Clinical & Translational Immunology最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148077551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty acid metabolism-an emerging regulatory node in T-cell immunometabolism.","authors":"Brett Chapel Arenberg, Michael N Sack, Jing Wu","doi":"10.1002/cti2.70091","DOIUrl":"10.1002/cti2.70091","url":null,"abstract":"<p><p>While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T-cell biology. We discuss the catabolic, anabolic and signalling aspects of lipid metabolism and their influence on immune function. Short-chain fatty acids modulate T-cell epigenetics through histone acetylation, thereby impacting gene expression. Medium- and long-chain fatty acids augment fatty acid oxidation (FAO), which supports the expansion and function of regulatory T-cell populations. Very-long-chain polyunsaturated fatty acids, when cleaved from the membrane, serve as precursors for both pro-inflammatory and pro-resolving signalling molecules. Additionally, <i>de novo</i> fatty acid synthesis contributes to membrane biogenesis and alters acetyl-CoA availability, linking lipid metabolism to epigenetic regulation. The mechanisms described above present promising opportunities to modulate inflammation through targeted therapies. In this review, we focus on emerging targets within fatty acid metabolism pathways that show potential for influencing inflammatory responses in translational models. Specifically, we review key transcription factors, metabolic enzymes and dietary interventions, while also addressing current limitations and challenges in translating these findings to clinical settings. Although studies in murine models have yielded encouraging results, substantial gaps remain-particularly in applying these metabolic strategies to human T-cell biology. We conclude by emphasising the importance of validating these targets in <i>ex vivo</i> human models as a critical step towards future clinical intervention.</p>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":"e70091"},"PeriodicalIF":3.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial omics for profiling the dynamic tumor microenvironment","authors":"Hao Nguyen,&nbsp;Merrin Mary Eapen,&nbsp;Quan Nguyen,&nbsp;Ankur Sharma","doi":"10.1002/cti2.70084","DOIUrl":"https://doi.org/10.1002/cti2.70084","url":null,"abstract":"<p>Spatial transcriptomics (ST) and spatial proteomics (SP) have revolutionised our ability to map RNA and protein distributions within intact tissues, shedding new light on the dynamic interactions that drive physiological processes in healthy and diseased tissues. We discuss how the latest ST and SP technologies, large public data resources and advanced computational pipelines can be applied to study the tumor microenvironment (TME), focussing on the interactions within the TME. We also highlight how these developments have enabled the in-depth spatial characterisation of tumors and their TME across the continuum of cancer progression, from initiation to metastasis. Despite these advances, major gaps persist in cross-platform integration, data standardisation and computational scalability for high-plex single-cell datasets. The integration of artificial intelligence (AI) holds great promise for biological and translational applications but requires standardised workflows, cost-effective pipelines, rigorous pre-clinical and clinical validation, and improved interpretability of AI models. Additional cross-disciplinary development of explainable, scalable tools for TME analysis of cellular interactions and disease progression will be essential to integrate spatial omics into daily precision cancer medicine.</p>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148076727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A characterisation of the immune cells in immunocompetent and immunodeficient mice with orthotopic brain tumors","authors":"Bryan Gardam,&nbsp;Eunwoo Nam,&nbsp;Paris M Kollis,&nbsp;Jasmine Kilyen-Coles,&nbsp;S Lenin,&nbsp;Briony L Gliddon,&nbsp;Melinda N Tea,&nbsp;Stuart M Pitson,&nbsp;Michael P Brown,&nbsp;Lisa M Ebert,&nbsp;Tessa Gargett","doi":"10.1002/cti2.70093","DOIUrl":"10.1002/cti2.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Glioblastoma is characterised by poor survival with few treatment advances for over 20 years. Immunotherapies, which have transformed treatment of other cancers, have been difficult to apply to glioblastoma because of its highly immune-suppressive microenvironment, and there is a growing appreciation that the disease also induces a global suppression of the systemic immune system. However, immunotherapy research is hampered by the lack of detailed characterisation of the whole immune system in murine brain tumor models, with studies until now having focussed mainly on tumor-infiltrating immune cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here, we have studied common murine models of intracranial brain tumors by using high-parameter flow cytometry and tissue immunofluorescence staining to fully characterise immune cells in the brain, draining lymph node, spleen and bone marrow.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The highly immune-compromised NSG mouse models were striking in their many immune perturbations, which extended beyond the known deficits in lymphocytes. Immunocompetent tumor models had significant changes in brain-resident immune cells compared to controls, as expected; however, systemic effects were also observed with significant reductions in subsets of monocytes, macrophages and dendritic cells in the spleen and increases in bone marrow.