016/j.jelectrocard.2026.154200","DOIUrl":"10.1016/j.jelectrocard.2026.154200","url":null,"abstract":"<div><h3>Background</h3><div>Accurate risk stratification is crucial for managing patients with coronary heart disease (CHD). This study aimed to investigate the value of baseline electrocardiogram (ECG) indicators in predicting one-year major adverse cardiovascular events (MACE) in patients with CHD.</div></div><div><h3>Methods</h3><div>This single-center, retrospective cohort study enrolled 200 hospitalized patients with a confirmed CHD diagnosis. Baseline demographic, clinical, echocardiographic, and 12-lead ECG data were collected. The primary endpoint was the occurrence of MACE (a composite of cardiac death, non-fatal acute MI, severe arrhythmia, severe heart failure, and stroke) within one year. Univariate and multivariable logistic regression analyses were performed to identify independent ECG predictors, with predictive performance evaluated using receiver operating characteristic (ROC) curve analysis.</div></div><div><h3>Results</h3><div>During a one-year follow-up, 29 of 200 patients (14.5%) experienced a MACE. Patients with MACE had significantly worse baseline cardiac function, including lower left ventricular ejection fraction (LVEF) and higher E/e' ratio. In multivariable analysis, higher resting heart rate (OR per 10 bpm: 1.54, 95% CI: 1.09-2.17, P=0.014), longer QRS duration (OR per 10 ms: 1.69, 95% CI: 1.16-2.47, P=0.006), and longer corrected QT (QTc) interval (OR per 10 ms: 1.63, 95% CI: 1.23-2.15, P&lt;0.001) were independent predictors of MACE. A combined model integrating these three parameters demonstrated excellent predictive accuracy (AUC=0.85, 95% CI: 0.78-0.92), superior to any single parameter. The QTc interval was the best single predictor (AUC=0.79).</div></div><div><h3>Conclusion</h3><div>Higher resting heart rate, longer QRS duration, and longer QTc interval are independent and powerful predictors of one-year MACE in patients with CHD. A combined model using these simple ECG markers provides robust risk stratification, offering significant incremental predictive value over baseline clinical factors.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154200"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic repolarization changes following conduction system pacing in pacemaker-induced cardiomyopathy","authors":"Ahmet Taha Sahin ,&nbsp;Ugur Canpolat ,&nbsp;Muhammet Dural ,&nbsp;Mert Dogan ,&nbsp;Gurbet Ozge Yunus ,&nbsp;Istiklal Ozkaya ,&nbsp;Serhat Kesriklioglu ,&nbsp;Meltem Uyaner Kan ,&nbsp;Ahmet Lutfu Sertdemir ,&nbsp;Enes Elvin Gul MD","doi":"10.1016/j.jelectrocard.2026.154197","DOIUrl":"10.1016/j.jelectrocard.2026.154197","url":null,"abstract":"<div><h3>Background</h3><div>Pacemaker-induced cardiomyopathy (PICM) occurs in a subset of patients exposed to chronic right ventricular pacing (RVP) and results in left ventricular dysfunction due to pacing-related dyssynchrony. Left bundle branch area pacing (LBBAP) has emerged as a physiologic pacing strategy capable of restoring conduction system activation and reversing PICM. However, the acute effects of LBBAP on ventricular repolarization in PICM remain unclear. This study evaluated immediate repolarization changes after LBBAP in PICM compared with a control cohort of non-ischemic dilated cardiomyopathy (DCM) patients undergoing LBBAP.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed clinical, electrocardiographic, and pacing data from patients receiving successful LBBAP. Baseline and post-implant ECG intervals (QT, QTc, Tp–Te) were manually measured; T-wave memory (TWM) was qualitatively assessed. Procedure parameters (RWPT, V6–V1 interpeak interval, output-dependent QRS transition), procedural success, and complications were recorded.</div></div><div><h3>Results</h3><div>Sixty patients were included (28 PICM vs. 32 DCM). Baseline LVEF was higher in patients with PICM compared to DCM (35 ± 8% vs. 29 ± 7%; <em>p</em> = 0.003). LBBAP success was similar (93% vs. 96%). PICM patients had wider paced QRS (149 ms vs. 128 ms; <em>p</em> = 0.02) and longer V6–V1 interval (46 ± 12 vs. 38 ± 10 ms; p = 0.02), but repolarization metrics showed no adverse changes and remained comparable between groups. QT shortened similarly (PICM: 476 → 437 ms; DCM: 466 → 432 ms), QTc minimally increased without group interaction, Tp–Te decreased, and TWM was frequent in both cohorts (63% vs. 64%). Complications rate was also comparable.</div></div><div><h3>Conclusion</h3><div>LBBAP does not induce unfavorable acute repolarization changes in PICM and yields repolarization responses comparable to DCM controls, supporting its safety and physiologic benefit in PICM upgrades.