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The mechanism by which cyclopiazonic acid potentiates accumulation of tetraphenylphosphonium in cultured renal epithelial cells. 环吡唑酸促进四苯基磷在培养肾上皮细胞积累的机制。
Journal of biochemical toxicology Pub Date : 1986-12-01 DOI: 10.1002/jbt.2570010403
R T Riley, J L Showker, R J Cole, J Dorner
{"title":"The mechanism by which cyclopiazonic acid potentiates accumulation of tetraphenylphosphonium in cultured renal epithelial cells.","authors":"R T Riley,&nbsp;J L Showker,&nbsp;R J Cole,&nbsp;J Dorner","doi":"10.1002/jbt.2570010403","DOIUrl":"https://doi.org/10.1002/jbt.2570010403","url":null,"abstract":"<p><p>Cyclopiazonic acid (CPA), a fungal metabolite produced by Aspergillus and Penicillium, potentiated the accumulation of the quaternary cation tetraphenylphosphonium (TPP+) in cultured pig renal epithelial cells. This is the first report of a natural product mediating the tight and apparently nonsaturable binding of a membrane potential probe to subcellular compartments. The potentiated TPP+ accumulation was dose dependent, nonsaturable, and not a result of hyperpolarization across the plasma membrane. Cyclopiazonic acid-potentiated accumulation was completely inhibited by the protonophore carbonylcyanide-m-chlorophenylhydrazone (CCCP). Dinitrophenol (DNP), tetrahexylammonium (THA), and n-ethylmaleimide (NEM) were also effective inhibitors of CPA-potentiated TPP+ accumulation. Although CPA-potentiated TPP+ uptake appeared to be energy dependent, TPP+ efflux (in the presence of CCCP) from CPA-treated cells was incomplete and most of the TPP+ accumulated in the presence of CPA was tightly bound. Dicyclohexylcarbodiimide (DCC), verapamil, and monensin also stimulated TPP+ accumulation, but the TPP+ which accumulated in the presence of these compounds was not tightly bound. As with controls, fractionation of cells which had accumulated TPP+ in the presence of DCC, verapamil, or monensin always resulted in near complete recovery (greater than 93%) of the TPP+ in the cytosolic fraction, whereas with CPA, greater than 88% of the TPP+ was recovered noncovalently bound in the plasma membrane and mitochondrial fractions. These results are consistent with the hypothesis that CPA-potentiated TPP+ accumulation is a result of potentiated partitioning of TPP+ into the plasma membranes and mitochondria of LLC-PK1 cells.</p>","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"1 4","pages":"13-29"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jbt.2570010403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14398496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces high-affinity binding of epidermal growth factor to cell surface receptors in C3H 10T1/2 cells. 2,3,7,8-四氯二苯并-对二恶英降低C3H 10T1/2细胞表皮生长因子与细胞表面受体的高亲和力结合。
Journal of biochemical toxicology Pub Date : 1986-12-01 DOI: 10.1002/jbt.2570010405
M Moriya, F Matsumura, G H Kalimi
{"title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces high-affinity binding of epidermal growth factor to cell surface receptors in C3H 10T1/2 cells.","authors":"M Moriya,&nbsp;F Matsumura,&nbsp;G H Kalimi","doi":"10.1002/jbt.2570010405","DOIUrl":"https://doi.org/10.1002/jbt.2570010405","url":null,"abstract":"<p><p>The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF)-binding characteristics was studied in a cultured embryonic fibroblast cell line, C3H 10T1/2. At very low concentrations, TCDD was found to cause a persistent decline in EFG binding, the median effective concentration (EC-50) being 10(-12) M. This particular effect was most conspicuous when TCDD was added at the time of medium change with fresh Dulbecco's modified Eagle's medium. Cells at an early stage of confluency were more responsive to TCDD than those at a later stage. Although most reported TCDD-evoked biological changes are recognized to occur slowly during the course of a few days to weeks, the response of C3H 10T1/2 cells to TCDD was swift, showing a sign of decline of EGF binding as early as three hours after TCDD addition. C3H 10T1/2 cells appear to be an excellent in vitro model to study TCDD's biochemical action mechanisms.