Journal of Cardiovascular Medicine最新文献

筛选
英文 中文
Serum uric acid level and risk of cardiovascular mortality and chronic kidney disease. 血清尿酸水平与心血管死亡和慢性肾病的风险。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.2459/JCM.0000000000001666
Martina Cacciapuoti, Lucia Federica Stefanelli, Federico Nalesso, Lorenzo A Calò
{"title":"Serum uric acid level and risk of cardiovascular mortality and chronic kidney disease.","authors":"Martina Cacciapuoti, Lucia Federica Stefanelli, Federico Nalesso, Lorenzo A Calò","doi":"10.2459/JCM.0000000000001666","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001666","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in cardiology: a peek at the future and the role of ChatGPT in cardiology practice. 心脏病学中的人工智能:窥视未来以及 ChatGPT 在心脏病学实践中的作用。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI: 10.2459/JCM.0000000000001664
Cristina Madaudo, Antonio Luca Maria Parlati, Daniela Di Lisi, Raffaele Carluccio, Vincenzo Sucato, Giuseppe Vadalà, Ermanno Nardi, Francesca Macaione, Antonio Cannata, Nilla Manzullo, Ciro Santoro, Adelaide Iervolino, Federica D'Angelo, Federica Marzano, Christian Basile, Paola Gargiulo, Egle Corrado, Stefania Paolillo, Giuseppina Novo, Alfredo Ruggero Galassi, Pasquale Perrone Filardi
{"title":"Artificial intelligence in cardiology: a peek at the future and the role of ChatGPT in cardiology practice.","authors":"Cristina Madaudo, Antonio Luca Maria Parlati, Daniela Di Lisi, Raffaele Carluccio, Vincenzo Sucato, Giuseppe Vadalà, Ermanno Nardi, Francesca Macaione, Antonio Cannata, Nilla Manzullo, Ciro Santoro, Adelaide Iervolino, Federica D'Angelo, Federica Marzano, Christian Basile, Paola Gargiulo, Egle Corrado, Stefania Paolillo, Giuseppina Novo, Alfredo Ruggero Galassi, Pasquale Perrone Filardi","doi":"10.2459/JCM.0000000000001664","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001664","url":null,"abstract":"<p><p>Artificial intelligence has increasingly become an integral part of our daily activities. ChatGPT, a natural language processing technology developed by OpenAI, is widely used in various industries, including healthcare. The application of ChatGPT in healthcare is still evolving, with studies exploring its potential in clinical decision-making, patient education, workflow optimization, and scientific literature. ChatGPT could be exploited in the medical field to improve patient education and information, thus increasing compliance. ChatGPT could facilitate information exchange on major cardiovascular diseases, provide clinical decision support, and improve patient communication and education. It could assist the clinician in differential diagnosis, suggest appropriate imaging modalities, and optimize treatment plans based on evidence-based guidelines. However, it is unclear whether it will be possible to use ChatGPT for the management of patients who require rapid decisions. Indeed, many drawbacks are associated with the daily use of these technologies in the medical field, such as insufficient expertise in specialized fields and a lack of comprehension of the context in which it works. The pros and cons of its use have been explored in this review, which was not written with the help of ChatGPT.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-hospital evolution of secondary mitral regurgitation in acutely decompensated heart failure. 急性失代偿性心力衰竭继发性二尖瓣反流的院内演变。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-13 DOI: 10.2459/JCM.0000000000001667
Daniele Cocianni, Maria Perotto, Davide Barbisan, Stefano Contessi, Jacopo Giulio Rizzi, Giulio Savonitto, Eugenio Zocca, Enrico Brollo, Elisa Soranzo, Antonio De Luca, Enrico Fabris, Marco Merlo, Gianfranco Sinagra, Davide Stolfo
{"title":"In-hospital evolution of secondary mitral regurgitation in acutely decompensated heart failure.","authors":"Daniele Cocianni, Maria Perotto, Davide Barbisan, Stefano Contessi, Jacopo Giulio Rizzi, Giulio Savonitto, Eugenio Zocca, Enrico Brollo, Elisa Soranzo, Antonio De Luca, Enrico Fabris, Marco Merlo, Gianfranco Sinagra, Davide Stolfo","doi":"10.2459/JCM.0000000000001667","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001667","url":null,"abstract":"<p><strong>Aims: </strong>Secondary mitral regurgitation (MR) negatively affects prognosis in acutely decompensated heart failure (ADHF), but can be rapidly sensitive to changes in volume status and medical interventions. We sought to assess the evolution of secondary MR in patients hospitalized for ADHF and its prognostic implications.