Journal of Dr. NTR University of Health Sciences最新文献_第6页

A comparative study to evaluate the efficacy of intraperitoneal instillation of 0.25% levobupivacaine with or without clonidine (0.75 μg/kg) for postoperative analgesia in patients undergoing laparoscopic cholecystectomy 采用腹腔注射0.25%左布比卡因联合或不联合可乐定(0.75 μg/kg)用于腹腔镜胆囊切除术患者术后镇痛的对比研究

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_119_21

Neena Jain, S. Sethi, B. Soni, Veena Patodi, Kavita Jain, D. Garg

{"title":"A comparative study to evaluate the efficacy of intraperitoneal instillation of 0.25% levobupivacaine with or without clonidine (0.75 μg/kg) for postoperative analgesia in patients undergoing laparoscopic cholecystectomy","authors":"Neena Jain, S. Sethi, B. Soni, Veena Patodi, Kavita Jain, D. Garg","doi":"10.4103/jdrntruhs.jdrntruhs_119_21","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_119_21","url":null,"abstract":"Background: In recent years, the use of intraperitoneal instillation of local anesthetics with adjuvants has become popular for postoperative analgesia in laparoscopic cholecystectomy. This study aimed to compare the analgesic efficacy and safety of levobupivacaine alone or with clonidine as an adjuvant given through intraperitoneal instillation in laparoscopic cholecystectomy under general anesthesia. Material and Methods: In this prospective randomized double-blind study, 100 patients, aged 18–60 years belonging to ASA physical status I or II, were randomly allocated into two groups. Group L (n = 50) received 0.25% levobupivacaine 28 ml + 2 ml normal saline, whereas Group LC (n = 50) received 0.25% levobupivacaine 28 ml + clonidine 0.75 μg/kg (diluted in 2 ml normal saline) as intraperitoneal instillation before removing trocar. The duration of analgesia, pain scores, total number of doses, and amount of rescue analgesic consumed in 24 h, sedation score, hemodynamics, and adverse effects was noted. Results: Duration of analgesia was significantly prolonged in Group LC (744.10 ± 96.72 min) compared to Group L (525.20 ± 67.91 min) (P < 0.05). Pain scores (VAS) were significantly lower in Group LC (P < 0.05). The total number of doses and amount of rescue analgesic consumption in 24 hours were less in Group LC as compared to Group L (P < 0.05). Sedation, hemodynamics, and side effect profile were comparable in two groups (P > 0.05). Conclusion: Clonidine (0.75 μg/kg) was found to be a safe and effective adjuvant to 0.25% levobupivacaine for intraperitoneal instillation in laparoscopic cholecystectomy in terms of prolonged postoperative analgesia, lower pain scores, reduced rescue analgesic consumption along with no significant sedation, hemodynamic changes, and adverse effects.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"47 1","pages":"126 - 133"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82682927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychiatric manifestations associated with neurocysticercosis 与神经囊虫病相关的神经精神表现

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_27_22

J. Rissardo, Ana Letícia Fornari Caprara

引用次数: 0

A rare case of primary renal leiomyosarcoma with peritoneal sarcomatosis – A case report 原发性肾平滑肌肉瘤合并腹膜肉瘤1例

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_152_21

M. Karri, Kaumudi Konkay, V. Mandava, Geethavani. Panchakarla, P. Chaganti

引用次数: 1

Unique tumors come in small packages: A single centre experience of histopathological spectrum of solid pediatric tumors in North West India 独特的肿瘤来在小包装:组织病理谱的单一中心经验的实体儿科肿瘤在印度西北部

