Journal of Cancer Research and Clinical Oncology最新文献

{"title":"Comment on \"Artificial intelligence construction: a review of the bridge between CT imaging features of lung ground-glass nodules adenocarcinoma and carcinogenic driver genes\".","authors":"V P Abel Jopaul, M Lingaraj","doi":"10.1007/s00432-026-06597-4","DOIUrl":"10.1007/s00432-026-06597-4","url":null,"abstract":"<p><p>Xue and Chen et al.'s review connects AI-derived CT features of lung ground-glass nodule adenocarcinoma to driver gene status. Three aspects are missing. There is no stated search strategy no databases, date range, or inclusion criteria despite drawing on more than 150 references, so readers cannot tell whether weaker or null results were sought out or just left aside. Individual studies are cited by their best accuracy or AUC figures, from approximately 0.64 to above 0.95, with no attempt to weigh them by sample size, design, or validation status. The framing does not match the evidence the review cites: the text calls AI transformative, but a systematic review it references reports a mean AUC of only ~0.64 for driver gene prediction from imaging. None of this undercuts the review's usefulness as a starting map of the field, but a stated search process, some quality-weighting of the cited numbers, and framing that matches the aggregate evidence would make it more reliable.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The imitation game: large language models versus multidisciplinary tumor boards: benchmarking AI against 21 sarcoma centers from the RING trial\".","authors":"M Shanmuga Priya, Aruthra, K Srinivasa Galu, A Anish Kumar","doi":"10.1007/s00432-026-06594-7","DOIUrl":"10.1007/s00432-026-06594-7","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of the use of psycho-oncological care.","authors":"J Schultke, M Reeh, J-E Michaelis, P Rothe, Y Hagmayer, F Braulke","doi":"10.1007/s00432-026-06584-9","DOIUrl":"10.1007/s00432-026-06584-9","url":null,"abstract":"<p><strong>Purpose: </strong>Psychosocial stressors and mental disorders can negatively affect the success of cancer treatments. Therefore, they should be addressed by target group-oriented psycho-oncological care. This study examined possible predictors of the use of psycho-oncological care.</p><p><strong>Methods: </strong>Routine data from 5217 patients of a German Comprehensive Cancer Center between 2020 and 2023 were analysed in a retrospective monocentric study. The effects of predictors (gender, age, distance to the center, subjective stress at intake, and tumor stage) on the use of psycho-oncological care (use vs. no use) and on the number of psycho-oncological care sessions lasting at least 20 min were explored using logistic and binomial regression analyses.</p><p><strong>Results: </strong>Women at younger age, experiencing subjective distress, and patients with advanced-stage cancer were significantly more likely to use psycho-oncological support. Female patients, younger patients, patients who lived closer to the treating centre, patients with subjective distress, and patients at higher tumor stages attended more sessions of psycho-oncological counselling. The analyses also indicated substantial differences between different organ-specific cancer centers.</p><p><strong>Conclusion: </strong>All patients should be screened for psychological distress and wish for psycho-oncological support by a structured and validated tool. Vulnerable patients, patients at risk, and those, who are hesitant to seek help, could be screened by an interview to reduce barriers.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slug-positive circulating tumor cells in mesenchymal malignancies: what remains to validate.","authors":"Arman A Gholami, Dilfuza Mirzaeva, Sitora Soleyeva","doi":"10.1007/s00432-026-06596-5","DOIUrl":"https://doi.org/10.1007/s00432-026-06596-5","url":null,"abstract":"<p><p>Circulating tumor cells show promise as noninvasive response biomarkers, but their utility in mesenchymal malignancies requires further validation. This commentary examines He and colleagues' study proposing Slug-positive circulating tumor cells as predictors of neoadjuvant chemotherapy response. While the study provides valuable exploratory data, three considerations warrant careful interpretation: (1) Response Evaluation Criteria in Solid Tumors criteria versus histopathological assessment, the preferred sarcoma reference standard; (2) potential Epithelial Cell Adhesion Molecule-enrichment limitations for low-EpCAM mesenchymal tumors; and (3) the need for larger validation cohorts. Further investigations incorporating sarcoma-specific endpoints, optimized circulating tumor cell platforms, and adequately powered studies are needed before clinical application.