Wang Ping, K. Low, J. Mclaren, Pascal Joubert des Ouches
{"title":"Muscle Activation of Participants while Walking on a Robotic-Assisted Locomotion Training","authors":"Wang Ping, K. Low, J. Mclaren, Pascal Joubert des Ouches","doi":"10.1109/NEBEC.2013.26","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.26","url":null,"abstract":"NaTUre-gaits (Natural and TUnable rehabilitation gait system), has been developed for a robotic-assisted overground walking training. Effects on muscle activation of participants during walking with the system were evaluated and analyzed. Clinical trials were conducted and electromyographic (EMG) signals were collected from major lower limb muscle groups. Comparisons of muscle activation were provided between healthy and SCI/stroke participants walking with the device. Preliminary results showed that this device can provide a training effect to rehabilitation.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"os-57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127718693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet S. Ozturk, V. Lee, Lingling Zhao, G. Dai, X. Intes
{"title":"Laminar Optical Tomography Applied to Reporter Genes Imaging in Engineered Tissue Constructs","authors":"Mehmet S. Ozturk, V. Lee, Lingling Zhao, G. Dai, X. Intes","doi":"10.1109/NEBEC.2013.106","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.106","url":null,"abstract":"Fluorescence imaging is the main method in assessing tissue engineered constructs. However, with the drive to develop thick engineered constructs, it is imperative to develop new fluorescence based techniques that can image beyond the depth capabilities of current microscopic techniques. Here we report the use of Laminar Optical Tomography (LOT) to image in 3D vascular channels, formed by GFP and mCherry carrier cells, in a thick printed constructs enclosed in a perfusion chamber. Results show the potential of LOT for locating and monitoring transfected cells in thick tissue with spatial accuracy.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127749842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Biochemical and Biophysical Factors on Endothelial-to-Mesenchymal Transformation","authors":"S. Dahal, Gretchen J. Mahler","doi":"10.1109/NEBEC.2013.135","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.135","url":null,"abstract":"The prevalence of calcific aortic valve disease is rising and is only treatable by surgical replacement of the stenotic valve. There is currently no biomarker or pharmacological therapy available for the treatment of early aortic valve disease and this is largely due to our limited understanding of the disease mechanisms. One potential mechanism of valve repair and potentially early valve disease is endothelial-to-mesenchymal transformation (EndMT), the initiating event of valvulogenesis. Our preliminary work has shown that extracellular matrix (ECM) composition that mimics diseased valve conditions strongly stimulates mesenchymal transformation. EndMT may be a mechanism for signaling valve interstitial cells toward either valve regeneration or disease and growing evidence indicates that communication between the interstitial cells and the endothelial cells is essential for valve homeostasis. Unfortunately, there is currently no known unifying mechanism of valve disease that connects endothelial cell dysfunction, interstitial cell differentiation, and pathological matrix remodeling. Our research seeks to reveal this mechanism using novel, unique to our laboratory tools, greatly facilitating the discovery and new clinical strategies for controlling early-detected valve disease with minimally invasive interventions.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130478262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Further Development of the F.O.C.U.S.: Facilitating On-going Concentration in Undergraduate Students","authors":"M. L. Thomas, J. Cezeaux","doi":"10.1109/NEBEC.2013.19","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.19","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is a common learning disability in many children and adults. A prototype device, the F.O.C.U.S., was developed to help improve the academic performance of students with this disorder. Further development of the F.O.C.U.S. consists of enhancing the current prototype to make it non-stigmatizing so that undergraduate students with ADHD can use it to help them improve their academic performance. A customer needs survey was distributed to students registered with Student Disability Services to determine aspects of the device. The device will include the eZ430-Chronos Development Tool (digital watch) which will control peripheral devices that will be set on the desk of the student. These peripheral devices can be prompted via the wireless signal from the watch to distribute reminder signals such as vibrations, beeping sounds, and flashing light.