Journal of Arrhythmia最新文献

{"title":"Comparative analysis of left bundle branch area pacing in patients with and without a history of open-heart surgery","authors":"Yasumasa Nohno MD,&nbsp;Ryosuke Kozu MD,&nbsp;Kii Ito MD,&nbsp;Yuta Chikazawa MD,&nbsp;Shusaku Maruyama MD,&nbsp;Tomoya Hasegawa MD,&nbsp;Hiromi Tsuchiya MD,&nbsp;Takahiro Tachibana MD,&nbsp;Hikaru Kimura MD,&nbsp;Yoshikazu Yazaki MD, PhD","doi":"10.1002/joa3.70010","DOIUrl":"10.1002/joa3.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Left bundle branch area pacing (LBBAP) is widely performed in routine clinical practice. Achieving LBBAP requires deep insertion of the lead into the interventricular septum. LBBAP may be challenging in patients with a history of open-heart surgery (OHS) because of myocardial fibrosis associated with surgical trauma. This study aimed to report the feasibility and safety of performing LBBAP in patients with a history of OHS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective analysis included patients who underwent successful LBBAP between November 2020 and September 2024, with approval from our institutional review board. LBBAP was performed using a 3830 SelectSecure lead, and pacing parameters were assessed before and after implantation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred patients were analyzed, including 26 in the OHS group and 74 in the non-OHS group. The success rates of LBBAP were 84.6% in the OHS group and 90.5% in the non-OHS group (<i>p =</i> 0.375). Notably, the number of LBBAP lead placements was higher in the OHS group (3.0 ± 2.1 vs. 2.0 ± 1.4, <i>p =</i> 0.017). The left ventricular activation time in lead V6 was comparable between the groups at implantation (73.6 ± 13.3 ms vs. 75.6 ± 12.1 ms, <i>p =</i> 0.522). The QRS duration was significantly wider in the OHS group at implantation (131.3 ± 14.6 vs. 121.1 ± 12.3 ms, <i>p =</i> 0.002), but parameters remained stable at 1 year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LBBAP in patients with a history of OHS may present a slightly higher level of technical difficulty, but it is both feasible and safe.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel mapping techniques for ablation of non-pulmonary vein foci using complex signal identification","authors":"Hiroyuki Kono MD,&nbsp;Kenichi Hiroshima MD,&nbsp;Kengo Korai MD,&nbsp;Kenji Ando MD","doi":"10.1002/joa3.13222","DOIUrl":"10.1002/joa3.13222","url":null,"abstract":"<p>The complex signal identification function of CARTO version 8 enables quantitative evaluation of local potential fractionation. We present a case where this advanced technology successfully identified non-pulmonary vein foci associated with fractionated potentials during sinus rhythm.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of left atrial size and appendage morphology in paroxysmal and persistent atrial fibrillation patients","authors":"J. Pongratz MD,&nbsp;L. Riess MD,&nbsp;S. Hartl MD,&nbsp;B. Brueck MD,&nbsp;C. Tesche MD, MHBA, FESC, FSCCT,&nbsp;D. Olbrich MD,&nbsp;M. Wankerl MD,&nbsp;U. Dorwarth MD,&nbsp;E. Hoffmann MD, FESC,&nbsp;F. Straube MD, FEHRA, FESC, FHRS","doi":"10.1002/joa3.13224","DOIUrl":"10.1002/joa3.13224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Pulmonary vein isolation (PVI) is effective in treating atrial fibrillation (AF), but outcomes are worse for persistent AF (persAF) patients than paroxysmal AF (PAF) patients. The study aimed to identify differences in left atrial (LA) and left atrial appendage (LAA) anatomy in different AF types.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a single-center observational study, a blinded retrospective analysis of preprocedural cardiac computed tomography angiography (CCTA) images was performed. The study evaluated the dimensions of the LA and pulmonary veins (PV), as well as the size and morphology of the LAA using a 3D electroanatomical mapping system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2012 and 2016, a total of 1103 patients underwent second-generation cryoballoon PVI. Of these, 725 patients (65.7%) had CCTA available, and 473 of these (65.2%) had sufficient quality for measurements. The mean age of the patients was 66.3 ± 9.5 years, and PAF was present in 277 (58.6%) participants. The study found that in persAF