</p>","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"1 4","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jbt.2570010405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14398498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Tricyclohexyltin hydroxide effects on cationic and substrate activation kinetics of beta-adrenergic-stimulated cardiac Ca2+-ATPase. 三环己基锡氢氧化锡对β -肾上腺素能刺激的心脏Ca2+- atp酶的阳离子和底物活化动力学的影响。
Journal of biochemical toxicology Pub Date : 1986-12-01 DOI: 10.1002/jbt.2570010406
K I Sahib, D Desaiah
{"title":"Tricyclohexyltin hydroxide effects on cationic and substrate activation kinetics of beta-adrenergic-stimulated cardiac Ca2+-ATPase.","authors":"K I Sahib,&nbsp;D Desaiah","doi":"10.1002/jbt.2570010406","DOIUrl":"https://doi.org/10.1002/jbt.2570010406","url":null,"abstract":"<p><p>Previous studies from this laboratory have indicated that tricyclohexyltin hydroxide (Plictran) is a potent inhibitor of both basal- and isoproterenol-stimulated cardiac sarcoplasmic reticulum (SR) Ca2+-ATPase, with an estimated IC-50 of 2.5 X 10(-8) M. The present studies were initiated to evaluate the mechanism of inhibition of Ca2+-ATPase by Plictran. Data on substrate and cationic activation kinetics of Ca2+-ATPase indicated alteration of Vmax and Km by Plictran (1 and 5 X 10(-8) M), suggesting a mixed type of inhibition. The beta-adrenergic agonist isoproterenol increased Vmax of both ATP- and Ca2+-dependent enzyme activities. However, the Km of enzyme was decreased only for Ca2+. Plictran inhibited isoproterenol-stimulated Ca2+-ATPase activity by altering both Vmax and Km of ATP as well as Ca2+-dependent enzyme activities, suggesting that after binding to a single independent site, Plictran inhibits enzyme catalysis by decreasing the affinity of enzyme for ATP as well as for Ca2+. Preincubation of enzyme with 15 microM cAMP or the addition of 2mM ATP to the reaction mixture resulted in slight activation of Plictran-inhibited enzyme. Pretreatment of SR with 5 X 10(-7) M propranolol and 5 X 10(-8) M Plictran resulted in inhibition of basal activity in addition to the loss of stimulated activity. Preincubation of heart SR preparation with 5 X 10(-5) M coenzyme A in combination with 5 X 10(-8) M Plictran partly restored the beta-adrenergic stimulation. These results suggest that some critical sites common to both basal- and beta-adrenergic-stimulated Ca2+-ATPase are sensitive to binding by Plictran, and the resultant conformational change may lead to inhibition of beta-adrenergic stimulation.</p>","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"1 4","pages":"55-66"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jbt.2570010406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13992889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Mechanisms of petroleum hydrocarbon toxicity: destruction of liver microsomal and mitochondrial calcium pump activities by a Prudhoe Bay crude oil. 石油碳氢化合物毒性机制:普拉德霍湾原油对肝微粒体和线粒体钙泵活性的破坏。
Journal of biochemical toxicology Pub Date : 1986-12-01 DOI: 10.1002/jbt.2570010404
S Khan, J F Payne, A D Rahimtula
{"title":"Mechanisms of petroleum hydrocarbon toxicity: destruction of liver microsomal and mitochondrial calcium pump activities by a Prudhoe Bay crude oil.","authors":"S Khan,&nbsp;J F Payne,&nbsp;A D Rahimtula","doi":"10.1002/jbt.2570010404","DOIUrl":"https://doi.org/10.1002/jbt.2570010404","url":null,"abstract":"<p><p>Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in an abrupt drop in liver mitochondrial and microsomal ATP-dependent calcium uptake activity. Also, in vitro incubations of either mitochondria or microsomes in the presence of a dimethyl sulfoxide (DMSO) extract of PBCO resulted in a dose-dependent inhibition of calcium influx. The release of calcium from calcium-loaded mitochondria and microsomes was also observed in the presence of the PBCO extract. At concentrations which effect calcium sequestration, the PBCO extract produced swelling of mitochondria. Microsomal ATPase activity in the presence or absence of calcium was unaffected by PBCO. The results indicate that increased permeability of the membranes to calcium is a contributory factor in the inhibition of calcium uptake by PBCO.