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132102113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gallium Containing Glass Polyalkenoate Bone Cements: Ion Release and E. coli Inhibition","authors":"L. Placek, A. Wren, A. Coughlan, M. Towler","doi":"10.1109/NEBEC.2013.99","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.99","url":null,"abstract":"The Glass Polyalkenoate Cement (GPC) series (LCon., LGa-1 and LGa-2) containing gallium (Ga) and a 50 wt% addition of E11 polyacrylic acid (PAA), previously developed, was evaluated for ion release, specifically Si, Ca, Zn and Ga, and E. coli inhibition. The maximum inhibition was observed in the t = 0 samples and was 0.35 mm for LCon. and 0.65 mm for LGa-1 and LGa-2.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122621382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Investigation into the Structure and Properties of CaO-ZnO-SiO2-TiO2-Na2O Bioactive Glass/Hydroxyapatite Composite","authors":"C. Yatongchai, M. Towler, A. Wren","doi":"10.1109/NEBEC.2013.51","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.51","url":null,"abstract":"Effect of the addition of CaO-ZnO-SiO2-TiO2-Na2O glass as a reinforcing phase on properties of hydroxyapatite/glass composites was investigated. The addition of the glass caused the decomposition of HA phase to tricalcium phosphate, inhibiting densification in the HA/glass composites. However, depending on the glass concentration, some of the glass can act as a sintering aid enhancing the densification in the composites.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122888741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced Skin Cell Fuctions on Bioactive Rosette Nanotube Composites","authors":"Linlin Sun, T. Webster, U. Hemraz, H. Fenniri","doi":"10.1109/NEBEC.2013.91","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.91","url":null,"abstract":"Over the past several decades, even with intensive research, it has still been difficult to achieve sufficient skin regeneration both functionally and for cosmetic satisfaction. Nanotechnology is a promising new approach to create new materials with enhanced biocompatibility and bioactivity with suitable mechanical properties for the development of novel skin regeneration materials. In this study, rosette nanotubes (RNTs) assembled from twin base linker molecules were used with poly(2-hydroxyethyl methacrylate) (pHEMA) for skin application. RNTs increased the adhesion and proliferation of both keratinocytes and fibroblasts.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121434267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Alamgir, X. Cai, Brian J. Roscoe, R. Wang, S. Sani, S. Schuckers, Alexandru Stoin, Charles J. Robinson
{"title":"Detection of Cardioseismographic Signals throughout the Body","authors":"Z. Alamgir, X. Cai, Brian J. Roscoe, R. Wang, S. Sani, S. Schuckers, Alexandru Stoin, Charles J. Robinson","doi":"10.1109/NEBEC.2013.78","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.78","url":null,"abstract":"An accelerometer placed on the chest produces a periodic ~1 Hz signal linked to the cardiac cycle. If one places accelerometers on the head, a 1 Hz background signal can also be detected in all three axes. This paper investigates the source of these head acceleration signals.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128931355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization and Solubility of SiO2-TiO2-CaO-Na2O/SrO Bioactive Glasses","authors":"Y. Li, A. Coughlan, A. Wren","doi":"10.1109/NEBEC.2013.64","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.64","url":null,"abstract":"This project investigates the characterization and solubility of a bioactive glass series where Strontium (Sr) and Sodium (Na) are substituted. X-ray diffraction (XRD) was employed to ensure that each starting material is amorphous. Differential Thermal Analysis (DTA) was used to determine the thermal profile of each material, in particular, the glass transition temperature (Tg), the crystallization temperature (Tc1) and the melting temperature (Tm). Magic Angle Spinning - Nuclear Magnetic Resonance (MAS-NMR) was used to probe the local 29Si environment. Simulated Body Fluid (SBF) testing revealed a CaP surface layer on each glass after 7 days.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128984397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delivery of Anti-Cancer Drugs Using Nanocarriers","authors":"Beth Lally, R. Gettens, Shabnam N. Sani","doi":"10.1109/NEBEC.2013.74","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.74","url":null,"abstract":"The most prevalent form of cancer treatment used today is chemotherapy, although it is widely known to be associated with frequent, high dosages and unwanted side effects. The application of nanocarriers to conventional cancer treatment aims to address these problems by encapsulating chemotherapeutic drugs within polymer or lipid nanoparticles. These drug delivery nanoparticles, known as nanocarriers, work to increase the stability and circulation time of drugs and can be used to target specific areas. This project aims to fabricate nanocarriers for the delivery of chemotherapeutic drugs in order to address the current problems of chemotherapy. These nanocarriers will reduce side effects and issues of conventional dosage forms by targeting tumor sites, releasing drug specifically and only where it is needed.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128838031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}