Journal of Current Glaucoma Practice最新文献

{"title":"Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study.","authors":"Nariman Nassiri,&nbsp;Shibandri Das,&nbsp;Vaama Patel,&nbsp;Aravindh Nirmalan,&nbsp;Dhir Patwa,&nbsp;Alexandra Heriford,&nbsp;Chaesik Kim,&nbsp;Haoxing Chen,&nbsp;Faisal Ridha,&nbsp;Justin Tannir,&nbsp;Anju Goyal,&nbsp;Mark S Juzych,&nbsp;Bret A Hughes","doi":"10.5005/jp-journals-10078-1350","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1350","url":null,"abstract":"<p><strong>Purpose: </strong>Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes.</p><p><strong>Patients and methods: </strong>This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glaucoma suspect eyes (i.e., concerning cup-to-disk ratio and/or intraocular pressure (IOP) >21 mm Hg), age ≥ 30 years old, follow-up time of 5 years, best-corrected visual acuity (BCVA) of 20/100 or better, spherical equivalent (SE) higher than 8 diopters and an astigmatism less than 3 diopters. Eyes with glaucoma-determined by two consecutive, reliable visual field tests-were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not.</p><p><strong>Results: </strong>In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression.</p><p><strong>Conclusion: </strong>Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes.</p><p><strong>How to cite this article: </strong>Nassiri N, Das S, Patel V, <i>et al.</i> Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. J Curr Glaucoma Pract 2022;16(1):11-16.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":" ","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/2b/jocgp-16-11.PMC9385390.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40349759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"Topography\" of Glaucomatous Defect Using OCT and Visual Field Examination.","authors":"Alessandro de Paula,&nbsp;Andrea Perdicchi,&nbsp;Augusto Pocobelli,&nbsp;Serena Fragiotta,&nbsp;Gianluca Scuderi","doi":"10.5005/jp-journals-10078-1353","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1353","url":null,"abstract":"<p><strong>Aim: </strong>To describe the modifications in the superior and inferior retinal nerve fiber layer (RNFL) thickness regarding the distribution of the VF defects for the horizontal meridians in glaucomatous patients and the differences in the RNFL thickness topography between glaucomatous and healthy subjects.</p><p><strong>Methods: </strong>One hundred twenty eyes of 91 patients affected by glaucoma and 94 eyes of 51 normal patients were retrospectively reviewed. Computerized 30°VF (Octopus G1 Dynamic strategy) and optical coherence tomography (OCT) ONH and 3D disk analysis were performed in all cases. The RNFL thickness measures analyzed in both groups were superior-nasal (SN), superior-temporal (ST), inferior-nasal (IN), and inferior temporal (IT) sectors. The VFs were classified according to the distribution of the VF defect as for the horizontal meridian in the pattern deviation plot as superior, inferior, predominantly superior, or predominantly inferior.</p><p><strong>Result: </strong>In the glaucomatous group, 78 eyes (65%) showed a predominantly superior VF defect, while 38 eyes (32%) showed a predominantly inferior VF defect. Fifty-six eyes (46.7%) presented an exclusively superior, and 27/120 eyes (22.5%) presented an exclusively inferior VF defect. In the control group, the thickest RNFL sector was IT. The ST sector showed the thickest RNFL in presence of an exclusive superior VF defect. In case of an exclusive inferior VF defect, the thickest RNFL was the IT sector. VF showing superior defect presented a more altered MD than the VF with an inferior defect.</p><p><strong>Conclusion: </strong>Glaucomatous damage affects both the superior and inferior neural rim almost simultaneously. However, the neural rim loss seems to be asymmetric, involving the inferior or superior rim depending on the predominant involvement of the superior or inferior hemifield at the VF test. Particularly, the IT sector appears to be the most compromised in glaucomatous eyes. Therefore, the asymmetry between superior and inferior RNFL could support the diagnosis of glaucoma.