Journal of Cancer Metastasis and Treatment最新文献_第6页

Tumour Microenvironment and Metastasis 肿瘤微环境与转移

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-12-05 DOI: 10.5772/INTECHOPEN.79319

Ke Wang

{"title":"Tumour Microenvironment and Metastasis","authors":"Ke Wang","doi":"10.5772/INTECHOPEN.79319","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79319","url":null,"abstract":"In recent years, cancer is more and more severe harm to the health of people in the world. Although tumour diagnosis and therapy have made some progresses, there is little improvement in overall. One of the main reasons is that the pathogenesis of cancer metastasis is still enigmatic. Cancer development and metastasis are a complicated process that depends on the antigenic properties of cancer cells and a favoured environment in organs. Cancer cells metastasis causes more than 90% cancer death in the lungs, liver, brain, and bone, and a primary tumour causes less than 10% death. Therefore, understanding the process of cancer metastasis is essential, and it is convenient to deal with the problem of cancer metastasis and reduce cancer-related thrombosis. It has shown that tumour microenvironment plays a significant role in cancer progression. A variety of carcinoma-associated fibroblasts, and tumour-related macrophages play expanding and critical functions in sustaining cell proliferation, evading growth suppressors, promoting survival, activating invasion and metastasis, and reprogramming energy metabolism, but the purpose of each constituent remains unknown. This chapter will focus on discussing the role of the microenvironment on tumour invasion and metastasis to improve molecular diagnostics and therapeutics.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"58 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83139782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Introductory Chapter: Cancer Metastasis 导论章:癌症转移

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-06 DOI: 10.5772/INTECHOPEN.81914

Gizem Çalıbaşı-Koçal, Y. Başbınar

引用次数: 0

Early Metastasis in Colorectal Cancer Poses an Option for New Diagnostic and Treatment Strategies 结直肠癌的早期转移为新的诊断和治疗策略提供了选择

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79637

H. Adwan, D. Elharouni, D. Habashy, N. Banna, R. Georges, Asim Pervaiz, M. Berger

{"title":"Early Metastasis in Colorectal Cancer Poses an Option for New Diagnostic and Treatment Strategies","authors":"H. Adwan, D. Elharouni, D. Habashy, N. Banna, R. Georges, Asim Pervaiz, M. Berger","doi":"10.5772/INTECHOPEN.79637","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79637","url":null,"abstract":"Metastasis is the spread of tumor cells from a primary site to a secondary site within the host’s body. It is initiated by the detachment of the tumor cells from the primary tumor followed by invasion into the surrounding tissue. Thereafter the cells migrate across the endothelium and into the blood vessels (intravasation). During the intravasation the cells have to survive the sheer forces and the immune response. Upon arrival to the target organ, the cells leave the circulation and cross the endothelium to reach the host organ. Once there, the tumor cells are greeted with the organ’s local immune cells and with a hostile or inappropriate environment, where they finally have to form proliferating colo -nies. Metastasis is therefore far from being a straight-forward or efficient process with less than 0.1% of disseminating tumor cells (around 1 × 109 cells per day for a 1 cm size tumor) succeeding in colonizing distal organs. The identification of the involved marker during the early metastasis process will be essential for establishment of new diagnostics tools, as well as development of novel treatment strategies.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"55 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76668034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genetic Mutations and Ubiquitination in Melanoma Growth and Metastasis 黑色素瘤生长和转移中的基因突变和泛素化