patients, LA dimensions such as LA volume [mL] (108; 125; <i>p</i> &lt; .001) or PV ostial dimensions were significantly larger than in those with PAF. LAA volume [mL] (8.3; 9.2; <i>p</i> = .005) and LAA ostial area [mm²] (325; 353; <i>p</i> = .01) were enlarged in persAF. There were no significant differences regarding LAA morphology, with the overall distribution being “windsock” (51%), “chicken-wing” (20%), “cauliflower” (15%), and “cactus” (13%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared to PAF, persAF patients had significantly larger LA as well as LAA dimensions. LAA morphological types were distributed equally in both groups suggesting that LAA morphology may not be associated with the underlying AF type.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial to “Novel mapping techniques for ablation of non-pulmonary vein foci using complex signal identification”","authors":"Yoshiaki Mizutani MD, PhD,&nbsp;Satoshi Yanagisawa MD, PhD,&nbsp;Yasuya Inden MD, PhD","doi":"10.1002/joa3.70006","DOIUrl":"10.1002/joa3.70006","url":null,"abstract":"&lt;p&gt;A mechanism of paroxysmal atrial fibrillation (AF) involves trigger activity mainly originating from a pulmonary vein (PV). Catheter ablation of PV isolation, using recent advanced technologies, is a promising approach to prevent AF incidence and related complications. However, some AF triggers originate from non-PV foci, which are associated with AF recurrence despite complete PV isolation.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; Although various approaches and techniques have been introduced for induction and provocation of non-PV foci, identifying the exact location of non-PV foci in the broad area of the left and right atriums is still challenging. Fractionated signal area in the atrial muscle (FAAM) map-guided ablation is a recently developed technique that highlights the fractionated signal area using the LUMIPOINT software in the ultrahigh-density RHYTHMIA mapping system (Boston Scientific, Marlborough, MA). These fractionated signal areas are significantly associated with the location of non-PV foci.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; The FAAM-guided ablation previously demonstrated a lower recurrence rate of atrial tachyarrhythmia compared to the non-FAAM ablation in patients with recurrent AF who underwent catheter ablation targeting non-PV foci.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Unfortunately, this specific FAAM map can only be used in the RHYTHMIA mapping system, underscoring the need for broader utility of this algorithm across all mapping systems in clinical practice.&lt;/p&gt;&lt;p&gt;In this issue of the &lt;i&gt;Journal of arrhythmia&lt;/i&gt;, Kono. et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; reported a successful non-PV foci ablation case for paroxysmal AF using a Complex Signal Identification (CSI) algorithm equipped with CARTO™ 3 system version 8 to automatically identify and tag complex fractionated potentials in atria. After PV isolation and cavotricuspid isthmus ablation, an additional ablation was performed using the CSI algorithm to target non-PV foci triggered by isoproterenol infusion, high-rate burst pacing, and adenosine triphosphate administration. High CSI tag scores were found in the anterior carina of the right superior PV (RSPV), extending to the anterior wall. The earliest activation site in the non-PV-foci corresponded to the highest CSI score of 9.8, with fractionated potentials where effective energization was applied. Additionally, the PV isolation line for the right superior PV was slightly extended to include the high CSI area of ≥7.5. At the end of the ablation, no AF was induced, and the patient maintained sinus rhythm without antiarrhythmic drugs for 6 months.&lt;/p&gt;&lt;p&gt;The CSI algorithm can arbitrarily calculate the abnormal potentials using four parameters: minimum fractionated score, time frame within the window of interest, bipolar amplitude of the complex signal, and minimum duration, implying a strict stratification for the relevant fractionated potentials from broad perspectives. Unfortunately, appropriate CSI setting and cutoff points have not been established,","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel omnipolar mapping technology for effective superior vena cava isolation: A randomized clinical trial","authors":"Naoto Oguri MD,&nbsp;Yousaku Okubo MD, PhD,&nbsp;Naoki Ishibashi MD,&nbsp;Junji Maeda MD,&nbsp;Takumi Sakai MD,&nbsp;Yukimi Uotani MD,&nbsp;Motoki Furutani MD,&nbsp;Shogo Miyamoto MD,&nbsp;Shunsuke Miyauchi MD, PhD,&nbsp;Sho Okamura MD, PhD,&nbsp;Takehito Tokuyama MD, PhD,&nbsp;Noboru Oda MD, PhD,&nbsp;Yukiko Nakano MD, PhD","doi":"10.1002/joa3.70007","DOIUrl":"10.1002/joa3.