Journal of Cancer Epidemiology最新文献_第10页

Adipokines do not mediate the association of obesity and colorectal adenoma. 脂肪因子不介导肥胖和结直肠腺瘤的关联。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-08-13 DOI: 10.1155/2014/371254

Heather M Ochs-Balcom, Rikki Cannioto, Jing Nie, Amy E Millen, Jo L Freudenheim, Zhengyi Chen, Cheryl L Thompson, Russell Tracy, Li Li

{"title":"Adipokines do not mediate the association of obesity and colorectal adenoma.","authors":"Heather M Ochs-Balcom, Rikki Cannioto, Jing Nie, Amy E Millen, Jo L Freudenheim, Zhengyi Chen, Cheryl L Thompson, Russell Tracy, Li Li","doi":"10.1155/2014/371254","DOIUrl":"https://doi.org/10.1155/2014/371254","url":null,"abstract":"Purpose. The association between obesity and colon neoplasia is well established but the underlying biological mechanisms are not fully understood. Rates of both obesity and colon cancer differ by race. Adipokines have been postulated as contributors to the observed association; however, few studies have examined the mediating effect of adipokines on the obesity-colon adenoma association with consideration of racial differences. Methods. We determined prediagnostic levels of adiponectin and leptin in Caucasians (217 cases and 650 controls) and African Americans (175 cases and 378 controls) participating in the Case Transdisciplinary Research on Energetics and Cancer Colon Adenoma Study. We evaluated mediating effects of adiponectin and leptin on the association of abdominal adiposity and colon adenoma separately according to race using mediational pathway analysis. Results. We observed differences in circulating adipokine concentrations by race; African Americans had higher levels of leptin and lower levels of adiponectin than Caucasians for both adenoma cases and controls (P values <0.001). Leptin and adiponectin did not mediate the waist-to-hip ratio (WHR) adenoma association in either group (all Sobel P values >0.27). Conclusions. We found no evidence that leptin or adiponectin mediates the abdominal obesity-colorectal adenoma pathway. Larger studies on how these associations vary by race, sex, and obesity are needed. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"371254"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/371254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32647225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Breast cancer pathology, receptor status, and patterns of metastasis in a rural appalachian population. 阿巴拉契亚农村人口乳腺癌病理、受体状态和转移模式。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-01-09 DOI: 10.1155/2014/170634

Linda Vona-Davis, David P Rose, Vijaya Gadiyaram, Barbara Ducatman, Gerald Hobbs, Hannah Hazard, Sobha Kurian, Jame Abraham

{"title":"Breast cancer pathology, receptor status, and patterns of metastasis in a rural appalachian population.","authors":"Linda Vona-Davis, David P Rose, Vijaya Gadiyaram, Barbara Ducatman, Gerald Hobbs, Hannah Hazard, Sobha Kurian, Jame Abraham","doi":"10.1155/2014/170634","DOIUrl":"https://doi.org/10.1155/2014/170634","url":null,"abstract":"Breast cancer patients in rural Appalachia have a high prevalence of obesity and poverty, together with more triple-negative phenotypes. We reviewed clinical records for tumor receptor status and time to distant metastasis. Body mass index, tumor size, grade, nodal status, and receptor status were related to metastatic patterns. For 687 patients, 13.8% developed metastases to bone (n = 42) or visceral sites (n = 53). Metastases to viscera occurred within five years, a latent period which was shorter than that for bone (P = 0.042). More women with visceral metastasis presented with grade 3 tumors compared with the bone and nonmetastatic groups (P = 0.0002). There were 135/574 women (23.5%) with triple-negative breast cancer, who presented with lymph node involvement and visceral metastases (68.2% versus 24.3%; P = 0.033). Triple-negative tumors that metastasized to visceral sites were larger (P = 0.007). Developing a visceral metastasis within 10 years was higher among women with triple-negative tumors. Across all breast cancer receptor subtypes, the probability of remaining distant metastasis-free was greater for brain and liver than for lung. The excess risk of metastatic spread to visceral organs in triple-negative breast cancers, even in the absence of positive nodes, was combined with the burden of larger and more advanced tumors. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"170634"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/170634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32115233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Epidemic of non-hodgkin lymphoma in new zealand remains unexplained. 非霍奇金淋巴瘤在新西兰的流行仍未得到解释。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-04-01 DOI: 10.1155/2014/315378

