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miR-34c抑制NLRP3炎性小体诱导的小胶质细胞焦亡机制研究 miR-34c抑制NLRP3炎性小体诱导的小胶质细胞焦亡机制研究
蚌埠医学院学报 Pub Date : 2023-05-15 DOI: 10.13898/j.cnki.issn.1000-2200.2023.05.001
骆嵩 | 李理 | 刘东亮 | 屈洪党
{"title":"miR-34c抑制NLRP3炎性小体诱导的小胶质细胞焦亡机制研究","authors":"骆嵩 | 李理 | 刘东亮 | 屈洪党","doi":"10.13898/j.cnki.issn.1000-2200.2023.05.001","DOIUrl":"https://doi.org/10.13898/j.cnki.issn.1000-2200.2023.05.001","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142027132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
醒脑静灌胃给药后莪术二酮在局灶性脑缺血大鼠血浆和脑组织中的药代动力学研究 醒脑静灌胃给药后莪术二酮在局灶性脑缺血大鼠血浆和脑组织中的药代动力学研究
蚌埠医学院学报 Pub Date : 2023-01-01 DOI: 10.26925/d.cnki.gbbyc.2023.000397
王自成
{"title":"醒脑静灌胃给药后莪术二酮在局灶性脑缺血大鼠血浆和脑组织中的药代动力学研究","authors":"王自成","doi":"10.26925/d.cnki.gbbyc.2023.000397","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2023.000397","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142030333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
西格列他钠经皮给药对糖尿病小鼠伤口促愈合作用的研究 西格列他钠经皮给药对糖尿病小鼠伤口促愈合作用的研究
蚌埠医学院学报 Pub Date : 2023-01-01 DOI: 10.26925/d.cnki.gbbyc.2023.000211
黄皓
{"title":"西格列他钠经皮给药对糖尿病小鼠伤口促愈合作用的研究","authors":"黄皓","doi":"10.26925/d.cnki.gbbyc.2023.000211","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2023.000211","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142030248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
血液自身抗体抗-XAGE3和抗-DNAJC12作为预测晚期NSCLC患者PD-1/PD-L1抑制剂疗效的生物标记物研究 血液自身抗体抗-XAGE3和抗-DNAJC12作为预测晚期NSCLC患者PD-1/PD-L1抑制剂疗效的生物标记物研究
蚌埠医学院学报 Pub Date : 2023-01-01 DOI: 10.26925/d.cnki.gbbyc.2023.000024
唐源
{"title":"血液自身抗体抗-XAGE3和抗-DNAJC12作为预测晚期NSCLC患者PD-1/PD-L1抑制剂疗效的生物标记物研究","authors":"唐源","doi":"10.26925/d.cnki.gbbyc.2023.000024","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2023.000024","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142030274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
商陆皂苷甲对大鼠脊髓损伤组织神经元的保护作用及机制 商陆皂苷甲对大鼠脊髓损伤组织神经元的保护作用及机制
蚌埠医学院学报 Pub Date : 2023-01-01 DOI: 10.26925/d.cnki.gbbyc.2023.000331
朱国庆
{"title":"商陆皂苷甲对大鼠脊髓损伤组织神经元的保护作用及机制","authors":"朱国庆","doi":"10.26925/d.cnki.gbbyc.2023.000331","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2023.000331","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142030332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
基于硼亲和作用的顺式二羟基类化合物分离新方法的研究 基于硼亲和作用的顺式二羟基类化合物分离新方法的研究
蚌埠医学院学报 Pub Date : 2022-01-01 DOI: 10.26925/d.cnki.gbbyc.2022.000295
李雪
{"title":"基于硼亲和作用的顺式二羟基类化合物分离新方法的研究","authors":"李雪","doi":"10.26925/d.cnki.gbbyc.2022.000295","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2022.000295","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142022799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
