Journal of Clinical Toxicology最新文献_第2页

Subacute Cutaneous Lupus Secondary to Trastuzumab Emtasine 曲妥珠单抗Emtasine继发的亚急性皮肤狼疮

Journal of Clinical Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2161-0495.21.S19.005

Joao Alves Teixeira, Costa Catarina, Santos Ines, Janeiro Claudia

引用次数: 0

Evaluation of the Prevalence of Vitamin D Deficiency and itsâ Correlation with Body Mass Index and Waist Circumference in Children 评估儿童维生素D缺乏症的患病率及其与体重指数和腰围的相关性

Journal of Clinical Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2161-0495.21.S19.002

Marzie Fatemi Abhari

{"title":"Evaluation of the Prevalence of Vitamin D Deficiency and itsâ Correlation with Body Mass Index and Waist Circumference in Children","authors":"Marzie Fatemi Abhari","doi":"10.35248/2161-0495.21.S19.002","DOIUrl":"https://doi.org/10.35248/2161-0495.21.S19.002","url":null,"abstract":"Introduction: Recent studies have suggested a link between vitamin D deficiency and an increase in body mass index and waist circumference. The aim of this study was to evaluate the vitamin D status and its’ correlation with body mass index and waist circumference in children aged 2-14 referred to the clinic of Imam Ali Hospital in Karaj in 2019-2020. Methods: Three Hundred seventy-nine (379) children aged 2-14 years referred to Clinic were enrolled in the study. Patients' height, weight (BMI calculated accordingly), waist circumference and serum vitamin D levels were measured. Chi-Square, Krystal-Wallis and Fishers exact tests were used, and the Bivariate Correlation test was used to determine the relationship between two variables. Results: The prevalence of vitamin D deficiency, insufficiency and adequate levels were reported 40.6%, 11.9%and 47.5%, respectively. Vitamin D deficiency was more common in girls. Vitamin D had a significant and weak relationship with BMI, but no association with waist circumference. Conclusion: The results of this study showed a high prevalence of vitamin D deficiency in patients. The prevalence of vitamin D deficiency and insufficiency were higher in girls. The highest levels of vitamin D were found in patients with normal weight. Vitamin D deficiency was most common in obese patients. Serum vitamin D were significantly associated with obesity, but had no significant association with waist circumference. A study with a larger sample size in this area, is recommended.","PeriodicalId":15433,"journal":{"name":"Journal of Clinical Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82338068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Study the Effectiveness of Platelet Transfusion in Management of Dengue Patients in Tertiary Care Hospital 目的探讨血小板输注在三级医院治疗登革热患者中的效果

Journal of Clinical Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2161-0495.21.S16.003

Ashu Dogra, Kaushik Rana, Devanshi Gosai

{"title":"To Study the Effectiveness of Platelet Transfusion in Management of Dengue Patients in Tertiary Care Hospital","authors":"Ashu Dogra, Kaushik Rana, Devanshi Gosai","doi":"10.35248/2161-0495.21.S16.003","DOIUrl":"https://doi.org/10.35248/2161-0495.21.S16.003","url":null,"abstract":"Background: Dengue has been emerging as rapidly spreading and dreaded mosquito borne disease caused by the bite of Aedes Aegypti Mosquito. Clinical features are variable and presents with Dengue fever or Dengue Hemorrhagic fever or more severe Dengue shock syndrome. Thrombocytopenia is presenting feature in in all Dengue cases and some often presents with bleeding. Platelet transfusions are given in patients with haemorrhagic symptoms. Present study thus aims to study the effectiveness of platelet transfusion in management of Dengue patients with Dengue haemorrhagic fever and Dengue shock syndrome. Results: In present study, a total of 20 patients were diagnosed as dengue confirmed cases by serological testing methods. Out of 20, 12 (60%) patients had dengue fever with platelet count in range of 50,000-80,000 per μl. Two patients with Dengue fever had Petechial spots with platelet count in range of 50,000 per μl and were given prophylactic Single Donor Platelet Transfusions. Eight patients (40%) presented with Dengue Haemorrhagic fever and platelet count of < 20,000 per μl. These patients were given single donor platelet transfusions. Six patients responded good with CCI of > 30,000 per μl and 2 patients recorded as non-responders. Conclusion: This study suggests that 25% Platelet transfusions are inappropriate. Platelet transfusions are more effective when it is given to patients with platelet count <20,000 per μl. Platelet transfusion should be given based on platelet count and hemorrhagic manifestations, as this decreases hospitalization of patients and complications of dengue.","PeriodicalId":15433,"journal":{"name":"Journal of Clinical Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90090460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Heavy Metals on Fishes: Toxicity and Bioaccumulation 重金属对鱼类的影响:毒性和生物蓄积

Journal of Clinical Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2161-0495.21.S18.001

