Journal of Cerebral Blood Flow & Metabolism最新文献_第7页

Fluctuations in intracranial pressure can be estimated non-invasively using near-infrared spectroscopy in non-human primates 在非人类灵长类动物中，可以使用近红外光谱非侵入性地估计颅内压的波动

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-27 DOI: 10.1177/0271678X19891359

Alexander Ruesch, Samantha E. Schmitt, Jason Yang, Matthew A. Smith, J. Kainerstorfer

{"title":"Fluctuations in intracranial pressure can be estimated non-invasively using near-infrared spectroscopy in non-human primates","authors":"Alexander Ruesch, Samantha E. Schmitt, Jason Yang, Matthew A. Smith, J. Kainerstorfer","doi":"10.1177/0271678X19891359","DOIUrl":"https://doi.org/10.1177/0271678X19891359","url":null,"abstract":"Intracranial pressure (ICP) is typically measured invasively through a sensor placed inside the brain or a needle inserted into the spinal canal, limiting the patient population on which this assessment can be performed. Currently, non-invasive methods are limited due to lack of sensitivity and thus only apply to extreme cases of increased ICP, instead of use in general clinical practice. We demonstrate a novel application for near-infrared spectroscopy (NIRS) to accurately estimate ICP changes over time. Using a non-human primate (Rhesus Macaque) model, we collected optical data while we induced ICP oscillations at multiple ICP levels obtained by manipulating the height of a fluid column connected via a catheter to the lateral ventricle. Hemodynamic responses to ICP changes were measured at the occipital pole and compared to changes detected by a conventional intraparenchymal ICP probe. We demonstrate that hemoglobin concentrations are highly correlated with induced ICP oscillations and that this response is frequency dependent. We translated the NIRS data into non-invasive ICP measurements via a fitted non-parametric transfer function, demonstrating a match in both magnitude and time alignment with an invasively measured reference. Our results demonstrate that NIRS has the potential for non-invasive ICP monitoring.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"9 1","pages":"2304 - 2314"},"PeriodicalIF":0.0,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88400520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Brain–kidney interaction: Renal dysfunction following ischemic stroke 脑肾相互作用:缺血性中风后的肾功能障碍

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-25 DOI: 10.1177/0271678X19890931

Qiang Zhao, T. Yan, M. Chopp, P. Venkat, Jieli Chen

引用次数: 33

Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical 阿尔茨海默病慢性小鼠模型中保存的神经血管耦合:方法学至关重要

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-23 DOI: 10.1177/0271678X19890830

P. Sharp, K. Ameen-Ali, L. Boorman, S. Harris, S. Wharton, C. Howarth, O. Shabir, P. Redgrave, J. Berwick

{"title":"Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical","authors":"P. Sharp, K. Ameen-Ali, L. Boorman, S. Harris, S. Wharton, C. Howarth, O. Shabir, P. Redgrave, J. Berwick","doi":"10.1177/0271678X19890830","DOIUrl":"https://doi.org/10.1177/0271678X19890830","url":null,"abstract":"Impaired neurovascular coupling has been suggested as an early pathogenic factor in Alzheimer’s disease (AD), which could serve as an early biomarker of cerebral pathology. We have established an anaesthetic regime to allow repeated measurements of neurovascular function over three months in the J20 mouse model of AD (J20-AD) and wild-type (WT) controls. Animals were 9–12 months old at the start of the experiment. Mice were chronically prepared with a cranial window through which 2-Dimensional optical imaging spectroscopy (2D-OIS) was used to generate functional maps of the cerebral blood volume and saturation changes evoked by whisker stimulation and vascular reactivity challenges. Unexpectedly, the hemodynamic responses were largely preserved in the J20-AD group. This result failed to confirm previous investigations using the J20-AD model. However, a final acute electrophysiology and 2D-OIS experiment was performed to measure both neural and hemodynamic responses concurrently. In this experiment, previously reported deficits in neurovascular coupling in the J20-AD model were observed. This suggests that J20-AD mice may be more susceptible to the physiologically stressing conditions of an acute experimental procedure compared to WT animals. These results therefore highlight the importance of experimental procedure when determining the characteristics of animal models of human disease.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"25 1","pages":"2289 - 2303"},"PeriodicalIF":0.0,"publicationDate":"2019-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73907388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Longitudinal study of cerebral blood flow regulation during exercise in pregnancy 孕期运动期间脑血流调节的纵向研究

