Journal of Drugs in Dermatology最新文献

{"title":"Biologics and Small-Molecule Inhibitors for the Treatment of Nummular Eczema: A Systematic Review.","authors":"Lucie Joerg, Julia Stolyar, Jared Jagdeo","doi":"10.36849/JDD.9756","DOIUrl":"https://doi.org/10.36849/JDD.9756","url":null,"abstract":"<p><strong>Background: </strong>Nummular eczema (NE) is a chronic, pruritic dermatitis with substantial patient burden and no FDA-approved therapies. Emerging data suggest that biologics and small-molecule inhibitors may be promising therapeutic options for NE.</p><p><strong>Methods: </strong>On October 29, 2025, PubMed, Embase, and the Cochrane Library were searched using PRISMA guidelines for English-language human clinical studies and cases evaluating biologics and small-molecule inhibitors for the treatment of NE.</p><p><strong>Results: </strong>Of 219 studies identified, 10 met the inclusion criteria. Grade of recommendation: B supporting dupilumab and tralokinumab. Grade of recommendation: C supporting roflumilast and delgocitinib. Grade of recommendation: B against apremilast.</p><p><strong>Conclusions: </strong>Current evidence supports dupilumab and tralokinumab for the treatment of NE. Roflumilast and delgocitinib should be reserved for selected cases, and apremilast is not recommended. Randomized controlled trials are needed to establish optimal treatment for patients with NE. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"919-924"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsy Type and Metastatic Recurrence in Melanoma: A Cohort Study.","authors":"Meng QingYin, Fu Yu, Mohammad Mussab Umair, Peng QingLan, Guo JiYin, Ding HaiYan, Zhang JinPing, Chen Yun, Xue YuanBo","doi":"10.36849/JDD.9771","DOIUrl":"https://doi.org/10.36849/JDD.9771","url":null,"abstract":"<p><strong>Background: </strong>Melanoma is a dynamic health problem caused by deteriorating melanocytes that generate aberrant melanin that gives color to the skin. It remains the leading cause of death from skin cancer. The incidence and mortality rates of melanoma emphasize the need for a suitable diagnostic biopsy, which is important for the optimal treatment of newly observed melanoma patients.</p><p><strong>Objectives: </strong>This study aims to evaluate the presence of melanoma metastases, mitotic rate, ulceration, and Breslow thickness, which are the most significant predictors of mortality from melanoma and are important for the diagnosis and optimal treatment of newly diagnosed melanoma patients.</p><p><strong>Methods: </strong>A cohort of 56 patients diagnosed with melanoma in the upper or lower limbs between 2020 and 2024 was analyzed to investigate whether partial biopsies influence melanoma metastasis. All patients underwent biopsy followed by complete resection and were followed for 3 years. We evaluated clinical characteristics, including Breslow thickness, surgical excision width, CLARK grade, ulcer presence, vascular invasion, and biopsy-excision interval, for their influence on recurrence time. The relationships between these factors and recurrence were assessed using the rank sum test and Spearman correlation analysis.</p><p><strong>Results: </strong>The results revealed that all patients had metastasis at varying intervals post-surgery, with different patterns observed between upper and lower limb melanomas. However, the correlation between recurrence duration and the analyzed characteristics was not statistically significant.</p><p><strong>Conclusion: </strong>Thus, our current revelations conclude that complete resection of the tumor lesions is sufficient for patients diagnosed with melanoma after biopsy, and extended resection is unnecessary. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"909-912"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Inflammatory Hyperpigmentation in Skin of Color Patients With Atopic Dermatitis.","authors":"Alexander J Jafari, Hayden P Schandua, Adelaide A Hebert","doi":"10.36849/JDD.9852","DOIUrl":"https://doi.org/10.36849/JDD.9852","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"975-977"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can't Believe It Can Be Cryo'd: Beyond Conventional Applications of Liquid Nitrogen.","authors":"Amreen Khakh, Ariana Zarghami, Caroline Clark, Adam Friedman","doi":"10.36849/JDD.1026","DOIUrl":"https://doi.org/10.36849/JDD.1026","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"981-982"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Atopic Dermatitis Comorbidity and Treatment Patterns by Race.","authors":"Robert Adler, Michael Kozlov, Shrividhya Babu, Isha Gandhi, Manan D Mehta, Emily Cowen, Katerina Svigos, Justin Wu Marson, Jessica Lori