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78733

Anushka Dikshit, Jennifer Y. Zhang

引用次数: 0

The Landscape of Histone Modification in Cancer Metastasis 组蛋白修饰在肿瘤转移中的研究进展

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78383

Zhaoping Qiu, Jianlin Wang, Yadi Wu

{"title":"The Landscape of Histone Modification in Cancer Metastasis","authors":"Zhaoping Qiu, Jianlin Wang, Yadi Wu","doi":"10.5772/INTECHOPEN.78383","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78383","url":null,"abstract":"Metastasis represents one of the most devastating aspects of cancer. Epithelial to mesen- chymal transition (EMT) has been shown to play a critical role in tumorigenic metastasis. During metastatic progression, both genetic and epigenetic modifications endow cancer cells with properties that modulate the capacity for metastatic success. Histone modifica tion is profoundly altered in cancer cells and contributes to cancer metastasis by con- trolling different metastatic phenotypes. Here, we first review histone modifications and discuss their roles in EMT and metastasis, with a particular focus on histone methylation and acetylation. Second, we review the major histone modification enzymes that control chromatin in cancer metastasis. Third, we discuss the transcriptional regulation concerted by these enzymes with EMT transcription factors at different molecular layers. Finally, we discuss pharmacologic manipulation of histone modification enzymes for metastasis treatment. A comprehensive understanding of histone modification in metastasis will not only provide new insights into our knowledge of cancer progression and metastasis, but also offer a novel approach for the development of innovative therapeutic strategies. gene","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"3 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75985969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Epithelial-Mesenchymal Transition in Tumor Microenvironment Induced by Hypoxia 缺氧诱导肿瘤微环境上皮-间质转化

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78717

G. Eskiizmir, E. Özgür

{"title":"Epithelial-Mesenchymal Transition in Tumor Microenvironment Induced by Hypoxia","authors":"G. Eskiizmir, E. Özgür","doi":"10.5772/INTECHOPEN.78717","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78717","url":null,"abstract":"A tumor microenvironment contains various noncancerous cells including adipocytes, fibroblasts, immune and inflammatory cells, neuroendocrine cells, pericytes, vascular and lymphatic endothelial cells, and the extracellular matrix that surrounds cancerous cells. In the tumor microenvironment, cancer cells interact and cross talk with noncancerous cells and orchestrate different mechanisms of cancer such as tumorigenesis, angiogenesis, and metastasis. Moreover, the expansive nature of cancer cells and chaotic angiogenesis affect microcirculation as well as alter the oxygen concentration progres - sively. Hypoxia, a key player in the multistep process of cancer metastasis, is important in different regions of the tumor microenvironment. Hypoxia may transform cancer cells to become more aggressive and invasive by triggering overexpression of several hypoxia-related factors that activate epithelial-mesenchymal transition (EMT). Herein, the current knowledge of how hypoxia-driven EMT is presented in the tumor microenvironment of solid cancers is discussed. EMT and CSC-like properties including resistance to treatment. Each step of the cancer adap tive process is regulated by HIF, NFĸB, PI3K, and MAPK pathways. Understanding the impact of hypoxia and clarifying the hypoxia-induced responses and signaling modalities may pave the way to achieve important steps against cancer via hypoxia/HIF-targeted treatments.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"71 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86907757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ovarian Clear Cell Carcinoma: Metastatic Pathways 卵巢透明细胞癌:转移途径

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79759

C. Sofoudis

引用次数: 0

Prognostic Biomarkers for Breast Cancer Metastasis 乳腺癌转移的预后生物标志物

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80576

Kwok Kin Lee, W. Chng, S. Jha

引用次数: 3

Recent trend in gastric cancer treatment in the USA. 美国胃癌治疗的最新趋势。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-04-04 Epub Date: 2018-04-26 DOI: 10.20517/2394-4722.2017.74

Kazuto Harada, Hideo Baba, Jaffer A Ajani

引用次数: 6

Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity. 中心体畸变和染色体不稳定有助于肿瘤的发生和肿瘤内的异质性。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-01-01 Epub Date: 2018-08-07 DOI: 10.20517/2394-4722.2018.24

Shirley Jusino, Fabiola M Fernández-Padín, Harold I Saavedra

{"title":"Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity.","authors":"Shirley Jusino, Fabiola M Fernández-Padín, Harold I Saavedra","doi":"10.20517/2394-4722.2018.24","DOIUrl":"https://doi.org/10.20517/2394-4722.2018.24","url":null,"abstract":"<p><p>Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokinesis failure. A long-standing postulate is that centrosome aberrations are involved in the initiation and progression of cancer. However, this notion has been a subject of controversy because until recently the relationship has been correlative. Recently, it was shown that numerical or structural centrosome aberrations can initiate tumors in certain tissues in mice, as well as invasion. Particularly, we will focus on centrosome amplification and chromosome instability as drivers of intra-tumor heterogeneity and their consequences in cancer. We will also discuss briefly the controversies surrounding this theory to highlight the fact that the role of both centrosome amplification and chromosome instability in cancer is highly context-dependent. Further, we will discuss single-cell sequencing as a novel technique to understand intra-tumor heterogeneity and some therapeutic approaches to target chromosome instability.</p>","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"4 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36624674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16