Journal of clinical & experimental dermatology research最新文献

{"title":"Skin Related Facet Effects of Cancer Immune Therapies","authors":"K. Jones","doi":"10.35248/2155-9554.21.12.E113","DOIUrl":"https://doi.org/10.35248/2155-9554.21.12.E113","url":null,"abstract":"","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"222 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76014730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Group and Human Leucocyte Antigen Sub-Type as Determinants to Keloid Formation and Recurrence in Keloid Patients: A Prospective Longitudinal Cohort Study","authors":"Nangole Fw, Ogeng o J, A. G., O. K, Omu A","doi":"10.46889/jdr.2021.2302","DOIUrl":"https://doi.org/10.46889/jdr.2021.2302","url":null,"abstract":"","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76473341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic antiaging and Dermal Restorative Effects of an Oral Bioactive Procollagen and Astaxanthin Supplement with A Topical Retinyl Palmitate, Vitamin C, Hyaluronic Acid and Alpha Hidroxy Acid Based Regimen","authors":"S. Manzanares, E. Arias, N. Floriach, S. M., F. A. Roldán","doi":"10.46889/jdr.2021.2301","DOIUrl":"https://doi.org/10.46889/jdr.2021.2301","url":null,"abstract":"Aging is a natural process undergone by every organism, with progressive changes that lead to an impairment of many biological processes. The human skin ages through several mechanisms which may cause changes to the morphology of skin leading to its reduced thickness, lower dermis density and to the presence of a subepidermal low echogenic band. These morphological changes are responsible for the visible changes of the skin such as reduced elasticity, firmness, luminosity and hydration. This study was conducted to investigate the antiageing effect and to assess the qualities and efficacy of a topical cosmetic products and a nutricosmetic product, after 84 days. Sixty women were divided into three groups and assigned different treatments (Group A: topical treatment, Group B: oral treatment and Group C: combination of topical and oral treatments). The topical treatment consisted in the application of a facial gel with alpha hydroxy acids and a facial cream with retinyl palmitate, hyaluronic acid and Vitamin C, whereas the oral treatment consisted in the daily ingestion of a drinkable solution composed of collagen peptides, astaxanthin, hyaluronic acid, vitamins and active other ingredients. Finally, Group C received a combination of the treatments in Group A and Group","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90578633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors that Predict Patients' Satisfaction with the Psychological Outcome and the Appearance of their Skin after Treatment","authors":"Charalambos Costeris, M. Petridou, Y. Ioannou","doi":"10.35248/2155-9554.21.12.552","DOIUrl":"https://doi.org/10.35248/2155-9554.21.12.552","url":null,"abstract":"Objective: The present study examined whether dermatological patients’ demographic and social characteristics could predict their satisfaction with the medical outcome. Moreover, it focused on two aspects of patients’ satisfaction; firstly, psychological factors that could predict satisfaction from the medical outcome and secondly, satisfaction from the appearance of their skin, after treatment. Methods: 108 patients (18~35 years) participated in the study. Fifty four were diagnosed by their Dermatologists with severe visible facial cystic acne (Group A) and 54 with non-visible psoriasis/eczema (Group B). The study included two assessment phases: prior to and post dermatological treatment phase. At prior to treatment phase, all patients agreed with their Dermatologist to begin medical treatment and were administered the Sociodemographic questionnaire, the BDD Diagnostic Module-for adults, the Multidimensional body–self relations questionnaire, the Interpersonal support evaluation list and the Rosenberg self-esteem scale. At post dermatological treatment phase (six months after patients completed their dermatological treatment), there was a follow-up assessment and all participants were administered the Questionnaire on patients' satisfaction with the medical outcome. Results: Patients’ previous address to a specialist for their skin disorder predicts lower levels of satisfaction with the medical outcome. Patients' lower overall appearance satisfaction at prior to dermatological treatment phase and the group in which patients belong (visible or non-visible skin disorder), predict higher satisfaction with the medical outcome. The higher the possibility that a patient has a visible skin disorder (group of acne) and the less satisfied they are with their overall appearance at prior to dermatological treatment phase, the higher their satisfaction with the appearance of their skin after treatment is predicted to be. Lastly, if a patient fulfills the criteria for the diagnosis of BDD and the higher their perceived social support at prior to dermatological treatment phase, the lower their satisfaction with the appearance of their skin after treatment is predicted to be. Conclusion: Satisfaction with the medical outcome and satisfaction with the appearance of the skin are two perceptually different areas for dermatological patients. They are both found to be predicted by various psychological factors and as such psychological assessment of patients prior to dermatological treatment is deemed necessary.