Journal of clinical gastroenterology最新文献

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Perceived Need for Mental Health Care in a Cohort of Persons With Inflammatory Bowel Disease. 炎症性肠病患者对心理健康护理的感知需求。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-07-21 DOI: 10.1097/MCG.0000000000001892
Charles N Bernstein, Casandra Dolovich, Madelaine Prichodko, John D Fisk, Lesley A Graff, Scott B Patten, James Bolton, Carol Hitchon, Ruth Ann Marrie
{"title":"Perceived Need for Mental Health Care in a Cohort of Persons With Inflammatory Bowel Disease.","authors":"Charles N Bernstein, Casandra Dolovich, Madelaine Prichodko, John D Fisk, Lesley A Graff, Scott B Patten, James Bolton, Carol Hitchon, Ruth Ann Marrie","doi":"10.1097/MCG.0000000000001892","DOIUrl":"10.1097/MCG.0000000000001892","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric comorbidity is common in inflammatory bowel disease (IBD) and can negatively affect disease outcomes. We explored the perceived need for mental health care among persons with IBD.</p><p><strong>Study: </strong>Persons with IBD completed self-report questionnaires, including the Hospital Anxiety and Depression Scale (HADS), and reported whether they wanted help with their mood. Each was also assessed using the Structured Clinical Interview for DSM-IV-TR Axis-I Disorders (SCIDs). We used logistic regression analyses to determine factors associated with the perceived need for mental health care.</p><p><strong>Results: </strong>Of 245 participants, 28% met the criteria for a past diagnosis of depression or anxiety disorder by SCID, and nearly 23% met the criteria for a current diagnosis of depression or anxiety disorder. One-third (n = 74) reported a perceived need for mental health care. Among those meeting criteria for a current SCID diagnosis of depression or anxiety, only 58% reported needing mental health care. Need for mental health care was reported by 79% of persons currently treated for either depression or 71% treated for anxiety. Persons with a perceived need for mental health care had higher mean HADS for depression and HADS for anxiety scores and also higher IBD symptom activity scores. Of those reporting no perceived need for mental health care, 13% had a current diagnosis of depression or anxiety disorder by SCID; even fewer had symptoms of depression or anxiety.</p><p><strong>Conclusions: </strong>Symptoms of depression or anxiety are more important than a formal diagnosis of depression or anxiety in predicting which persons with IBD will perceive a need for mental health care.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review and Meta-analysis. 急性胰腺炎患者早期喂养与延迟喂养的效果:系统回顾与元分析》。
IF 2.8 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-07-10 DOI: 10.1097/MCG.0000000000001886
Xi-Ying Liang, Xin-An Wu, Ying Tian, Hang Gao, Jing-Jing Chen, Quan-Xin Feng
{"title":"Effects of Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review and Meta-analysis.","authors":"Xi-Ying Liang, Xin-An Wu, Ying Tian, Hang Gao, Jing-Jing Chen, Quan-Xin Feng","doi":"10.1097/MCG.0000000000001886","DOIUrl":"10.1097/MCG.0000000000001886","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to summarize the optimal strategy for early feeding in patients with acute pancreatitis.</p><p><strong>Methods: </strong>The search was undertaken in electronic databases, which compared early with delayed feeding in acute pancreatitis. The primary outcome was the length of hospital stay (LOHS). The second outcomes were intolerance of refeeding, mortality, and total cost of each patient. This meta-analysis followed the \"Preferred Reporting Items for Systematic Reviews and Meta-analyses\" guideline. Research is registered by PROSPERO, CRD42020192133.</p><p><strong>Results: </strong>A total of 20 trials involving 2168 patients were included, randomly assigned to the early feeding group (N = 1033) and delayed feeding group (N = 1135). The LOHS was significantly lower in the early feeding group than the delayed feeding group (mean difference: -2.35, 95% CI: -2.89 to -1.80; P < 0.0001), no matter the mild or severe subgroup ( Pint = 0.69). The secondary outcome of feeding intolerance and mortality were no significant difference (risk ratio: 0.96, 0.40 to 2.16, P = 0.87 and 0.91, 0.57 to 1.46, P = 0.69; respectively). Moreover, the hospitalization cost was significantly less in the early feeding group, resulting in an average savings of 50%. In patients with severe pancreatitis, early feeding after 24 hours may be beneficial ( Pint = 0.001).