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In-vitro release study of Racecadotril from granule sachets: influence of Brij-35 消旋卡多曲颗粒剂体外释放研究:Brij-35的影响
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-09-04 DOI: 10.25135/jcm.91.2307.2837
Cem Çalışkan, Onur Çakır, Muge Guleli, Yavuz Selim Toksöz, H. I. Uğraş
{"title":"In-vitro release study of Racecadotril from granule sachets: influence of Brij-35","authors":"Cem Çalışkan, Onur Çakır, Muge Guleli, Yavuz Selim Toksöz, H. I. Uğraş","doi":"10.25135/jcm.91.2307.2837","DOIUrl":"https://doi.org/10.25135/jcm.91.2307.2837","url":null,"abstract":": For sachet drug forms containing Racecadotril, which are freely soluble in methanol and methylene chloride but practically insoluble in water, used as an anti-diarrhea, suitable dissolution media meeting the parameters requested by the authorities are not available in the literature and monographs. For this reason, a suitable dissolution medium was determined in accordance with the guidelines and the dissolution profiles of reference product and samples used in the study. The profiles were compared, and the method was validated. In order to determine the most suitable medium for the release of drug product, in vitro dissolution tests were performed in media prepared by different buffers similar to the pH of the gastrointestinal tract (GIT) and media containing Brij 35. In this context, the effects of buffers, pH, and different surfactants were evaluated, and it was found that Polyoxyethylene 23 lauryl ether (Brij-35), a nonionic surfactant, increased the solubility. The results were obtained with RP-HPLC method using Kromasil C18 150 mm x 4.6 mm, 5 µm column with a flow rate of 1.5 ml/min at 210 nm wavelength in 7 minutes for Racecadotril, which dissolves at least 60% of the label value after 45 minutes after the dissolution studies performed with a type II apparatus at 37°C. A suitable dissolution medium was found for sachet drug forms containing Racecadotril, and the analytical method was validated in accordance with the ICH Q2 (R1) guideline. In addition, the difference factor (f 1 ) and similarity factor (f 2 ) were calculated to compare the dissolution profiles of the reference product and samples in this determined dissolution medium.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48408583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of quantitative NMR analysis: a case study of lignin 定量核磁共振分析的准确性:以木质素为例
Journal of Chemical Metrology Pub Date : 2023-06-29 DOI: 10.25135/jcm.88.2304.2753
Shrikant Shivaji Pawade, Ivo Leito, Koit Herodes, Lauri Toom
{"title":"Accuracy of quantitative NMR analysis: a case study of lignin","authors":"Shrikant Shivaji Pawade, Ivo Leito, Koit Herodes, Lauri Toom","doi":"10.25135/jcm.88.2304.2753","DOIUrl":"https://doi.org/10.25135/jcm.88.2304.2753","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134999380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Certification of buffer solutions reference materials using Baucke cell for supporting the quality of pH measurements 使用Baucke电池支持pH测量质量的缓冲溶液标准物质的认证
Journal of Chemical Metrology Pub Date : 2023-06-29 DOI: 10.25135/jcm.87.2303.2773
Adel Shehata, Abdulrahman R. Alaskar, Rashed A. Aldosari, Fahad R. Almutairi
{"title":"Certification of buffer solutions reference materials using Baucke cell for supporting the quality of pH measurements","authors":"Adel Shehata, Abdulrahman R. Alaskar, Rashed A. Aldosari, Fahad R. Almutairi","doi":"10.25135/jcm.87.2303.2773","DOIUrl":"https://doi.org/10.25135/jcm.87.2303.2773","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134999378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a stability-indicating HPLC method for Lasmiditan and its process related impurities with characterization of degradation products by LCMS/MS 拉西米坦及其工艺相关杂质的稳定性指示HPLC方法的建立及其降解产物的LCMS/MS表征
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-06-29 DOI: 10.25135/jcm.89.2304.2767
Venkateswara Rao Anna, Chilakabattina Naga Narasimha Babu, Bhagya Kumar Tatavarti, N. Vijaya, Cherukula Srinivasa Reddy
{"title":"Development of a stability-indicating HPLC method for Lasmiditan and its process related impurities with characterization of degradation products by LCMS/MS","authors":"Venkateswara Rao Anna, Chilakabattina Naga Narasimha Babu, Bhagya Kumar Tatavarti, N. Vijaya, Cherukula Srinivasa Reddy","doi":"10.25135/jcm.89.2304.2767","DOIUrl":"https://doi.org/10.25135/jcm.89.2304.2767","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45206877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Determination of adulteration in hair serums by LC-HRMS § LC-HRMS法测定头发血清中的掺假
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-06-29 DOI: 10.25135/jcm.90.2304.2599
A. Gören, T. Akalin, S. Yalçin, Aysenur Gunaydin Akyildiz
{"title":"Determination of adulteration in hair serums by LC-HRMS §","authors":"A. Gören, T. Akalin, S. Yalçin, Aysenur Gunaydin Akyildiz","doi":"10.25135/jcm.90.2304.2599","DOIUrl":"https://doi.org/10.25135/jcm.90.2304.2599","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46687070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemometrics assisted UV-spectrophotometric method for simultaneous estimation of aliskiren and hydrochlorothiazide in bulk and their pharmaceutical dosage form 化学计学辅助紫外分光光度法同时测定散装阿利吉仑和氢氯噻嗪及其剂型