</p>","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"1 4","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jbt.2570010404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14398497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A convenient preparative method of 3-hydroxy acids, and the reaction of 3-hydroxy acids with acidic materials 一种简便的3-羟基酸的制备方法，以及3-羟基酸与酸性物质的反应
Journal of biochemical toxicology Pub Date : 1978-02-21 DOI: 10.1002/JBT.2570270504
T. Fujita, K. Suga, S. Watanabe, Ryuichi Yanagi
{"title":"A convenient preparative method of 3-hydroxy acids, and the reaction of 3-hydroxy acids with acidic materials","authors":"T. Fujita, K. Suga, S. Watanabe, Ryuichi Yanagi","doi":"10.1002/JBT.2570270504","DOIUrl":"https://doi.org/10.1002/JBT.2570270504","url":null,"abstract":"3-Hydroxy acids were synthesised in good yield from ketones and carboxylic acids using lithium naphthalenide in the presence of diethylamine. From cyclohexanone and propionic acid, 2-(1′-hydroxycyclohexan-1′-yl) propionic acid (I) was obtained in 98.3% yield. 3-Hydroxy acids were treated with various acidic materials to give 3,4-unsaturated carboxylic acids and γ-butyrolactones. From the reaction of (I) with p-toluenesulphonic acid or potassium bisulphate, 2-(cyclohexen-1′-yl) propionic acid (II) (a 3,4-unsaturated acid) was obtained (yield 98%), and with 97% sulphuric acid 2-(1′-hydroxycyclohexan-1′-yl) propionic acid lactone (III) was formed (93% yield). Several new γ-butyrolactones were obtained in good yield by this method.","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"36 1","pages":"593-598"},"PeriodicalIF":0.0,"publicationDate":"1978-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90417349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Alkylaminoanthraquinones as dyes for polypropylene fibres 烷基胺蒽醌作为聚丙烯纤维染料
Journal of biochemical toxicology Pub Date : 1978-01-24 DOI: 10.1002/JBT.2570270153
W. Lord, A. T. Peters
{"title":"Alkylaminoanthraquinones as dyes for polypropylene fibres","authors":"W. Lord, A. T. Peters","doi":"10.1002/JBT.2570270153","DOIUrl":"https://doi.org/10.1002/JBT.2570270153","url":null,"abstract":"The synthesis of a series of 1-alkylaminoanthraquinones is described. In general, dyeing properties and light fastness of these compounds on unmodified polypropylene fibres improves with increase in length of the alkyl chain. The presence of the n-octadecylamino group is particularly advantageous and a range of new dyes containing this substituent is described.","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"16 1","pages":"362-368"},"PeriodicalIF":0.0,"publicationDate":"1978-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74383232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Convenient synthesis of perhydroindene derivatives from 2,7-dimethyl-1,3,7-octatriene 2,7-二甲基-1,3,7-辛三烯过氢茚衍生物的便捷合成
Journal of biochemical toxicology Pub Date : 1977-11-29 DOI: 10.1002/JBT.2570270209
S. Watanabe, K. Suga, H. Tsuruta, Toshiya Sato
