Journal of Cerebral Blood Flow & Metabolism最新文献_第7页

MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea 阻塞性睡眠呼吸暂停患者脑血管反应性的MRI评价

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-06-01 DOI: 10.1177/0271678X19862182

Pei-Hsin Wu, Ana E. Rodriguez-Soto, Zachary B. Rodgers, Erin K. Englund, A. Wiemken, M. Langham, J. Detre, R. Schwab, Wensheng Guo, F. Wehrli

{"title":"MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea","authors":"Pei-Hsin Wu, Ana E. Rodriguez-Soto, Zachary B. Rodgers, Erin K. Englund, A. Wiemken, M. Langham, J. Detre, R. Schwab, Wensheng Guo, F. Wehrli","doi":"10.1177/0271678X19862182","DOIUrl":"https://doi.org/10.1177/0271678X19862182","url":null,"abstract":"Obstructive sleep apnea (OSA) is characterized by intermittent obstruction of the airways during sleep. Cerebrovascular reactivity (CVR) is an index of cerebral vessels' ability to respond to a vasoactive stimulus, such as increased CO2. We hypothesized that OSA alters CVR, expressed as a breath-hold index (BHI) defined as the rate of change in CBF or BOLD signal during a controlled breath-hold stimulus mimicking spontaneous apneas by being both hypercapnic and hypoxic. In 37 OSA and 23 matched non sleep apnea (NSA) subjects, we obtained high temporal resolution CBF and BOLD MRI data before, during, and between five consecutive BH stimuli of 24 s, each averaged to yield a single BHI value. Greater BHI was observed in OSA relative to NSA as derived from whole-brain CBF (78.6 ± 29.6 vs. 60.0 ± 20.0 mL/min2/100 g, P = 0.010) as well as from flow velocity in the superior sagittal sinus (0.48 ± 0.18 vs. 0.36 ± 0.10 cm/s2, P = 0.014). Similarly, BOLD-based BHI was greater in OSA in whole brain (0.19 ± 0.08 vs. 0.15 ± 0.03%/s, P = 0.009), gray matter (0.22 ± 0.09 vs. 0.17 ± 0.03%/s, P = 0.011), and white matter (0.14 ± 0.06 vs. 0.10 ± 0.02%/s, P = 0.010). The greater CVR is not currently understood but may represent a compensatory mechanism of the brain to maintain oxygen supply during intermittent apneas.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"14 1","pages":"1328 - 1337"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87298396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative. 脑血管疾病中的脑萎缩：程度、后果、技术限制和观点：HARNESS倡议。

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-02-01 Epub Date: 2019-11-20 DOI: 10.1177/0271678X19888967

François De Guio, Marco Duering, Franz Fazekas, Frank-Erik De Leeuw, Steven M Greenberg, Leonardo Pantoni, Agnès Aghetti, Eric E Smith, Joanna Wardlaw, Eric Jouvent

引用次数: 0

A combination of Deferoxamine mesylate and minimally invasive surgery with hematoma lysis for evacuation of intracerebral hemorrhage 甲磺酸去铁胺联合微创血肿溶解手术治疗脑出血

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-12-02 DOI: 10.1177/0271678X19892660

A. Pandey, B. Daou, N. Chaudhary, G. Xi

引用次数: 10

Fluctuations in intracranial pressure can be estimated non-invasively using near-infrared spectroscopy in non-human primates 在非人类灵长类动物中，可以使用近红外光谱非侵入性地估计颅内压的波动

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-27 DOI: 10.1177/0271678X19891359

Alexander Ruesch, Samantha E. Schmitt, Jason Yang, Matthew A. Smith, J. Kainerstorfer