</p><p><strong>Methods: </strong>We retrospectively enrolled 782 patients admitted for ADHF with at least two in-hospital echocardiographic evaluations of MR. We classified MR severity as none-mild or moderate-severe. Based on MR evolution, patients were divided into 'persistent moderate-severe MR', 'improved MR' (from moderate-severe to none-mild) and 'persistent none-mild MR'.</p><p><strong>Results: </strong>Four hundred and forty patients (56%) had moderate-severe MR at first evaluation, of whom 144 (33% of patients with baseline moderate-severe MR) had 'improved MR', while 296 (67%) had 'persistent moderate-severe MR'. Patients with improved MR had better clinical, laboratory and echocardiographic parameters of decongestion at discharge compared with those with persistent moderate-severe MR and showed a higher up-titration of recommended therapies. Left ventricular volume, ejection fraction and serum urea were the predictors of improved MR at multivariable analysis. After adjustment, no differences in 5-years survival (primary outcome) were observed according to baseline MR severity. When patients were stratified according to the in-hospital changes in MR severity, improved MR was associated with lower risk of 5-years mortality, compared with both persistent none-mild MR [hazard ratio (HR) = 0.505, P = 0.032] and persistent moderate-severe MR (HR = 0.556, P = 0.040).</p><p><strong>Conclusions: </strong>The severity of MR frequently improved during hospitalization for ADHF; the extent and the changes in MR severity during the in-hospital stay identified distinct patient phenotypes, and seemed to portend different long-term outcomes, with higher 5-years survival associated with improvement in MR.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image-based ECG analyzing deep-learning algorithm to predict biological age and mortality risks: interethnic validation. 基于图像的心电图分析深度学习算法预测生物年龄和死亡风险:种族间验证。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.2459/JCM.0000000000001670
Youngjin Cho, Ji Soo Kim, Joonghee Kim, Yeonyee E Yoon, Se Young Jung
{"title":"Image-based ECG analyzing deep-learning algorithm to predict biological age and mortality risks: interethnic validation.","authors":"Youngjin Cho, Ji Soo Kim, Joonghee Kim, Yeonyee E Yoon, Se Young Jung","doi":"10.2459/JCM.0000000000001670","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001670","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular risk assessment is a critical component of healthcare, guiding preventive and therapeutic strategies. In this study, we developed and evaluated an image-based electrocardiogram (ECG) analyzing an artificial intelligence (AI) model that estimates biological age and mortality risk.</p><p><strong>Methods: </strong>Using a dataset of 978 319 ECGs from 250 145 patients at Seoul National University Bundang Hospital, we developed a deep-learning model utilizing printed 12-lead ECG images to estimate patients' age (ECG-Age) and 1- and 5-year mortality risks. The model was validated externally using the CODE-15% dataset from Brazil.</p><p><strong>Results: </strong>The ECG-Age showed a high correlation with chronological age in both the internal and external validation datasets (Pearson's R = 0.888 and 0.852, respectively). In the internal validation, the direct mortality risk prediction models showed area under the curves (AUCs) of 0.843 and 0.867 for 5- and 1-year all-cause mortality, respectively. For 5- and 1-year cardiovascular mortality, the AUCs were 0.920 and 0.916, respectively. In the CODE-15%, the mortality risk predictions showed AUCs of 0.818 and 0.836 for the prediction of 5- and 1-year all-cause mortality, respectively. Compared to the neutral Delta-Age (ECG-Age - chronological age) group, hazard ratios for deaths were 1.88 [95% confidence interval (CI): 1.14-3.92], 2.12 (95% CI: 1.15-3.92), 4.46 (95% CI: 2.22-8.96) and 7.68 (95% CI: 3.32-17.76) for positive Delta-Age groups (5-10, 10-15, 15-20, >20), respectively.</p><p><strong>Conclusion: </strong>An image-based AI-ECG model is a feasible tool for estimating biological age and assessing all-cause and cardiovascular mortality risks, providing a practical approach for utilizing standardized ECG images in predicting long-term health outcomes.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Could ChatGPT become a future cardiologist? Navigating requirements and risks. ChatGPT 能否成为未来的心脏病专家?把握要求和风险。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.2459/JCM.0000000000001663
Youngjin Cho, Joonghee Kim
{"title":"Could ChatGPT become a future cardiologist? Navigating requirements and risks.","authors":"Youngjin Cho, Joonghee Kim","doi":"10.2459/JCM.0000000000001663","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001663","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variants in patients with recurrent pericarditis. 复发性心包炎患者的基因变异。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI: 10.2459/JCM.0000000000001669