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154197"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic atrial cardiomyopathy markers in sinus rhythm and the risk of incident atrial fibrillation and ischemic stroke a retrospective cohort study","authors":"Sefa Erdi Ömür MD,&nbsp;Çağrı Zorlu MD,&nbsp;Gülşen Genç Tapar MD,&nbsp;Kayıhan Karaman MD,&nbsp;Metin Karayakali MD,&nbsp;Ataç Çelik MD","doi":"10.1016/j.jelectrocard.2026.154208","DOIUrl":"10.1016/j.jelectrocard.2026.154208","url":null,"abstract":"<div><h3>Background</h3><div>Electrocardiographic (ECG) markers of atrial cardiomyopathy obtained in sinus rhythm may help identify outpatients at increased risk of incident atrial fibrillation (AF) and related adverse outcomes.</div></div><div><h3>Aim</h3><div>To evaluate the associations of P-wave terminal force in lead V1 (PTFV1) and deep terminal negativity of the P wave in V1 (DTNPV1) with incident AF and clinical outcomes in a contemporary outpatient cohort.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of consecutive adults undergoing clinically indicated outpatient 12‑lead ECG in sinus rhythm between September 2022 and September 2025. Abnormal PTFV1 was defined as ≥4000 μV·ms and DTNPV1 as a biphasic P wave in V1 with terminal negative amplitude &gt;100 μV. The primary endpoint was incident AF, defined as the first new AF episode after the index ECG requiring objective rhythm documentation on a 12‑lead ECG/rhythm strip or ambulatory monitor report (≥30 s); diagnostic codes alone were not sufficient. Secondary endpoints were incident ischemic stroke/TIA, heart failure (HF) hospitalization, all-cause mortality, and a composite outcome. Associations were assessed using Cox proportional hazards models with prespecified multivariable adjustment.</div></div><div><h3>Results</h3><div>The final cohort included 1500 patients; 400 (26.7%) had abnormal PTFV1. Over a median follow-up of 3.2 years, incident AF occurred in 301 patients (20.1%). AF incidence was higher in the abnormal vs normal PTFV1 groups (31.0% vs 16.1%), and abnormal PTFV1 independently predicted incident AF (adjusted HR 1.35, 95% CI 1.03–1.77). Abnormal PTFV1 was also associated with incident stroke/TIA (7.8% vs 4.0%; adjusted HR 1.34, 95% CI 1.01–1.78), incident HF hospitalization (17.5% vs 10.0%; adjusted HR 1.22, 95% CI 1.01–1.48), and the composite endpoint (37.5% vs 30.0%; adjusted HR 1.28, 95% CI 1.10–1.48). All-cause mortality was numerically higher but not statistically significant after adjustment (6.3% vs 4.5%; adjusted HR 1.35, 95% CI 0.82–2.21). DTNPV1 was not independently associated with incident AF after adjustment.</div></div><div><h3>Conclusion</h3><div>In outpatients with sinus-rhythm ECGs, abnormal PTFV1 is independently associated with higher risk of incident AF and other clinically relevant outcomes, supporting its potential role in targeted rhythm surveillance and risk stratification.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154208"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new and modified northern occlusion myocardial infarction pattern","authors":"Honglin Ni ,&nbsp;Xiao Wan ,&nbsp;Ting Shi ,&nbsp;Zhicheng Gao ,&nbsp;Haihua Pan","doi":"10.1016/j.jelectrocard.2026.154212","DOIUrl":"10.1016/j.jelectrocard.2026.154212","url":null,"abstract":"<div><h3>Background</h3><div>Currently, it is challenging to identify atypical occlusive myocardial infarction (OMI) in clinical practice.</div></div><div><h3>Objective</h3><div>To analyze and discuss the potential electrocardiogram (ECG) manifestations of the recently proposed Northern occlusive myocardial infarction (Northern OMI) in the context of acute coronary syndrome (ACS), as well as the associated vessel types.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of clinical data from patients who exhibited ST-segment elevation (STE) in leads aVR and aVL on electrocardiography over the past 18 months. Patients with typical ECG manifestations associated with ST-segment elevation occlusive myocardial infarction (STE-OMI) were excluded. All included patients underwent emergent coronary angiography to confirm the presence of coronary artery lesions.</div></div><div><h3>Results</h3><div>A total of 9 patients with STE in leads aVR and aVL were included in the study. Their ECG findings did not fully meet the current diagnostic criteria for Northern OMI. Among these patients, 8 were diagnosed with OMI, with culprit vessels involving both single-vessel and multivessel lesions, 7 received timely coronary intervention treatment and 1 declined coronary intervention owing to advanced age and comorbidities, opting instead for conservative treatment. The remaining case was attributed to acute brainstem hemorrhage, timely therapeutic intervention was administered.