Vascular Medicine (London, England)最新文献

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Images in Vascular Medicine: Multiple Rasmussen aneurysms in noncavitary, multidrug-resistant tuberculosis. 血管医学影像:多药耐药肺结核非腔内多发拉斯穆森动脉瘤。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2022-06-01 Epub Date: 2021-11-22 DOI: 10.1177/1358863X211056681
Guillermo Cueto-Robledo, Luis-Eugenio Graniel-Palafox, Marisol Garcia-Cesar, Hector-Daniel Cueto-Romero, Ernesto Roldan-Valadez
{"title":"Images in Vascular Medicine: Multiple Rasmussen aneurysms in noncavitary, multidrug-resistant tuberculosis.","authors":"Guillermo Cueto-Robledo, Luis-Eugenio Graniel-Palafox, Marisol Garcia-Cesar, Hector-Daniel Cueto-Romero, Ernesto Roldan-Valadez","doi":"10.1177/1358863X211056681","DOIUrl":"https://doi.org/10.1177/1358863X211056681","url":null,"abstract":"","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"308-309"},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39753309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No difference in outcome between therapeutic and preventive anticoagulation in patients with superficial vein thrombosis involving the saphenous-femoral junction. 治疗性抗凝和预防性抗凝在累及股隐交界处的浅静脉血栓患者中的预后无差异。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2022-06-01 Epub Date: 2022-01-30 DOI: 10.1177/1358863X211066962
Paolo Prandoni, Raffaele Pesavento, Franca Bilora, José Luis Fernández Reyes, Olga Madridano, Silvia Soler, Manuel Monreal
{"title":"No difference in outcome between therapeutic and preventive anticoagulation in patients with superficial vein thrombosis involving the saphenous-femoral junction.","authors":"Paolo Prandoni, Raffaele Pesavento, Franca Bilora, José Luis Fernández Reyes, Olga Madridano, Silvia Soler, Manuel Monreal","doi":"10.1177/1358863X211066962","DOIUrl":"https://doi.org/10.1177/1358863X211066962","url":null,"abstract":"Following the demonstration that thrombosis involving the superficial veins of the lower extremities (SVT) is a less benign disease than previously thought,1 several controlled studies have consistently shown that fondaparinux in preventive doses, low-molecular-weight heparins (LMWHs) in intermediate doses, and rivaroxaban in preventive doses are effective and safe strategies for preventing extension or recurrence of the disease, as well as progression to the deep vein system and migration to the pulmonary circulation.2-6 In all these clinical trials, patients with the thrombus head within 3 cm from the saphenous–femoral junction were not eligible for recruitment, as they were perceived as being at a higher risk of venous thromboembolic complications in the absence of an active drug, nor were they in studies addressing the treatment of deep vein thrombosis (DVT) because of the lack of involvement of the deep vein system. Accordingly, which is the most proper therapeutic conduct in these patients is unknown. International guidelines are elusive in this regard.7,8 Although most physicians end up managing these patients with therapeutic doses of anticoagulants because of the feared risk of progression to the deep vein system, as far as we know there is no evidence of treatment failure coming from the long-term follow-up of patients managed with lower doses. Here we report the findings from an international registry. The Computerized Registry of Patients with Venous Thromboembolism (RIETE) (ClinicalTrials.gov Identifier: NCT02832245) is a large prospective registry that has been enrolling patients with objectively confirmed VTE since 2001.9 The main objective of RIETE is to provide information to help physicians to improve their knowledge on the natural history of thromboembolic disease, including epidemiologic, diagnostic, prophylactic, and therapeutic information. All enrollees provide written or verbal informed consent according to the local ethics protocols of enrolling centers. The institutional review board at each enrolling center approves participation in RIETE for the site investigators and allows the entry of de-identified patient information into the RIETE database. Out of 1320 patients with isolated SVT (i.e., without simultaneous involvement of the deep venous system, as assessed by systematic bilateral ultrasonography) who were enrolled in the RIETE registry between March 2015 and June 2021, 374 (28.3%) had a thrombosis involving the most proximal tract of the greater saphenous with the thrombus head being within 3 cm from the saphenous–femoral junction. Of these patients, 227 (60.7%) were managed with full-dose LMWH or therapeutic doses of fondaparinux overlapped with and/or followed by vitamin K antagonists or direct oral anticoagulants. The remaining 147 patients (39.3%) were managed with preventive doses of fondaparinux or intermediate-dose LMWH. Table 1 illustrates the main demographic and clinical characteristics of the recruited ","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"290-292"},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39874078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