{"title":"Fluctuations in intracranial pressure can be estimated non-invasively using near-infrared spectroscopy in non-human primates","authors":"Alexander Ruesch, Samantha E. Schmitt, Jason Yang, Matthew A. Smith, J. Kainerstorfer","doi":"10.1177/0271678X19891359","DOIUrl":"https://doi.org/10.1177/0271678X19891359","url":null,"abstract":"Intracranial pressure (ICP) is typically measured invasively through a sensor placed inside the brain or a needle inserted into the spinal canal, limiting the patient population on which this assessment can be performed. Currently, non-invasive methods are limited due to lack of sensitivity and thus only apply to extreme cases of increased ICP, instead of use in general clinical practice. We demonstrate a novel application for near-infrared spectroscopy (NIRS) to accurately estimate ICP changes over time. Using a non-human primate (Rhesus Macaque) model, we collected optical data while we induced ICP oscillations at multiple ICP levels obtained by manipulating the height of a fluid column connected via a catheter to the lateral ventricle. Hemodynamic responses to ICP changes were measured at the occipital pole and compared to changes detected by a conventional intraparenchymal ICP probe. We demonstrate that hemoglobin concentrations are highly correlated with induced ICP oscillations and that this response is frequency dependent. We translated the NIRS data into non-invasive ICP measurements via a fitted non-parametric transfer function, demonstrating a match in both magnitude and time alignment with an invasively measured reference. Our results demonstrate that NIRS has the potential for non-invasive ICP monitoring.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"9 1","pages":"2304 - 2314"},"PeriodicalIF":0.0,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88400520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Brain–kidney interaction: Renal dysfunction following ischemic stroke 脑肾相互作用:缺血性中风后的肾功能障碍

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-25 DOI: 10.1177/0271678X19890931

Qiang Zhao, T. Yan, M. Chopp, P. Venkat, Jieli Chen

引用次数: 33

Longitudinal study of cerebral blood flow regulation during exercise in pregnancy 孕期运动期间脑血流调节的纵向研究

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-21 DOI: 10.1177/0271678X19889089

Brittany A. Matenchuk, M. James, Rachel J. Skow, Paige K Wakefield, Christina M. MacKay, C. Steinback, Margie H. Davenport

{"title":"Longitudinal study of cerebral blood flow regulation during exercise in pregnancy","authors":"Brittany A. Matenchuk, M. James, Rachel J. Skow, Paige K Wakefield, Christina M. MacKay, C. Steinback, Margie H. Davenport","doi":"10.1177/0271678X19889089","DOIUrl":"https://doi.org/10.1177/0271678X19889089","url":null,"abstract":"Cerebrovascular adaptation to pregnancy is poorly understood. We sought to assess cerebrovascular regulation in response to visual stimulation, hypercapnia and exercise across the three trimesters of pregnancy. Using transcranial Doppler (TCD) ultrasound, middle and posterior cerebral artery mean blood velocities (MCAvmean and PCAvmean) were measured continuously at rest and in response to (1) visual stimulation to assess neurovascular coupling (NVC); (2) a modified Duffin hyperoxic CO2 rebreathe test, and (3) an incremental cycling exercise test to volitional fatigue in non-pregnant (n = 26; NP) and pregnant women (ﬁrst trimester [n = 13; TM1], second trimester [n = 21; TM2], and third trimester [n = 20; TM3]) in total 47 women. At rest, MCAvmean and PETCO2 were lower in TM2 compared to NP. PCAvmean was lower in TM2 but not TM1 or TM3 compared to NP. Cerebrovascular reactivity in MCAvmean and PCAvmean during the hypercapnic rebreathing test was not different between pregnant and non-pregnant women. MCAvmean continued to increase over the second half of the exercise test in TM2 and TM3, while it decreased in NP due to differences in ΔPETCO2 between groups. Pregnant women experienced a delayed decrease in MCAvmean in response to maximal exercise compared to non-pregnant controls which was explained by CO2 reactivity and PETCO2 level.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"61 1","pages":"2278 - 2288"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81404403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias 利用深度卷积神经网络预测多对比MRI 15O-Water PET脑血流量图，并评估训练队列偏差

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-13 DOI: 10.1177/0271678X19888123