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-21 DOI: 10.1177/0271678X19889089

Brittany A. Matenchuk, M. James, Rachel J. Skow, Paige K Wakefield, Christina M. MacKay, C. Steinback, Margie H. Davenport

{"title":"Longitudinal study of cerebral blood flow regulation during exercise in pregnancy","authors":"Brittany A. Matenchuk, M. James, Rachel J. Skow, Paige K Wakefield, Christina M. MacKay, C. Steinback, Margie H. Davenport","doi":"10.1177/0271678X19889089","DOIUrl":"https://doi.org/10.1177/0271678X19889089","url":null,"abstract":"Cerebrovascular adaptation to pregnancy is poorly understood. We sought to assess cerebrovascular regulation in response to visual stimulation, hypercapnia and exercise across the three trimesters of pregnancy. Using transcranial Doppler (TCD) ultrasound, middle and posterior cerebral artery mean blood velocities (MCAvmean and PCAvmean) were measured continuously at rest and in response to (1) visual stimulation to assess neurovascular coupling (NVC); (2) a modified Duffin hyperoxic CO2 rebreathe test, and (3) an incremental cycling exercise test to volitional fatigue in non-pregnant (n = 26; NP) and pregnant women (ﬁrst trimester [n = 13; TM1], second trimester [n = 21; TM2], and third trimester [n = 20; TM3]) in total 47 women. At rest, MCAvmean and PETCO2 were lower in TM2 compared to NP. PCAvmean was lower in TM2 but not TM1 or TM3 compared to NP. Cerebrovascular reactivity in MCAvmean and PCAvmean during the hypercapnic rebreathing test was not different between pregnant and non-pregnant women. MCAvmean continued to increase over the second half of the exercise test in TM2 and TM3, while it decreased in NP due to differences in ΔPETCO2 between groups. Pregnant women experienced a delayed decrease in MCAvmean in response to maximal exercise compared to non-pregnant controls which was explained by CO2 reactivity and PETCO2 level.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"61 1","pages":"2278 - 2288"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81404403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative 脑血管疾病中的脑萎缩:程度、后果、技术限制和观点:HARNESS倡议

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-20 DOI: 10.1177/0271678X19888967

F. De Guio, M. Duering, F. Fazekas, F. de Leeuw, S. Greenberg, L. Pantoni, Agnès Aghetti, Eric E. Smith, J. Wardlaw, E. Jouvent

引用次数: 36

Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias 利用深度卷积神经网络预测多对比MRI 15O-Water PET脑血流量图，并评估训练队列偏差

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-13 DOI: 10.1177/0271678X19888123

Jia Guo, E. Gong, A. Fan, M. Goubran, M. Khalighi, G. Zaharchuk

{"title":"Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias","authors":"Jia Guo, E. Gong, A. Fan, M. Goubran, M. Khalighi, G. Zaharchuk","doi":"10.1177/0271678X19888123","DOIUrl":"https://doi.org/10.1177/0271678X19888123","url":null,"abstract":"To improve the quality of MRI-based cerebral blood flow (CBF) measurements, a deep convolutional neural network (dCNN) was trained to combine single- and multi-delay arterial spin labeling (ASL) and structural images to predict gold-standard 15O-water PET CBF images obtained on a simultaneous PET/MRI scanner. The dCNN was trained and tested on 64 scans in 16 healthy controls (HC) and 16 cerebrovascular disease patients (PT) with 4-fold cross-validation. Fidelity to the PET CBF images and the effects of bias due to training on different cohorts were examined. The dCNN significantly improved CBF image quality compared with ASL alone (mean ± standard deviation): structural similarity index (0.854 ± 0.036 vs. 0.743 ± 0.045 [single-delay] and 0.732 ± 0.041 [multi-delay], P < 0.0001); normalized root mean squared error (0.209 ± 0.039 vs. 0.326 ± 0.050 [single-delay] and 0.344 ± 0.055 [multi-delay], P < 0.0001). The dCNN also yielded mean CBF with reduced estimation error in both HC and PT (P < 0.001), and demonstrated better correlation with PET. The dCNN trained with the mixed HC and PT cohort performed the best. The results also suggested that models should be trained on cases representative of the target population.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"48 1","pages":"2240 - 2253"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85765212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Characterizing pulsatility in distal cerebral arteries using 4D flow MRI 利用4D血流MRI表征脑远端动脉搏动性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-13 DOI: 10.1177/0271678X19886667

