Journal of chemical neuroanatomy最新文献

{"title":"Brain Mechanisms – An evolving perspective on the future of neuroscience","authors":"Goran Šimić, Gail M. Rodney","doi":"10.1016/j.jchemneu.2024.102482","DOIUrl":"10.1016/j.jchemneu.2024.102482","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"142 ","pages":"Article 102482"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pramipexole and rasagiline treatment enhances dendritic spine structural neuroplasticity in striatal and prefrontal cortex neurons of rats with bilateral intrastriatal 6-hydroxydopamine lesions","authors":"Alfonso Boyzo Montes de Oca ,&nbsp;Hiram Tendilla-Beltrán ,&nbsp;María E. Bringas ,&nbsp;Gonzalo Flores ,&nbsp;Jorge Aceves","doi":"10.1016/j.jchemneu.2024.102468","DOIUrl":"10.1016/j.jchemneu.2024.102468","url":null,"abstract":"<div><div>Parkinson's disease manifests as neurological alterations within dendritic spines in the striatal and neocortical brain regions, where their functionality closely correlates with morphology. However, the impact of current pharmacotherapy on dendritic spine neuroplasticity, crucial for novel drug development in neurological and psychiatric disorders, remains unclear. This study investigated the effects of 6-OHDA intrastriatal bilateral lesions in male adult rats on behavior and dendritic spine neuroplasticity in striatal and cortical neurons. Furthermore, it evaluated the influence of chronic co-administration of pramipexole (PPX), a D3 receptor agonist, and rasagiline (Ras), a selective MAO-B inhibitor, on these alterations. Lesioned animals exhibited impaired balance behavior, with no improvement following PPX-Ras treatment. The 6-OHDA lesion decreased dendritic spine density in caudate putamen (CPU) spiny projection neurons (SPNs), a change unaffected by treatment, though PPX-Ras increased mushroom spines and reduced stubby spines in these neurons. In nucleus accumbens (NAcc) SPNs and prefrontal cortex layer 3 (PFC-3) pyramidal cells, dendritic spine density remained unaltered, but PPX-Ras decreased mushroom spines and increased bifurcated spines in the NAcc, while increasing mushroom spines and decreasing stubby spines in PFC-3 in lesioned rats. These findings emphasize the importance of dendritic spines as promising targets for innovative pharmacotherapies for Parkinson’s disease.</div></div>","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102468"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and Aβ (1–42) pathway in the hippocampus: An in vivo approach” [J. Chem. Neuroanat. 133 (2023) 102340]","authors":"Khadga Raj Aran ,&nbsp;G.D. Gupta ,&nbsp;Shamsher Singh","doi":"10.1016/j.jchemneu.2024.102471","DOIUrl":"10.1016/j.jchemneu.2024.102471","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102471"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus” [J. Chem. Neuroanat. 114(2021) 101946]","authors":"Reza Sardar ,&nbsp;Javad Hami ,&nbsp;Mansoureh Soleimani ,&nbsp;Mohammad-Taghi Joghataei ,&nbsp;Reza Shirazi ,&nbsp;Fereshteh Golab ,&nbsp;Zeinab Namjoo ,&nbsp;Zahra Zandieh","doi":"10.1016/j.jchemneu.2024.102469","DOIUrl":"10.1016/j.jchemneu.2024.102469","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102469"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet” [J. Chem. Neuroanat. 136 (2024) 102389]","authors":"Davood Dorranipour ,&nbsp;Fahimeh Pourjafari ,&nbsp;Reza Malekpour-Afshar ,&nbsp;Mohsen Basiri ,&nbsp;Mehran Hosseini","doi":"10.1016/j.jchemneu.2024.102474","DOIUrl":"10.1016/j.jchemneu.2024.102474","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102474"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats” [J. Chem. Neuroanat. 135 (2024) 102365]","authors":"Felix U. Enemali,&nbsp;Kingsley Afoke Iteire,&nbsp;Raphael E. Uweigho,&nbsp;Ogunberi Blessing,&nbsp;Gbayisomore Tolulope Judah","doi":"10.1016/j.jchemneu.2024.102470","DOIUrl":"10.1016/j.jchemneu.2024.102470","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102470"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol” [J. Chem. Neuroanat. 135 (2024) 102367]","authors":"Majid Keyhanifard ,&nbsp;Roghayeh Javan ,&nbsp;Reza Ataee Disfani ,&nbsp;Maryam Bahrami ,&nbsp;Mohamad Sedigh Mirzaie ,&nbsp;Saeid Taghiloo ,&nbsp;Hossein Mokhtari ,&nbsp;Davood Nasiry ,&nbsp;Zahra Sadrzadeh Aghajani ,&nbsp;Mahdi Shooraj","doi":"10.1016/j.jchemneu.2024.102472","DOIUrl":"10.1016/j.jchemneu.2024.102472","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"141 ","pages":"Article 102472"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments","authors":"Irina T. Sinakevitch ,&nbsp;Kelsey E. McDermott ,&nbsp;Daniel T. Gray ,&nbsp;Carol A. Barnes","doi":"10.1016/j.jchemneu.2024.102449","DOIUrl":"10.1016/j.jchemneu.2024.102449","url":null,"abstract":"<div><p>Locus coeruleus (LC) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical regions, and spinal cord. Many aspects of cognition are known to be dependent on the noradrenergic system, and it has been suggested that dysfunction in this system may play central roles in cognitive decline associated with both normative aging and neurodegenerative disease. While basic anatomical and biochemical features of the LC have been examined