Journal of Developing Drugs最新文献

{"title":"Analytical Method Validation of Testosterone Undecanoate Soft Gelatin Capsule by RP-HPLC Method","authors":"Didarul Islam, M. MehediHasan, T. Mohiuddin, M. Hassan, Asheful Latif, Papia Haque","doi":"10.4172/2329-6631.1000184","DOIUrl":"https://doi.org/10.4172/2329-6631.1000184","url":null,"abstract":"A rapid, sensitive, selective reversed phase HPLC method has been validated for the quantification of testosterone undecanoate from Andriol® soft gelatin capsule. During validation active pharmaceutical ingredient (API) has been separated by C18 (4.6 mm × 250 mm, 5 μm) column, 100% methanol as mobile phase, flow rate of 0.8 ml/min and detection wavelength at 240 nm. The method was validated according to USP and ICH guideline requirements which includes specificity, accuracy, precision, linearity and range and robustness. Linearity of standard spiked sample was observed for each working day and coefficient of determination (r2) has been found >0.99 each day in concentration ranging from 20-60 ppm. Recovery was found from 98.87-100.02% for 20, 40 and 60 ppm of testosterone undecanoate spiked sample. Precision and intermediate precision showed that % RSD of test sample solution were 0.26 and 0.19 respectively and absolute difference between them was 0.52, all of the values were within acceptable limit. The method was also found robust in changing column oven temperature (± 5°C) and flow rate change (± 0.1).","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"2 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83405591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSAR and Structure Based Modeling of Marine Derived Anticancer Hymenialdisine Compounds","authors":"Ankita Sharma, Deepak Teotia, S. Nandi","doi":"10.4172/2329-6631.1000185","DOIUrl":"https://doi.org/10.4172/2329-6631.1000185","url":null,"abstract":"Drug discovery research based on marine organisms is a big challenge. However, lack of facilities and competent human resources stand as a barrier on the way of research. More in-depth study especially on deep-sea natural products needs to be carried out to solidify the research on the potential for marine organisms to contribute to the future of drug discovery. The total drug discovery processes including collection of marine organisms, extraction, isolation, structure elucidation, biological assay and experimental screening as well as clinical trials is a very long journey and big challenge. Therefore, researchers pay a big attempt to design and discovery of synthetic congeneric leads by derivatizing the natural potent compounds. Therefore, In-silico High throughput screening based on QSAR and molecular docking has been attempted in the present study for the design and discovery of promising anticancer compounds considering existed marine sponge-derived hymenialdisine analogs which are protein kinase inhibitors having nanomolar activities against CDKs, Mek1, GSK 3β and CK1. It may crystallize crucial features for the design and discovery of promising anticancer HMD compounds which could be proposed for further synthesis and testing. QSAR and molecular docking analysis of HMD analogs are being carried out by freely accessible open source software which are very economical and potential in drug discovery attempt.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"71 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86393373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured Lipid Carriers: A Review","authors":"A. Sharma, Ashish Baldi","doi":"10.4172/2329-6631.1000191","DOIUrl":"https://doi.org/10.4172/2329-6631.1000191","url":null,"abstract":"Lipid-containing drug delivery systems like NLC are well-established methods for preparing pharmaceuticals for all major kind of drug delivery systems of nanoscience. Lipid formulations require a variety of product-related requirements and problems associated with NLC, which is discussed thoroughly in this chapter. There are multiple DDS currently available which leads to enhance the solubility of the drugs in different medium as well as also increase the bioavailability of the drugs in different conditions and environments. NLC’s are a novel type of DDS which are stable in different environment and which have capabilities to form concentrated dispersions. In this chapter, we discussed different process variables, steps involved in the manufacturing of NLC and responses with their outcome. NLC’s can increase the drug distribution to the target organ, change the pharmacokinetic characteristics of drug carriers to enhance the therapeutic effect, and reduce adverse side effects.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"102 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76913002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Characterization of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique","authors":"Ayesha Siddiqua Gazi, A. Sailaja","doi":"10.4172/2329-6631.1000183","DOIUrl":"https://doi.org/10.4172/2329-6631.1000183","url":null,"abstract":"The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO) technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"14 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75244816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Modified Liposome for Transdermal Drug","authors":"Ghule Mm, Bhoyar Gs","doi":"10.4172/2329-6631.1000186","DOIUrl":"https://doi.org/10.4172/2329-6631.1000186","url":null,"abstract":"Objective: Pramipexole is widely used in the treatment of anti-Parkinson’s, however it is associated with several side effects so the objective was to develop liposomal drug delivery of