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"174 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83255685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Challenging Case of Atypical Adult Onset Still's Disease Clinically Mimicking Dermatomyositis with Distinctive Histopathologic Findings","authors":"Andjela Egger, Mir, A. Rosenberg, Alex, R. Price, J. Cho-Vega","doi":"10.35248/2155-9554.20.11.540","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.540","url":null,"abstract":"A 23-year-old woman from Bangladesh presented with a 6-week history of spiking fevers, myalgias, arthralgias, pruritic rash, marked granulocytosis and lymphadenopathy. On presentation to the emergency department she had brown lichenified plaques on the upper chest and neck; her back had flagellate-like erythema. Hand exam revealed hyperpigmented papules over the metacarpophalangeal joints without periungual capillary loop dilatation. Labs were notable for: minimally positive ANA (1:40), mild transaminitis (AST 56, ALT 73), as well as elevated aldolase (13.8), LDH (1,368), sedimentation rate (>140), C reactive protein (7.5) and ferritin (10,248). She also had a negative Anti Jo1 antibody, rheumatoid factor, and CK (<20). An extensive infectious workup was negative. CT of the chest/ abdomen showed generalized lymphadenopathy with mild splenomegaly. Punch biopsies from the hands and back revealed multiple necrotic keratinocytes mainly in the upper epidermis and within parakeratotic stratum corneum, infiltration of lymphocytes and neutrophils in the papillary and mid dermis and numerous intradermal eosinophils without evidence of vasculitis. In the setting of meeting original Yamaguchi criteria for Adult Onset Still’s Disease (AOSD), negative infectious workup, constellation of lab and imaging findings and characteristic histopathologic findings, the patient was diagnosed with atypical AOSD. She was treated with systemic steroids and had resolution of her symptoms. Atypical presentations of AOSD clinically mimicking dermatomyositis show a distinguishing pattern on histology: dyskeratotic and necrotic keratinocytes in the upper layers of the epidermis, inflammatory infiltrate in the upper and mid dermis, and no evidence of vasculitis, as seen in this patient.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"70 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88284487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Epidermolysis Bullosa Pruriginosa with Anti-IgE Therapy (Omalizumab): A Case Report and Four Years Follow Up","authors":"S. Taha, M. Al-Nesf, A. Al-Obaidli","doi":"10.35248/2155-9554.20.11.520","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.520","url":null,"abstract":"Importance: Epidermolysis bullosa pruriginosa (EBP) is a rare adult-onset heredo-familial skin disorder. Bullous skin lesions are triggered by intense pruritus, which is the hallmark of the disease. Eosinophilic infiltrates and elevated IgE levels in serum and lesions have been reported, but their pathological role is yet to be determined. Although treatment with anti-IgE therapy (Omalizumab) has been used successfully in autoimmune bullous diseases but not in EBP to our knowledge. Observation: We report a case of a 34-year-old female with adult-onset pruritic and blistering disease of the skin. Sub epidermal blisters with viable roofs and numerous epidermal neutrophils and eosinophilic infiltrate were detected histopathologically; however, the absence of IgA, IgG, IgM, C1q, and C3 deposits made the diagnosis of Epidermolysis bullosa acquisita and Bullous pemphigoid uncertain. Whilst testing for intra-lesional IgE autoantibodies was not performed, total and specific serum IgE concentrations increased during her illness in the absence of an allergic or parasitic disease. Because no improvement in her symptoms was observed with conventional treatments, whole exome sequencing was performed which showed a non-conservative Glycine substitution in the G2481D residue in the COL7A1 gene suggestive of EBP. Off-label use of anti-IgE drug (Omalizumab) was attempted due to severity of her symptoms and elevated levels of IgE. On initiating the treatment, the patient showed a significant improvement in her skin condition; however, a trial to taper off Omalizumab two years later was unsuccessful. Conclusion: This case suggests a possible role of IgE autoantibodies in EBP that requires further research, consolidated by the fact that our patient showed improvement with anti-IgE therapy. Furthermore anti-IgE therapy offers a possible new targeted treatment for EBP in the absence of curative treatments.