</div></div><div><h3>Conclusion</h3><div>The current diagnostic model for Northern OMI may have limitations. This study proposes an modified diagnostic criterion characterized by ST-segment elevation in leads aVR and aVL, accompanied by reciprocal ST-segment depression (STD) in at least leads II, III, and aVF.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154212"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic assessment of ventricular repolarization variables in patients with wild-type transthyretin amyloid cardiomyopathy","authors":"Mustafa Yenerçağ ,&nbsp;Metin Çoksevim ,&nbsp;Mustafa Kürşat Şahin ,&nbsp;Serkan Sivri ,&nbsp;Faruk Boyaci ,&nbsp;Güney Erdogan ,&nbsp;Berkant Öztürk ,&nbsp;Mustafa Yilmaz ,&nbsp;Mustafa Berkay Yilmaz","doi":"10.1016/j.jelectrocard.2025.154183","DOIUrl":"10.1016/j.jelectrocard.2025.154183","url":null,"abstract":"<div><h3>Introduction</h3><div>Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is a progressive infiltrative cardiomyopathy characterized by extracellular deposition of misfolded transthyretin protein. This condition has been associated with an increased risk of ventricular arrhythmias. Electrocardiographic repolarization indices such as Tp-e interval and Tp-e/QT ratios are emerging as markers of arrhythmic risk. This study aimed to evaluate ventricular repolarization parameters in ATTRwt-CM patients compared to healthy individuals.</div></div><div><h3>Methods</h3><div>95 newly diagnosed ATTRwt-CM patients and 95 age- and sex-matched healthy controls were enrolled between August 2023 and August 2025. Electrocardiographic parameters, including Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios, were measured. Left ventricular mass index (LVMI), left atrial volume index (LAVI), and left ventricular diastolic function parameters were evaluated via echocardiography.</div></div><div><h3>Results</h3><div>The Tp-e interval (81.7 ± 4.6 ms vs. 71.1 ± 5.7 ms; <em>p</em> &lt; 0.001), Tp-e/QT ratio (0.21 ± 0.01 vs. 0.19 ± 0.02; p &lt; 0.001), and Tp-e/QTc ratio (0.18 ± 0.01 vs. 0.17 ± 0.01; p &lt; 0.001) were significantly prolonged in the ATTRwt-CM group. A significant positive correlation was observed between Tp-e indices and LVMI, LAVI, mean E/e' ratio, and NT-proBNP levels.</div></div><div><h3>Conclusion</h3><div>Our study showed that Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio, which are evaluated electrocardiographically in patients with ATTRwt-CM, were prolonged compared with normal healthy individuals. A positive correlation was determined between repolarization parameters and markers of myocardial remodeling. We believe that pre-treatment evaluation of repolarization parameters in ATTRwt-CM patients would be beneficial for predicting ventricular arrhythmia risk.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154183"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145940569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal R-peak detection using a swin transformer network with dynamic encoding and parallel decoding","authors":"S.R. Breesha ,&nbsp;S.S. Vinsley ,&nbsp;M. Nisha","doi":"10.1016/j.jelectrocard.2025.154176","DOIUrl":"10.1016/j.jelectrocard.2025.154176","url":null,"abstract":"<div><div>The FHR Detection employing dynamic encoding and parallel decoding swin transformer-based fetal R-peak detection network (DPSTFR-Net) was developed to address this issue. A cascaded Sparse Low-Rank and Kernel Recursive Least Squares (CSKL) filter is used to pre-process the input signals in order to eliminate high-frequency noise and baseline interference. DPSTFR-Net with adaptive position encoding is used to combine the position information of multiple receptor fields in order to perform the binary classification. Additionally, the parallel decoder's contextual information is used to reduce the impact of incorrectly categorized data points. Accuracy, precision, Mean Average Error (MAE), and other metrics are assessed using the PhysioNet/Computing in Cardiology Challenge database (PCDB) and the abdominal and direct fECG database (ADFECGDB). The proposed approach obtained 97.02 % accuracy, 98.25 % precision, 97.35 % recall, 97.28 % F1-score, 0.10 TNR, 0.55 FPR, and 0.56 MAE on the PCDB dataset. The approach obtained 97.52 % accuracy, 98.25 % precision, 97.05 % recall, 97.28 % F1-score, 0.09 TNR, 0.60 FPR, and 0.66 MAE for the ADFECGDB dataset. The outcomes of the experiment show that the proposed method is capable of effectively estimating FHR from abdominal ECG data. Commercial applications, such as long-term maternal and fetal monitoring systems, can use the proposed paradigm.