</p><p><strong>How to cite this article: </strong>de Paula A, Perdicchi A, Pocobelli A, <i>et al.</i> The \"Topography\" of Glaucomatous Defect Using OCT and Visual Field Examination. J Curr Glaucoma Pract 2022;16(1):31-35.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":" ","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/e6/jocgp-16-31.PMC9385384.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40348249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensual Ophthalmotonic Reaction Following Selective Laser Trabeculoplasty.","authors":"Nariman Nassiri,&nbsp;Frank Mei,&nbsp;Hassan Tokko,&nbsp;John Zeiter,&nbsp;Sarah Syeda,&nbsp;Chaesik Kim,&nbsp;Ronald Swendris,&nbsp;Anju Goyal,&nbsp;Elise In'T Veld,&nbsp;Alma Mas-Ramirez,&nbsp;Sonia W Rana,&nbsp;Mark S Juzych,&nbsp;Bret A Hughes","doi":"10.5005/jp-journals-10078-1361","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1361","url":null,"abstract":"<p><strong>Aim: </strong>\"Consensual ophthalmotonic reaction\" refers to changes in intraocular pressure (IOP) in one eye, which is accompanied by a corresponding change in IOP in the contralateral eye. This study evaluates whether monocular administration of selective laser trabeculoplasty (SLT) leads to a consensual ophthalmotonic reaction and how long this effect lasts.</p><p><strong>Materials and methods: </strong>A retrospective chart review was performed on patients receiving SLT at Kresge Eye Institute in Detroit, MI, from January 2015 to August 2016. Patients were excluded if they had previous history of glaucoma incisional and/or laser procedures; required additional laser trabeculoplasty; had glaucoma medication changes during the follow-up period; experienced no decrease in IOP during the follow-up period; or had a diagnosis of angle closure on gonioscopy. Various demographic, clinical, and surgical data were collected. IOP measurements were collected at baseline and postoperatively at 1-3 months, 4-9 months, and 12-15 months.</p><p><strong>Results: </strong>At all follow-up periods, the IOP of the treated eye was decreased from baseline IOP (<i>p</i> ≤ 0.05, paired <i>t</i>-test). For the fellow eye, there was a statistically significantly decrease from baseline up to the 4-9 months follow-up period (<i>p</i> ≤ 0.05, paired <i>t</i>-test). Linear regression analysis of the percent reduction in IOP from baseline in the SLT-treated eye with the fellow eye shows a mild correlation at all-time points: R² = 0.284 (<i>p</i> < 0.001) at 1-3 months; R² = 0.348 (<i>p</i> < 0.001) at 4-9 months; R² = 0.118 (<i>p</i> = 0.054) at 12-15 months.</p><p><strong>Conclusion: </strong>This study showed that monocular administration of SLT results in a consensual ophthalmotonic reaction. The consensual ophthalmotonic reaction appears to last for up to 4-9 months.</p><p><strong>Clinical significance: </strong>Therefore, although SLT does lead to a consensual ophthalmotonic reaction, monocular administration of SLT is not a reliable method of long-term IOP control for the contralateral non-SLT-treated eye.</p><p><strong>How to cite this article: </strong>Nassiri N, Mei F, Tokko H, <i>et al.</i> Consensual Ophthalmotonic Reaction Following Selective Laser Trabeculoplasty. J Curr Glaucoma Pract 2022;16(1):36-40.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":" ","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/7c/jocgp-16-36.PMC9385382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40348253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XEN-Augmented Deep Sclerectomy: Step-by-step Description of a Novel Surgical Technique for the Management of Open-angle Glaucoma.","authors":"Laëtitia J Niegowski,&nbsp;Kevin Gillmann,&nbsp;J-M Baumgartner","doi":"10.5005/jp-journals-10078-1311","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1311","url":null,"abstract":"<p><strong>Aim and background: </strong>The present case report describes a novel surgical technique combining XEN gel stent implantation and deep sclerectomy: XEN-augmented deep sclerectomy (XEN-DS).