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-sparing radiotherapy in solid tumors: radiation-induced lymphopenia, circulating immune-cell dose, and biomarker-guided optimization of radioimmunotherapy.","authors":"Shiduo Yang, E Erdemutu, Yuan Ren, Xinyu Jia, Qiaochu Ding, Chang Yang, Yu Lin","doi":"10.1007/s00432-026-06593-8","DOIUrl":"10.1007/s00432-026-06593-8","url":null,"abstract":"<p><strong>Purpose: </strong>Radiotherapy is a central component of solid tumor management and can enhance antitumor immunity through antigen release, immunogenic cell death, innate immune activation, and tumor microenvironment remodeling. However, radiotherapy can also induce systemic immune injury by depleting circulating lymphocytes and irradiating lymphoid organs. This review aims to examine radiation-induced lymphopenia (RIL) as a clinically relevant manifestation of systemic immune injury and its potential implications for radioimmunotherapy.</p><p><strong>Methods: </strong>This narrative review discusses the biological basis of RIL, including lymphocyte radiosensitivity, circulating blood exposure, lymphoid-organ irradiation, treatment volume, fractionation, systemic therapy, and patient immune reserve. It also summarizes clinical evidence regarding the association of severe or persistent RIL with outcomes across solid tumors and examines emerging dosimetric and biological biomarkers relevant to immune-sparing radiotherapy.</p><p><strong>Results: </strong>Severe or persistent RIL has been associated with inferior outcomes across multiple solid tumors and may be particularly relevant in patients receiving immune checkpoint inhibitors. Emerging dosimetric biomarkers include effective dose to immune cells, estimated dose of radiation to immune cells, circulating blood dose, blood dose-volume histograms, immune dose-volume histograms, marrow dose, spleen dose, and low-dose bath metrics. Potential biological biomarkers include baseline absolute lymphocyte count, treatment-related lymphocyte decline, immune recovery kinetics, inflammatory indices, immune-cell subsets, circulating tumor DNA (ctDNA) dynamics, and plan-derived immune exposure. Together, these parameters may support a biomarker-guided framework for immune-sparing radiotherapy.</p><p><strong>Conclusions: </strong>RIL should not be regarded merely as a laboratory abnormality, but as a clinically relevant systemic immune injury that may reflect reduced systemic immune competence and influence radioimmunotherapy efficacy. Immune-sparing radiotherapy should not compromise target coverage or tumor control, but may provide a clinically meaningful direction for optimizing radioimmunotherapy in solid tumors.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13569815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Euphorbia helioscopia L. extract suppresses hepatitis B virus-related hepatocellular carcinoma via alpha serine/threonine-protein kinase and Caspase-3.","authors":"Dan Xiong, Minyong Gong, Yanjun Hou, Haibing Chen, Tiexin Gao, Liuxin He","doi":"10.1007/s00432-026-06572-z","DOIUrl":"10.1007/s00432-026-06572-z","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of high-grade squamous intraepithelial lesions in women aged 30 years or younger: a retrospective cohort study.","authors":"Oliver M Schleicher, Anna K Dietl, Annika S Behrens, Lena Brueckner, Sebastian Trnovec, Carla E Schulmeyer, Patrik Pöschke, Julius Emons, Carol Geppert, Arndt Hartmann, Antje Knöll, Matthias W Beckmann, Anja Seibold, Frederik A Stuebs","doi":"10.1007/s00432-026-06578-7","DOIUrl":"10.1007/s00432-026-06578-7","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the rate and timing of spontaneous regression of high-grade cervical intraepithelial lesions (CIN2/HSIL and CIN3/HSIL) in young women and to identify associated factors.