</p><p><strong>Conclusion: </strong>Early oral feeding can significantly reduce the LOHS and hospitalization costs in patients with acute pancreatitis without increasing feeding intolerance or mortality. In patients with severe pancreatitis, early feeding after 24 hours may be beneficial.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10141051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Bariatric Surgery on Disease Outcomes in Patients With Inflammatory Bowel Disease: A US-based Propensity Matched Cohort Study. 减肥手术对炎症性肠病患者疾病预后的影响:一项基于美国的倾向匹配队列研究。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-06-27 DOI: 10.1097/MCG.0000000000001879
Aakash Desai, Jana G Hashash, Gianna Baker, Francis A Farraye, Nisheet Waghray, Gursimran S Kochhar
{"title":"Effect of Bariatric Surgery on Disease Outcomes in Patients With Inflammatory Bowel Disease: A US-based Propensity Matched Cohort Study.","authors":"Aakash Desai, Jana G Hashash, Gianna Baker, Francis A Farraye, Nisheet Waghray, Gursimran S Kochhar","doi":"10.1097/MCG.0000000000001879","DOIUrl":"10.1097/MCG.0000000000001879","url":null,"abstract":"<p><strong>Introduction and aim: </strong>A growing body of evidence suggests a negative impact of obesity on the disease activity of inflammatory bowel disease (IBD). The primary aim of the study was to evaluate disease outcomes of IBD in patients after bariatric surgery (BS).</p><p><strong>Methods: </strong>Patients with IBD and morbid obesity who underwent BS were compared with patients with IBD and morbid obesity without BS in a retrospective, propensity-score matched cohort study using TriNetX, a multi-institutional database. The primary aim was to assess the 2-year risk of a composite of disease-related complications, which included intravenous steroid use or IBD-related surgery. Risk was expressed as adjusted odds ratios (aOR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>In all, 482 patients (3.4%) with IBD and morbid obesity underwent BS (mean age 46.9±11.2 y old, mean BMI 42.1±7.72 kg/m 2 , Crohn's disease 60%). After propensity-score matching, the BS cohort had a lower risk (aOR 0.31, 95% CI 0.17-0.56) of a composite of IBD-related complications compared with the control cohort. After propensity-score matching, the BS cohort with sleeve gastrectomy had a decreased risk (aOR 0.45, 95% CI 0.31-0.66) of a composite of IBD-related complications. There was no difference in the risk (aOR 0.77, 95% CI 0.45-1.31) of a composite of IBD-related complications between the BS cohort with Roux-en-Y gastric bypass (RYGB) compared with the control cohort.</p><p><strong>Conclusion: </strong>Sleeve gastrectomy but not Roux-en-Y gastric bypass is associated with improved disease-specific outcomes in patients with IBD and morbid obesity.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9726870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Renin-Angiotensin-Aldosterone System Blocking Agents on the Long-term Disease Course of Patients With Crohn's Disease. 肾素-血管紧张素-醛固酮系统阻断剂对克罗恩病患者长期病程的影响
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-06-26 DOI: 10.1097/MCG.0000000000001881
Christian Karime, Jana G Hashash, Michael F Picco, Emily C Craver, Joseph A Murray, Francis A Farraye
{"title":"The Effect of Renin-Angiotensin-Aldosterone System Blocking Agents on the Long-term Disease Course of Patients With Crohn's Disease.","authors":"Christian Karime, Jana G Hashash, Michael F Picco, Emily C Craver, Joseph A Murray, Francis A Farraye","doi":"10.1097/MCG.0000000000001881","DOIUrl":"10.1097/MCG.0000000000001881","url":null,"abstract":"<p><strong>Background: </strong>The renin-angiotensin-aldosterone system (RAAS) has been associated with gastrointestinal inflammation and fibrosis, suggesting that RAAS blockade may be beneficial in patients with inflammatory bowel disease. Using retrospective analysis, we aimed to compare the disease course of patients with Crohn's disease (CD) taking two commonly prescribed classes of RAAS-blocking agents.</p><p><strong>Study: </strong>Patients with CD initiated on an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) between 2000 and 2016 were enrolled. Data on clinical, radiologic, and procedural surrogate markers of inflammatory bowel disease were collected in the subsequent 3, 5, and 10 years and compared with matched controls using univariate and multivariate analyses.