Journal Of Chemical Society Of Nigeria最新文献_第3页

ADSORTION POTENTIAL OF GARLIC, GINGER AND LEMON IN THE REMOVAL OF HEAVY METALS FROM AQUEOUS SOLUTIONS 大蒜、生姜和柠檬在去除水溶液中重金属方面的吸附潜力

Journal Of Chemical Society Of Nigeria Pub Date : 2024-03-05 DOI: 10.46602/jcsn.v49i1.953

G. .. Cookey, B. Tambari, D. P. Wokocha

引用次数: 0

THERMODYNAMIC STUDIES OF THE INTERACTIONS OF CETYLTRIMETHYL AMMONIUM BROMIDE (CTAB) AND METHYL ORANGE DYE IN ETHANOL-WATER MIXED SOLVENTS 十六烷基三甲基溴化铵（ctab）和甲基橙染料在乙醇-水混合溶剂中相互作用的热力学研究

Journal Of Chemical Society Of Nigeria Pub Date : 2024-02-27 DOI: 10.46602/jcsn.v49i1.945

G. .. Cookey, C. B. Giomene, N. Boisa

{"title":"THERMODYNAMIC STUDIES OF THE INTERACTIONS OF CETYLTRIMETHYL AMMONIUM BROMIDE (CTAB) AND METHYL ORANGE DYE IN ETHANOL-WATER MIXED SOLVENTS","authors":"G. .. Cookey, C. B. Giomene, N. Boisa","doi":"10.46602/jcsn.v49i1.945","DOIUrl":"https://doi.org/10.46602/jcsn.v49i1.945","url":null,"abstract":"The interaction between Cetyltrimethylammonium bromide (CTAB) and Methyl Orange dye in water and ethanol-water mixed solvent media at varying temperatures was studied by conductometry. The critical micelle concentrations and thermodynamic parameters of micelle formation such as enthalpy, entropy and Gibbs free energy were determined at different temperatures and volume fractions of ethanol. Results show that the CMC of CTAB increased with increasing volume fraction of ethanol indicating that the solubility of CTAB in aqueous solution may have decreased with increasing volume fraction of ethanol. The CMC of the surfactant solution also increased in the presence of the dye which may be attributed to steric hindrance due to the bulkiness of the azo dye. The increased CMC observed with temperature may suggest breakdown of structured water molecules surrounding the hydrophobic alkyl chain as well as increased molecular freedom of the surfactant molecules due to higher kinetic energy. The decreasing negative values of Gibbs free energy may indicate that micellization was thermodynamically feasible but less spontaneous on increasing volume fraction of ethanol, in the presence of the dye and with increasing temperature. However, temperature effect was not large. The enthalpy of the process shows that the interaction between the dye and surfactant was exothermic (?H 0m ? ? ) and the observed positive values of ?Sm is suggestive of entropy driven micellization process. ","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"7 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSESSMENT OF PHYSICOCHEMICAL PROPERTIES OF WATER FROM ELEME RIVER, SOUTH-SOUTH NIGERIA 尼日利亚南部埃莱姆河水的理化性质评估

Journal Of Chemical Society Of Nigeria Pub Date : 2024-02-27 DOI: 10.46602/jcsn.v49i1.947