</p><p><strong>Methods: </strong>This retrospective cohort study included patients aged ≤ 30 years diagnosed with HSIL (CIN2 or CIN3) at the certified dysplasia unit of the Department of Gynecology, University Hospital Erlangen, between April 2014 and November 2025 who underwent observational management. Regression was defined as partial regression (low-grade squamous intraepithelial lesion; LSIL) or complete regression (less than LSIL), with histology as the reference standard.</p><p><strong>Results: </strong>45 patients with CIN3/HSIL and 38 with CIN2/HSIL were included. In the CIN3/HSIL cohort, regression was observed in 21 of 45 patients (46.7%), including regression to LSIL in 6 (13.3%) and complete regression in 15 (33.3%) cases. The median time to regression (≤ LSIL) was 236 days (IQR, 126-308 days). The CIN2/HSIL cohort showed even higher regression rates, with partial or complete regression in 24 of 38 cases (63.2%). Regression was associated with HPV clearance in both groups and with HPV16 negativity and HPV vaccination in the CIN2/HSIL cohort. No cases of progression to (micro)invasive disease were observed in either group. The probability of regression did not differ between patients aged ≤ 24 and > 24 years.</p><p><strong>Conclusion: </strong>In this selected cohort of women aged ≤ 30 years managed conservatively, spontaneous regression of CIN2/HSIL and CIN3/HSIL occurred frequently, particularly during the first year of follow-up, without progression to invasive disease. HPV clearance, HPV16 and vaccination status may help guide patient selection for observational management.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 8","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated multi-omics analysis reveals that tumour cell-intrinsic DCLK1 is associated with an angiogenic tumour microenvironment in cholangiocarcinoma via NF-κB/CXCL5.","authors":"Ziqing Kong, Rui Yan, Ziwei Liang, Guangyu An, Yang Ge","doi":"10.1007/s00432-026-06568-9","DOIUrl":"https://doi.org/10.1007/s00432-026-06568-9","url":null,"abstract":"<p><strong>Purpose: </strong>Cholangiocarcinoma (CCA) is an aggressive malignancy with a poor prognosis and complex tumour microenvironment. We previously demonstrated that doublecortin-like kinase 1 (DCLK1) is associated with epithelial-mesenchymal transition (EMT) in CCA; however, its biological functions and clinical relevance remain unclear. Herein, we elucidated the role of DCLK1 in CCA progression, focusing on its effects on angiogenesis, and evaluated its potential as a prognostic marker.</p><p><strong>Methods: </strong>We analysed bulk and single-cell RNA sequencing data to characterise DCLK1 expression and function in CCA. Functional validation was performed using conditioned medium from DCLK1-modified CCA cells, as well as endothelial tube formation, migration, and invasion assays. Tumour vascular density was assessed using a xenograft model. We used a human angiogenesis-related antibody array, western blotting, quantitative real-time PCR, and nuclear translocation assays to examine CXCL5 expression and NF-κB pathway activity.</p><p><strong>Result: </strong>We found that DCLK1 was upregulated in CCA and correlated with advanced disease and poor survival. DCLK1⁺ malignant cells displayed pro-angiogenic features and increased paracrine interaction with endothelial cells. Conditioned medium from DCLK1-overexpressing tumour cells enhanced endothelial tube formation, migration, and invasion, whereas DCLK1 knockout reversed these effects. DCLK1-expressing tumours showed increased vascular density in vivo. Mechanistically, an angiogenesis antibody array and western blotting demonstrated that DCLK1 activated the NF-κB pathway to upregulate CXCL5 expression. Pharmacological inhibition of NF-κB or neutralization of CXCL5 significantly attenuated DCLK1-related pro-angiogenic responses in vitro.</p><p><strong>Conclusion: </strong>DCLK1 activated the NF-κB pathway to upregulate CXCL5 secretion; inhibiting NF-κB or CXCL5 reduced DCLK1-related pro-angiogenic capacity.