</p><p><strong>Results: </strong>Compared with controls, patients taking ARBs had fewer instances of corticosteroid use (1.06 vs 2.88, P < 0.01) at 10 years. Patients taking ACEIs had an overall worse disease course, with more imaging studies (3.00 vs 1.75, P = 0.03) and endoscopic procedures (2.70 vs 1.78, P = 0.01) at 5 years, and more imaging studies (6.19 vs 3.50, P < 0.01), endoscopic procedures (5.91 vs 3.78, P < 0.01), and gastrointestinal operations (0.59 vs 0.18, P < 0.02) at 10 years. Results remained significant on multivariate analysis, adjusting for CD characteristics and the use of other antihypertensive medications.</p><p><strong>Conclusions: </strong>Our study provides insight into the long-term use of RAAS-blocking agents in patients with CD, suggesting that differences exist among commonly prescribed medication classes. While ACEIs were associated with an overall worse disease course at 5 and 10 years, patients taking ARBs were noted to have fewer instances of corticosteroid use at 10 years. Future large-scale studies are needed to further explore this association.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Anti- Saccharomyces Cerevisiae Antibodies (ASCA) in Patients With Irritable Bowel Syndrome (IBS). A Case-control Study. 肠易激综合征(IBS)患者体内抗酵母菌抗体(ASCA)的流行率。病例对照研究。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-08-04 DOI: 10.1097/MCG.0000000000001896
Pablo Thomas-Dupont, Irma Yadira Izaguirre-Hernández, Federico Roesch-Dietlen, Peter Grube-Pagola, Job Reyes-Huerta, José María Remes-Troche
{"title":"Prevalence of Anti- Saccharomyces Cerevisiae Antibodies (ASCA) in Patients With Irritable Bowel Syndrome (IBS). A Case-control Study.","authors":"Pablo Thomas-Dupont, Irma Yadira Izaguirre-Hernández, Federico Roesch-Dietlen, Peter Grube-Pagola, Job Reyes-Huerta, José María Remes-Troche","doi":"10.1097/MCG.0000000000001896","DOIUrl":"10.1097/MCG.0000000000001896","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction that affects patients' quality. Recent research has shown variations in the mycobiome of individuals with IBS, particularly involving Saccharomyces cerevisiae , and its association with dysbiosis and visceral hypersensitivity. However, the role of Anti-Saccharomyces cerevisiae antibodies (ASCA) in IBS remains unclear, despite their significance as markers of disease severity in inflammatory bowel disease.</p><p><strong>Objective: </strong>This study aimed to investigate the role of ASCA in Mexican IBS patients compared with healthy controls (HCs) and determine whether these antibodies could help differentiate between IBS patients and healthy individuals.</p><p><strong>Methods: </strong>Serum samples from 400 IBS patients and 400 HC were analyzed. ASCA IgG levels were measured using enzyme-linked immunosorbent assay (ELISA). The IBS patients were further categorized into subtypes: constipation predominant (IBS-C), diarrhea predominant (IBS-D), and mixed (IBS-M).</p><p><strong>Results: </strong>Among the participants, 66 IBS patients (16.5%) and 63 HC (15.75%) tested positive for ASCA IgG. No significant difference was observed in ASCA IgG levels between the 2 groups ( P value: 0.8451). The prevalence of ASCA IgG positivity was 14.5% in IBS-C, 17.8% in IBS-D, and 15.9% in IBS-M.</p><p><strong>Conclusion: </strong>Surprisingly, a high prevalence of ASCA IgG was found in the HC group in Mexico. Furthermore, there was no significant difference in ASCA IgG levels between IBS patients and controls. These findings suggest that ASCA is not useful as a discriminatory biomarker for distinguishing IBS patients from healthy individuals and cannot serve as a surrogate marker for visceral hypersensitivity.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Esophageal Lichen Planus: A Descriptive Multicenter Report. 食管扁平苔藓:多中心描述性报告
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-06-29 DOI: 10.1097/MCG.0000000000001885
Elizabeth S Aby, Jason D Eckmann, Jad Abimansour, David A Katzka, Claire Beveridge, Joseph R Triggs, Mohamad Dbouk, Tsion Abdi, Kevin O Turner, Catiele Antunes, Justin Zhuo, Afrin N Kamal, Parth Patel, C Prakash Gyawali, Joshua A Sloan
