Journal of Clinical Cardiology最新文献

{"title":"A Case Report of Aspergillus Endocarditis, its Complications and Associated Morbidities","authors":"Tan Jian Jing, Lee Sheldon Shao Guang, C. Chew, See Jason Jia Hao","doi":"10.23937/2378-2951/1410170","DOIUrl":"https://doi.org/10.23937/2378-2951/1410170","url":null,"abstract":"Fungal endocarditis is a notorious disease with a high mortality rate and commonly presents with embolic phenomenon. We report a case of prosthetic valve-related Aspergillus endocarditis with aortic root pseudoaneurysm that presented with acute limb ischemia. In addition, we highlight the significant morbidity that is associated with this fungal infection. With a high clinical index of suspicion and a multidisciplinary team approach, a favourable outcome can be achieved. CaSe reporT","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75763411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Bacterial Thrombotic (Marantic) Endocarditis of the Aortic Valve: A Rare Cause of STEMI Revealing a Polycythemia","authors":"Özse Judit, Knur Rainer, Beckerath Nicolas Von","doi":"10.23937/2378-2951/1410169","DOIUrl":"https://doi.org/10.23937/2378-2951/1410169","url":null,"abstract":"• Page 1 of 5 • Özse et al. Int J Clin Cardiol 2020, 7:169 Citation: Özse J, Knur R, Beckerath NV (2020) Non-Bacterial Thrombotic (Marantic) Endocarditis of the Aortic Valve: A Rare Cause of STEMI Revealing a Polycythemia. Int J Clin Cardiol 7:169. doi. org/10.23937/2378-2951/1410169 Accepted: March 21, 2020; Published: March 24, 2020 Copyright: © 2020 Özse J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. drome, JAK-2 mutation was negative, blood level of erythropoietin was normal. His haematologist diagnosed most likely a reactive polyglobulie and he was treated symptomatic with phlebotomy. Splenectomy was done in 1984 after traffic accident.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"459 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79805712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean Platelet Volume, Platelet/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio as Predictors of Severity of Coronary Artery Disease Assessed by Multidetector CT Coronary Angiography","authors":"Selim Nada Mahmoud, Elsherbiny Islam Abdelmoneem, M. Magdy, Seaoud Elshaimaa Aly M Elsadek","doi":"10.23937/2378-2951/1410168","DOIUrl":"https://doi.org/10.23937/2378-2951/1410168","url":null,"abstract":"","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82766539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Ablation as a Treatment Modality for Hypertrophic Cardiomyopathy","authors":"Ibrahim Kareem M. M.","doi":"10.23937/2378-2951/1410167","DOIUrl":"https://doi.org/10.23937/2378-2951/1410167","url":null,"abstract":"Hypertrophic cardiomyopathy is one of the major causes of cardiac death that affects 1 in every 500 persons worldwide. Surgical myectomy and alcohol septal ablation have been the gold standard well established procedures for the treatment of this condition. Starting 2004 a new procedure, radiofrequency septal ablation, has been applied and showed significant improvement in the NYHA classification as well as the left ventricular outflow tract (LVOT) gradients of these patients. With overall less complications, as compared to the surgical myectomy and the alcohol septal ablation, this procedure could take the upper hand in the treatment during the next few decades.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"84 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77855251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Repair of an Aortic Pseudoaneurysm Status Post-Surgical Repair of Stanford Type A Dissection","authors":"Kanda Brinder S, Hoyt Nicholas E, H. John, Tavaf-Motamen Houman, M. Ronald, W. Tina, Saum Kenneth, M. Michael","doi":"10.23937/2378-2951/1410166","DOIUrl":"https://doi.org/10.23937/2378-2951/1410166","url":null,"abstract":"A middle-aged Caucasian woman presented with an ascending aortic pseudoaneurysm (AAP) located at the suture site of her previous surgical dissection repair. The pseudoaneurysm was located along the anterior aspect of the ascending thoracic aorta, above the right coronary cusp. We demonstrate successful percutaneous repair of the pseudoaneurysm using a ventricular septal occluder (VSO) and discuss the significance of this procedure for future cardiovascular care.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87736718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Large Pericardial Effusion and Cardiac Tamponade in Children with Down Syndrome","authors":"Aleem Numra, Qasim Amna, M AlyAshraf","doi":"10.23937/2378-2951/1410165","DOIUrl":"https://doi.org/10.23937/2378-2951/1410165","url":null,"abstract":"• Page 1 of 3 • Aleem et al. Int J Clin Cardiol 2020, 7:165 Citation: Aleem N, Qasim A, Aly AM (2020) Idiopathic Large Pericardial Effusion and Cardiac Tamponade in Children with Down Syndrome. Int J Clin Cardiol 7:165. doi.org/10.23937/2378-2951/1410165 Accepted: February 24, 2020; Published: February 26, 2020 Copyright: © 2020 Aleem N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. patient is being managed conservatively. She remains asymptomatic and the most recent ECHO at 5 years of age showed a 7-9 mm PE.