老年腔隙性脑梗死病人尿液AD7c-NTP及血清C反应蛋白与血管性轻度认知功能障碍的相关性 老年腔隙性脑梗死病人尿液AD7c-NTP及血清C反应蛋白与血管性轻度认知功能障碍的相关性
蚌埠医学院学报 Pub Date : 2021-07-15 DOI: 10.13898/j.cnki.issn.1000-2200.2021.07.007
冯玉婧 | 袁建新 | 杨秀平 | 王大鹏
{"title":"老年腔隙性脑梗死病人尿液AD7c-NTP及血清C反应蛋白与血管性轻度认知功能障碍的相关性","authors":"冯玉婧 | 袁建新 | 杨秀平 | 王大鹏","doi":"10.13898/j.cnki.issn.1000-2200.2021.07.007","DOIUrl":"https://doi.org/10.13898/j.cnki.issn.1000-2200.2021.07.007","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142064383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
华蟾素对非小细胞肺癌细胞株A549细胞增殖及PTEN/AKT/mTOR信号通路表达的影响 华蟾素对非小细胞肺癌细胞株A549细胞增殖及PTEN/AKT/mTOR信号通路表达的影响
蚌埠医学院学报 Pub Date : 2020-09-15 DOI: 10.13898/j.cnki.issn.1000-2200.2020.09.004
张生义, 张己为, 张旭峰, 张逸, 许斌斌, 左顺庆
{"title":"华蟾素对非小细胞肺癌细胞株A549细胞增殖及PTEN/AKT/mTOR信号通路表达的影响","authors":"张生义, 张己为, 张旭峰, 张逸, 许斌斌, 左顺庆","doi":"10.13898/j.cnki.issn.1000-2200.2020.09.004","DOIUrl":"https://doi.org/10.13898/j.cnki.issn.1000-2200.2020.09.004","url":null,"abstract":"目的观察华蟾素对肺癌细胞A549及PTEN/AKT/mTOR信号通路蛋白表达的影响。 方法在培养肺癌细胞株NCI-A549中分别加入不同浓度的华蟾素，应用细胞计数试剂盒-8检测24、48、72 h后细胞增殖活力，Ki67及EdU检测72 h细胞增殖活力，免疫印迹法检测磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白以及磷酸化第10号染色体缺失的磷酸酶和张力蛋白的同源基因（phosphorylated-phosphatase and tensin homolog deleted on chromosome ten，p-PTEN）蛋白表达。 结果0.2 μg/mL华蟾素作用于A549细胞株48 h后显示明显抑制增殖作用（P 0.05）。 结论华蟾素可能通过抑制PI3K/AKT/mTOR信号通路蛋白磷酸化，抑制肺癌细胞A549的增殖。","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"45 9","pages":"1159-1162"},"PeriodicalIF":0.0,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-溴丙酮酸脂质立方液晶的处方筛选及制备工艺优化 3-溴丙酮酸脂质立方液晶的处方筛选及制备工艺优化
蚌埠医学院学报 Pub Date : 2020-05-15 DOI: 10.13898/j.cnki.issn.1000-2200.2020.05.023
侯方燕 | 王海蓉 | 田勇 | 刘浩 | 赵军军 | 李见春
{"title":"3-溴丙酮酸脂质立方液晶的处方筛选及制备工艺优化","authors":"侯方燕 | 王海蓉 | 田勇 | 刘浩 | 赵军军 | 李见春","doi":"10.13898/j.cnki.issn.1000-2200.2020.05.023","DOIUrl":"https://doi.org/10.13898/j.cnki.issn.1000-2200.2020.05.023","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142059511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
叶酸修饰的3-溴丙酮酸脂质立方液晶给药体系的构建与评价 叶酸修饰的3-溴丙酮酸脂质立方液晶给药体系的构建与评价
蚌埠医学院学报 Pub Date : 2020-01-01 DOI: 10.26925/d.cnki.gbbyc.2020.000255
侯方燕
{"title":"叶酸修饰的3-溴丙酮酸脂质立方液晶给药体系的构建与评价","authors":"侯方燕","doi":"10.26925/d.cnki.gbbyc.2020.000255","DOIUrl":"https://doi.org/10.26925/d.cnki.gbbyc.2020.000255","url":null,"abstract":"","PeriodicalId":15256,"journal":{"name":"蚌埠医学院学报","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142061349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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