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_5_22

S. Narang, P. Selhi, R. Tyagi, H. Dhingra, N. Sood, Sumit Dhuria

{"title":"Unique tumors come in small packages: A single centre experience of histopathological spectrum of solid pediatric tumors in North West India","authors":"S. Narang, P. Selhi, R. Tyagi, H. Dhingra, N. Sood, Sumit Dhuria","doi":"10.4103/jdrntruhs.jdrntruhs_5_22","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_5_22","url":null,"abstract":"Introduction: Nonhematologic tumors in children differ biologically and histologically from adults in terms of incidence, type of tumor, and tendency to regress spontaneously. The study was aimed to evaluate the pattern, frequency, and histopathological spectrum of solid tumors and to correlate histopathological findings with immunohistochemistry (IHC) wherever feasible. Materials and Methods: This observational study was a retrospective analysis of all solid tumors of children less than 18 years, conducted over a period of 5 years. The specimens were analyzed grossly and microscopically with IHC wherever feasible. All leukemias and myeloproliferative neoplasms/myeloproliferative disorders were excluded from the study. Results: A total of 261 solid tumors were seen in the age of 2 days to 17 years with the median age being 10.41 years. The M: F ratio was 1.6:1. Benign tumors were more common (59.39%), with soft tissue tumors being more frequent. Lymphomas and reticuloendothelial cell tumors constituted the majority (27%) of malignant tumors. Conclusion: This institution-based study depicted the pattern of childhood tumors. As most of the studies have focused on malignant tumors, data on the prevalence of benign pediatric tumors is scarce. Pediatric tumors need to have a dedicated pediatric cancer registry for assessing the magnitude of the problem. This study provides useful insight into the pattern of benign and malignant pediatric tumors in the northwest region of India, which can be utilized in planning health policies. The present study also proves the importance of IHC in making the final diagnosis.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"81 1","pages":"118 - 125"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91239826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of genetic pattern in isoniazid-resistant PTB cases and its association with other TB-resistance drugs 异烟肼耐药肺结核病例遗传模式的流行及其与其他结核耐药的关系

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_200_20

S. Kumari, S. Raghu, K. Devi, Aswina Sundari, D. Sudheer, P. Sanjana

{"title":"Prevalence of genetic pattern in isoniazid-resistant PTB cases and its association with other TB-resistance drugs","authors":"S. Kumari, S. Raghu, K. Devi, Aswina Sundari, D. Sudheer, P. Sanjana","doi":"10.4103/jdrntruhs.jdrntruhs_200_20","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_200_20","url":null,"abstract":"Introduction: Isoniazid (H) is one of the most important first-line antituberculosis drugs used for the treatment of active tuberculosis (TB) and latent TB infection (LTBI) with high bactericidal activity and a good safety profile. The emergence of TB strains resistant to isoniazid threatens to reduce the effectiveness of TB treatment. Specific INH resistance allele is more frequently associated with resistance to other drugs. Aim and Objectives: To analyze the prevalence of mutations in genes associated with isoniazid resistance and to explore the association of specific mutations conferring other drugs resistance. Material and Methods: This is a prospective study done from October 2018 to July 2020 in the Department of Pulmonary Medicine, Guntur Medical College, Govt. Fever Hospital, Guntur. A total of 369 sputum-positive isoniazid-resistant pulmonary TB cases were included in the study and subjected to line probe assay (LPA). Results: The prevalence of InhA and KatG gene mutation is 63.14% and 36.85%, respectively. InhA gene is associated with fifampicin mutation in 7.72%, fluoroquinolone (FQ) in 6%, and second-line injectables (SLI) in 1.71% cases. KatG gene is associated with rifampicin mutation in 13.23%, FQ in 7.35%, and SLI in 1.47% cases. Conclusion: InhA gene is the most common gene pattern observed in isoniazid-resistant cases and associated equivalently with other drug resistance patterns such as KatG indicating the recent change in the level of resistance of InhA-resistant strains.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"38 1","pages":"134 - 137"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82451889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of saliva aspartate aminotransferase in diagnosing periodontal disease: A clinical and biochemical study 利用唾液天冬氨酸转氨酶诊断牙周病的临床和生化研究

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-04-01 DOI: 10.4103/jdrntruhs.jdrntruhs_90_20