Massimo Imazio, Flavio Faletra, Jessica Zucco, Catia Mio, Matteo Carraro, Alberto Maria Gava, Marzia De Biasio, Giuseppe Damante, Valentino Collini
{"title":"Genetic variants in patients with recurrent pericarditis.","authors":"Massimo Imazio, Flavio Faletra, Jessica Zucco, Catia Mio, Matteo Carraro, Alberto Maria Gava, Marzia De Biasio, Giuseppe Damante, Valentino Collini","doi":"10.2459/JCM.0000000000001669","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001669","url":null,"abstract":"<p><strong>Aims: </strong>Presence of family cases and multiple recurrences of pericarditis suggest the existence of a possible genetic background in at least 10% of cases. The aim of the present study is to describe the genetic landscape of a cohort of patients with multiple recurrences (at least two recurrences).</p><p><strong>Methods: </strong>Retrospective cohort study of consecutive adult patients referred for at least two episodes of recurrences in a tertiary referral centre. Genetic testing was performed by whole exome sequencing (WES).</p><p><strong>Results: </strong>Our cohort included 108 consecutive patients with recurrent pericarditis [median age 32 years, interquartile range (IQR) 18.5; 67.6% females, all Caucasian, idiopathic aetiology in 71.1%] with a median number of recurrences of 5 (IQR 2). Overall, 16 patients (14.8%) had variants in genes related to the inflammatory response. Eleven variants were located in genes already associated with recurrent pericarditis (NLRP3, TNFRSF1A and MEFV) and five in inflammation/immunodeficiency-related genes (IFIH1, NFKBIA, JAK1, NOD2 and ALPK1). Furthermore, we identified 10 patients with variants located in genes associated with conduction system-related diseases, and 22 variants in 21 patients with genes associated with heart structural-related diseases.</p><p><strong>Conclusion: </strong>In this first observational study using WES to assess genetic variants in patients with multiple recurrences of pericarditis, about 15% of patients bore at least one variant that may be related to the disease. These findings highlight the importance of addressing the role of genetic predisposition in recurrent pericarditis. Moreover, 28.7% of patients carry variants in different cardiac genes, worthy of a deeper investigation.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conduit flow computation is the missing key to understanding the potential effects of left-to-right shunting in heart failure patients. 导流计算是了解心衰患者左向右分流潜在影响的关键所在。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.2459/JCM.0000000000001672
Paolo N Marino, Jacopo Zanaboni, Alice Panizza
{"title":"Conduit flow computation is the missing key to understanding the potential effects of left-to-right shunting in heart failure patients.","authors":"Paolo N Marino, Jacopo Zanaboni, Alice Panizza","doi":"10.2459/JCM.0000000000001672","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001672","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-related differences in demographics, diagnosis and management of patients with chronic coronary syndromes. 慢性冠状动脉综合征患者在人口统计学、诊断和管理方面的性别差异。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-10-29 DOI: 10.2459/JCM.0000000000001675
Marco Mojoli, Pier Luigi Temporelli, Daniela Pavan, Maurizio Giuseppe Abrignani, Lucio Gonzini, Donata Lucci, Federico Piscione, Stefano Provasoli, Michele Massimo Gulizia, Domenico Gabrielli, Furio Colivicchi, Fabrizio Oliva, Leonardo De Luca
{"title":"Sex-related differences in demographics, diagnosis and management of patients with chronic coronary syndromes.","authors":"Marco Mojoli, Pier Luigi Temporelli, Daniela Pavan, Maurizio Giuseppe Abrignani, Lucio Gonzini, Donata Lucci, Federico Piscione, Stefano Provasoli, Michele Massimo Gulizia, Domenico Gabrielli, Furio Colivicchi, Fabrizio Oliva, Leonardo De Luca","doi":"10.2459/JCM.0000000000001675","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001675","url":null,"abstract":"<p><strong>Aims: </strong>The impact of sex-related factors on current clinical management and outcomes of chronic coronary syndromes (CCS) are unclear.</p><p><strong>Methods: </strong>All patients belonging to the prospective, nationwide START registry were included. Their baseline characteristics, diagnostic workup, revascularization strategy, pharmacological treatment and 1-year clinical outcomes were compared with respect to sex overall and in age tertiles.