V. C. Okabekwa, R. U. Arinze, B. I. Tabugbo, V. N. Okafor

{"title":"ASSESSMENT OF PHYSICOCHEMICAL PROPERTIES OF WATER FROM ELEME RIVER, SOUTH-SOUTH NIGERIA","authors":"V. C. Okabekwa, R. U. Arinze, B. I. Tabugbo, V. N. Okafor","doi":"10.46602/jcsn.v49i1.947","DOIUrl":"https://doi.org/10.46602/jcsn.v49i1.947","url":null,"abstract":"This study evaluated the physicochemical characteristics of water from the Eleme river in Rivers State, South-South Nigeria, to assess the water quality in the river. To determine pH, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), total solids (TS), dissolved oxygen (DO), five-day biochemical oxygen demand (BOD5), total organic carbon (TOC), chloride ion (Cl-), calcium ion (Ca2+), magnesium ion (Mg2+), and potassium ion (K+) using their standard methods, water samples were collected at two different points: station 1 (S1) and station 2 (S2). The results show that EC (1221, 1410 ?- 1cm-1), TSS (312.78, 372.01 mg/l), DO (6.09, 5.95 mg/l), Cl- (1056.41, 1056.89 mg/l) and K+ (15.24, 14.84 mg/l ) for S1 and S2 respectively were observed to be above the permissible limits recommended by some government regulatory bodies. pH of the water from S1 and S2 are 6.10 and 6.72 respectively which indicates that S1 water is below the permissible limits while S2 water is within the limits and TDS (611.09, 619.90 mg/l) for S1 and S2 respectively were within the permissible limits while TS (923.87, 991.00 mg/l), BOD5 (4.87, 4.92 mg/l), TOC (190.41, 112.01 mg/l), Ca2+ (30.90, 38.22) and Mg2+ (23.71, 28.41 mg/l) for S1 and S2 respectively were below the permissible limits. The study has shown that large volumes of untreated industrial effluents and toxicological chemicals released into the Eleme river were the primary cause of pollution loading, which was attributed to EC, TSS, DO, Cl-, and K+.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"53 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARING KEY PHYSICAL PARAMETERS OF ARTISANAL AND REGULAR DPK AND PMS PRODUCTS IN RIVERS STATE-NIGERIA 比较尼日利亚河流州的手工和正规 DPK 及 PMS 产品的主要物理参数

Journal Of Chemical Society Of Nigeria Pub Date : 2024-02-27 DOI: 10.46602/jcsn.v49i1.946

M. S. ABU-MADOJEMU, A. C. Marcus, O. M. Frank

{"title":"COMPARING KEY PHYSICAL PARAMETERS OF ARTISANAL AND REGULAR DPK AND PMS PRODUCTS IN RIVERS STATE-NIGERIA","authors":"M. S. ABU-MADOJEMU, A. C. Marcus, O. M. Frank","doi":"10.46602/jcsn.v49i1.946","DOIUrl":"https://doi.org/10.46602/jcsn.v49i1.946","url":null,"abstract":"Refineries in Nigeria are producing below installed capacities and this has resulted in the inability to refine enough PMS and DPK to meet local consumption. This has led to increase in the activities of artisanal refining in the Niger Delta, which invariably adulterates the product. This study was aimed at comparing the physical parameters of artisanal with regular Premium Motor Spirit (PMS) and Dual-Purpose Kerosene (DPK) to compare their compliance with ASTM standards. The artisanal PMS and DPK samples were purchased, prepared and analyzed by SOP as stated by ASTM. The results obtained for PMS were: density of artisanal PMS (APMS) (0.768±0.00035) and regular PMS (RPMS) (0.764±0.00028), Reid vapour pressure (RVP) of APMS (27.67±2.52kPa) and RPMS (45.00±1.41kPa), specific gravity of APMS (0.769±0.0004) and RPMS (0.765±0.0003), Flash point of APMS (30±0.0010C) and RPMS (<300C). Those of DPK were: density of artisanal DPK (ADPK) (0.820±0.0001) and regular DPK (RDPK) (0.787±0.420C), Specific gravity of ADPK (0.821±0.001) and RDPK (0.788±0.0001), RVP of ADPK (<1KPa) and RDPK (<1KPa), Flash point of ADPK (72.30±2.520C) and RDPK (75±2.830C). The findings revealed that specific gravity for both artisanal and regular PMS and DPK were within ASTM specification, while RVP for APMS was below ASTM specification but within ASTM specification for RPMS. Also, distillation ranges of APMS were above ASTM specification but were within ASTM specification for RPMS. Distillation ranges of ADPK before 90% were below ASTM specification but became above thereafter. Based on these findings, the study concludes that, the refining process of artisanal PMS and DPK may not have been appropriate or adulteration may have taken place which may cause problems in automotive engines, human health and the environment. However, this domestic innovation of refining can be upgraded to bring about improved quality of PMS and DPK.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"59 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GREEN HYDROTHERMAL SYNTHESIS OF Ag@Guajavapsidium LEAF BIOCHAR NANOCOMPOSITE AND THE EVALUATION OF THE PHOTOCATALYTIC AND ANTIMICROBIAL ACTIVITIES Ag@Guajavapsidium 叶片生物炭纳米复合物的绿色水合合成及其光催化和抗微生物活性评价