{"title":"Convenient synthesis of perhydroindene derivatives from 2,7-dimethyl-1,3,7-octatriene","authors":"S. Watanabe, K. Suga, H. Tsuruta, Toshiya Sato","doi":"10.1002/JBT.2570270209","DOIUrl":"https://doi.org/10.1002/JBT.2570270209","url":null,"abstract":"Several perhydroindene derivatives were prepared from 2,7-dimethyl-1,3,7-octatriene (I) via Diels Alder reaction followed by cyclisation. For example, the Diels Alder reaction between I and methyl vinyl ketone (II) in the presence of Lewis acid afforded 4-acetyl-3-(3-methylbut-3-enyl)-1-methylcyclohexene (IIIa), which, upon treatment with phosphoric acid, was converted to a mixture of 2-acetyl-5,7,7-trimethyl-bicyclo [4,3,0]-non-1-(6)-ene (IV), 2-acetyl-5,7,7-trimethylbicyclo[4,3,0]-non-1-ene (VI) and 2-isopropyl-3,6-dimethylindene (V).","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"26 1","pages":"423-427"},"PeriodicalIF":0.0,"publicationDate":"1977-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85037035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lightfastness, phototendering and fluorescence of 3-methoxybenzanthrone 3-甲氧基苯并蒽醌的耐光性、透光性和荧光性
Journal of biochemical toxicology Pub Date : 1977-10-18 DOI: 10.1002/JBT.2570270140
N. Allen, J. McKellar, S. Protopapas
{"title":"Lightfastness, phototendering and fluorescence of 3-methoxybenzanthrone","authors":"N. Allen, J. McKellar, S. Protopapas","doi":"10.1002/JBT.2570270140","DOIUrl":"https://doi.org/10.1002/JBT.2570270140","url":null,"abstract":"Studies have been made of the fluorescence quantum yields and lifetimes, the photostability and the phototendering behaviour of 3-methoxybenzanthrone in nylon 6,6 and in polyester to determine the nature of the primary process responsible for nylon phototendering. The results indicate that in a polar environment such as nylon 6,6 there is an increased probability of dye-substrate interaction. The results of a study of the fluorescence quenching by amines of varying ionisation potential indicates that the primary process responsible for nylon phototendering may be one of electron abstraction from the substrate.","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"12 1","pages":"269-274"},"PeriodicalIF":0.0,"publicationDate":"1977-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78518841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Catalytic oxidation of methanol over molybdenum oxide–tungsten oxide 甲醇在氧化钼-氧化钨上的催化氧化
Journal of biochemical toxicology Pub Date : 1977-08-02 DOI: 10.1002/JBT.2570270129
R. S. Mann, S. Jain, M. Dosi
{"title":"Catalytic oxidation of methanol over molybdenum oxide–tungsten oxide","authors":"R. S. Mann, S. Jain, M. Dosi","doi":"10.1002/JBT.2570270129","DOIUrl":"https://doi.org/10.1002/JBT.2570270129","url":null,"abstract":"The vapour phase oxidation of methanol to formaldehyde over molybdenum oxide, tungsten oxide and their mixtures has been investigated in an integral flow reactor at atmospheric pressure. The effect of several process variables on the conversion and yield were determined. A high conversion of 95.6% methanol with nearly 95% selectivity was obtained at 430°C. A rate expression has been derived from the kinetics of the reaction.","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"19 1","pages":"198-204"},"PeriodicalIF":0.0,"publicationDate":"1977-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74390719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A convenient preparative method for 1,4-diketones from carboxylic acids 一种由羧酸制备1,4-二酮的简便方法
Journal of biochemical toxicology Pub Date : 1977-07-19 DOI: 10.1002/JBT.2570270117
S. Watanabe, T. Fujita, K. Suga, Haruhiko Abe
{"title":"A convenient preparative method for 1,4-diketones from carboxylic acids","authors":"S. Watanabe, T. Fujita, K. Suga, Haruhiko Abe","doi":"10.1002/JBT.2570270117","DOIUrl":"https://doi.org/10.1002/JBT.2570270117","url":null,"abstract":"Various 1,4-diketones were prepared from carboxylic acids via two steps: Grignard reaction with vinylmagnesium chloride and oxidation with Jones reagent catalysed by mercuric propionate. For example, 2,5-undecanedione was prepared from heptanoic acid via 1-undecen-5-one.","PeriodicalId":15255,"journal":{"name":"Journal of biochemical toxicology","volume":"7 1","pages":"117-120"},"PeriodicalIF":0.0,"publicationDate":"1977-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86607239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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