</p><p><strong>Case description: </strong>An active 96-year-old Caucasian woman suffering from pseudoexfoliative glaucoma (PEXG) presented with intraocular pressure (IOP) of 24 mm Hg and a double arcuate visual field defect [mean deviation (MD) -9.6 dB] in her only functional eye despite maximal medical therapy. Considering (1) the magnitude of IOP reduction sought, (2) the risk of complications associated with trabeculectomies and glaucoma drainage devices, and (3) the risk of missed appointments due to the patient's personal and social circumstances, it was decided to tailor the surgical treatment to this patient's specific characteristics combining two existing surgical techniques. Following conjunctival dissection, a superficial scleral flap was lifted 2 mm more posteriorly than in conventional DS, and a XEN gel stent was implanted <i>ab externo</i> through the anterior wall of the deep sclerectomy, into the anterior chamber. A mitomycin C-soaked autologous space maintainer was used. No peri- or postoperative complications were observed. Following XEN-DS, her IOP stabilized between 5 mm Hg and 8 mm Hg through 6 months, and her visual field MD improved to -1.5 dB.</p><p><strong>Discussion: </strong>The present case report is a proof of concept for this novel surgical technique, confirming that XEN-DS has the potential to achieve substantial and persistent IOP reductions in PEXG with a satisfactory safety profile. Clinical studies are warranted to confirm these results.</p><p><strong>How to cite this article: </strong>Niegowski LJ, Gillmann K, Baumgartner JM. XEN-Augmented Deep Sclerectomy: Step-by-step Description of a Novel Surgical Technique for the Management of Open-angle Glaucoma. J Curr Glaucoma Pract 2021;15(3):144-148.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"144-148"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/af/jocgp-15-144.PMC8807939.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Glaucomatous Visual Field Defects in Rural Australia with an iPad.","authors":"Mark A Chia,&nbsp;Edward Trang,&nbsp;Ashish Agar,&nbsp;Algis J Vingrys,&nbsp;Jenny Hepschke,&nbsp;George Yx Kong,&nbsp;Angus W Turner","doi":"10.5005/jp-journals-10078-1312","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1312","url":null,"abstract":"<p><strong>Aim and objective: </strong>Developing improved methods for early detection of visual field defects is pivotal to reducing glaucoma-related vision loss. The Melbourne Rapid Fields screening module (MRF-S) is an iPad-based test, which allows suprathreshold screening with zone-based analysis to rapidly assess the risk of manifest glaucoma. The versatility of MRF-S has potential utility in rural areas and during infectious pandemics. This study evaluates the utility of MRF-S for detecting field defects in non-metropolitan settings.</p><p><strong>Materials and methods: </strong>This was a prospective, multicenter, cross-sectional validation study. Two hundred and fifty-two eyes of 142 participants were recruited from rural sites through two outreach eye services in Australia. Participants were tested using MRF-S and compared with a reference standard; either Zeiss Humphrey Field Analyzer or Haag-Streit Octopus performed at the same visit. Standardized questionnaires were used to assess user acceptability. Major outcome measures were the area under the curve (AUC) for detecting mild and moderate field defects defined by the reference tests, along with corresponding performance characteristics (sensitivity, specificity).</p><p><strong>Results: </strong>The mean test duration for MRF-S was 1.88 minutes compared with 5.92 minutes for reference tests. The AUCs for mild and moderate field defects were 0.81 [95% confidence interval (CI): 0.75-0.87] and 0.87 (95% CI: 0.83-0.92), respectively, indicating very good diagnostic accuracy. Using a risk criterion of 55%, MRF-S identified moderate field defects with a sensitivity and specificity of 88.4 and 81.0%, respectively.</p><p><strong>Conclusion and clinical significance: </strong>The MRF-S iPad module can identify patients with mild and moderate field defects while delivering favorable user acceptability and short test duration. This has potential application within rural locations and amidst infectious pandemics.