Journal of Cancer Research and Therapeutic Oncology最新文献

Construction and Analysis of Adverse Reaction Prediction Model for Patients with Hepatocellular Carcinoma Undergoing Radiotherapy and Chemotherapy Based on Image Detection 基于图像检测的肝癌放化疗不良反应预测模型的构建与分析

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2023-03-01 DOI: 10.13189/cor.2023.080101

G. Sonawane, Santosh Singh, Kajal Pansare, Chandrashekhar Patil, Deepak B. Somavanshi

引用次数: 0

To Assess the Efficacy Outcomes of Patients Undergoing Androgen Deprivation Therapy in a Tertiary Care Hospital: A Retrospective Study 评价三级医院雄激素剥夺治疗患者的疗效结局:一项回顾性研究

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2022-06-01 DOI: 10.13189/cor.2022.080101

E. George, Anjali Ambrose, Shaji George, J. Aaron

引用次数: 0

Ribociclib Improves Clinical Outcomes in Breast Cancer Brain Metastases: A Case Report Ribociclib改善乳腺癌脑转移的临床结果:1例报告

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2022-01-01 DOI: 10.17303/jcrto.2022.10.102

S. Guarino

引用次数: 0

Translationally Controlled Tumor Protein: A Key Target to Abrogate DNA Repair and Therapeutic Resistance in Cancer 翻译控制肿瘤蛋白:消除肿瘤DNA修复和治疗耐药的关键靶点

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2022-01-01 DOI: 10.17303/jcrto.2022.10.101

K. Omabe

引用次数: 0

Osseous Metastases of Renal Epithelioid Angiomyolipoma with Dramatic Response Through mTOR Inhibitor Therapy 通过mTOR抑制剂治疗肾上皮样血管平滑肌脂肪瘤骨转移的显著反应

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-11-01 DOI: 10.17303/jcrto.2021.9.205

SL Barton

引用次数: 0

Serum X Linked Inhibitor of Apoptosis Protein (XIAP) as a Biomarker for Predicting Recurrence of Low Grade Renal Cell Carcinoma 血清X连锁凋亡抑制蛋白(XIAP)作为预测低级别肾细胞癌复发的生物标志物

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-10-01 DOI: 10.17303/jcrto.2021.9.204

F. Hongo

引用次数: 0

The Influence of Pre PARP-Inhibitor Platinum Chemotherapy in BRCA Mutated Ovarian Cancer, A Monocentric Experience parp抑制剂铂前化疗对BRCA突变卵巢癌的影响，一项单中心研究

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-07-01 DOI: 10.17303/jcrto.2021.9.202

Andrea Grego

引用次数: 0

Emphasis on Organoids in Cancer Research 类器官在癌症研究中的重点

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-07-01 DOI: 10.13189/cor.2021.070201

Kartiki Bhandari, Rupali R. Patil, P. Pingale, S. Amrutkar

{"title":"Emphasis on Organoids in Cancer Research","authors":"Kartiki Bhandari, Rupali R. Patil, P. Pingale, S. Amrutkar","doi":"10.13189/cor.2021.070201","DOIUrl":"https://doi.org/10.13189/cor.2021.070201","url":null,"abstract":"Cancer has been one of the deadliest diseases for several decades and there is no precise and standard treatment option available up to date. Statistical data indicate that cancer has been one of the principal reasons for mortality worldwide. Although most of the novel techniques assist in the acceleration of cancer research, the available anticancer therapy does not exhibit expected success rates. This is due to a lack of understanding about the root cause of the disease, which can be accomplished by studying different types of tumors and the effects of various anti-cancer agents on the tumors. These studies require various in vitro study models which can mimic real, in vivo cancers. Conventional experimental models such as animal models, two-dimensional (2D) cell lines, patient-derived xenografts (PDX) are key models in cancer study but they have some shortcomings that are overcome by three-dimensional (3D), in-vitro tumor organoids derived from embryonic, induced pluripotent, or adult stem cells (ESCs, iPSCs, ASCs respectively). These organoid models closely recapitulate the original tumor present in vivo and thereby benefit in studying the development of cancer, efficacy, and safety of various anti-cancer agents, drug development, personalized therapy, low and high throughput screening. As a result, 3D organoids are becoming more successful experimental models over conventional 2D models. Therefore, this review emphasizes the effectiveness of organoid models in cancer study, their method of preparation, advantages and applications, drawbacks with solutions to address, followed by a brief outline on 4D organoids (assembloids), and future perspectives.","PeriodicalId":15189,"journal":{"name":"Journal of Cancer Research and Therapeutic Oncology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84725305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Presentation of a Large Embryonal Rhabdomyosarcoma at Retroperitoneal Region with Intra-thoracic Extension & Misdiagnosed as Lower Respiratory Tract Infection: A Case Report 一例罕见的腹膜后巨大胚胎性横纹肌肉瘤伴胸内扩张，误诊为下呼吸道感染1例

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-03-01 DOI: 10.13189/COR.2021.070101

S. Kadam, Pradeep Tripathi, Tejaswini Kadam

{"title":"A Rare Presentation of a Large Embryonal Rhabdomyosarcoma at Retroperitoneal Region with Intra-thoracic Extension & Misdiagnosed as Lower Respiratory Tract Infection: A Case Report","authors":"S. Kadam, Pradeep Tripathi, Tejaswini Kadam","doi":"10.13189/COR.2021.070101","DOIUrl":"https://doi.org/10.13189/COR.2021.070101","url":null,"abstract":"Introduction : We are reporting a case of 18 year old boy who presented with features of lower respiratory tract infections and labelled as suffering from left suprarenal gland tumor. However, after complete evaluation, it is diagnosed as left retroperitoneal tumor extending into left thoracic cavity with involvement of left lower lobe lung. He underwent debulking surgery. Rhabdomyosarcoma (RMS) originates from immature striated muscle and it is considered as the most aggressive malignant mesenchymal tumor. The most common location of RMS is head and neck region. The retroperitoneal presentation of embryonal RMS is extremely rare. The four histological features of RMS, classified by WHO are embryonal, alveolar, pleomorphic and spindle cell or sclerosing. Pleomorphic RMS has worse prognosis. The incidence of embryonal tumors is higher in males with bimodal age distribution, between 2-6 years and second peak between 10-18 years. Their detection is incidental when the size is small and as the size enlarges, symptoms helps in detection. Due to its rarity at retroperitoneal location, there is a lack of literature over the adjuvant treatment. As the size enlarges at retroperitoneal region, enblock resection with clear margins becomes a difficult task and if planned for R0 resection, multiorgan resection escalates surgical morbidity rate. Conclusion : It is a rare location of embryonal rhabdomyosarcoma at retroperitoneal region with rare presentation of intra-thoracic infiltration. R0 resection is the principle goal of surgical excision of retroperitoneal sarcoma.","PeriodicalId":15189,"journal":{"name":"Journal of Cancer Research and Therapeutic Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83444645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 患者骨髓穿刺探讨环氧化酶(cox)在多发性骨髓瘤中的作用

Journal of Cancer Research and Therapeutic Oncology Pub Date : 2021-01-18 DOI: 10.17303/jcrto.2021.9.103

引用次数: 1