Journal Of Chemical Society Of Nigeria Pub Date : 2024-01-12 DOI: 10.46602/jcsn.v48i6.944

F. Nworie, N. Mgbemena, U. D. Nwanneka, I. Ikelle, O. V. Mgboh

{"title":"GREEN HYDROTHERMAL SYNTHESIS OF Ag@Guajavapsidium LEAF BIOCHAR NANOCOMPOSITE AND THE EVALUATION OF THE PHOTOCATALYTIC AND ANTIMICROBIAL ACTIVITIES","authors":"F. Nworie, N. Mgbemena, U. D. Nwanneka, I. Ikelle, O. V. Mgboh","doi":"10.46602/jcsn.v48i6.944","DOIUrl":"https://doi.org/10.46602/jcsn.v48i6.944","url":null,"abstract":"An Environmental and health concern requires an alternative fabrication route for nanomaterials because of the high toxicity and cost of reagents. In this study, the phyto-fabrication of silver grafted guava leaf extract and biomass biochar nanocomposite was executed using a novel, facile, low cost, sustainable and eco-friendly route. The formation of the nanocomposite was evidenced through UV spectroscopic analysis with surface plasmon resonance peak at 349 nm. The Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDX) also confirmed the formation of the nanocomposite as illustrated by the spectra change and presence of Ag+ ions on the surface of the nanocomposite respectively. The x-ray diffraction (XRD) and scanning electron microscopy (SEM) confirmed the crystal structure and spherical, porous nature with a size range of 25 to 40 nm of the nanocomposite respectively. The potential of nanocomposite in the removal of MBwas evident under different conditions as it reached nearly 100% under the optimum reaction conditions (methylene blue (MB) concentration; 10 ppm, a dose of Ag/extract /biochar; 0.01 g, temperature; 25 °C). The novel nanocomposite regeneration and reusability was promising, as the removal efficiency of MB from solution after five cycle reuse was above 80 %. Antimicrobial evaluation of the nanocomposite using Escherichia coli Klebsiella pneumonia, staphylococcus aureus and salmonella specie revealed that it is an excellent antimicrobial agent with 9, 8, 15 and 5 mm zones of inhibition respectively.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETECTION OF SOME ORGANOCHLORINE PESTICIDES IN LARGE AFRICAN SNAILS FROM OJE MARKET, IBADAN, NIGERIA 尼日利亚伊巴丹市奥杰市场非洲大蜗牛体内某些有机氯农药的检测

Journal Of Chemical Society Of Nigeria Pub Date : 2024-01-11 DOI: 10.46602/jcsn.v48i6.943

E. O. Ayoola, V.N. Enwemiwe, H.O. Erhenhi, E. Esiwo, C.C. Obi

{"title":"DETECTION OF SOME ORGANOCHLORINE PESTICIDES IN LARGE AFRICAN SNAILS FROM OJE MARKET, IBADAN, NIGERIA","authors":"E. O. Ayoola, V.N. Enwemiwe, H.O. Erhenhi, E. Esiwo, C.C. Obi","doi":"10.46602/jcsn.v48i6.943","DOIUrl":"https://doi.org/10.46602/jcsn.v48i6.943","url":null,"abstract":"Snails (Mollusca: Achatinadae) are crucial fauna species on earth that serve the functions of food and biological indicators of environmental pollution. Numerous chemical discharges from agricultural applications of pesticides and industrial outlets could destroy human body parts and deplete the environment. This study assessed the occurrence of some organochlorine pesticides in giant African snails from Oje Market, Ibadan, Nigeria. Aldrin, dichlorodiphenyltrichloroethane (DDT), and heptachlor epoxide levels were measured in snails taken at random from thirty (30) sample points in the Oje market in Ibadan. Snails were weighed, labeled, and then divided into three groups of ten (10). The forte extraction method was used, and gas chromatography with an electron capture detector (GC/ECD) was used to analyze the various pesticide types in the snail sample. The mean concentration of heptachlor epoxide is 41.65 mg/kg, higher than aldrin and dichlorodiphenyltrichloroethane (9.44 mg/kg and 4.17 mg/kg, respectively). The concentrations of pesticides range from 4.27 mg/kg - 21.77 mg/kg for aldrin, 2.80 mg/kg to 6.92 mg/kg for dichlorodiphenyltrichloroethane, and 22.87 mg/kg to 75.15 mg/kg for heptachlor epoxide. The Pearson correlation coefficient between Aldrin and DDT is 0.939, while that of Aldrin and Heptachlor epoxide is 0.945, and that of Heptachlor epoxide and dichlorodiphenyltrichloroethane is 0.981. The analysis revealed a solid positive correlation between the concentration of pesticides. The pesticide levels observed in the snail samples exceeded those of the World Health Organization and the Food and Agriculture Organization. Therefore, snails' consumption should be monitored to avoid toxicity in humans.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"30 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PHOTOCATALYTIC DEGRADATION OF 3-CHLOROPHENOL USING Pd/Ag DOPED ON P25 DEGUSSA TiO2 NANOPARTICLE WITH UV RADIATION 用紫外线照射 P25 DEGUSSA TiO2 纳米颗粒上的钯/银对 3-氯苯酚进行光解法降解