H. Shinde, Reetika Gaddale, K. Ilangovan

{"title":"Use of saliva aspartate aminotransferase in diagnosing periodontal disease: A clinical and biochemical study","authors":"H. Shinde, Reetika Gaddale, K. Ilangovan","doi":"10.4103/jdrntruhs.jdrntruhs_90_20","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_90_20","url":null,"abstract":"Background and Aims: Periodontal disease is one of the common inflammatory diseases. Several enzymes in saliva and gingival crevicular fluid are evaluated for early diagnosis of periodontal disease. The objective of our study was to evaluate the relationship between aspartate aminotransferase (AST) levels in saliva and periodontal status indicated by the Community Periodontal Index of Treatment Needs (CPITN). Methods: Thirty patients were assigned to each one of four groups C0, C1, C3, and C4, based on their largest CPITN code among the examined sites, totaling 120 participants. Un-stimulated saliva was collected from the individuals. Biochemical analysis of saliva samples was carried out with an RA-XT auto analyzer by using the International Federation of Clinical Chemistry method in order to quantify their AST concentration. Results: There were statistically significant differences between levels of AST (IU/L) from groups C0 (24.07 ± 15.16 IU/L), C1 (39.73 ± 21.46 IU/L), C3 (68.27 ± 44.41 IU/L), and C4 (175.93 ± 137.39 IU/L). There was a significant positive correlation between clinical parameters and AST concentration in saliva in each group. Conclusion: AST levels in saliva increased with an increase in the CPITN score, Group C0 had the least and Group C4 had the highest AST levels. Periodontal destruction such as periodontal pockets, gingival bleeding seems to be related to AST levels in saliva. Salivary AST levels represent useful adjuncts to the diagnostic of screening periodontal diseases.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"7 1","pages":"107 - 112"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86957551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic lupus erythematosus presenting as unprovoked brachio-cephalic vein thrombosis: A case report 以无端头臂静脉血栓形成为表现的系统性红斑狼疮1例

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-01-01 DOI: 10.4103/jdrntruhs.jdrntruhs_129_21

Gautam Jesrani, Samiksha Gupta, Shivani Gupta, T. Raju, Monica Gupta

引用次数: 0

Pattern of poly pharmacy among geriatric patients in a tertiary care teaching hospital: A cross-sectional study 某三级教学医院老年患者多药模式的横断面研究

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-01-01 DOI: 10.4103/jdrntruhs.jdrntruhs_133_20

K. Vijaya, KJ. S Surya Prabha, P. Sai Shri, E. Ravi Kiran

{"title":"Pattern of poly pharmacy among geriatric patients in a tertiary care teaching hospital: A cross-sectional study","authors":"K. Vijaya, KJ. S Surya Prabha, P. Sai Shri, E. Ravi Kiran","doi":"10.4103/jdrntruhs.jdrntruhs_133_20","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_133_20","url":null,"abstract":"Background: In older adults multimorbidity increases with age and this increases the consumption of medications and the risk of Polypharmacy (PP). Along with this, the use of Potentially Inappropriate Medications (PIMs) among the elderly patients is a very common public concern. Objectives: The primary objective is to assess the pattern of PP and estimate the proportion of PP and PIMs among the geriatric in-patients. The secondary objective is to find out the association between serum creatinine and PP. Methods: A cross-sectional observational study was conducted among the geriatric in-patients aged ≥65 years admitted in medical wards by reviewing the case sheets. PIMs use was identified using Beer's criteria. Descriptive statistics like mean, range, standard deviation and proportions were used for Polypharmacy and PIMS. Inferential statistics like Pearson's Chi-squared test was used to find out association between serum creatinine and PP. Results: A total of 84 geriatric in-patients were enrolled as study subjects. Mean number of drugs prescribed was 6.9 (±3.2) and range 2-18. Proportion of PP was 73.8% and that of PIMs was found in 33.3% in the patients. There was significant association between an increase in serum creatinine levels with an increase in consumption of drugs. (p = 0.009) Conclusion: The proportion of PP and PIM and was found to be high among the geriatric patients. There was an increase in serum creatinine levels with increased consumption of drugs.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"28 1","pages":"1 - 5"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84422014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on acceptance of COVID-19 vaccination among health-care workers in a tertiary care hospital in Eastern India 印度东部一家三级医院卫生保健工作者接受COVID-19疫苗接种情况的研究