Pramipexole and thus reduce its side effect and toxicity and improve bioavaibility, efficacy and therapeutic index. Further study to modify drug delivery and to determine effect of stearylamine and sodium cholate content on the liposomal characteristics was investigated.Methods: In the present study the modified liposomes were prepared by using Pramipexole, phosphotidylcholine, cholesterol, stearylamine and sodium cholate in different ratio. These liposomes were prepared using thin film hydration method and characterized for vesicle size, drug entrapment studies, in-vitro release, and zeta potential, ex-vivo study.Results: The preparation of pramipexole loaded liposome was initiated by studying the influencing of drug lipid ratio on drug entrapment in vesicles. The drug bearing capacity of liposome was found to be invariably dependent on drug lipid ratio employed in liposomal composition, then formulation addition of stearylamine and sodium cholate to determine penetration enhancer. Modified liposome of optimized liposomal batches was formulated. Further modified liposomes were evaluated for entrapment efficiency, in-vitro release, zeta potential, and vesicle size. Thus, positive charged liposome seen to be promising as carrier for pramipexole drug thought transdermal drug delivery system.Conclusion: Incorporation of stearylamine enhanced the percent entrapment of pramipexole owing to rigidizaton effect on the membrane packing. Modified Liposomes of pramipexole can be promising carriers for the effective treatment of Parkinson’s.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"1 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90920059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Licozinat Matrix Tablet","authors":"D. Otgonsuren, Davaasuren Ts, B. Enkhtuul, D. Davaadagva, D. Jambaninj","doi":"10.4172/2329-6631.1000190","DOIUrl":"https://doi.org/10.4172/2329-6631.1000190","url":null,"abstract":"Objective: Monoammonium glycyrrhizinate of Glycyrrhiza root has been used as an expectorant, detoxificator, anti-allergic, and antioxidant. Japanese researchers have been determined it has anti-viral activity in case of hepatitis A, B, C, D. We have isolated monoammonium glycyrrhizinate from Glycyrrhiza root, grown in Mongolia through a method presented in a previous study. The objective of the study was to develop prolonged release matrix tablet with hepatoprotective effect and to evaluate their pharmacotechnical qualities and the in vivo performance. Licozinat matrix tablets contained monoammonium glycyrrhizinate 140 mg; glycine 50 mg; LD-methionin 50 mg in each tablet. Methods: In the present study the matrix tablet were prepared using HPMC K4000, lactose, glucose, microcrystalline cellulose, PVP-K30, talc and magnesium stearate in different ratios. The matrix tablet were prepared by wet granulation method and evaluated for weight variation, hardness, friability, in-vitro release, and in vivo study. Results: Appropriate excipients were chosen for the matrix tablets: lactose as a diluent, 5% of PVP-K30 as a binder, HPMC as a matrix former, 3% of talc and 1% of magnesium stearate as a glidiant or lubricant. We have prepared the matrix tablets by wet granulation method and compressed the tablet mixture by a 2.5 kPa pressure. Formulation 5 (F5) was determined to be the most appropriate tablet design and it released the drug in a prolonged way during the in vitro testing. The hepatoprotective effect of matrix tablet in comparison to Glycyron tablet, were studied on CCl4 induced hepatotoxicity in rats. The effect of Licozinat matrix tablet were compared with the Glycyron tablet that were administered to CCl4 treated rats. On administration Licozinat matrix tablet decreased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and alkaline phosphatise (ALP). Conclusion: We have developed and evaluated prolonged/controlled release matrix tablets with hepatoprotective effect. The Licozinat matrix tablets satisfied the quality criteria. On administration Licozinat matrix tablet decreased the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin and alkaline phosphatise (ALP).","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"14 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87149878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Respiratory Distress Syndrome Associated with Intravenous Lipid Emulsion Therapy for Verapamil Toxicity, Successfully Treated with Veno-Venous ECMO","authors":"T. Friedman, Y. Feld, Z. Adler, G. Bolotin, Y. Bentur","doi":"10.4172/2329-6631.1000182","DOIUrl":"https://doi.org/10.4172/2329-6631.1000182","url":null,"abstract":"Calcium channel blocker (CCB) overdose is a potentially fatal poisoning. The use of intravenous lipid emulsion (ILE) therapy for CCB poisoning has emerged in the past few years. In 2017, the American College of Medical Toxicology published interim guidance for the use of ILE resuscitation in these cases. We report an uncommon complication of ILE, acute respiratory distress syndrome, treated with veno-venous extracorporeal membrane oxygenation (ECMO). Case report: A 40-year-old hypertensive woman presented with shock (blood pressure 62/34 mmHg, pulse 86/ min) following ingestion of 4,800 mg verapamil slow release and 1,500 mcg clonidine during a suicide attempt. She was treated with calcium gluconate, sodium bicarbonate, IV high dose insulin, IV glucagon, cardiac amines and vasopressors without response (blood pressure 69/37 mmHg, pulse 78/min). ILE was initiated, and two hours later, she developed acute respiratory failure necessitating intubation and mechanical ventilation. Due to poor oxygenation (pO2 44 mmHg; FiO2 100%) emergent veno-venous ECMO was instituted. After one hour her blood pressure increased to 104/50 mmHg (pulse 80, pO2 75 mmHg), and continued so until weaning from ECMO and ventilation. Conclusion: Acute respiratory distress syndrome can be a major life threating complication following ILE; venovenous ECMO is suggested for its treatment.