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 10","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149267703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isorhamnetin inhibits bladder cancer progression by mediating glycolysis through targeting the SRC/PI3K/Akt axis.","authors":"Feng Haiya, Li Qianqian, Lu Yangjun, Wang Hui","doi":"10.1007/s00432-026-06577-8","DOIUrl":"https://doi.org/10.1007/s00432-026-06577-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the anti-tumor effects of the natural flavonoid Isorhamnetin (ISO) on BC and elucidate its underlying molecular mechanisms.</p><p><strong>Methods: </strong>We integrated network pharmacology and bioinformatic analysis to predict the core targets and pathways between BC and ISO. In vitro functional assays were performed using the human BC cell line 5637. Cell viability, proliferation, apoptosis, migration, invasion, and adhesion were assessed via CCK-8, colony formation, flow cytometry, Transwell, and adhesion assays. Glycolytic function was evaluated by measuring extracellular acidification rate (ECAR), oxygen consumption rate (OCR), glucose uptake, and lactate production. Molecular docking and cellular thermal shift assays (CETSA) were used to validate ISO-SRC binding. Western blot and RT-qPCR analyses were conducted to examine protein and mRNA expression of key signaling and glycolytic components. For the rescue experiments, SRC was overexpressed along with treatment using the PI3K inhibitor LY294002.</p><p><strong>Results: </strong>ISO significantly inhibited BC cell proliferation, migration, invasion, adhesion, and glycolysis while inducing G0/G1 phase arrest and apoptosis. Network pharmacology and molecular docking identified SRC as a direct target of ISO, with CETSA confirming their binding. ISO treatment downregulated phosphorylation of SRC and its downstream effectors (PI3K, Akt, mTOR), reduced the expression of glycolytic enzymes (HK2, GLUT1, PFKFB3), and decreased ECAR, OCR, glucose uptake, and lactate production. SRC overexpression reversed the anti-tumor and anti-glycolytic effects of ISO. Furthermore, administration of LY294002 on this basis counteracted the effects induced by SRC overexpression, confirming the critical role of the SRC/PI3K/Akt axis.</p><p><strong>Conclusion: </strong>ISO inhibits the malignant progression of BC by directly targeting SRC to suppress glycolysis mediated by the PI3K/Akt signaling pathway. These findings provide a mechanistic basis for considering ISO as a potential metabolic-targeting agent for BC, warranting further preclinical evaluation.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 10","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149267790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity-modulated radiotherapy combined with albumin-bound paclitaxel and platinum-based chemotherapy for locoregional recurrent cervical cancer: a single-institutional phase II investigator-initiated nonrandomized clinical trial.","authors":"Chi Fang, Suping Liu, Jie Xia, Xiaohua Wu, Guihao Ke, Jun Zhu","doi":"10.1007/s00432-026-06555-0","DOIUrl":"https://doi.org/10.1007/s00432-026-06555-0","url":null,"abstract":"<p><strong>Objective: </strong>To prospectively explore efficacy and safety of radiotherapy combined with albumin-bound paclitaxel and platinum-based chemotherapy for locoregional recurrent cervical cancer (CC).</p><p><strong>Methods: </strong>Patients with locoregional recurrent CC were enrolled in the analysis. The enrolled patients received radiotherapy and albumin-bound paclitaxel and platinum-based chemotherapy. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), objective response rate (ORR), and safety.</p><p><strong>Results: </strong>99 patients were enrolled. For all patients, the 3-year PFS and 3-year OS were 48.5% and 58.6%. 17.2% of patients achieved CR and 67.7% of patients achieved PR. The ORR was 84.8%. Moreover, 10.1% of patients were confirmed SD. The DCR was 94.9%.</p><p><strong>Conclusion: </strong>Locoregional recurrent CC could benefit from radiotherapy combined with albumin-bound paclitaxel and platinum-based chemotherapy.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 10","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149267768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}