Brian Cox, Chih-Wei Liu, Mary J Sneyd, Claire M Cameron

{"title":"Epidemic of non-hodgkin lymphoma in new zealand remains unexplained.","authors":"Brian Cox, Chih-Wei Liu, Mary J Sneyd, Claire M Cameron","doi":"10.1155/2014/315378","DOIUrl":"https://doi.org/10.1155/2014/315378","url":null,"abstract":"Background. Non-Hodgkin lymphoma (NHL) incidence rates have increased considerably in New Zealand. Methods. Incidence and mortality rates for NHL from 1981 to 2010 were calculated. Trends in age-specific rates were analysed and age-period-cohort models fitted to explore generation-specific changes in incidence and mortality. Results. NHL incidence increased by 67% for men and 74% for women between the 1981-1985 and 2006-2010 time periods in New Zealand. For women born about 1936 and men born about 1946, NHL incidence and mortality have diverged suggesting an improved prognosis for recent generations. Conclusion. The strong generation effects suggest that an exposure before 25 years of age is of major importance in determining the lifetime risk of NHL in New Zealand. NHL incidence rates in New Zealand will continue to increase in the future and probably more in females than males, as generations with increased risk age. Current hypotheses for the cause of NHL do not explain the trends observed. A decline in the prevalence of a protective factor may have also contributed to these trends. Examination of trends for subtypes of NHL and innovative testable hypotheses that may explain these trends are needed. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"315378"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/315378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32316731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cancer incidence in egypt: results of the national population-based cancer registry program. 埃及癌症发病率:国家基于人口的癌症登记项目的结果。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-09-21 DOI: 10.1155/2014/437971

Amal S Ibrahim, Hussein M Khaled, Nabiel Nh Mikhail, Hoda Baraka, Hossam Kamel

{"title":"Cancer incidence in egypt: results of the national population-based cancer registry program.","authors":"Amal S Ibrahim, Hussein M Khaled, Nabiel Nh Mikhail, Hoda Baraka, Hossam Kamel","doi":"10.1155/2014/437971","DOIUrl":"https://doi.org/10.1155/2014/437971","url":null,"abstract":"Background. This paper aims to present cancer incidence rates at national and regional level of Egypt, based upon results of National Cancer Registry Program (NCRP). Methods. NCRP stratified Egypt into 3 geographical strata: lower, middle, and upper. One governorate represented each region. Abstractors collected data from medical records of cancer centers, national tertiary care institutions, Health Insurance Organization, Government-Subsidized Treatment Program, and death records. Data entry was online. Incidence rates were calculated at a regional and a national level. Future projection up to 2050 was also calculated. Results. Age-standardized incidence rates per 100,000 were 166.6 (both sexes), 175.9 (males), and 157.0 (females). Commonest sites were liver (23.8%), breast (15.4%), and bladder (6.9%) (both sexes): liver (33.6%) and bladder (10.7%) among men, and breast (32.0%) and liver (13.5%) among women. By 2050, a 3-fold increase in incident cancer relative to 2013 was estimated. Conclusion. These data are the only available cancer rates at national and regional levels of Egypt. The pattern of cancer indicated the increased burden of liver cancer. Breast cancer occupied the second rank. Study of rates of individual sites of cancer might help in giving clues for preventive programs. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"437971"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/437971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32757633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 866

Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers. 乳腺癌生存由ER/PR/HER2亚型和肿瘤分级和免疫组织化学生物标志物的替代分类定义。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-05-26 DOI: 10.1155/2014/469251

Carol A Parise, Vincent Caggiano

{"title":"Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers.","authors":"Carol A Parise, Vincent Caggiano","doi":"10.1155/2014/469251","DOIUrl":"https://doi.org/10.1155/2014/469251","url":null,"abstract":"Introduction. ER, PR, and HER2 are routinely available in breast cancer specimens. The purpose of this study is to contrast breast cancer-specific survival for the eight ER/PR/HER2 subtypes with survival of an immunohistochemical surrogate for the molecular subtype based on the ER/PR/HER2 subtypes and tumor grade. Methods. We identified 123,780 cases of stages 1-3 primary female invasive breast cancer from California Cancer Registry. The surrogate classification was derived using ER/PR/HER2 and tumor grade. Kaplan-Meier survival analysis and Cox proportional hazards modeling were used to assess differences in survival and risk of mortality for the ER/PR/HER2 subtypes and surrogate classification within each stage. Results. The luminal B/HER2- surrogate classification had a higher risk of mortality than the luminal B/HER2+ for all stages of disease. There was no difference in risk of mortality between the ER+/PR+/HER2- and ER+/PR+/HER2+ in stage 3. With one exception in stage 3, the ER-negative subtypes all had an increased risk of mortality when compared with the ER-positive subtypes. Conclusions. Assessment of survival using ER/PR/HER2 illustrates the heterogeneity of HER2+ subtypes. The surrogate classification provides clear separation in survival and adjusted mortality but underestimates the wide variability within the subtypes that make up the classification. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"469251"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/469251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32446644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 232