{"title":"Esophageal Lichen Planus: A Descriptive Multicenter Report.","authors":"Elizabeth S Aby, Jason D Eckmann, Jad Abimansour, David A Katzka, Claire Beveridge, Joseph R Triggs, Mohamad Dbouk, Tsion Abdi, Kevin O Turner, Catiele Antunes, Justin Zhuo, Afrin N Kamal, Parth Patel, C Prakash Gyawali, Joshua A Sloan","doi":"10.1097/MCG.0000000000001885","DOIUrl":"10.1097/MCG.0000000000001885","url":null,"abstract":"<p><strong>Goals: </strong>To better understand the characteristics, treatment approaches, and outcomes of patients with esophageal lichen planus (ELP).</p><p><strong>Background: </strong>ELP is a rare, often unrecognized and misdiagnosed disorder. Data on this unique patient population are currently limited to small, single-center series.</p><p><strong>Study: </strong>A multicenter, retrospective descriptive study was conducted of adults diagnosed with ELP over a 5-year period, between January 1, 2015, and October 10, 2020, from 7 centers across the United States.</p><p><strong>Results: </strong>Seventy-eight patients (average age 65 y, 86% female, 90% Caucasian) were included. Over half had at least 1 extraesophageal manifestation. Esophageal strictures (54%) and abnormal mucosa (50%) were frequent endoscopic findings, with the proximal esophagus the most common site of stricture. Approximately 20% had normal endoscopic findings. Topical steroids (64%) and/or proton pump inhibitors (74%) dominated management; endoscopic response favored steroids (43% vs. 29% respectively). Almost half of the patients required switching treatment modalities during the study period. Adjunctive therapies varied significantly between centers.</p><p><strong>Conclusions: </strong>Given its at times subtle clinical and endoscopic signs, a high index of suspicion and biopsy will improve ELP diagnosis, especially in those with extraesophageal manifestations. Effective therapies are lacking and vary significantly. Prospective investigations into optimal treatment regimens are necessary.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics Associated With Posttransplant Survival Among Adults 70 Years Old or Older Undergoing Liver Transplantation. 70岁及以上成人肝移植术后生存的临床特征
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-06-07 DOI: 10.1097/MCG.0000000000001870
Melinda Wang, Jin Ge, Nghiem Ha, Amy M Shui, Chiung-Yu Huang, Giuseppe Cullaro, Jennifer C Lai
{"title":"Clinical Characteristics Associated With Posttransplant Survival Among Adults 70 Years Old or Older Undergoing Liver Transplantation.","authors":"Melinda Wang, Jin Ge, Nghiem Ha, Amy M Shui, Chiung-Yu Huang, Giuseppe Cullaro, Jennifer C Lai","doi":"10.1097/MCG.0000000000001870","DOIUrl":"10.1097/MCG.0000000000001870","url":null,"abstract":"<p><strong>Goals: </strong>We sought to identify pre-liver transplantation (LT) characteristics among older adults associated with post-LT survival.</p><p><strong>Background: </strong>The proportion of older patients undergoing deceased-donor liver transplantation (DDLT) has increased over time.</p><p><strong>Study: </strong>We analyzed adult DDLT recipients in the United Network for Organ Sharing registry from 2016 through 2020, excluding patients listed as status 1 or with a model of end-stage liver disease exceptions for hepatocellular carcinoma. Kaplan-Meier methods were used to estimate post-LT survival probabilities among older recipients (age ≥70 y). Associations between clinical covariates and post-LT mortality were assessed using Cox regressions.</p><p><strong>Results: </strong>Of 22,862 DDLT recipients, 897 (4%) were 70 years old or older. Compared with younger recipients, older recipients had worse overall survival ( P < 0.01) (1 y: 88% vs 92%, 3 y: 77% vs 86%, and 5 y: 67% vs 78%). Among older adults, in univariate Cox regressions, dialysis [hazards ratio (HR): 1.96, 95% CI: 1.38-2.77] and poor functional status [defined as Karnofsky Performance Score (KPS) <40] (HR: 1.82, 95% CI: 1.31-2.53) were each associated with mortality, remaining significant on multivariable Cox regressions. The effect of dialysis and KPS <40 at LT on post-LT survival (HR: 2.67, 95% CI: 1.77-4.01) was worse than the effects of either KPS <40 (HR: 1.52, 95% CI: 1.03-2.23) or dialysis alone (HR: 1.44, 95% CI: 0.62-3.36). Older recipients with KPS >40 without dialysis had comparable survival rates compared with younger recipients ( P = 0.30).</p><p><strong>Conclusions: </strong>While older DDLT recipients had worse overall post-LT survival compared with younger recipients, favorable survival rates were observed among older adults who did not require dialysis and had poor functional status. Poor functional status and dialysis at LT may be useful to stratify older adults at higher risk for poor post-LT outcomes.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mild Thrombocytopenia, a Predictor of Outcomes After Laparoscopic Cholecystectomy: Assessment of Surgical Risk in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease. 轻度血小板减少症是腹腔镜胆囊切除术后预后的一个因素:评估代谢功能障碍相关性脂肪肝患者的手术风险。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-05-01 Epub Date: 2023-09-14 DOI: 10.1097/MCG.0000000000001926