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Successful isolation of the superior vena cava (SVC) using a functional conduction block between the right atrium (RA) and SVC has been documented. However, a comparison of this approach with the conventional method (CM) of circumferential ablation of the RA-SVC junction, based on angiography, remains unexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In this study, we employed the innovative omnipolar mapping technology (OT) to discern the RA-SVC connection and compared clinical outcomes with those from CM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-two patients undergoing SVC isolation were randomly assigned in a 1:1 ratio to either the OT or CM group. No significant differences in the baseline characteristics were observed between the two groups. We assessed the efficacy and safety of both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both groups showed comparable acute success rates (96%) in SVC isolation, but the procedure in the OT group required fewer radiofrequency (RF) applications (13.6 ± 6.0 vs. 19.8 ± 10.9, <i>p</i> = .046) and shorter procedure time (9.6 ± 6.8 min vs. 14.3 ± 6.8 min, <i>p</i> = .007). The overall absorbed dose was notably lower in the OT group (69.6 ± 47.6 mGy vs. 90.3 ± 30.3 mGy, <i>p</i> = .023).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The OT enhances the efficacy of SVC isolation, requiring fewer RF applications and reducing procedure time compared to conventional treatment methods.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of successful salvage despite right ventricular perforation during AVEIR VR leadless pacemaker implantation","authors":"Masanori Matsuo MD, PhD,&nbsp;Kenji Shimeno MD, PhD,&nbsp;Naoki Matsumoto MD,&nbsp;Yukio Abe MD, PhD,&nbsp;Daiju Fukuda MD, PhD","doi":"10.1002/joa3.70000","DOIUrl":"10.1002/joa3.70000","url":null,"abstract":"<p>To prevent cardiac tamponade caused by catheter tip slippage during the retraction of the protective sleeve in Aveir VR implantation, it is crucial to carefully evaluate not only the bulge of the protective sleeve but also the shape of the system's shaft using fluoroscopic imaging.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of optimal fluoroscopic angulation to facilitate effective pulsed field ablation in a patient with atrial fibrillation","authors":"Shintaro Yamagami MD,&nbsp;Shumpei Mori MD, PhD,&nbsp;Tomohiro Sato MD,&nbsp;Hirokazu Kondo MD, PhD,&nbsp;Toshihiro Tamura MD, PhD","doi":"10.1002/joa3.70005","DOIUrl":"10.1002/joa3.70005","url":null,"abstract":"<p>The circular-shaped PulseSelect™ PFA catheter has demonstrated comparable efficacy to traditional thermal catheter ablation in achieving pulmonary vein isolation (PVI), while preventing thermally mediated complications. However, this catheter does not have any objective parameters to confirm real-time tissue-catheter contact. We report a case in which PVI was achieved through PFA using optimal biplane fluoroscopic angulations which were more useful for accurately assessing and adjusting the position and rotation of the circular catheter electrodes than the conventional fluoroscopic angulations.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial to “Feasibility and efficacy of 50 W ablation with the TactiFlex catheter for the initial pulmonary vein isolation of atrial fibrillation”","authors":"Naoto Otsuka MD, PhD,&nbsp;Yasuo Okumura MD, PhD","doi":"10.1002/joa3.13215","DOIUrl":"10.1002/joa3.13215","url":null,"abstract":"&lt;p&gt;Radiofrequency (RF) ablation has become an established primary treatment for atrial fibrillation (AF), with pulmonary vein isolation (PVI) as the cornerstone of therapy. Multiple RF ablation catheter options and strategies are available, including high-power short-duration ablation using 50 W output. Recently, an innovative contact