Journal of Cardiovascular Medicine最新文献

{"title":"Atrial fibrillation ablation versus medical therapy in arrhythmia-induced cardiomyopathy: a propensity score analysis.","authors":"Sofia Capocci, Luca Tomasi, Bruna Bolzan, Anna Piccoli, Elena Franchi, Daniele Battistella, Flavio Luciano Ribichini, Giacomo Mugnai","doi":"10.2459/JCM.0000000000001736","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001736","url":null,"abstract":"<p><strong>Introduction: </strong>Arrhythmia-induced cardiomyopathy (AIC) due to atrial fibrillation is probably related to high ventricular rates and irregular rhythm caused by atrial fibrillation. We sought to investigate the efficacy of pulmonary vein isolation (PVI) using radiofrequency catheter ablation (RFCA) compared to conventional medical therapy in terms of rate of hospitalizations and atrial fibrillation recurrence.</p><p><strong>Methods: </strong>All patients diagnosed with atrial fibrillation associated with heart failure and left ventricular ejection fraction (LVEF) less than 50%, with no other identifiable cause of heart failure aside from the tachyarrhythmia, were included. A 1 : 1 propensity score matching was carried out including age, sex, diabetes, LVEF and BMI in the logistic regression model. The primary endpoint was to assess recurrences of hospitalizations for heart failure; secondary endpoints included hospitalizations for all causes and recurrence of atrial fibrillation during the follow-up.</p><p><strong>Results: </strong>Seventeen patients who had undergone RFCA were matched and compared with 17 patients under conventional medical therapy. Over a median follow-up of 26 months [interquartile range (IQR) 13.4-32], the RFCA group exhibited a significantly lower rate of heart failure-related hospitalization compared with the control group (23.5 versus 58.8%, P = 0.04). The rates of all-cause hospitalizations and atrial fibrillation recurrence were also significantly lower in the RFCA group. The RFCA group also showed a significant increase in LVEF and a significant reduction in left atrial volume compared with medical therapy alone.</p><p><strong>Conclusion: </strong>In patients with AIC due to atrial fibrillation, catheter ablation seems to favor the reverse remodeling and to be effective in reducing atrial recurrence and the rate of all-cause and heart failure-related hospitalizations.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"314-319"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OBITUARY OF ELIGIO PICCOLO (1928-2025).","authors":"","doi":"10.2459/JCM.0000000000001745","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001745","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"257"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical external compression devices to manage bleeding during mechanical circulatory support with Impella CP.","authors":"Andrea Mariani, Domenico Simone Castiello, Mario Iannaccone, Giacomo Giovanni Boccuzzi, Raffaele Piccolo, Giovanni Esposito","doi":"10.2459/JCM.0000000000001727","DOIUrl":"10.2459/JCM.0000000000001727","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been a significant increase in the use of mechanical circulatory support devices, including the Impella device (Abiomed, Danvers, MA, USA), as hemodynamic support during high-risk percutaneous coronary intervention (PCI) and in acute management of cardiogenic shock.</p><p><strong>Results: </strong>In this case series, we present two patients with non-ST-elevation myocardial infarction complicated by cardiogenic shock treated with Impella CP-protected PCI. After the revascularization, for both patients, a clinically relevant, access-site bleeding occurred, challenging the Impella CP maintenance. However, hemostasis was successfully achieved with a mechanical external compression device, allowing Impella hemodynamic support to continue.</p><p><strong>Major findings: </strong>In this case series we propose a novel and easy approach to manage access-site bleeding while using the Impella catheter.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"312-313"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined use of cardiac magnetic resonance and optical coherence tomography to unravel a MINOCA presentation.","authors":"Antonino Imbesi, Maria Sara Mauro, Maria Cristina Inserra, Davide Capodanno","doi":"10.2459/JCM.0000000000001743","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001743","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"322-323"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor XI inhibitors: is it time for a paradigm shift in anticoagulation?","authors":"Paolo Ossola, Claudio Ciampi, Andrea Cesari, Luca Villanova, Niccolò Grieco, Giovanna Viola, Alice Sacco, Leonardo De Luca, Fabrizio Oliva","doi":"10.2459/JCM.0000000000001735","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001735","url":null,"abstract":"<p><p>Factor XI (FXI) is one of the components of the coagulation cascade, connecting its intrinsic and common pathway. FXI inhibitors have emerged in these few years as interesting therapeutic drugs, with potential advantages over standard anticoagulants in terms of lowering thrombotic risk and limiting bleeding consequences. Better knowledge of the underlying processes of thrombosis led to the design of several clinical trials based on the inhibition of this factor. The discovery of molecules, antibodies, and antisense oligonucleotides capable of binding to this factor is paving the way for new anticoagulation strategies, which will be analyzed in this review.