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-06-29 DOI: 10.25135/rnp.84.2212.2661
Shantilal Padhiyar, Kamlesh M Jivani, J. Upadhyay, Tejas Patel, V. Bhavsar, B. Suhagia
{"title":"Chemometrics assisted UV-spectrophotometric method for simultaneous estimation of aliskiren and hydrochlorothiazide in bulk and their pharmaceutical dosage form","authors":"Shantilal Padhiyar, Kamlesh M Jivani, J. Upadhyay, Tejas Patel, V. Bhavsar, B. Suhagia","doi":"10.25135/rnp.84.2212.2661","DOIUrl":"https://doi.org/10.25135/rnp.84.2212.2661","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45467834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Certification of buffer solutions reference materials using Baucke cell for supporting the quality of pH measurements 使用Baucke池支持pH测量质量的缓冲溶液参考材料的认证
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-05-19 DOI: 10.25135/rnp.87.2303.2773
A. Shehata, A. R. Alaskar, Rashed A. Aldosari, F. Almutairi
{"title":"Certification of buffer solutions reference materials using Baucke cell for supporting the quality of pH measurements","authors":"A. Shehata, A. R. Alaskar, Rashed A. Aldosari, F. Almutairi","doi":"10.25135/rnp.87.2303.2773","DOIUrl":"https://doi.org/10.25135/rnp.87.2303.2773","url":null,"abstract":": The need for certified pH reference materials to support the traceability claims and quality of the daily large volume of pH measurements is very strong. In this work, three batches of buffer solutions were prepared, and their pH values were certified in accordance with the IUPAC Recommendation 2002. The first batch was prepared from potassium tetraoxalate (dihydrate) and disodium oxalate to provide pH4 and the second batch was prepared from disodium hydrogen phosphate and potassium dihydrogen phosphate to provide pH7. The third batch was prepared from sodium hydrogen carbonate and sodium carbonate to provide pH10. Every batch was homogenized by mechanical shaking for one night and bottled into 50 HDPE bottles, each is 250 mL. A number of bottles were systematically selected for homogeneity, stability and characterization studies of the buffer reference materials. These studies were carried out in accordance with the requirements of ISO 17034 and ISO Guide 35 using Baucke cell. The pH values 4, 7 and 10 of the secondary buffers were restandardized with regard to the pH values 4, 7 and 10 of the primary buffers produced by the Slovak National Metrology Institute, SMU. The results obtained showed that the produced buffer RMs were homogeneous and stable enough and their certified pH values were found 4.001±0.019, 7.005±0.015 and 10.002±0.023. These CRMs will be very useful as calibrants and as PT samples for analytical laboratories performing pH measurements in various fields.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41900886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of the localized surface plasmon resonance of silver nanoparticles for the determination of ethion in water samples 银纳米粒子的局域表面等离子体共振在测定水样中乙硫醇中的应用
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-04-30 DOI: 10.25135/jcm.86.2303.2728
S. H. Ahmadi, H. Daneshyar, N. Dalali
{"title":"Application of the localized surface plasmon resonance of silver nanoparticles for the determination of ethion in water samples","authors":"S. H. Ahmadi, H. Daneshyar, N. Dalali","doi":"10.25135/jcm.86.2303.2728","DOIUrl":"https://doi.org/10.25135/jcm.86.2303.2728","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43902609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1H NMR spectroscopy-based serum metabolomics analysis of iron deficiency anemia 基于1H核磁共振波谱的缺铁性贫血血清代谢组学分析
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-04-28 DOI: 10.25135/jcm.85.2303.2727
M. Demirel, Ayşe Zehra Gül, Fatmanur Köktaşoğlu, Halime Ağaç, A. Gören, C. Karatoprak, Ş. Selek
{"title":"1H NMR spectroscopy-based serum metabolomics analysis of iron deficiency anemia","authors":"M. Demirel, Ayşe Zehra Gül, Fatmanur Köktaşoğlu, Halime Ağaç, A. Gören, C. Karatoprak, Ş. Selek","doi":"10.25135/jcm.85.2303.2727","DOIUrl":"https://doi.org/10.25135/jcm.85.2303.2727","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44057719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA quantification via nanodrop spectrophotometer: estimation of method uncertainty using DNA from standard reference materials, sprague dawley rats, and humans 通过纳米滴分光光度计进行DNA定量:使用标准参比物质、大鼠和人的DNA进行方法不确定度的估计
IF 1.3
Journal of Chemical Metrology Pub Date : 2023-04-04 DOI: 10.25135/jcm.83.2301.2676
Alejandro M García Alegría, I. Anduro-Corona, C. J. Pérez-Martínez, Trinidad Quizán-Plata, L. Armenta-Villegas, M. L. Rascón-Durán, H. Astiazarán-García
{"title":"DNA quantification via nanodrop spectrophotometer: estimation of method uncertainty using DNA from standard reference materials, sprague dawley rats, and humans","authors":"Alejandro M García Alegría, I. Anduro-Corona, C. J. Pérez-Martínez, Trinidad Quizán-Plata, L. Armenta-Villegas, M. L. Rascón-Durán, H. Astiazarán-García","doi":"10.25135/jcm.83.2301.2676","DOIUrl":"https://doi.org/10.25135/jcm.83.2301.2676","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46961578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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