{"title":"盐析法制备负载对乙酰氨基酚的乌龙茶S100纳米颗粒及表征","authors":"Ayesha Siddiqua Gazi, A. Sailaja","doi":"10.4172/2329-6631.1000183","DOIUrl":null,"url":null,"abstract":"The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO) technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.","PeriodicalId":15589,"journal":{"name":"Journal of Developing Drugs","volume":"14 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Preparation and Characterization of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique\",\"authors\":\"Ayesha Siddiqua Gazi, A. Sailaja\",\"doi\":\"10.4172/2329-6631.1000183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO) technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.\",\"PeriodicalId\":15589,\"journal\":{\"name\":\"Journal of Developing Drugs\",\"volume\":\"14 1\",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Developing Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2329-6631.1000183\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Developing Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-6631.1000183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Preparation and Characterization of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique
The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO) technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.
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