Tomas Vikner, L. Nyberg, Madelene Holmgren, J. Malm, A. Eklund, A. Wåhlin

引用次数: 20

The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms 线粒体钙单转运体对快速皮层网络节律的产生至关重要

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-13 DOI: 10.1177/0271678X19887777

C. Bas-Orth, Justus Schneider, A. Lewen, Jamie McQueen, K. Hasenpusch-Theil, T. Theil, G. Hardingham, H. Bading, O. Kann

{"title":"The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms","authors":"C. Bas-Orth, Justus Schneider, A. Lewen, Jamie McQueen, K. Hasenpusch-Theil, T. Theil, G. Hardingham, H. Bading, O. Kann","doi":"10.1177/0271678X19887777","DOIUrl":"https://doi.org/10.1177/0271678X19887777","url":null,"abstract":"The role of the mitochondrial calcium uniporter (MCU) gene (Mcu) in cellular energy homeostasis and generation of electrical brain rhythms is widely unknown. We investigated this issue in mice and rats using Mcu-knockout and -knockdown strategies in vivo and in situ and determined the effects of these genetic manipulations on hippocampal gamma oscillations (30–70 Hz) and sharp wave-ripples. These physiological network states require precise neurotransmission between pyramidal cells and inhibitory interneurons, support spike-timing and synaptic plasticity and are associated with perception, attention and memory. Absence of the MCU resulted in (i) gamma oscillations with decreased power (by >40%) and lower synchrony, including less precise neural action potential generation (‘spiking'), (ii) sharp waves with decreased incidence (by about 22%) and decreased fast ripple frequency (by about 3%) and (iii) lack of activity-dependent pyruvate dehydrogenase dephosphorylation. However, compensatory adaptation in gene expression related to mitochondrial function and glucose metabolism was not detected. These data suggest that the neuronal MCU is crucial for the generation of network rhythms, most likely by influences on oxidative phosphorylation and perhaps by controlling cytoplasmic Ca2+ homeostasis. This work contributes to an increased understanding of mitochondrial Ca2+ uptake in cortical information processing underlying cognition and behaviour.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"19 1","pages":"2225 - 2239"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88550420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Low-level carbon monoxide exposure affects BOLD fMRI response 低浓度一氧化碳暴露影响BOLD fMRI反应

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-11 DOI: 10.1177/0271678X19887358

Caroline Bendell, S. Moosavi, M. Herigstad

引用次数: 2

Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease 认知正常成人和阿尔茨海默病患者[18F]MK-6240定量结果的重测特征

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-11 DOI: 10.1177/0271678X19887781

C. Salinas, Talakad G. Lohith, Ajay Purohit, A. Struyk, C. Sur, I. Bennacef, J. Beaver, L. Martarello

{"title":"Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease","authors":"C. Salinas, Talakad G. Lohith, Ajay Purohit, A. Struyk, C. Sur, I. Bennacef, J. Beaver, L. Martarello","doi":"10.1177/0271678X19887781","DOIUrl":"https://doi.org/10.1177/0271678X19887781","url":null,"abstract":"[18F]MK-6240 is a selective, high-affinity PET radiotracer for imaging neurofibrillary tangles (NFT) in Alzheimer’s disease (AD). Herein, we report test–retest (T–RT) reproducibility of [18F]MK-6240 in AD and healthy volunteers (HV). Twelve subjects with AD and three cognitively normal HV were enrolled in the study and dynamically scanned for 150 min with [18F]MK-6240 under a T–RT protocol. Two radioactivity doses were investigated: 165 ± 3 MBq (n = 6) and 300 ± 40 MBq (n = 9). Serial arterial blood samples were taken for each scan to obtain metabolite-corrected input functions. Following intravenous administration of [18F]MK-6240, the tracer rapidly partitioned into the brain and its heterogenous distribution pattern was consistent with known NFT pathology in AD. In contrast, uptake in HV was low and uniform across the brain parenchyma. Across all subjects, average T–RT variabilities in NFT-rich regions were ∼21%, ∼14% and ∼6% for various quantitative metrics: total distribution volume (VT), binding potential (BPND), and standardized uptake ratio (SUVR90–120), respectively. No significant differences in SUVR T–RT variability were observed between the high and low injected radioactivity groups (5.6% and 6.1%, respectively). This work suggests [18F]MK-6240 has adequate SUVR T–RT characteristics supporting the use of this outcome in future studies.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"56 1","pages":"2179 - 2187"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18