</p><p><strong>Results: </strong>A total of 5070 consecutive patients were included. Most patients were males (80.1%). As expected, the prevalence of females increased with age. Distribution of risk factors and history of cardiovascular disease were different depending on sex, as well as diagnostic workup, with lower use of exercise stress testing in women (25.1% vs. 36.7%, P < 0.0001). The use of coronary angiography was similar in the two groups. Women had lower rates of multivessel coronary artery disease (CAD) (33.0% vs. 40.6% P < 0.0001) and higher rates of nonobstructive CAD (18.3% vs. 11.3%, P < 0.0001). Rates of myocardial revascularization were similar, but women were more likely to receive percutaneous coronary intervention than men (84.3% vs. 77.8%, P < 0.0001) and less likely to receive surgical/hybrid revascularization (10.0% vs. 15.1%, P < 0.0001). At 12-month follow-up, no differences were observed for the combined endpoint of all-cause mortality, re-hospitalization for myocardial infarction, heart failure, stroke or myocardial revascularization between males and females; however, a significantly worse perceived quality of life was observed in women.</p><p><strong>Conclusions: </strong>In a large nationwide cohort of patients with CCS, clinical outcomes were not different depending on sex. However, several differences in the diagnostic work-up, treatment strategies and quality of life were found between sexes.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pericardial constrictive syndromes: a neglected cause of reversible heart failure. 心包收缩综合征:被忽视的可逆性心力衰竭病因。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-10-25 DOI: 10.2459/JCM.0000000000001679
Massimo Imazio
{"title":"Pericardial constrictive syndromes: a neglected cause of reversible heart failure.","authors":"Massimo Imazio","doi":"10.2459/JCM.0000000000001679","DOIUrl":"https://doi.org/10.2459/JCM.0000000000001679","url":null,"abstract":"","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic impact of peripheral artery disease-related parameters in patients with acute coronary syndrome. 急性冠状动脉综合征患者外周动脉疾病相关参数的预后影响。
IF 2.9 3区 医学
Journal of Cardiovascular Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-01 DOI: 10.2459/JCM.0000000000001653
Gabriele Masini, Luna Gargani, Carmela Morizzo, Giacinta Guarini, Ida Rebecca Bort, Matteo Baldini, Pietro Paolo Tamborrino, Carlo Vitale, Carlo Palombo, Raffaele De Caterina
{"title":"Prognostic impact of peripheral artery disease-related parameters in patients with acute coronary syndrome.","authors":"Gabriele Masini, Luna Gargani, Carmela Morizzo, Giacinta Guarini, Ida Rebecca Bort, Matteo Baldini, Pietro Paolo Tamborrino, Carlo Vitale, Carlo Palombo, Raffaele De Caterina","doi":"10.2459/JCM.0000000000001653","DOIUrl":"10.2459/JCM.0000000000001653","url":null,"abstract":"<p><strong>Background: </strong>Lower extremity arterial disease (LEAD) and increased aortic stiffness are associated with higher mortality in patients with chronic coronary syndrome, while their prognostic significance after an acute coronary syndrome (ACS) is less known.</p><p><strong>Methods: </strong>We analyzed prevalence, clinical phenotypes and association of LEAD - assessed by the ankle-brachial index (ABI) - and increased aortic stiffness - assessed by the aortic pulse wave velocity (PWV) - with all-cause mortality and major adverse cardiovascular events (MACE) in patients admitted with an ACS.</p><p><strong>Results: </strong>Among 270 patients admitted for ACS (mean age 67 years, 80% males), 41 (15%) had an ABI ≤0.9, with 14 of them (34%) presenting with intermittent claudication (symptomatic LEAD). Patients with symptomatic LEAD, compared with those with asymptomatic LEAD or without LEAD, had higher prevalence of cardiovascular risk factors, lower estimated glomerular filtration rate and higher high-sensitivity C-reactive protein. Patients with LEAD, either symptomatic or asymptomatic, more frequently presented with non-ST-elevation myocardial infarction and more frequently had multivessel coronary artery disease. Both symptomatic and asymptomatic LEAD were significantly associated with all-cause mortality after adjustment for confounders, including multivessel disease or carotid artery disease (hazard ratio 4.03, 95% confidence interval 1.61-10.08, P  < 0.01), whereas PWV was not associated with the outcome in the univariable model. LEAD and PWV were not associated with a higher risk of MACE (myocardial infarction or unstable angina, stroke, or transient ischemic attack).</p><p><strong>Conclusions: </strong>LEAD, either clinical or subclinical, but not increased aortic stiffness, is an independent predictor of all-cause mortality in patients admitted for ACS.</p>","PeriodicalId":15228,"journal":{"name":"Journal of Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信