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78280011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Researching Prospect of Correspondence between Prescription and Syndromes on the Pathologic Basis of Yin Deficiency Syndrome of Liver and Kidney and Effective Mechanism of Decoction of Yiguan Jian","authors":"Yao Wl, Fan Ww, Chen Xl, S. My, Mu Yp, P. Liu, H. Zhang","doi":"10.4172/2329-6631.1000176","DOIUrl":"https://doi.org/10.4172/2329-6631.1000176","url":null,"abstract":"The theory of correspondence between prescription and syndrome is an important starting point for studying modern TCM. Yin deficiency syndrome of liver and kidney is a common clinical syndrome found in many chronic diseases, and modern researches had found its pathobiological basis involving synthetic and metabolic disorders of the body material, chronic inflammation, and damage and apoptosis of cells, etc. Decoction of Yiguan Jian is an effective prescription for Yin deficiency syndrome of liver and kidney, commonly used in clinical treatment of a variety of chronic diseases. Based on summarizing studies on pathobiological basis of Yin deficiency syndrome of liver and kidney and clinical effects of Decoction of Yiguan Jian, this article has discussed the meaning of correspondence between prescription and syndrome in the treatment of Yin deficiency syndrome of liver and kidney with decoction of Yiguan Jian, demonstrated the practical values and developing prospects, and provided new ideas for the study of correlation of syndrome and treatment.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"25 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78052701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coin Image of Action of Atropa belladonna in Crude and in Homoeopathic Potentised Form","authors":"Neeta Chavan","doi":"10.4172/2329-6631.1000175","DOIUrl":"https://doi.org/10.4172/2329-6631.1000175","url":null,"abstract":"Atropa belladonna is a bifurcating herbaceous plant from Solanaceae natural order. Germination of seeds is difficult. Plant contains various alkaloids with various percentage in plant parts. Alkaloids are as Belladonnaare Atropine, Hyoscine (scopolamine), Hyoscyamine, and Belladonine having anticholinergic properties. They act through parasympathetic and sympathetic nervous system. Hyoscyamine is an antagonist of muscarinic acetylcholine receptors. Atropine and Hyoscine having anticholinergic properties. By combine action they produce stimulation of higher centers of brain initially and then motor centers. Atropa belladonna is recommended in various pharmacological doses for various health disorders. According to Homeopathic fundamental principles homeopathic remedy Belladonna is prepared using entire Belladonna plant and its medication is used to cure a number of health conditions, particularly unexpected onset of infections with inflammation and intense heat. The Belladonna plant is highly noxious. But when is given as a homeopathic medication, it does not preserve the slightest trace of toxicity and become safe for human consumption along with its different indications. Homeopathic Belladonna is completely safe and effective for many health concerns and has different indications than pharmacological suggestions.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"308 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79915275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Silica Nanoparticles: A Review","authors":"Asad Mehmood, H. Ghafar, Samiya Yaqoob, Umar Farooq Gohar, B. Ahmad","doi":"10.4172/2329-6631.1000174","DOIUrl":"https://doi.org/10.4172/2329-6631.1000174","url":null,"abstract":"One of the greatest challenges in the field of medicine is the effective and efficient drug delivery to the defected cells or tumor cells with minimal toxic side effects. Due to lacking properties like specification and solubility of drug molecule, patient requires high doses of the drug to attain the desired therapeutic effect for the disease treatment. To overcome this problem various drug carriers are available in the pharmaceutical field, which help in delivering the therapeutic drug/ gene to the target site. For this purpose, mesoporous silica nanoparticles (MSNs) are found to be biocompatible, chemically and thermally stable nanoparticles. Their unique structural properties facilitate the loading of drug/gene and subsequent controlled delivery of drug to the target site. During recent years research on MSNs has been extensively increase. Since 2001, when MCM-41 was first proposed and later on SBA-15 and MCM-48 as drug carrier for controlled delivery system. Morphological characteristics like pore size, pore volume, particle size, surface area, pH and loading capacity of drug are widely effects the MSNs, when altered. Meanwhile, functionalization of MSNs using organic and inorganic group elaborates the delivery of drug to targeted site. This review article also deals with the recent research on synthesis methods of MSNs and their applications in the field of medicine, imaging, diagnosis, cellular uptake, target drug delivery, cell tracing and bio-sensing.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"49 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72622169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}