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154176"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145870488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward self-validating ECG Systems: A personalized, uncertainty-aware approach for detecting and estimating lead misplacement","authors":"Alireza Rafiei ,&nbsp;Trisha Dwivedi ,&nbsp;Joel Xue ,&nbsp;Daphne E. Schlesinger ,&nbsp;Nasim Katebi ,&nbsp;David E. Albert ,&nbsp;Gari D. Clifford","doi":"10.1016/j.jelectrocard.2026.154204","DOIUrl":"10.1016/j.jelectrocard.2026.154204","url":null,"abstract":"<div><h3>Background:</h3><div>Electrode positioning directly influences the interpretation and diagnostic quality of ECG recordings. While current solutions mainly focus on detecting lead swaps in standard full-lead configurations, the growing adoption of portable and reduced-lead devices underscores the need for effective methods to identify and quantify electrode misplacement in various settings.</div></div><div><h3>Methods:</h3><div>We developed and evaluated an end-to-end, personalized, uncertainty-aware framework that took ECG waveforms as input and automatically detected and estimated potential electrode misplacement, using an annotated dataset of 4608 Mayo Clinic 12-lead ECGs. The pipeline combined a deep convolutional encoder to identify the lead source area with a regression head that leveraged the learned representation to estimate misplacement direction and magnitude. It also incorporated patient-specific ECG morphology for personalization and integrated an uncertainty quantification mechanism based on Monte Carlo dropout to enhance decision confidence.</div></div><div><h3>Results:</h3><div>The proposed method achieved over 94% classification accuracy in detecting the lead source area and estimated lead misplacement with a mean absolute error (MAE) of 2.2 cm. Incorporating personalized information enhanced results, reaching 97.5% accuracy and an MAE of 2.0 cm, while also largely maintaining performance for ECG determinations such as myocardial infarction and atrial fibrillation. The uncertainty-aware layer further reduced false corrections by flagging unfamiliar or ambiguous cases, boosting accuracy to 98.6% and lowering the MAE to 1.8 cm.</div></div><div><h3>Conclusion:</h3><div>This study introduced a practical solution to improve ECG lead placement accuracy, enabling self-validating lead positioning that can enhance diagnostic reliability and support broader adoption of ECG technology in both clinical and decentralized care.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"95 ","pages":"Article 154204"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic criteria for silent myocardial infarction: Impact of different definitions on detection rates and prognostic significance in the atherosclerosis risk in communities (ARIC) study: A comparison with evolving bundle branch blocks","authors":"R. Brandon Stacey MD, MS ,&nbsp;Ronald J. Prineas MD, PhD ,&nbsp;Zhu-Ming Zhang MD, MPH ,&nbsp;Bruce M. Psaty MD, PhD ,&nbsp;Wayne Rosamond PhD ,&nbsp;Lynne Wagenknecht DrPH ,&nbsp;Elsayed Z. Soliman MD, MSc, MS","doi":"10.1016/j.jelectrocard.2025.154174","DOIUrl":"10.1016/j.jelectrocard.2025.154174","url":null,"abstract":"<div><h3>Introduction</h3><div>It is unclear how differences in the electrocardiographic (ECG) definition of myocardial infarction (MI) impact detection rates and prognostic significance of silent MI (SMI).</div></div><div><h3>Methods</h3><div>This analysis included 9188 participants (57.4 % women, 20 % black, age 62.6 ± 6.0 years) enrolled in the Atherosclerosis Risk in Communities study who had serial ECGs obtained between visit 1 (1987–1989) and visit 4 (1996–1998). Exclusions included known cardiovascular disease (CVD) prior to visit 1, ECG findings of MI or bundle branch block (BBB) at visit 1, or an adjudicated fatal and non-fatal MI events between visits 1 and 4. Using the Minnesota Code (MC) ECG Classification and in the absence of adjudicated MI, the following SMI definitions were derived: Standard MC MI [major Q-wave abnormality, or minor Q-wave abnormality plus major ST/T abnormality], only major Q-wave abnormality, standard significant serial Q-wave changes [Q1 to Q7], expanded MC serial Q-wave changes[Q1 to Q8], standard MC significant serial Q-wave changes or Standard MC significant serial ST/T changes, and evolving MC BBB. Cox proportional hazard models were used to examine the association of different definitions of SMI (compared to no new MI or evolving BBB) with fatal or non-fatal MI events ascertained after visit 4 until December 2016.