force (CF) sensing catheter featuring a mesh-shaped irrigation tip (TactiFlex™ SE, Abbott) has been introduced into clinical practice. However, clinical data remain limited, and the safety and efficacy of this catheter in real-world practice have yet to be fully clarified. In this article,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Matsumoto et al. evaluated the clinical safety and efficacy of the TactiFlex catheter for AF treatment. Their study reported that first-pass PVI was achieved in 82% of right pulmonary veins (RPV) and 87% of left pulmonary veins (LPV) in 100 AF patients, including those with paroxysmal AF (PAF) and non-PAF. Ablation parameters included a CF range of 5–20 g, an ablation duration of 15–20 s, and a fixed power of 50 W. The authors adjusted ablation duration based on impedance measurements; for pre-ablation impedance &gt;120 ohms, the duration was 20 s, while for lower values, it was set at 15 s. The study reported only one gastric hypomotility following left atrial box ablation, with no fatal complications, including steam pops. The authors also identified a cut-off value for impedance drop to achieve first-pass isolation: 13.5 ohms for LPV and 14.5 ohms for RPV. This finding underscores the importance of monitoring impedance drop to achieve effective PVI. A previous study has shown that approximately 80% of steam pops occur when the impedance drop exceeds 18 ohms.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Interestingly, the threshold impedance drop for achieving first-pass isolation in this study (13.5–14.5 ohms) is close to the reported cut-off for preventing steam pops (18 ohms). While the risk of steam pop remains a concern, the TactiFlex catheter appears to have a significantly lower rate of steam pops compared to the SmartTouch Surround Flow (STSF) catheter (1.7% vs. 65.7% at 50 W).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This lower risk is attributed to the catheter's unique mesh-shaped irrigation tip, which enhances irrigation efficiency and reduces the risk of char and thrombus formation. One year after ablation, the AF-free rates were 81.7% in the PAF group and 76.3% in the non-PAF group. Among the 16 patients who experienced AF recurrence, 10 underwent a second ablation session. Of these, two had PV reconnection, five had residual potentials in the carina region without PV reconnection, and three had neither. These results demonstrate the durability of PVI lesions created with the TactiFlex catheter over the long term. Notably, the absence of significant differences in first-pass isolation rates between attending physicians and fellows (RPV: 81.3% vs. 83.3%, &lt;i&gt;p&lt;/i&gt; = 0.839; LPV: 93.8% vs. 85.7%, &lt;i&gt;p&lt;/i&gt; = 0.381) highlights the ","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial to “Association between ventricular arrhythmia (premature ventricular contractions burden and non-sustained ventricular tachycardia) and cardiovascular events in patients without structural heart disease”","authors":"Wei Sheng Jonathan Ong MBBS,&nbsp;Chi Keong Ching MBBS, FHRS","doi":"10.1002/joa3.13219","DOIUrl":"10.1002/joa3.13219","url":null,"abstract":"&lt;p&gt;Whether frequent premature ventricular contractions (PVCs) in patients without structural heart disease are of prognostic significance is a subject of debate.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Once considered to be a benign condition, it is now widely known that it can be causative for tachycardia-induced cardiomyopathy. While only a minority of patients with frequent PVCs (&gt;1000 PVCs/day) develop ventricular dysfunction after 5 years of follow-up,&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; catheter ablation is curative for these patients with normalization of cardiac function. The minimal threshold for the development of LV dysfunction is a PVC burden of 10% while a PVC burden of &gt;20% portends a higher risk. Upfront catheter ablation is also indicated in symptomatic patients without structural heart disease when the PVCs are of right ventricular outflow tract or fascicular origin.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Beyond the above select patient groups, however, it remains unclear whether frequent PVCs are associated with cardiovascular events in patients without structural heart disease.