Jia Guo, E. Gong, A. Fan, M. Goubran, M. Khalighi, G. Zaharchuk

{"title":"Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias","authors":"Jia Guo, E. Gong, A. Fan, M. Goubran, M. Khalighi, G. Zaharchuk","doi":"10.1177/0271678X19888123","DOIUrl":"https://doi.org/10.1177/0271678X19888123","url":null,"abstract":"To improve the quality of MRI-based cerebral blood flow (CBF) measurements, a deep convolutional neural network (dCNN) was trained to combine single- and multi-delay arterial spin labeling (ASL) and structural images to predict gold-standard 15O-water PET CBF images obtained on a simultaneous PET/MRI scanner. The dCNN was trained and tested on 64 scans in 16 healthy controls (HC) and 16 cerebrovascular disease patients (PT) with 4-fold cross-validation. Fidelity to the PET CBF images and the effects of bias due to training on different cohorts were examined. The dCNN significantly improved CBF image quality compared with ASL alone (mean ± standard deviation): structural similarity index (0.854 ± 0.036 vs. 0.743 ± 0.045 [single-delay] and 0.732 ± 0.041 [multi-delay], P < 0.0001); normalized root mean squared error (0.209 ± 0.039 vs. 0.326 ± 0.050 [single-delay] and 0.344 ± 0.055 [multi-delay], P < 0.0001). The dCNN also yielded mean CBF with reduced estimation error in both HC and PT (P < 0.001), and demonstrated better correlation with PET. The dCNN trained with the mixed HC and PT cohort performed the best. The results also suggested that models should be trained on cases representative of the target population.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"48 1","pages":"2240 - 2253"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85765212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Characterizing pulsatility in distal cerebral arteries using 4D flow MRI 利用4D血流MRI表征脑远端动脉搏动性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-13 DOI: 10.1177/0271678X19886667

Tomas Vikner, L. Nyberg, Madelene Holmgren, J. Malm, A. Eklund, A. Wåhlin

引用次数: 20

Low-level carbon monoxide exposure affects BOLD fMRI response 低浓度一氧化碳暴露影响BOLD fMRI反应

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-11 DOI: 10.1177/0271678X19887358

Caroline Bendell, S. Moosavi, M. Herigstad

引用次数: 2

Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease 认知正常成人和阿尔茨海默病患者[18F]MK-6240定量结果的重测特征

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-11-11 DOI: 10.1177/0271678X19887781

C. Salinas, Talakad G. Lohith, Ajay Purohit, A. Struyk, C. Sur, I. Bennacef, J. Beaver, L. Martarello

{"title":"Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease","authors":"C. Salinas, Talakad G. Lohith, Ajay Purohit, A. Struyk, C. Sur, I. Bennacef, J. Beaver, L. Martarello","doi":"10.1177/0271678X19887781","DOIUrl":"https://doi.org/10.1177/0271678X19887781","url":null,"abstract":"[18F]MK-6240 is a selective, high-affinity PET radiotracer for imaging neurofibrillary tangles (NFT) in Alzheimer’s disease (AD). Herein, we report test–retest (T–RT) reproducibility of [18F]MK-6240 in AD and healthy volunteers (HV). Twelve subjects with AD and three cognitively normal HV were enrolled in the study and dynamically scanned for 150 min with [18F]MK-6240 under a T–RT protocol. Two radioactivity doses were investigated: 165 ± 3 MBq (n = 6) and 300 ± 40 MBq (n = 9). Serial arterial blood samples were taken for each scan to obtain metabolite-corrected input functions. Following intravenous administration of [18F]MK-6240, the tracer rapidly partitioned into the brain and its heterogenous distribution pattern was consistent with known NFT pathology in AD. In contrast, uptake in HV was low and uniform across the brain parenchyma. Across all subjects, average T–RT variabilities in NFT-rich regions were ∼21%, ∼14% and ∼6% for various quantitative metrics: total distribution volume (VT), binding potential (BPND), and standardized uptake ratio (SUVR90–120), respectively. No significant differences in SUVR T–RT variability were observed between the high and low injected radioactivity groups (5.6% and 6.1%, respectively). This work suggests [18F]MK-6240 has adequate SUVR T–RT characteristics supporting the use of this outcome in future studies.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"56 1","pages":"2179 - 2187"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18