SCAI/ACR/APMA/SCVS/SIR/SVM/SVS/VESS Position Statement on Competencies for Endovascular Specialists Providing CLTI Care SCAI/ACR/APMA/SCVS/SIR/SVM/SVS/VESS血管内专家提供CLTI护理能力立场声明
Vascular Medicine (London, England) Pub Date : 2022-04-25 DOI: 10.1177/1358863X221095278
B. Hawkins, Jun Li, L. Wilkins, T. Carman, A. Reed, D. Armstrong, P. Goodney, C. White, A. Fischman, M. Schermerhorn, D. Feldman, S. Parikh, M. Shishehbor
{"title":"SCAI/ACR/APMA/SCVS/SIR/SVM/SVS/VESS Position Statement on Competencies for Endovascular Specialists Providing CLTI Care","authors":"B. Hawkins, Jun Li, L. Wilkins, T. Carman, A. Reed, D. Armstrong, P. Goodney, C. White, A. Fischman, M. Schermerhorn, D. Feldman, S. Parikh, M. Shishehbor","doi":"10.1177/1358863X221095278","DOIUrl":"https://doi.org/10.1177/1358863X221095278","url":null,"abstract":"Chronic limb-threatening ischemia (CLTI) is the advanced stage of peripheral artery disease (PAD) characterized by rest pain or tissue loss. Up to 2 million individuals have this condition in the United States, and prevalence is anticipated to grow owing to aging of the population and increase in atherosclerotic risk factors such as diabetes and renal disease.1 In addition to the threat of limb dysfunction and amputation, patients with CLTI are at a high risk of cardioand cerebrovascular morbidity and mortality, with risk that exceeds that of most other cardiovascular patients. Within 1 year, 1 in 5 CLTI patients dies, and an additional one quarter will require major limb amputation.2 Care of the CLTI patient is complex, multifaceted, and multidisciplinary. Medical therapy, wound care, interpretation of noninvasive and invasive vascular testing, and the performance of revascularization procedures are integral to achieve limb salvage. Both surgical and endovascular revascularization have been established as effective treatment modalities that alleviate symptoms and promote healing. Decisions regarding revascularization strategy for individual patients are nuanced and depend in part on comorbidities, anatomy, functional status, conduit availability, presence of suitable bypass target, and other factors. Endovascular revascularization is performed by physicians across a variety of disciplines including vascular surgeons— the only specialty providing both endovascular and open surgical intervention—interventional radiologists, interventional cardiologists, and others.3 Irrespective of specialty, the endovascular specialist focused on CLTI should understand the role of surgical revascularization, understand the likelihood of short-term and long-term success with each type of revascularization, possess competencies that extend beyond catheter-based therapies, and integrate other CLTI SCAI/ACR/APMA/SCVS/SIR/SVM/SVS/VESS Position Statement on Competencies for Endovascular Specialists Providing CLTI Care","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116785284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of habitual sedentary patterns on popliteal artery endothelial-dependent vasodilation in healthy adults 习惯久坐模式对健康成人腘动脉内皮依赖性血管舒张的影响
Vascular Medicine (London, England) Pub Date : 2022-03-02 DOI: 10.1177/1358863X211065494
Madeline E. Shivgulam, M. O'Brien, Jarrett A. Johns, Jennifer L. Petterson, Yanlin Wu, Ryan J. Frayne, D. Kimmerly
{"title":"Impact of habitual sedentary patterns on popliteal artery endothelial-dependent vasodilation in healthy adults","authors":"Madeline E. Shivgulam, M. O'Brien, Jarrett A. Johns, Jennifer L. Petterson, Yanlin Wu, Ryan J. Frayne, D. Kimmerly","doi":"10.1177/1358863X211065494","DOIUrl":"https://doi.org/10.1177/1358863X211065494","url":null,"abstract":"Introduction: Acute, laboratory-based bouts of prolonged sitting attenuate lower-limb arterial endothelial-dependent vasodilation. However, the impact of habitual sedentary patterns on popliteal artery endothelial health is unclear. We tested the hypothesis that greater habitual total sedentary time, more time spent in prolonged sedentary bouts, and fewer sedentary breaks would be associated with worse popliteal