Journal Of Chemical Society Of Nigeria Pub Date : 2024-01-11 DOI: 10.46602/jcsn.v48i6.942

A. Aroh, C. Gimba, K. Omoniyi, K. I. Abba, M. Yilleng

{"title":"PHOTOCATALYTIC DEGRADATION OF 3-CHLOROPHENOL USING Pd/Ag DOPED ON P25 DEGUSSA TiO2 NANOPARTICLE WITH UV RADIATION","authors":"A. Aroh, C. Gimba, K. Omoniyi, K. I. Abba, M. Yilleng","doi":"10.46602/jcsn.v48i6.942","DOIUrl":"https://doi.org/10.46602/jcsn.v48i6.942","url":null,"abstract":"Photocatalytic degradation of 3-chlorophenol was investigated using Pd/Ag doped on P25 Degussa TiO2. The Pd/AgTiO2 photocatalysts were prepared by sol immobilization method. A fabricated photo-reactor was used in photocatalytic degradation of 3-chlorophenol and monitored using HPLC. The experimental results indicates that doping of Pd/Ag on TiO2 increases the photocatalytic efficiency of TiO2. The experimental results indicates that Pd/ TiO2 has a photodegradation efficiency of 40.44% while Ag/TiO2 has a photodegradation efficiency of 60.44%. The dried catalysts were subsequently used again under the same experimental condition with a fresh 3-chlorophenol up to four (4) times. The result indicates that the re-used catalysts remain active for up to four (4) times of usage with minor reduction in activity, which is attributed to metal leaching. Ag/TiO2 has higher rate constant of - 0.019 than Pd/TiO2 which is -0.031, the rate constant for the degradation followed first-order reaction kinetics. The photocatalytic degradation of 3-chlorophenol indicates unstable degradation due to effect of inductive and mesomeric effect which is less on meta-position. The use of nanotechnology in wastewater treatment plants to curtail the environmental and health consequences of a widespread of organic pollutants should be encouraged.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"11 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REPRECIPITATION OF RESIN FROM CRUDE OIL MALTENE USING SINGLE LOWER N-ALKANE SOLVENT AND ITS BINARY MIXTURE 使用单一低级正烷烃溶剂及其二元混合物从原油麦芽烯中再沉淀树脂

Journal Of Chemical Society Of Nigeria Pub Date : 2024-01-03 DOI: 10.46602/jcsn.v48i6.941

M. C. Utin, R. Ogali, O. Achugasim

引用次数: 0

HEXAMETHYLENETETRAMINE (C6H12N4) INDUCED HIGH-DENSITY NITROGEN DOPED REDUCED GRAPHENE: A NOVEL SONO-MICROWAVE ASSISTED SYNTHESIS AND CHARACTERIZATION TOWARDS RENEWABLE ENERGIES APPLICATIONS. 六亚甲基四胺(c6h12n4)诱导高密度氮掺杂还原石墨烯:一种新的声纳微波辅助合成和表征，可再生能源应用。

Journal Of Chemical Society Of Nigeria Pub Date : 2023-08-27 DOI: 10.46602/jcsn.v48i4.910