&lt;/p&gt;&lt;p&gt;In this issue of the &lt;i&gt;Journal of Arrhythmia&lt;/i&gt;, Ogiso et al. conducted a single-center retrospective study with 6332 patients, stratified by the number of baseline PVCs and the presence or absence of non-sustained ventricular tachycardia (NSVT). The primary endpoint was defined as the incidence of cardiovascular events, including all-cause death, acute coronary syndrome, ischemic stroke, systemic embolism, and hospitalization for heart failure. The authors reported that, over a 3 year follow-up period, the frequency of PVCs was not associated with cardiovascular events while the presence of NSVT was associated with a higher risk of heart failure hospitalization. In the NSVT study population, only one of the five cases of heart failure had a reduced ejection fraction.&lt;/p&gt;&lt;p&gt;Notably, these results differ from previous studies&lt;span&gt;&lt;sup&gt;4, 5&lt;/sup&gt;&lt;/span&gt;; however, this can be explained on more careful examination of key study differences. Prior studies have shown that the decrease in cardiac function, increase in heart failure events, and mortality among patients with frequent PVCs were normally noted beyond 5 years of follow-up.&lt;span&gt;&lt;sup&gt;4, 5&lt;/sup&gt;&lt;/span&gt; This suggests that the 3 year follow-up period in the study may have been inadequate to detect these differences. Furthermore, as pointed out by the authors, increased use of medical interventions such as anti-arrhythmic drugs and catheter ablation in patients with a larger number of PVCs and NSVT may have contributed to a better prognosis and outcome.&lt;/p&gt;&lt;p&gt;Ogiso et al. reported that one patient with NSVT and heart failure was later diagnosed with hypertrophic cardiomyopathy. This was not detected at baseline with echocardiography. As frequent PVCs and NSVT may indicate subclinical abnormalities, the authors opined that further investigations, including cardiac magnetic resonance imaging (MRI), may be needed in select patients.","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of intrinsic antitachycardia pacing","authors":"Koumei Onuki MD,&nbsp;Michio Nagashima MD,&nbsp;Masato Fukunaga MD,&nbsp;Keigo Misonou MD,&nbsp;Maiko Kuroda MD,&nbsp;Hiroyuki Kono MD,&nbsp;Tomonori Katsuki MD,&nbsp;Rei Kuji MD,&nbsp;Kengo Korai MD,&nbsp;Kenichi Hiroshima MD,&nbsp;Kenji Ando MD","doi":"10.1002/joa3.13221","DOIUrl":"10.1002/joa3.13221","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The clinical outcomes of a novel antitachycardia pacing (ATP) algorithm—intrinsic ATP (iATP)—compared to conventional ATP (cATP) have yet to be fully elucidated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analyzed 128 patients and 1962 ventricular tachycardia (VT) episodes treated with the iATP or the cATP at Kokura Memorial Hospital. Patients were categorized into two groups: the iATP group (23 patients, 182 episodes) and the cATP group (105 patients, 1780 episodes). We evaluated ATP success rates and baseline patient characteristics on a per-patient basis. Additionally, we extracted VT that were not terminated by a single ATP and compared ATP success rates using propensity score matching.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Per patient; The iATP group exhibited significantly lower creatinine levels (1.18 ± 0.40 mg/dL vs. 1.82 ± 1.61 mg/dL, <i>p</i> = .021) and a shorter follow-up period (609 ± 323 days vs. 1017 ± 252 days, <i>p</i> &lt; .001) compared to the cATP group. ATP success was observed in 19 patients in the iATP group and 62 patients in the cATP group (82.6% vs. 59%, <i>p</i> = .054). Per episode; there was no significant difference in ATP success rate (91.8% vs. 92.7%, <i>p</i> = .645) or in acceleration rate (1.1% vs. 2.4%, <i>p</i> = .274). However, when limited to episodes in which VT was not terminated by a single ATP and propensity score matching was performed, the iATP showed a higher VT termination rate (84.1% vs. 53.6%, <i>p</i> &lt; .001) and a lower acceleration rate (0% vs. 10.1%, <i>p</i> = .013) than the cATP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The efficacy and safety of the iATP for VT that was not terminated by the first sequence of ATP was demonstrated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}