Pramita Garai, P. Banerjee, P. Mondal, Nimai Ch, R. Saha

{"title":"Effect of Heavy Metals on Fishes: Toxicity and Bioaccumulation","authors":"Pramita Garai, P. Banerjee, P. Mondal, Nimai Ch, R. Saha","doi":"10.35248/2161-0495.21.S18.001","DOIUrl":"https://doi.org/10.35248/2161-0495.21.S18.001","url":null,"abstract":"Heavy metal pollution is a serious problem for the environment due to their toxicity, persistency, bioaccumulation, and bio magnifications property. Heavy metal contamination in the environment can occur from different natural and anthropogenic sources. The natural sources of heavy metals are mainly volcanic eruption and weathering of metal-bearing rocks, while the anthropogenic sources of heavy metals include agricultural and industrial activities, combustion of fossil fuel and gasoline, waste incinerators, mining, etc. The mobilization of these heavy metals to the aquatic ecosystem alters the physicochemical property of water which is hazardous for aquatic organisms. Heavy metals mainly enter the fish body through gills, body surface and digestive tract during ingestion of metal accumulated food materials. Cadmium, chromium, nickel, arsenic, copper, mercury, lead and zinc are the most common heavy metal pollutants that cause severe toxicity in fishes. Development of oxidative stress is the fundamental molecular mechanism of metal toxicity. The stress weakens the immune system, causes tissue and organ damage, growth defect and reduces reproductive ability. The rich source of high-quality protein filled with vitamins and omega-3 fatty acids encourage the human being to uptake fish as a major food source. So, accumulated heavy metals in the fish tissues directly transfer to the human body and cause toxic effects to expedite various diseases. Therefore, it is necessary to discuss the sources of heavy metals and their toxic effect on fish health to enforce the law and legislations regarding their protection in the aquatic environment and also to save human life.","PeriodicalId":15433,"journal":{"name":"Journal of Clinical Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88546807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Cardiovascular Toxicology and Pharmacology 心血管毒理学和药理学

Journal of Clinical Toxicology Pub Date : 2021-01-01 DOI: 10.35248/2161-0495.21.S16.E001

S. Gad

引用次数: 0

Acute Renal Failure Following Poisoning by Juniper Tar (Cade Oil) 杜松焦油(凯德油)中毒后急性肾衰竭

Journal of Clinical Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2161-0495.20.10.442

I. F. S. Ezzaki, N. Mtioui, S. Khayat, G. Medkouri, M. Zamed, M.benghanem B.Ramdani

引用次数: 1

Toxicology Latest Innovations 毒理学最新创新

Journal of Clinical Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2155-0495.10.2.E127

M. Akhgari

引用次数: 0

Evaluation of the Effect of Luteolin on the Hepatic and Hematopoietic Systems in Albino Rats 木犀草素对白化大鼠肝脏和造血系统影响的评价

Journal of Clinical Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2161-0495.20.10.434

Chima E. Orji, C. Okpoko, C. Agbata, J. Okoyeh, A. Okeke, C. Ihekwereme

{"title":"Evaluation of the Effect of Luteolin on the Hepatic and Hematopoietic Systems in Albino Rats","authors":"Chima E. Orji, C. Okpoko, C. Agbata, J. Okoyeh, A. Okeke, C. Ihekwereme","doi":"10.35248/2161-0495.20.10.434","DOIUrl":"https://doi.org/10.35248/2161-0495.20.10.434","url":null,"abstract":"Background: Luteolin is a flavonoid with some useful pharmacological properties yet its safety profile has not been fully delineated .Objectives of the study were to investigate the effects of luteolin on blood and liver functions, and make necessary recommendations regarding therapeutic use of luteolin. Methods: A total of 33 adult albino rats (average weight) were used in this study. Oral LD50 of luteolin was carried out with 13 rats using modified Lorke’s method. The other 20 rats were divided into 4 groups comprising of 5 rats per group (n=5 per group) for biochemical, haematological and histopathological studies which were carried out for 28 days. Group I was used as control and received orally 10 ml/kg of distilled water. Groups II,III and IV also orally received 50 mg/kg,100 mg/kg and 200 mg/kg of luteolin respectively. Blood samples were collected from each rat in the different groups before treatment, on 14th and 28th days respectively and after repeated daily dosing. The liver of the rats were extracted and examined for histological changes. Results: Results show that all doses of luteolin had significant (p<0.05) elevation of some blood indices (RBCs, PCV, Hb) while WBCs was not elevated. There was significant (p<0.05) increase in liver enzymes such as ALT, AST and ALP. Conclusion: The study indicates that high doses ( ≥ 200 mg/kg) and prolonged use of luteolin may increase hepatic enzyme activity while low doses ( ≤ 50 mg/kg) and are hepatoprotective. No significant liver damage was observed based on histopathological results.","PeriodicalId":15433,"journal":{"name":"Journal of Clinical Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90288618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acute Hypoxemic Respiratory Failure due to Mercury Inhalation in a Two-Year Old Female 2岁女童汞吸入致急性低氧性呼吸衰竭

Journal of Clinical Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2161-0495.20.10.446

Tiffany Byerly

引用次数: 0

An Unintentional Overdose: A Case Report 意外用药过量:一个案例报告

Journal of Clinical Toxicology Pub Date : 2020-01-01 DOI: 10.35248/2161-0495.20.10.445

A. A. Abbott

引用次数: 0