</div></div><div><h3>Results</h3><div>The prevalence of SMI ranged from 0.6 % to 7.0 % depending on the ECG criteria defining SMI. Presence of SMI was predictive of fatal/non-fatal MI regardless of the definition but with varying levels of association. Standard MC expanded serial Q-wave changes had the strongest adjusted relationship [Hazard Ratio: 2.53 (95 % Confidence Interval (CI): 1.60–4.01)] while evolving BBB had the weakest adjusted association [HR: 1.39 (95 % CI: 0.80–2.40)].</div></div><div><h3>Conclusions</h3><div>The prevalence and prognostic significance of SMI are impacted by the ECG criteria defining MI. A uniform approach(s) for detection of SMI in population studies which builds on the available standard definitions that fit different research scenarios is needed.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"94 ","pages":"Article 154174"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise practice and short-QT interval on ECG","authors":"Giuseppe Mascia ,&nbsp;Josep Brugada ,&nbsp;Elena Arbelo ,&nbsp;Andrea Minghini ,&nbsp;Lorenzo Bianchi ,&nbsp;Luca Barca ,&nbsp;Nicola Pierucci ,&nbsp;Cinzia Monaco ,&nbsp;Paolo Di Donna ,&nbsp;Italo Porto","doi":"10.1016/j.jelectrocard.2025.154173","DOIUrl":"10.1016/j.jelectrocard.2025.154173","url":null,"abstract":"<div><div>A short-QT interval is a potential electrocardiographic finding, while short-QT syndrome (SQTS) is a rare, inherited channelopathy characterized by pathological shortening of the action potential duration leading to an increased risk of life-threatening arrhythmias. In contrast to the long QT syndrome (LQTS), data on the prevalence, diagnosis, risk stratification, treatment and prognosis of short-QT syndrome are scarce. Understanding the true risk of adverse events in exercise population or sporting activities by the patient with short-QT on 12‑leads electrocardiogram is complex: here, we summarize current knowledge and raise questions regarding the challenging relationship between the difficult SQTS diagnosis and exercise practice.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"94 ","pages":"Article 154173"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of non-alcoholic fatty liver disease with arrhythmic disorders and electrocardiogram traits: A Mendelian randomization study","authors":"Panji Wang ,&nbsp;Ruixia Yuan ,&nbsp;Yuan Meng ,&nbsp;Hengdao Liu ,&nbsp;Shenzhen Gong ,&nbsp;Zhaowei Sun ,&nbsp;Hailong Tao","doi":"10.1016/j.jelectrocard.2025.154158","DOIUrl":"10.1016/j.jelectrocard.2025.154158","url":null,"abstract":"<div><h3>Introduction</h3><div>Observational studies indicate a link between arrhythmias, electrocardiogram (ECG) characteristics, and non-alcoholic fatty liver disease (NAFLD). However, it is uncertain whether NAFLD acts merely as a risk marker or directly contributes to the development and progression of these arrhythmic disorders. Mendelian randomization (MR) was employed to investigate the causal relationship of NAFLD on arrhythmias and ECG traits.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian randomization (MR) analysis was performed to examine the causal relationship of genetically predicted NAFLD (imaging and biopsy confirmed NAFLD) on arrhythmias [i.e., atrial fibrillation (AF), left bundle branch block (LBBB), right bundle branch block (RBBB), and atrioventricular block (AVB)] and ECG traits [i.e., P wave duration (PWD), PR interval, QT interval, and QRS duration]. We utilized the inverse variance weighted method as the principal analytical approach, supplemented by a range of sensitivity analyses.</div></div><div><h3>Results</h3><div>Inverse-variance weighted method showed a statistically significant association between genetically predicted NAFLD and LBBB (OR: 1.261, 95% CI: 1.066-1.491, <em>p</em> = 0.0068). However, there was insufficient evidence to support a significant association between genetically predicted NAFLD and other arrhythmias or electrocardiographic characteristics. Sensitivity analyses revealed low heterogeneity and the absence of horizontal pleiotropy, suggesting that the findings are robust.</div></div><div><h3>Conclusion</h3><div>The study indicates a causal relationship between genetically predicted NAFLD and LBBB, suggesting that NAFLD may influence cardiac electrical activity.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"94 ","pages":"Article 154158"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}