</p><p><strong>How to cite this article: </strong>Chia MA, Trang E, Agar A, <i>et al.</i> Screening for Glaucomatous Visual Field Defects in Rural Australia with an iPad. J Curr Glaucoma Pract 2021;15(3):125-131.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"125-131"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/94/jocgp-15-125.PMC8807937.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeat Selective Laser Trabeculoplasty for Glaucoma Patients: A Systematic Review and Meta-analysis.","authors":"Hyunsoo J Jang,&nbsp;Brian Yu,&nbsp;William Hodge,&nbsp;Monali S Malvankar-Mehta","doi":"10.5005/jp-journals-10078-1302","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1302","url":null,"abstract":"<p><strong>Aim and objective: </strong>To evaluate repeat selective laser trabeculoplasty (SLT) for treating primary open-angle glaucoma (POAG).</p><p><strong>Materials and methods: </strong>PubMed, CINAHL, and EMBASE were systematically searched along with grey literature. All English articles that measured intraocular pressure (IOP) before and after repeat SLT on adult patients with POAG were included. Studies were not filtered by location or publication date. Covidence was used to screen imported articles. Risk of bias assessment and data extraction was performed after screening. Meta-analysis was performed using STATA 16.0. Fixed-effect or random-effects models were developed depending on the presence of heterogeneity.</p><p><strong>Results: </strong>Database and grey literature search identified 512 unique studies. After duplicate removal and screening, 12 articles were included and data from included studies were synthesized. Nine articles were included in the meta-analysis. Three studies were prospective observational studies, and nine studies were retrospective chart reviews. Due to the presence of heterogeneity, a random-effects model has been utilized that suggested significant IOP reduction (IOPR) by repeat SLT at 24 months follow-up.</p><p><strong>Conclusion: </strong>Based on our results, repeat SLT could be an effective procedure in reducing IOP for patients with glaucoma for up to 24 months. Efficacy of third, fourth, or further SLT remains to be verified. More data from long-term, high-quality randomized-controlled trials (RCTs) are required to make conclusions.</p><p><strong>Clinical significance: </strong>Repeat SLT may be an effective treatment for lowering IOP with minimal complications or safety issues. This may allow the use of SLT as a primary treatment for POGA, allowing the discontinuation of medications or eye drops and lead to additional benefits.</p><p><strong>How to cite this article: </strong>Jang HJ, Yu B, Hodge W, <i>et al.</i> Repeat Selective Laser Trabeculoplasty for Glaucoma Patients: A Systematic Review and Meta-analysis. J Curr Glaucoma Pract 2021;15(3):117-124.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"117-124"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/2b/jocgp-15-117.PMC8807942.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset Endophthalmitis after XEN45^® Implantation: A Retrospective Case Series and Literature Review.","authors":"Raquel Burggraaf-Sánchez de Las Matas,&nbsp;Laura Such-Irusta,&nbsp;Enrique A Alfonso-Muñoz,&nbsp;Héctor Mascarós-Mena,&nbsp;Aitor Lanzagorta-Aresti,&nbsp;Jorge Mataix-Boronat,&nbsp;Carolina Font-Julià","doi":"10.5005/jp-journals-10078-1316","DOIUrl":"10.5005/jp-journals-10078-1316","url":null,"abstract":"<p><strong>Aim and objective: </strong>To report the incidence of late-onset endophthalmitis following XEN45^® stent implantation.</p><p><strong>Background: </strong>Long-term safety profile and efficacy in relation to the so-called microinvasive glaucoma surgery (MIGS) techniques are still under evaluation. The XEN45^® gel stent entails a bleb formation and often requires postoperative conjunctival management, differing from the current reviewed concept of minimally invasive procedures. Endophthalmitis has been described among the complications, triggered in the majority of cases by tube extrusion.