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"239 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75295257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Procedural Approach to Minimize the Risk of Embolization of Blood Vessels with Soft-Tissue Fillers","authors":"M. Angelo-Khattar","doi":"10.35248/2155-9554.11.S7.544","DOIUrl":"https://doi.org/10.35248/2155-9554.11.S7.544","url":null,"abstract":"Background: Soft-tissue filler injections are amongst the most widely used treatments in nonsurgical facial rejuvenation. Although generally deemed safe, rare catastrophic side effects are regularly reported in the literature, the most devastating of which is irreversible blindness. The avoidance of these serious vascular events is of the utmost importance during soft tissue filler injections. Objective: This article suggests a procedural protocol to greatly minimize the risk of embolization of blood vessels with soft-tissue fillers. Discussion: Extensive cadaver studies have shown significant inter-individual and intra-individual variations in vascular anatomy. Hence, detailed knowledge of anatomy, albeit very important, is not always sufficient to prevent the accidental cannulation of major arteries. Furthermore, the recent inclusion of xylocaine, a known vasodilator, in several proprietary filler substances, may increase the probability of intravascular injection. Hence, avoidance remains the single most important factor in preventing the dire outcomes of vascular complications with filler substances. Conclusion: The outlined treatment recommendation, if diligently followed, may greatly minimize the risk of intraluminal injection with soft-tissue fillers.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"71 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83819780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Reactive Papulotranslucent Acrokeratoderma: A Case Report","authors":"Mohammed H. Abduljabbar","doi":"10.35248/2155-9554.11.S7.545","DOIUrl":"https://doi.org/10.35248/2155-9554.11.S7.545","url":null,"abstract":"Transient Reactive Papulotranslucent Acrokeratoderma (TRPA) is an acquired or hereditary skin disorder of unknown etiology. It is characterized by edema, wrinkling and white papules and plaques of the palms and soles following contact with water for 3-5 minutes that typically resolves within a short period of time after drying.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"2673 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80938585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermolysis Bullosa Acquisita: A Case Report","authors":"Lafuente Cevallos Lizeth Veronica, Urena Lopez Valeria Alex, Ra, Lascano Gallegos Nathalie, Palacios Alvarez Santiago Alberto","doi":"10.35248/2155-9554.11.S7.546","DOIUrl":"https://doi.org/10.35248/2155-9554.11.S7.546","url":null,"abstract":"Epidermolysis Bullosa Acquisita (EBA) is a chronic autoimmune subepidermal blistering disease developed after damage to type VII collagen by autoantibodies. Type VII collagen is the major component of anchoring fibrils in the sub-lamina densa hemidesmosomes of the skin and squamous mucosas. The worldwide incidence is estimated between 0.2-0.5/million inhabitants per year. Two major clinical variants have been described: the mechanobullous, and the inflammatory EBA.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78911397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus Vulgaris Revealing Pulmonary Tuberculosis","authors":"S. Belmourida, Z. Mehsas, H. Palamino, M. Meziane, N. Ismaili, L. Benzekri, B. Hassam, K. Senouci","doi":"10.35248/2155-9554.20.11.530","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.530","url":null,"abstract":"Cutaneous tuberculosis is rare, it accounts for 2% of all extrapulmonary tuberculosis and is one of the multiple clinical presentations of extrapulmonary tuberculosis. The lupus vulgaris is a particular clinical form and is often represented by a single lesion, the multiple forms associated with pulmonary tuberculosis are rare. We present a new case of multiple skin lesions of the face of a lupus vulgaris revealing pulmonary tuberculosis.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"11 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}