Smokeless tobacco and oral cancer in South Asia: a systematic review with meta-analysis. 南亚的无烟烟草与口腔癌：系统回顾与荟萃分析。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-07-06 DOI: 10.1155/2014/394696

Zohaib Khan, Justus Tönnies, Steffen Müller

{"title":"Smokeless tobacco and oral cancer in South Asia: a systematic review with meta-analysis.","authors":"Zohaib Khan, Justus Tönnies, Steffen Müller","doi":"10.1155/2014/394696","DOIUrl":"10.1155/2014/394696","url":null,"abstract":"Introduction. Smokeless tobacco is considered one of the major risk factors for oral cancer. It is estimated that over 90% of the global smokeless tobacco use burden is in South Asia. This paper aims to systematically review publications reporting epidemiological observational studies published in South Asia from 1984 till 2013. Methods. An electronic search in \"Medline\" and \"ISI Web of Knowledge\" yielded 734 publications out of which 21 were included in this review. All publications were assessed for quality using a standard quality assessment tool. Effect estimates (odds ratios (OR)) were abstracted or calculated from the given data. A random effects meta-analysis was performed to assess the risk of oral cancer with the use of different forms of smokeless tobacco. Results and Conclusion. The pooled OR for chewing tobacco and risk of oral cancer was 4.7 [3.1-7.1] and for paan with tobacco and risk of oral cancer was 7.1 [4.5-11.1]. The findings of this study suggest a strong causal link between oral cancer and various forms of smokeless tobacco. Public health policies in affected countries should consider SLT specific cessation programs in addition to campaigns and activities incorporated into smoking cessation programs. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"394696"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32563921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis. 按诊断年龄划分的小儿急性淋巴细胞白血病存活模式。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-09-17 DOI: 10.1155/2014/865979

Md Jobayer Hossain, Li Xie, Suzanne M McCahan

{"title":"Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis.","authors":"Md Jobayer Hossain, Li Xie, Suzanne M McCahan","doi":"10.1155/2014/865979","DOIUrl":"10.1155/2014/865979","url":null,"abstract":"Age at diagnosis is a key prognostic factor in pediatric acute lymphoblastic leukemia (ALL) survivorship. However, literature providing adequate assessment of the survival variability by age at diagnosis is scarce. The aim of this study is to assess the impact of this prognostic factor in pediatric ALL survival. We estimated incidence rate of mortality, 5-year survival rate, Kaplan-Meier survival function, and hazard ratio using the Surveillance Epidemiology and End Results (SEER) data during 1973-2009. There was significant variability in pediatric ALL survival by age at diagnosis. Survival peaked among children diagnosed at 1-4 years and steadily declined among those diagnosed at older ages. Infants (<1 year) had the lowest survivorship. In a multivariable Cox proportional hazard model stratified by year of diagnosis, those diagnosed in age groups 1-4, 5-9, 10-14, and 15-19 years were 82%, 75%, 57%, and 32% less likely to die compared to children diagnosed in infancy, respectively. Age at diagnosis remained to be a crucial determinant of the survival variability of pediatric ALL patients, after adjusting for sex, race, radiation therapy, primary tumor sites, immunophenotype, and year of diagnosis. Further research is warranted to disentangle the effects of age-dependent biological and environmental processes on this association. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"865979"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32742033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and outcomes of desmoplastic small round cell tumor: results from the surveillance, epidemiology, and end results database. 结缔组织增生小圆细胞瘤的发病率和预后:来自监测、流行病学和最终结果数据库的结果。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-11-05 DOI: 10.1155/2014/680126

Christina K Lettieri, Pamela Garcia-Filion, Pooja Hingorani

{"title":"Incidence and outcomes of desmoplastic small round cell tumor: results from the surveillance, epidemiology, and end results database.","authors":"Christina K Lettieri, Pamela Garcia-Filion, Pooja Hingorani","doi":"10.1155/2014/680126","DOIUrl":"https://doi.org/10.1155/2014/680126","url":null,"abstract":"Desmoplastic small round cell tumor (DSRCT) is a rare but highly fatal malignancy. Due to the rarity of this neoplasm, no large population based studies exist. Procedure. This is a retrospective cohort analysis. Incidence rates were calculated based on sex and ethnicity and compared statistically. Gender-, ethnicity-, and treatment- based survival were calculated using the Kaplan-Meier method. Results. A total of 192 cases of DSRCT were identified. Peak incidence age was between 20 and 24 years. Age-adjusted incidence rate for blacks was 0.5 cases/million and for whites was 0.2 cases/million (P = 0.037). There was no statistically significant difference in survival based on gender or ethnicity. When adjusted for age, there was no statistically significant difference in survival amongst patients who received radiation therapy compared to those who did not (HRadj = 0.73; 95% CI 0.49, 1.11). There was a statistically significant survival advantage for patients who received radiation after surgery compared to those who did not (HR 0.49; 95% CI 0.30, 0.79). Conclusion. DSRCT is more common in males and in people of African-American descent. Although overall survival remains poor, radiation therapy following surgery seems to improve outcome in these patients. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"680126"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/680126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32843429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