Feig","doi":"10.36849/JDD.9650","DOIUrl":"https://doi.org/10.36849/JDD.9650","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"978-979"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sodium-Glucose Cotransporter-2 Inhibitors and Vulvar Pruritus Without Vulvovaginal Candidiasis: A TriNetX-Based Analysis.","authors":"Sarahi Mera, Jessica Saoub, Ivan Rybkin, Daniel Novak, Ashley Elsensohn, Amylee Sam","doi":"10.36849/JDD.10305","DOIUrl":"https://doi.org/10.36849/JDD.10305","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"e89-e90"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDIVIDUAL ARTICLE: Ammonium Lactate in Clinical Practice: Optimizing Treatment of Xerotic and Hyperkeratotic Skin Conditions.","authors":"Latanya Benjamin","doi":"10.36849/JDD.946302","DOIUrl":"https://doi.org/10.36849/JDD.946302","url":null,"abstract":"<p><p>Ammonium lactate is a well-established, time-tested dermatologic therapy with a substantial body of clinical evidence supporting its use in xerotic and hyperkeratotic skin conditions. Although its use in routine practice has evolved over time, interest in ammonium lactate has been renewed by advances in the understanding of lactate biology and its role in skin physiology. Xerosis is characterized by reduced water content, impaired corneocyte turnover, and structural disruption of the stratum corneum, leading to scaling, roughness, and discomfort. As a pH-balanced source of L-lactic acid, ammonium lactate exerts biomimetic effects, aligning with physiologic skin processes. This pHdependent delivery allows effective lactic acid activity at clinically relevant concentrations while maintaining a favorable tolerability profile. Emerging insights into the role of lactate as both a natural moisturizing factor component and a regulator of epidermal function provide a more contemporary framework for understanding its clinical activity. Through combined humectant and desquamating activity, ammonium lactate boosts moisture balance, surface smoothness, and overall skin quality. Clinical evidence supports its use in conditions including ichthyosis, atopic dermatitis, psoriasis, keratosis pilaris, acanthosis nigricans, as well as visible \"ashiness\", a distinct clinical feature associated with xerosis in skin of color. Treatment outcomes are influenced by concentration, formulation, and disease severity, endorsing a tailored therapeutic approach. This review provides a clinically focused framework for the use of ammonium lactate, positioning it as a versatile and physiologically aligned treatment option within contemporary dermatologic practice. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"946302s4-946302s9"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDIVIDUAL ARTICLE: Beyond Moisturization: Ammonium Lactate as a Biomimetic Regulator of Skin Barrier Function.","authors":"Heather Woolery-Lloyd","doi":"10.36849/JDD.946301","DOIUrl":"https://doi.org/10.36849/JDD.946301","url":null,"abstract":"<p><p>The stratum corneum (SC) is essential for maintaining skin barrier integrity through coordinated interactions between corneocytes, intercellular lipids, and natural moisturizing factors (NMFs). Lactate is a key NMF component that contributes to hydration, pH regulation, and enzymatic activity within the SC. Recent advances in understanding the distinctions between lactate, lactic acid, and ammonium lactate have clarified their respective roles within the skin, providing a novel framework for their clinical use. The use of ammonium lactate, a pH-balanced source of L-lactic acid, in skincare offers a biomimetic approach to restoring skin barrier function. Its activity is governed by pH-dependent equilibrium and diffusion processes within the SC, enabling targeted availability of L-lactic acid in superficial layers where xerotic changes are most pronounced. Mechanisms of action include humectant effects, normalization of desquamation, and support of epidermal homeostasis. Clinical relevance extends across xerotic and hyperkeratotic conditions, including atopic dermatitis, ichthyosis, and psoriasis, as well as in skin of color, where xerosis may present as visible ashy skin. Benefit has also been shown in conditions such as acanthosis nigricans. This review summarizes the mechanistic and clinical rationale supporting ammonium lactate as a physiologically aligned and increasingly well-characterized therapeutic option. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"946301s10-946301s14"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Essential Role of Topical Targeted Therapy in Atopic Dermatitis.","authors":"Peter Lio, Latanya Benjamin, Mercedes E Gonzalez, Sophie Guénin, Adelaide A Hebert, Pearl C Kwong, Nanette Silverberg, Lawrence A Schachner","doi":"10.36849/JDD.10052","DOIUrl":"https://doi.org/10.36849/JDD.10052","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by immune dysregulation, epidermal barrier dysfunction, microbiome imbalance, pruritus, and xerosis. Despite therapeutic advances, topical treatments remain the foundation of AD management across all severities. However, most existing topicals address only limited aspects of the disease such as itch or inflammation, resulting in frequent relapse and patient dissatisfaction.</p><p><strong>Methods: </strong>A focused literature review of topical AD therapies published between January 2015 and July 2025 was conducted, emphasizing efficacy and safety. Recent findings were synthesized in this narrative review to highlight the ongoing role of topical treatments in AD management.</p><p><strong>Results: </strong>AD is a multifactorial condition influenced by Staphylococcus aureus colonization, immune dysregulation, genetic susceptibility, and environmental factors. These contribute to disease pathogenesis, the itch-scratch cycle, and barrier disruption. While systemic therapies are important, AD treatment continues to rely heavily on topical agents. Optimal management should target inflammation, restore barrier function, and address microbiome dysbiosis. Most current treatments focus on individual disease components, with few addressing the full pathogenic spectrum. Emerging evidence on zabalafin (9.5%) hydrogel, a novel botanical topical therapy, suggests potential multi-target benefits, including anti-inflammatory, antipruritic, antimicrobial, and anti-xerotic effects.</p><p><strong>Conclusion: </strong>There remains a significant unmet need for topical therapies that comprehensively address the AD continuum, including inflammation, itch, barrier dysfunction, and microbial imbalance. Novel agents such as zabalafin may help bridge this gap. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"898-902"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable NASHA Gel Skinbooster for Facial Skin Aging in Premenopausal and Postmenopausal Women With Estrogen Deficiency-Associated Not Receiving Hormone Therapy: A Case Series.","authors":"Magda Belmontesi, M D Martinelli","doi":"10.36849/JDD.10402","DOIUrl":"https://doi.org/10.36849/JDD.10402","url":null,"abstract":"<p><strong>Background: </strong>Estrogen deficiency contributes substantially to intrinsic skin aging by reducing dermal collagen, impairing hydration, decreasing elasticity, and compromising overall skin quality. Although hormone therapy may attenuate these changes, many are either unwilling or unable to receive systemic hormonal treatment. Injectable nonanimal stabilized hyaluronic acid (NASHA) gel skinboosters may represent a nonhormonal approach for improving skin quality in this population.</p><p><strong>Objective: </strong>To evaluate the efficacy of an infiltrative treatment of injectable hyaluronic acid NASHA gel skinbooster antiaging treatment to improve and restore skin quality in premenopausal and postmenopausal women with estrogen deficiency&ndash;associated skin aging who were not receiving hormone therapy.</p><p><strong>Methods: </strong>This prospective observational case series included 10 women (5 premenopausal and 5 postmenopausal) with mild-to-moderate climacteric symptoms and no history of hormone therapy. All participants underwent gynecologic-hormonal and dermatologic evaluation before receiving 3 monthly treatment sessions with injectable NASHA gel skinbooster. Clinical assessments, standardized photography, and patient-reported outcomes were obtained at baseline(T0), after 3 monthly treatments (T1), after 4 months (T2), and after 6 months (T3).</p><p><strong>Results: </strong>Participants demonstrated clinical improvement in multiple parameters of facial skin quality following treatment. Improvements were observed in hydration, texture, elasticity, and the appearance of fine lines and roughness. Standardized photographs showed progressive aesthetic improvement throughout follow-up, and patients reported high levels of treatment satisfaction. The treatment protocol was well tolerated, with only minor transient injection-related reactions.</p><p><strong>Conclusions: </strong>In this case series, treatment with injectable NASHA gel skinbooster was associated with improvements in facial skin quality in women with estrogen deficiency who were not receiving hormone therapy. These findings suggest that injectable NASHA gel skinbooster may represent a useful adjunctive nonhormonal approach for improving visible manifestations of estrogen-deficiency-related facial skin aging. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 10","pages":"903-908"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}