Journal of Cancer Metastasis and Treatment最新文献

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Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression. 结肠癌的两面:小鼠模拟人类结肠癌发生和发展的解剖区域差异

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2018-01-01 Epub Date: 2018-09-27 DOI: 10.20517/2394-4722.2018.39

Jessica Felton, Kunrong Cheng, Aaron C Shang, Shien Hu, Shannon M Larabee, Cinthia B Drachenberg, Jean-Pierre Raufman

{"title":"Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression.","authors":"Jessica Felton, Kunrong Cheng, Aaron C Shang, Shien Hu, Shannon M Larabee, Cinthia B Drachenberg, Jean-Pierre Raufman","doi":"10.20517/2394-4722.2018.39","DOIUrl":"10.20517/2394-4722.2018.39","url":null,"abstract":"Aim: Strong evidence reveals important differences between cancers in the proximal vs. distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important limitations. We explored whether there were regional differences in the location of murine colon cancers and assessed the utility of murine models to explore the biological basis for such differences.Methods: We re-analyzed data from our previous studies to assess the regional distribution of murine colon cancer. In survival surgery experiments, we injected HT-29 human colon cancer cells into the wall of the cecum or distal colon of Nu(NCr)-Foxn1nu or NOD.Cg-PrkdcscidIl2rgTim1Wji/SzJ mice and compared the development of primary tumors and metastases.Results: Within 7-17 weeks after intramural cecal injection of HT-29 cells, eight mice failed to develop solid primary tumors or metastases. In contrast, within four weeks after cell injection into the distal colon, 13 mice developed metastases - 12 mice developed subcutaneous metastases; of these, four developed liver metastases and one developed both liver and lung metastases. One mouse developed liver metastases only. Histological examination confirmed these lesions were adenocarcinomas.Conclusion: Our findings reveal the preferential growth of murine colon neoplasia and invasive human orthotopic xenografts in the distal mouse colon. The new approach of injecting cells into the distal colon wall results in a pattern of colon cancer development that closely mimics the progression of metastatic colon cancer in humans. This novel model of colon neoplasia has great potential for exploring anatomical differences in colon cancer and testing novel therapeutics.","PeriodicalId":15167,"journal":{"name":"Journal of Cancer Metastasis and Treatment","volume":"4 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47223058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using circulating tumor cells to advance precision medicine in prostate cancer. 利用循环肿瘤细胞推进前列腺癌精准医疗。

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-27 DOI: 10.20517/2394-4722.2017.45

Giuseppe Galletti, Daniel Worroll, David M Nanus, Paraskevi Giannakakou

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引用次数: 8

Muscarinic receptor signaling and colon cancer progression. 毒蕈碱受体信号传导与结肠癌进展

IF 1.9

Journal of Cancer Metastasis and Treatment Pub Date : 2016-06-15 DOI: 10.20517/2394-4722.2016.05

Guofeng Xie, Jean-Pierre Raufman

引用次数: 0

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