Cancer in the elderly. 老年人的癌症。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-04-30 DOI: 10.1155/2014/872029

Frank Buntinx, Christine Campbell, Marjan van den Akker

{"title":"Cancer in the elderly.","authors":"Frank Buntinx, Christine Campbell, Marjan van den Akker","doi":"10.1155/2014/872029","DOIUrl":"https://doi.org/10.1155/2014/872029","url":null,"abstract":"Part 1 Introduction: sickness and health in old age, R.E.Irvine epidemiology of cancer in the elderly, D.W.Lamont hopes and fears of the elderly cancer patient, I.B.Brewin. Part 2 Principles of management of cancer in the elderly: principles of surgery, Henry Tankel principles of radiotherapy, Thurston Brewin principles of chemotherapy, Craig Lewis, Kaye & Calman terminal care, J.Welsh. Part 3 Complications of cancer in the elderly: metabolic aspects, H.M.Hodkinson paraneoplastic CNS syndromes, Chen-Ya Huang. Part 4 Organs and systems: breast cancer, Allan Langlands bronchus lung tumours, Gordon P.Canning and F.J. Caird Oesophagus, P.T.D. Symonds stomach gastric cancers, Alan Jewkes, Simon Rowley and T.J. & Priestman colon, and rectum and anus, Philip F.Schofield liver, gallbladder, and pancreas, John Chalstrey kidney, ureter and bladder, Philip P.Clark cancer of the prostate, Malcolm A.Bagshaw gynaecological cancer malignancy, L.N.Hudson skin, Rona M.MacKie lymphoma and leukaemia and malignant, John M.Dagg myeloma, J.S.Malpas, Wallace Stewart eye ophthalmic neoplasia, Bertil E.Damato and Foulds malignant disorders of bone, Frank J.Frassica, Lester E.Wold and Franklin H. & Sim head and neck cancer, D.F.N.Harrison brain and spinal cord, David A.Stewart and F.J.Caird.","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"872029"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/872029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32380996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 88

Colorectal cancer incidence and mortality disparities in new Mexico. 新墨西哥州结直肠癌发病率和死亡率差异。

IF 1.8

Journal of Cancer Epidemiology Pub Date : 2014-01-01 Epub Date: 2014-01-02 DOI: 10.1155/2014/239619

Richard M Hoffman, David K Espey, Robert L Rhyne, Melissa Gonzales, Ashwani Rajput, Shiraz I Mishra, S Noell Stone, Charles L Wiggins

{"title":"Colorectal cancer incidence and mortality disparities in new Mexico.","authors":"Richard M Hoffman, David K Espey, Robert L Rhyne, Melissa Gonzales, Ashwani Rajput, Shiraz I Mishra, S Noell Stone, Charles L Wiggins","doi":"10.1155/2014/239619","DOIUrl":"10.1155/2014/239619","url":null,"abstract":"Background. Previous analyses indicated that New Mexican Hispanics and American Indians (AI) did not experience the declining colorectal cancer (CRC) incidence and mortality rates observed among non-Hispanic whites (NHW). We evaluated more recent data to determine whether racial/ethnic differences persisted. Methods. We used New Mexico Surveillance Epidemiology and End Results data from 1995 to 2009 to calculate age-specific incidence rates and age-adjusted incidence rates overall and by tumor stage. We calculated mortality rates using National Center for Health Statistics' data. We used joinpoint regression to determine annual percentage change (APC) in age-adjusted incidence rates. Analyses were stratified by race/ethnicity and gender. Results. Incidence rates continued declining in NHW (APC -1.45% men, -1.06% women), while nonsignificantly increasing for AI (1.67% men, 1.26% women) and Hispanic women (0.24%). The APC initially increased in Hispanic men through 2001 (3.33%, P = 0.06), before declining (-3.10%, P = 0.003). Incidence rates declined in NHW and Hispanics aged 75 and older. Incidence rates for distant-stage cancer remained stable for all groups. Mortality rates declined significantly in NHW and Hispanics. Conclusions. Racial/ethnic disparities in CRC persist in New Mexico. Incidence differences could be related to risk factors or access to screening; mortality differences could be due to patterns of care for screening or treatment. ","PeriodicalId":15366,"journal":{"name":"Journal of Cancer Epidemiology","volume":"2014 ","pages":"239619"},"PeriodicalIF":1.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/239619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32115235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14