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87003524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Cardioversion: A Review","authors":"E ValentinuzziMax, Arriascu Luis Aguinaga","doi":"10.23937/2378-2951/1410164","DOIUrl":"https://doi.org/10.23937/2378-2951/1410164","url":null,"abstract":"• Page 1 of 6 • Valentinuzzi and Arriascu. Int J Clin Cardiol 2020, 7:164 Citation: Valentinuzzi ME, Arriascu LS (2020) Electrical Cardioversion: A Review. Int J Clin Cardiol 7:164. doi.org/10.23937/2378-2951/1410164 Accepted: January 21, 2020; Published: January 23, 2020 Copyright: © 2020 Valentinuzzi ME, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. flammatory disease. AF can affect people at any age but is rare in children and is more common in the elderly population; it reaches about 0.5% of the world's population. According to the Centers for Disease Control and Prevention (CDC), of Atlanta, Georgia, USA, approximately 2% of people younger than 65-yearsold have AF, while about 9% ages 65 and older have it (data as for Nov 26, 2018).","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74172783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A View on the Contribution of Hedgehog Signalling to Ventricular Septal Development","authors":"Christoph Gerhardt","doi":"10.33696/cardiology.1.005","DOIUrl":"https://doi.org/10.33696/cardiology.1.005","url":null,"abstract":"40 The ventricular septal defect (VSD) is the most frequent congenital heart disease in humans. It is defined as an opening in the septum separating the left and the right ventricle. This gap results in a mixture of oxygenated and deoxygenated blood and in an enhanced blood flow towards the lung and the left ventricle [1], a condition that leads to severe diseases such as left ventricular hypertrophy as well as pulmonary edema and dilatation [2, 3]. The molecular mechanisms underlying the development of VSDs are poorly understood. The recently published review article entitled “The Role of Hedgehog Signalling in the Formation of the Ventricular Septum” discusses the importance of the Hedgehog (HH) signalling pathway in the formation of the ventricular septum (VS) [4]. HH signalling begins with the binding of the HH protein to its receptor Patched (PTC1) which localises in the membrane of primary cilia, little cellular protrusions dedicated to signal mediation. Low-density lipoprotein receptor related protein 2 (LRP2) participates in this binding event [5]. The HH/PTC1 complex leaves the cilium and, in turn, Smoothened (SMO) enters the ciliary membrane. Subsequently, SMO releases the full-length Glioblastoma 2 (GLI2) and Glioblastoma 3 (GLI3) proteins from a complex with Suppressor of Fused (SUFU) and converts them into transcriptional activators (GLI2-A and GLI3-A) [6,7]. Proteins such as Broad-Minded (BROMI), Ellis Van Creveld 1 (EVC1) and Ellis Van Creveld 2 (EVC2) are involved in the activation of GLI2 and GLI3 [8-14]. GLI2-A and GLI3-A enter the nucleus and induce the expression of HH target genes. The Intraflagellar transport proteins 25 and 27 (IFT25 and IFT27) ensure the transport of several HH signaling components and the deficiency of IFT25 or IFT27 results in reduced HH target gene expression [15-17]. Without the HH ligand, PTC1 remains in the ciliary membrane and blocks the ciliary entry of SMO. In the absence of SMO, the full-length GLI2 and GLI3 proteins are proteolytically processed into transcriptional repressors (GLI2-R and GLI3-R) by the cilia-regulated proteasome [18-20]. Further proteins such as Protein kinase A (PKA), Casein kinase 1 (CK1), Glycogen synthase kinase 3-β (GSK3-β), Kinesin family member 7 (KIF7) and Fuzzy (FUZ) are required for GLI2 and GLI3 processing [21-26].","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82506310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest Pain in Repeated Emergency Department Visitors","authors":"K. Slankamenac, M. Stucki, D. Keller","doi":"10.33696/CARDIOLOGY.1.001","DOIUrl":"https://doi.org/10.33696/CARDIOLOGY.1.001","url":null,"abstract":"Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits [1-3] and is also one of the major reasons of repeated ED visits, causing around 6% of these cases [1]. Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause [4-6]. International literature describes an all-population based, one-month mortality rate of AMI between 8 to 24% [7,8] and an all-population based, one-year mortality rate of 19% [9]. Therefore, AMI has to be diagnosed or ruled out quickly. For this purpose, a fast clinical assessment including cardiac biomarker testing and the rapid execution of an electrocardiogram (ECG) are necessary. Based on the leading symptoms and clinical presentation, ECG-findings and in combination Abstract","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72389748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxical Low Flow Aortic Stenosis: A Clinical Dilemma","authors":"Adriana Rosario, S. Masri","doi":"10.33696/cardiology.1.003","DOIUrl":"https://doi.org/10.33696/cardiology.1.003","url":null,"abstract":"Internists as well as cardiologists often receive echocardiogram reports which failed to offer a clear definition of the aortic stenosis (AS) severity due to discordant data regarding the aortic valve gradients and the valve area. Sometimes AS appears severe according to the valve area criteria, in spite of the fact that gradients across the valve are not in the severe range. This implies a clinical dilemma and potential under or over diagnoses Abstract","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89107006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}