William S Reiche, Ryan W Walters, Bryce F Schutte, Sandeep Mukherjee, Haitam M Buaisha
{"title":"Mild Thrombocytopenia, a Predictor of Outcomes After Laparoscopic Cholecystectomy: Assessment of Surgical Risk in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"William S Reiche, Ryan W Walters, Bryce F Schutte, Sandeep Mukherjee, Haitam M Buaisha","doi":"10.1097/MCG.0000000000001926","DOIUrl":"10.1097/MCG.0000000000001926","url":null,"abstract":"<p><strong>Background: </strong>A common cause of mild thrombocytopenia is chronic liver disease, the most common etiology being metabolic dysfunction-associated steatotic liver disease (MASLD). Mild thrombocytopenia is a well-defined, independent marker of hepatic fibrosis in patients with chronic liver disease. Currently, there is a paucity of information available to characterize perioperative risk in patients with MASLD; therefore, the characterization of perioperative morbidity is paramount. We used a platelet threshold of 150×10 9 as a surrogate for fibrosis in patients undergoing laparoscopic cholecystectomy to study its effect on perioperative complications and mortality.</p><p><strong>Patients and methods: </strong>We queried the American College of Surgeons National Surgical Quality Improvement Program database for laparoscopic cholecystectomies occurring from 2005 through 2018. Demographic differences between patients with and without thrombocytopenia were evaluated using the t test or the χ 2 test, whereas adjusted and unadjusted differences in outcome risk were evaluated using log-binomial regression models.</p><p><strong>Results: </strong>We identified 437,630 laparoscopic cholecystectomies of which 6.9% included patients with thrombocytopenia. Patients with thrombocytopenia were more often males, older, and with chronic disease. Patients with thrombocytopenia and higher Aspartate Aminotransferase to Platelet Ratio Index scores had 30-day mortality rates risk ratio of 5.3 (95% CI: 4.8-5.9), with higher complication rates risk ratio of 2.4 (95% CI: 2.3-2.5). The most frequent complications included the need for transfusion, renal, respiratory, and cardiac.</p><p><strong>Conclusions: </strong>Perioperatively, patients with mild thrombocytopenia undergoing laparoscopic cholecystectomy had higher mortality rates and complications compared with patients with normal platelet counts. Thrombocytopenia may be a promising, cost-effective tool to identify patients with MASLD and estimate perioperative risk, especially if used in high-risk populations.</p>","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Gastric Per-Oral Endoscopic Myotomy (G-POEM): A Systematic Review and Meta-Analysis. 胃经口腔内窥镜肌切开术(G-POEM)的有效性和安全性:系统回顾与元分析》。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-04-30 DOI: 10.1097/mcg.0000000000002010
Russell D Dolan, Thomas R McCarty, Ahmad Najdat Bazarbashi, Christopher C Thompson
{"title":"Efficacy and Safety of Gastric Per-Oral Endoscopic Myotomy (G-POEM): A Systematic Review and Meta-Analysis.","authors":"Russell D Dolan, Thomas R McCarty, Ahmad Najdat Bazarbashi, Christopher C Thompson","doi":"10.1097/mcg.0000000000002010","DOIUrl":"https://doi.org/10.1097/mcg.0000000000002010","url":null,"abstract":"Gastric per-oral endoscopic myotomy (G-POEM) is an innovative treatment that has become increasingly utilized for patients with refractory gastroparesis. The aim of this systematic review and meta-analysis was to evaluate the safety and effectiveness of G-POEM for the treatment of gastroparesis.","PeriodicalId":15457,"journal":{"name":"Journal of clinical gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140838141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body Compositions Correlate With Overt Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt: A Multicentre Cohort Study. 经颈静脉肝内门体分流术后体质与肝性脑病的相关性:一项多中心队列研究。
IF 2.9 4区 医学
Journal of clinical gastroenterology Pub Date : 2024-04-30 DOI: 10.1097/mcg.0000000000002014
Wenfeng Shi, Weiguo Xu, Ningning Fan, Yong Li, Xiaoqiong Chen, Yujie Zhao, Xiao Bai, Yang Yang
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