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our extensive and quantitative characterisation of the immune system in murine models of glioblastoma will allow for a better-informed selection of models and advance the search for new immune-based treatments for this deadly disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological insights into gastric polyps: pathogenesis, inflammation and neoplastic potential","authors":"Kshitija Kale,&nbsp;Pranav S. Renavikar,&nbsp;Anjali D. Amarapurkar","doi":"10.1002/cti2.70092","DOIUrl":"10.1002/cti2.70092","url":null,"abstract":"<p>Gastric polyps are a heterogeneous group of mucosal lesions increasingly detected during routine endoscopy, encompassing entities with distinct pathogenesis, immune landscapes and variable malignant potential. Accumulating evidence highlights the central role of gastric mucosal immunity in driving polyp initiation, progression, and, in select subtypes, neoplastic transformation. This review synthesises current knowledge on the immunopathogenesis of major gastric polyp subtypes, including hyperplastic, fundic gland, adenomatous, neuroendocrine and inflammatory fibroid polyps, with a particular emphasis on the interplay between chronic inflammation, epithelial injury and immune-mediated tissue remodelling. We discuss how <i>Helicobacter pylori</i> infection, autoimmune gastritis, proton pump inhibitor–induced hypergastrinemia and genetic syndromes shape distinct immune microenvironments characterised by specific cytokine profiles, immune cell infiltrates and epithelial responses. Special attention is given to mechanisms linking sustained immune activation to dysplasia and carcinogenesis, including oxidative stress, cytokine-driven proliferation, immune surveillance failure and early engagement of immune checkpoint pathways such as PD-1/PD-L1. Furthermore, we explore emerging diagnostic, prognostic and therapeutic implications of immune profiling in gastric polyps, ranging from <i>H. pylori</i> eradication and chemoprevention to the potential role of immunomodulatory strategies in high-risk lesions. By integrating immunology with histopathology and clinical behaviour, this review provides a comprehensive framework for understanding gastric polyp biology and identifies key gaps and future directions for precision surveillance and immune-targeted prevention of gastric neoplasia.</p>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial transcriptomic analysis of the immune landscape following NBUVB treatment of vitiligo skin","authors":"Abhik Dutta,&nbsp;Divya Gupta,&nbsp;Johan Ajnabi,&nbsp;Binita Dam,&nbsp;Shilpashree P,&nbsp;Colin Jamora","doi":"10.1002/cti2.70080","DOIUrl":"10.1002/cti2.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Vitiligo is an autoimmune disorder characterised by the presence of depigmented lesions on the skin. The autoreactive cytotoxic T cells at the epidermal-dermal junction of the skin facilitate the targeted destruction of epidermal melanocytes, leading to the development of vitiligo lesions. Narrow-band UVB (NBUVB) phototherapy is a widely used non-invasive treatment that promotes transient repigmentation of lesions. However, the specific effects of NBUVB on skin dermal T cells in vitiligo patients remain largely unexplored. Insights into the mechanism of action of NBUVB phototherapy can guide therapies against cytotoxic T cells, enabling effective and sustained remission of vitiligo lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Indian patients with active vitiligo lesions underwent 3 months of NBUVB phototherapy, thereby leading to successful repigmentation of vitiligo lesions. Spatial transcriptomic and histological analyses were employed to investigate the gene expression profiles of dermal T cells at the epidermal-dermal junction, both before and after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comprehensive spatial transcriptome analysis of skin dermal T cells revealed that NBUVB phototherapy leads to the overall suppression of inflammatory genes and immune regulatory pathways that are upregulated in vitiligo patients before treatment. Consequently, tissue-resident innate and adaptive immune cells significantly decrease post-UVB phototherapy. Interestingly, we observe an increase in naïve CD4⁺ T cells post-UVB phototherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NBUVB phototherapy effectively suppresses the innate and adaptive immune cell populations and immune regulatory pathways while promoting an increase in naïve CD4⁺ T cells. These findings underscore a previously unrecognised immunomodulatory role of NBUVB phototherapy in vitiligo patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 4","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helminths as architects of trained tolerance: implications for human health","authors":"Quinn Moroz,&nbsp;Jorge Lucas Nascimento Souza,&nbsp;Neima Briggs","doi":"10.1002/cti2.70086","DOIUrl":"https://doi.org/10.1002/cti2.70086","url":null,"abstract":"<p>Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low-resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years-long persistence and reinfection. We put forward the concept of ‘trained tolerance’, which describes the durable yet reversible system-wide immunological programme helminths exert on the host to promote their own survival. In humans, this altered immune set point shapes host responses to concurrent challenges, including cancer immunity, allergy, autoimmunity, coinfections and vaccine effectiveness. Here, we outline research priorities, including defining species-specific immune correlates of protection versus tolerance, integrating longitudinal cohorts and controlled human infection studies with single-cell and spatial profiling, establishing standardised biomarker panels to track immune recalibration after parasite clearance and evaluating the impact of anthelmintic treatment prior to immunisation campaigns to restore germinal centre function and durable protection.