</p><p><strong>Cases description: </strong>From our chart of 293 eyes operated on between November 2016 and November 2019, five (1.7%) patients developed endophthalmitis, which took place in the months 3, 4, 5, 11, and 14 after surgery, respectively. Sixty percent had undergone previous needling procedures. All of them showed a previous flat bleb and developed perforation of the conjunctiva caused by the distal portion of the tube. One patient was early eviscerated due to a fateful course. Treatment consisted of intravitreal, oral, and topical antibiotics, as well as topical corticosteroids. Eighty percent underwent device withdrawal, conjunctival gap suturing, anterior chamber washout, aqueous humor (AH) tab extraction (one positive for <i>S. epidermidis</i> and one for <i>Streptococcus agalactiae</i>), and pars plana vitrectomy. A second patient was eviscerated due to phthisis bulbi. Out of three remaining patients, one underwent vitrectomy for retinal detachment, while two patients required glaucoma surgery for intraocular pressure control. The final VA was ≤20/125 in all patients.</p><p><strong>Conclusion: </strong>The XEN45^® device appears to trigger endophthalmitis by extruding the stent or unnoticed leakage through conjunctival defects. Special attention should be paid to flat and avascular blebs.</p><p><strong>Clinical significance: </strong>This series shows a higher rate of endophthalmitis (1.7%) compared with previous studies with a significant sample size (0.4-1.4%).</p><p><strong>How to cite this article: </strong>Burggraaf-Sánchez de las Matas R, Such-Irusta L, Alfonso-Muñoz EA, <i>et al.</i> Late-onset Endophthalmitis after XEN45^® Implantation: A Retrospective Case Series and Literature Review. J Curr Glaucoma Pract 2021;15(3):153-160.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/c5/jocgp-15-153.PMC8807934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XEN Gel Staining with Trypan Blue: A Simple and Effective Technique to Improve Device Visualization during Implantation.","authors":"Vincenzo Ramovecchi,&nbsp;Fabrizio Franco,&nbsp;Giuseppe Ruben Barbera","doi":"10.5005/jp-journals-10078-1318","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1318","url":null,"abstract":"<p><p>The Xen Gel Stent (Allergan, Irvine, CA, USA) is a hydrophilic collagen-based gelatin tube of 6 mm in length which creates a channel of communication between the anterior chamber and the subconjunctival space allowing aqueous humor outflow. XEN is an <i>ab interno</i>, minimally invasive, glaucoma surgery device which has a better safety profile and offers a less invasive way of lowering intraocular pressure. Unfortunately, one of its weaknesses is that visualization of the implant during surgery is difficult, and this difficulty may be exacerbated, for instance, by a subconjunctival hemorrhage. The purpose of this paper is to describe a simple and effective technique for improving device visualization (XEN 45 μm) during the implantation. <b>How to cite this article:</b> Ramovecchi V, Franco F, Barbera GR. XEN Gel Staining with Trypan Blue: A Simple and Effective Technique to Improve Device Visualization during Implantation. J Curr Glaucoma Pract 2021;15(3):161-163.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"161-163"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/14/jocgp-15-161.PMC8807932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Toxicity Evaluation of New Generic Latanost^® and Latacom^® as an Ophthalmic Formulation.","authors":"Jessica Sze Chia Ng,&nbsp;Yi Xin Tan,&nbsp;Nor Amalina Ahmad Alwi,&nbsp;Kar Ming Yee,&nbsp;Ahmad Hazri Abdul Rashid,&nbsp;Ka-Liong Tan,&nbsp;Chuei Wuei Leong","doi":"10.5005/jp-journals-10078-1319","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1319","url":null,"abstract":"<p><strong>Aim and objective: </strong>To evaluate the safety of two new generic ophthalmic formulations, Latanost^® (latanoprost) and Latacom^® (latanoprost and timolol) by utilizing the three-dimensional reconstructed human cornea-like epithelium (RhCE) tissue constructs as an <i>in vitro</i> model in the assessment of ocular irritation.