in many species, detailed characterizations of the structure and function of the LC across the lifespan are not currently available. This includes the rhesus macaque, which is an important model of human brain function because of their striking similarities in brain architecture and behavioral capacities. In the present study, we describe a method to combine structural MRI, Nissl, and immunofluorescent histology from individual monkeys to reconstruct, in 3 dimensions, the entire macaque LC nucleus. Using these combined methods, a standardized volume of the LC was determined, and high-resolution confocal images of tyrosine hydroxylase-positive neurons were mapped into this volume. This detailed representation of the LC allows definitions to be proposed for three distinct subnuclei, including a medial region and a lateral region (based on location with respect to the central gray, inside or outside, respectively), and a compact region (defined by densely packed neurons within the medial compartment). This enabled the volume to be estimated and cell density to be calculated independently in each LC subnucleus for the first time. This combination of methods should allow precise characterization of the LC and has the potential to do the same for other nuclei with distinct molecular features.</p></div>","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"140 ","pages":"Article 102449"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0891061824000656/pdfft?md5=dc6955e013d1e65d49d1187fd626c617&pid=1-s2.0-S0891061824000656-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential cholinergic innervation of lemniscal versus non-lemniscal regions of the inferior colliculus","authors":"William A. Noftz ,&nbsp;Emily E. Echols ,&nbsp;Nichole L. Beebe ,&nbsp;Jeffrey G. Mellott ,&nbsp;Brett R. Schofield","doi":"10.1016/j.jchemneu.2024.102443","DOIUrl":"10.1016/j.jchemneu.2024.102443","url":null,"abstract":"<div><p>The inferior colliculus (IC), a midbrain hub for integration of auditory information, receives dense cholinergic input that could modulate nearly all aspects of hearing. A key step in understanding cholinergic modulation is to identify the source(s) and termination patterns of cholinergic input. These issues have not been addressed for the IC in mice, an increasingly important model for study of hearing. We examined cholinergic inputs to the IC in adult male and female mice. We used retrograde tracing and immunochemistry to identify three sources of cholinergic innervation of the mouse IC: the pedunculopontine tegmental nucleus (PPT), the laterodorsal tegmental nucleus (LDT) and the lateral paragigantocellular nucleus (LPGi). We then used Cre-dependent labeling of cholinergic neurons in normal-hearing ChAT-Cre mice to selectively label the cholinergic projections to the IC from each of the cholinergic sources. Labeling of cholinergic projections from the PPT and LDT revealed cholinergic axons and boutons terminating throughout the IC, with the ipsilateral projection being denser. Electron microscopic examination showed that these cholinergic axons can form traditional synaptic junctions with IC neurons. In separate experiments, selective labeling of cholinergic projections from the LPGi revealed bilateral projections to the IC. The LPGi axons exhibited relatively equal densities on ipsilateral and contralateral sides, but on both sides the terminations were largely restricted to the non-lemniscal regions of the IC (i.e., the dorsal cortex, lateral cortex and intercollicular tegmentum). We conclude first that cholinergic axons can form traditional synapses in the IC. In addition, lemniscal and non-lemniscal regions of the IC receive different patterns of cholinergic innervation. The lemniscal IC (IC central nucleus) is innervated by cholinergic neurons in the PPT and the LDT whereas the non-lemniscal “shell” areas of the IC are innervated by the PPT and LDT and by cholinergic neurons in the LPGi.</p></div><div><h3>Data Availability</h3><p>Data will be made available on request.</p></div>","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"139 ","pages":"Article 102443"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0891061824000577/pdfft?md5=0ba7fa7d7b0108c426d9a93ac7c12f45&pid=1-s2.0-S0891061824000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Gelatin/polyethylene glycol-loaded magnesium hydroxide nanocomposite to attenuate acetylcholinesterase, neurotoxicity, and activation of GPR55 protein in rat models of Alzheimer's disease” [J. Chem. Neuroanat. 133 (2023) 102337]","authors":"Manickam Rajkumar ,&nbsp;Sundarraj Navaneethakrishnan ,&nbsp;Sundarapandian Muthukumar ,&nbsp;Ramasundaram Thangaraj ,&nbsp;Magudeeswaran Sivanandam ,&nbsp;Karuppaiya Vimala ,&nbsp;Soundarapandian Kannan","doi":"10.1016/j.jchemneu.2024.102448","DOIUrl":"10.1016/j.jchemneu.2024.102448","url":null,"abstract":"","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"139 ","pages":"Article 102448"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0891061824000644/pdfft?md5=7059509c479510217a979130b1ec3c74&pid=1-s2.0-S0891061824000644-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}