</p>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"cGAS inhibitor IMSB301 modifies interferon signalling in peripheral mononuclear cells of SAMHD1 genetic interferonopathy in vitro","authors":"Velda X Han,&nbsp;Jessica P Hayes,&nbsp;Lijun Sun,&nbsp;Teresa Mooneyham,&nbsp;Michelle Lorentzos,&nbsp;Hiroya Nishida,&nbsp;Markus J Hofer,&nbsp;Brian Gloss,&nbsp;Ruwani Dissanayake,&nbsp;Xianzhong Lau,&nbsp;Shekeeb S Mohammad,&nbsp;Shrujna Patel,&nbsp;Russell C Dale","doi":"10.1002/cti2.70090","DOIUrl":"https://doi.org/10.1002/cti2.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Aicardi–Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism that lacks effective disease modifying therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-cell RNA sequencing was performed on peripheral blood mononuclear cells (PBMCs) obtained from a patient with AGS because of pathogenic biallelic <i>SAMHD1</i> variants to assess baseline gene dysregulation compared to an age- and sex-matched control. The patient and control's PBMCs were incubated with the novel clinical stage cGAS inhibitor IMSB301 for 24 h, followed by evaluation of its effects on <i>in vitro</i> gene expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In PBMCs from the patient with <i>SAMHD1</i> mutation, at baseline, the most upregulated enriched pathways were ‘response to virus’ and ‘response to type 1 interferon’; these were also the most downregulated pathways after <i>in vitro</i> IMSB301 treatment. The top five most upregulated genes at baseline were interferon-stimulated genes (ISG) <i>IFIT1, IFIT3, IFI44L, ISG15, OAS1</i>, which were downregulated to control levels after <i>in vitro</i> treatment with IMSB301.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The cGAS inhibitor IMSB301 resulted in specific reduction in interferon signalling <i>in vitro</i> in PBMCs from a patient with <i>SAMHD1</i> mutation, indicating a potential therapeutic role in genetic interferonopathy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ad26-MVA-BN-based therapeutic vaccine targeting HPV16 and HPV18 related disease is immunogenic in preclinical models and in women with persistent HPV infections","authors":"Selina Khan,&nbsp;Satish Boedhoe,&nbsp;Miranda Baert,&nbsp;Jan Serroyen,&nbsp;Thierry Verbinnen,&nbsp;Ariane Volkmann,&nbsp;Markus Kalla,&nbsp;Katrin Weidner,&nbsp;Mathieu Le Gars,&nbsp;Jerry Sadoff,&nbsp;Michal Sarnecki,&nbsp;Jort Vellinga,&nbsp;Jerome Custers,&nbsp;Gert Scheper,&nbsp;Hanneke Schuitemaker,&nbsp;Roland Zahn","doi":"10.1002/cti2.70089","DOIUrl":"https://doi.org/10.1002/cti2.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To develop a therapeutic human papillomavirus (HPV) vaccine capable of intercepting HPV-related cervical disease to reduce the number of new cancer cases and associated deaths.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We previously reported that replication-deficient adenovirus type 26 and 35-based vectors (Ad26, Ad35) expressing a fusion protein of E2, E6 and E7 (E2SH) from HPV16 and HPV18 induced robust HPV-specific T-cell immunity capable of reducing HPV16+ tumors in mice. Here, we assessed immune responses induced by Ad26 and Modified Vaccinia Virus Ankara—strain Bavarian Nordic (MVA-BN) viral vectors expressing E2SH in heterologous vaccination regimens in mice, macaques and a limited number of persistently HPV-infected women (<i>N</i> = 5).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The magnitude and breadth of cellular immune responses were higher in mice that received Ad26.HPV16/18-MVA-BN.HPV16/18 than in those that received Ad26.HPV16/18-Ad35.HPV16/18, all expressing the fusion protein E2SH of HPV16 and HPV18. Sustained and broad antigen-specific systemic T-cell responses against HPV16 and HPV18 proteins were induced in macaques. In the Phase 1/2a trial, a 2-dose heterologous immunisation with Ad26.HPV16 or Ad26.HPV18 in Week 0 and MVA-BN.HPV16/18 in Week 8 induced long-lived antigen-specific cytokine-producing T cells. After Week 8, HPV16/18 infection was no longer detected in 5/5 active vaccines and 1/4 placebo recipients during the study period of approximately 1 year. The small number of vaccinated participants did not allow concluding on the relationship between immune responses and viral clearance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These data show the ability of Ad26.HPV16/18-MVA-BN.HPV16/18 heterologous regimens to elicit HPV-specific T-cell responses and warrant further clinical studies to evaluate vaccine efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":152,"journal":{"name":"Clinical & Translational Immunology","volume":"15 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cti2.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}