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-01-01 DOI: 10.4103/jdrntruhs.jdrntruhs_98_21

M. Basu, V. Shukla, Vanlaldiki Chhakchhuak, Prince Kerketta, R. Bysack, Anamitra Chakraborty

{"title":"A study on acceptance of COVID-19 vaccination among health-care workers in a tertiary care hospital in Eastern India","authors":"M. Basu, V. Shukla, Vanlaldiki Chhakchhuak, Prince Kerketta, R. Bysack, Anamitra Chakraborty","doi":"10.4103/jdrntruhs.jdrntruhs_98_21","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_98_21","url":null,"abstract":"Background and Objectives: Vaccination is perhaps the only modality for providing specific protection to the general population against the ongoing coronavirus disease-19 (COVID-19) pandemic. This study was conducted among the health-care workers of a tertiary care hospital in Kolkata with objectives to estimate the proportion of the acceptance of vaccination against COVID-19 as well as to find the factors associated with vaccine acceptance. Methodology: A cross-sectional observational study was conducted among 350 health-care workers of a tertiary care hospital in Kolkata using a predesigned, pretested, structured schedule by face-to-face interview method. Data were analyzed using SPSS 25.0. Pearson's Chi-square test and multivariable binary logistic regression were performed to find the factors associated with vaccine acceptance. Results: The proportion of vaccine acceptance was 88.7%. Education above secondary level, occupation—doctor, and living with family and friends had higher odds of vaccine acceptance. Age above 55 years and residing in rented house/flat were significantly associated with vaccine denial. Conclusion: There was a high proportion of vaccine acceptance in our study. However, concerns about vaccine safety are prevalent and this may affect vaccine uptake in the future.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"3 1","pages":"37 - 45"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85416396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of knowledge and awareness of general public on COVID-19 in Hyderabad city: A cross-sectional study 海得拉巴市公众对COVID-19的知识和意识评估:一项横断面研究

Journal of Dr. NTR University of Health Sciences Pub Date : 2022-01-01 DOI: 10.4103/jdrntruhs.jdrntruhs_75_21

M. Banu, V. Priya, V. Krishna Murthy, MilanS Mali

{"title":"Assessment of knowledge and awareness of general public on COVID-19 in Hyderabad city: A cross-sectional study","authors":"M. Banu, V. Priya, V. Krishna Murthy, MilanS Mali","doi":"10.4103/jdrntruhs.jdrntruhs_75_21","DOIUrl":"https://doi.org/10.4103/jdrntruhs.jdrntruhs_75_21","url":null,"abstract":"Background: Coronavirus disease, also called COVID-19, is caused by the SARS-CoV-2 virus. Since it has turned to be a pandemic, the main management aims at prevention protocols. It is important to understand the knowledge and awareness levels of the general public regarding this infection to form guidelines and implement them. Objectives: The study is focused on the evaluation of knowledge and awareness levels, their attitude, and the practices being followed by both adults and children in Hyderabad about the COVID-19 pandemic and thus, helping in eliminating possible barriers related to implementation and practicing of guidelines by the public and formation of customized guidelines for the population under study. Methodology: A cross-sectional online questionnaire study was conducted among the general population of Hyderabad during the peak incidence of COVID-19 cases in the city. The questionnaire consisted of 22 questions which were divided into two parts: Sociodemographic details and the COVID-19 questionnaire. Results: A total of 682 responses were obtained from all age groups (20 years and above) with varied frequency. Nearly 98% population was aware of the ongoing pandemic and the majority knew the important details about the virus. 93% public followed a combination of preventive measures. The majority of children were staying at home. Only 18% were aware of the helpline numbers. Conclusion: The main strategy to prevent or limit COVID-19 is campaigns and events to enhance health education and awareness. Also, changing the attitude of the public and forming strict guidelines will help in the long run.","PeriodicalId":15571,"journal":{"name":"Journal of Dr. NTR University of Health Sciences","volume":"31 1","pages":"46 - 51"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84372516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0