F. Oladoyinbo

{"title":"HEXAMETHYLENETETRAMINE (C6H12N4) INDUCED HIGH-DENSITY NITROGEN DOPED REDUCED GRAPHENE: A NOVEL SONO-MICROWAVE ASSISTED SYNTHESIS AND CHARACTERIZATION TOWARDS RENEWABLE ENERGIES APPLICATIONS.","authors":"F. Oladoyinbo","doi":"10.46602/jcsn.v48i4.910","DOIUrl":"https://doi.org/10.46602/jcsn.v48i4.910","url":null,"abstract":"Development of low-cost electrocatalytic material for hydrogen evolution and oxygen reduction reaction (HER and ORR) is the main requirement for many renewable energies like the, Proton Exchange Membrane Fuel Cell (PEMFC) and Proton Exchange Membrane Electrolysers (PEME) Photo-electrochemical Water Splitting (PEWS) technologies. Herein, we report a novel, simple, economical and rapid one-pot Sono-microwave assisted synthesis of nitrogen doped graphene (NG) from graphene oxide in presence of a nitrogen precursor (Hexamethylenetetramine). The obtained NG was optimized by varying the ratio of GO to Hexamethylenetetramine to find the optimized N content in the catalyst and investigated as electrocatalyst for the ORR. Transmission electronic microscopy (TEM) and field emission scanning electronic microscopy (FE-SEM) micrograph of optimized NG showed well exfoliated graphene oxide with few layers of graphene while the X-ray photoelectron spectroscopy (XPS) depicts that about 11 % of nitrogen doping into the graphene lattice active forms of pyrrolic-N, pyridinic-N, and graphitic-N in 1:3NG catalyst is 55.00, 33.69, and 11.31 % respectively. Demonstrating the potential attributes of the Material in electrocatalytic renewable energy applications.","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89235358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INSILICO DETERMINATION OF ANTI CANCER ACTIVITY OF PHYTOCHEMICAL FROM CLOVE (Syzygium aromaticum L) SEED 丁香种子植物化学成分抗癌活性的硅质测定

Journal Of Chemical Society Of Nigeria Pub Date : 2023-08-27 DOI: 10.46602/jcsn.v48i4.911

U. J. M. Ikezu, S. Ugariogu, C. B. Ikpa, B. Adindu, T. Maduka

{"title":"INSILICO DETERMINATION OF ANTI CANCER ACTIVITY OF PHYTOCHEMICAL FROM CLOVE (Syzygium aromaticum L) SEED","authors":"U. J. M. Ikezu, S. Ugariogu, C. B. Ikpa, B. Adindu, T. Maduka","doi":"10.46602/jcsn.v48i4.911","DOIUrl":"https://doi.org/10.46602/jcsn.v48i4.911","url":null,"abstract":"Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in preparation of food which have been acclaimed and reported by previous researchers to have anticancer activities potentials. Due to the rising burden of cancer worldwide its severity and fatality coupled with side effects of synthetic drugs calls for an alternative treatment solution. Hence the current research studied the phytocompounds from the seed by extracting and screening the compounds using solvent maceration method and gas chromatography coupled to mass selective detector respectively to extract, identify and quantify the component phytochemicals present in the seed. Site directed multi-ligand docking of the identified compounds was performance on progesterone receptor protein responsible for breast cancer development using the compounds from GCMS results and compared with four standard breast cancer drugs by molecular docking method. The result showed that the alpha cubebene (-7 kcal/mol), Velerena -4, 7- (II) diene (-7.1 kcal/mol), caryophyllene (-7.4 kcal/mol), caryophyllene oxide (-7.4 kcal/mol), dibutyl phthalate have binding affinity close to the standard breast cancer drugs Abemaciclib (-8.3), Anastrozole (-7.2 kcal/mol) and Paclitaxel (-8.8 kcal/mol) and they have better binding affinity than the drug Cyclophasphamide (-5.6 kcal/mol). The result also revealed that some compounds from the GC-MS were found to have a binding affinity closer tothat of thecocrystallized ligand (-10.7 kcal/mol). Other compounds from clove seed showed favourable docking scores in comparison with the drugs as many of the compounds have docking scores of more than (-6 kcal/mol) suggesting that the compounds have anti breast cancer activities since their amino acids showed hydrogen bonding corresponding to that on the binding site","PeriodicalId":15357,"journal":{"name":"Journal Of Chemical Society Of Nigeria","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87443999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0