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"303-311"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of scores for all-cause mortality in patients with cardiogenic shock.","authors":"Domenico Simone Castiello, Alberto Polimeni, Antonio Curcio","doi":"10.2459/JCM.0000000000001728","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001728","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"280-283"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary approach and combination pharmacotherapy for the management of cardiometabolic patients.","authors":"Giuseppe M C Rosano, Cristiana Vitale, Ilaria Spoletini, Kamlesh Khunti, Kostantinos Tsioufis, Sarah Onida, Marisa Papaluca, Alberto Zambon","doi":"10.2459/JCM.0000000000001734","DOIUrl":"10.2459/JCM.0000000000001734","url":null,"abstract":"<p><p>Cardiometabolic disorders such as hypertension, coronary artery disease, dyslipidaemia, heart failure, and diabetes often cluster together, resulting in patients affected by multiple, related disorders. Therefore, there is a clear need for a multidisciplinary approach when managing these complex patients. Also, therapeutic measures targeting cardiometabolic disorders are expected to influence their common pathogenic mechanisms, such as inflammation and oxidative stress. These were key highlights from a recent forum on cardiometabolic health including various experts across cardiology, endocrinology, and primary care. This consensus document highlights the importance of a combined treatment approach rather than siloed specialties.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"297-302"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single vs. dual antithrombotic therapy in patients with oral anticoagulation and stabilized coronary artery disease: a systematic review and meta-analysis of randomized-controlled trials.","authors":"Giuseppe Gargiulo, Raffaele Piccolo, Duk-Woo Park, Gi-Byoung Nam, Yasuo Okumura, Giovanni Esposito, Marco Valgimigli","doi":"10.2459/JCM.0000000000001723","DOIUrl":"10.2459/JCM.0000000000001723","url":null,"abstract":"<p><strong>Aims: </strong>Despite consistent recommendations from clinical guidelines, data from randomized trials on a long-term antithrombotic treatment strategy for patients with oral anticoagulation (OAC) and stabilized coronary artery disease (CAD) are still limited and underpowered for ischaemic events. Therefore, we investigated the safety and efficacy of single vs. dual antithrombotic therapy (SAT vs. DAT) in patients with OAC and stabilized CAD.</p><p><strong>Methods: </strong>A systematic review and meta-analysis was performed using PubMed to search for randomized clinical trials comparing SAT vs. DAT in patients with OAC and stabilized CAD.</p><p><strong>Results: </strong>Five trials encompassing 5758 patients (SAT = 2897 vs. DAT = 2861) were included. The predominant indication of OAC was atrial fibrillation (n = 5495, 95.4%). Most of the patients had prior percutaneous coronary intervention (PCI) (81.1%). The primary safety outcome (trial-defined major bleeding) was lower with SAT compared with DAT [hazard ratio 0.58, 95% confidence interval (95% CI) 0.40-0.83; P < 0.001; I2 = 65.9%] as was the composite of major bleeding or clinically relevant nonmajor (CRNM) bleeding (hazard ratio 0.62, 95% CI 0.400.96; P = 0.03; I2 = 54.6%). There were no differences between the groups in terms of all-cause death, myocardial infarction, stroke, and the trial-defined composite of major adverse cardiovascular events. These findings were consistent among sensitivity analyses.</p><p><strong>Conclusion: </strong>In OAC patients with stabilized CAD, largely due to atrial fibrillation and prior (6-12 months) PCI, SAT is associated with lower major bleeding without increased risk of ischaemic complications compared with DAT.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"258-265"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral anticoagulation alone in atrial fibrillation and stable coronary artery disease: evidence silences doubt.","authors":"Felice Gragnano, Vincenzo De Sio, Dominick J Angiolillo, Paolo Calabrò","doi":"10.2459/JCM.0000000000001732","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001732","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":"26 6","pages":"266-268"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging antiplatelet therapies in patients undergoing surgery: a meta-analysis.","authors":"Riccardo Scalamera, Stefano Benenati, Rocco Vergallo, Italo Porto","doi":"10.2459/JCM.0000000000001739","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001739","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}