</p><p><strong>Materials and methods: </strong><i>In vitro</i> irritation test was conducted on Latanost^® (LTN) and Latacom^® (LTC) and their corresponding innovators, Xalatan^® (XLT) and Xalacom^® (XLC), respectively, by using RhCE. According to the OECD guidelines No. 492 on the testing of chemicals, the ophthalmic formulations were assessed via topical exposure of the formulations on <i>in vitro</i> RhCE tissue. Cell viability was measured by MTT assay.</p><p><strong>Results: </strong>The mean cell viability percentage of LTN and XLT was 70.5 and 75.7%, respectively, whereas, for LTC and XLC, the percentage viability was 95.3 and 85.7%, respectively. The two new generic formulations (LTN and LTC) did not reduce the cell viability of the RhCE tissue to ≤60%. Thus, both can be considered as nonirritant.</p><p><strong>Conclusion: </strong>Both newly developed generics are nonocular irritants.</p><p><strong>Clinical significance: </strong>This study informs the safety assessment of new generic antiglaucoma ophthalmic solutions applicable for long-term glaucoma treatment. The formulations aim to keep eye irritation to a minimum level.</p><p><strong>How to cite this article: </strong>Ng JSC, Tan YX, Alwi NAA, <i>et al. In Vitro</i> Toxicity Evaluation of New Generic Latanost^® and Latacom^® as an Ophthalmic Formulation. J Curr Glaucoma Pract 2021;15(3):139-143.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"139-143"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/b0/jocgp-15-139.PMC8807938.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Malignant Glaucoma from Complete Subluxation of Lens into Anterior Chamber.","authors":"Soshian Sarrafpour,&nbsp;Isaiah Davies,&nbsp;Osama Ahmed,&nbsp;Ji Liu,&nbsp;Christopher C Teng","doi":"10.5005/jp-journals-10078-1320","DOIUrl":"https://doi.org/10.5005/jp-journals-10078-1320","url":null,"abstract":"<p><strong>Aim and objective: </strong>To report an unusual and difficult case of malignant glaucoma induced by a traumatic mature cataract that had migrated into the anterior chamber in a developmentally delayed patient.</p><p><strong>Background: </strong>Malignant glaucoma can present due to multiple mechanisms, including trauma-induced cataract migration into the anterior chamber.</p><p><strong>Case description: </strong>A developmentally delayed female in her 40s with a history of self-abuse was found to have malignant glaucoma in the setting of a traumatic cataract that had migrated in front of the iris into the anterior chamber. Exam under anesthesia and ultrasound biomicroscopy (UBM) demonstrated complete subluxation of the lens into the anterior chamber. Perioperative techniques included prophylactic pars plana vitrectomy to alleviate posterior pressure as well as the creation of an irido-zonulo-hyaloido-vitrectomy (IZHV), which allowed for reformation of the anterior chamber. These maneuvers allowed for cataract surgery to be performed through a clear corneal incision, with anterior chamber intraocular lens implantation. The patient had improved vision, pressure, and pain.</p><p><strong>Conclusion: </strong>Malignant glaucoma can present in unique ways and the presence of a flat anterior chamber and increased posterior pressure can make surgery challenging. Initial pars plana vitrectomy in addition to the creation of an IZHV can help relieve posterior pressure and facilitate cataract extraction. It is important to factor in patient-specific situations and goals while selecting an intraocular lens.</p><p><strong>Clinical significance: </strong>Traumatic cataracts and malignant glaucoma can present in unique scenarios that may prove difficult to treat. Certain techniques can facilitate these challenging surgeries and provide the optimal outcome for patients.</p><p><strong>How to cite this article: </strong>Sarrafpour S, Davies I, Ahmed O, <i>et al</i>. Cataract Surgery in Malignant Glaucoma from Complete Subluxation of Lens into Anterior Chamber. J Curr Glaucoma Pract 2021;15(3):164-167.</p>","PeriodicalId":15419,"journal":{"name":"Journal of Current Glaucoma Practice","volume":"15 3","pages":"164-167"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/85/jocgp-15-164.PMC8807931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}