flow-mediated dilation (FMD) responses. Methods: This cross-sectional study used 98 healthy participants (19–77 years, 53 females) that wore an activPAL monitor on the thigh for 6.4 ± 0.8 days to objectively measure sedentary activity and completed a popliteal ultrasound assessment to determine FMD. Both relative (%baseline diameter) and absolute (mm) FMD were calculated. Using bivariate correlation and multiple regression analyses, we examined if there were relationships between sedentary outcomes and FMD while statistically controlling for any potential confounders. Results: In the multiple regression model, age (p = 0.006, β = −0.030, 95% CI = −0.051, −0.009) and total time in sedentary bouts > 1 hour (p = 0.031, β = −0.005, 95% CI = −0.009, −0.001) were independent predictors of relative FMD. Age (β = −0.002, 95% CI = −0.003, −0.001), mean blood flow (β = 0.013, 95% CI = 0.002, 0.024), moderate-intensity physical activity (β = 155.9E−5, 95% CI = 22.4E−5, 289.4E−5), sedentary breaks (β = 0.036, 95% CI = 0.007, 0.066), and total time spent in sedentary bouts > 1 hour (β = −25.02E−5, 95% CI = −47.67E−5, −2.378E−5) were predictors of absolute FMD (all, p < 0.047). All independent outcomes remained significant after partially controlling for all other predictor variables (all, p < 0.031). Conclusions: Habitual prolonged sedentary bouts and sedentary breaks, but not total sedentary time, were predictors of popliteal endothelial-dependent vasodilatory function. The patterns by which sedentary time is accumulated may be more important than the total sedentary time on lower-limb arterial health.","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134244362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Images in Vascular Medicine: Vena cava syndrome mimicking caput medusae. 血管医学影像:模仿水母头的腔静脉综合征。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-07-16 DOI: 10.1177/1358863X211028296
Amanda von Bismarck, Tobias Weinberger, Julius Steffen
{"title":"Images in Vascular Medicine: Vena cava syndrome mimicking caput medusae.","authors":"Amanda von Bismarck,&nbsp;Tobias Weinberger,&nbsp;Julius Steffen","doi":"10.1177/1358863X211028296","DOIUrl":"https://doi.org/10.1177/1358863X211028296","url":null,"abstract":"During planning for a transcatheter aortic valve replacement for severe aortic stenosis in a 76-year-old man, physical examination showed pronounced varicose veins of the abdomen (Panel A). Thorough clinical history revealed their development after a thymectomy and radiotherapy for thymic carcinoma about 40 years ago. The patient had long accepted the varicosities as a mere cosmetic issue. Liver cirrhosis and portal hypertension were ruled out and the patient was prepared for aortic valve replacement. However, in the preprocedural CT angiography, the contrast agent injected into the left cubital vein drained via the superficial epigastric veins into the femoral veins before entering the inferior vena cava (Panel B; CT reconstruction). Panels C and D show coronal CT images with arrows pointing at the occluded superior vena cava (AO, aorta; LA, left atrium; PA, pulmonary artery; RA, right atrium; SVC/IVC, superior/inferior vena cava; VJI, internal jugular vein). Clinical relevance emerged, when, after successful aortic valve replacement, implantation of the temporary pacemaker lead through the","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"672-673"},"PeriodicalIF":3.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1358863X211028296","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Regulation of reactive oxygen species in the pathogenesis of matrix vesicles induced calcification of recipient vascular smooth muscle cells. 活性氧在基质囊泡诱导受体血管平滑肌细胞钙化发病机制中的调控作用。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-08-02 DOI: 10.1177/1358863X211024721
Neal X Chen, Kalisha D O'Neill, James M Dominguez, Sharon M Moe
{"title":"Regulation of reactive oxygen species in the pathogenesis of matrix vesicles induced calcification of recipient vascular smooth muscle cells.","authors":"Neal X Chen,&nbsp;Kalisha D O'Neill,&nbsp;James M Dominguez,&nbsp;Sharon M Moe","doi":"10.1177/1358863X211024721","DOIUrl":"https://doi.org/10.1177/1358863X211024721","url":null,"abstract":"<p><strong>Introduction: </strong>Increased oxidative stress is associated with vascular calcification in patients with chronic kidney disease (CKD). We have previously demonstrated that cellular-derived matrix vesicles (MV), but not media-derived MV, are endocytosed in the presence of phosphorus by recipient normal rat vascular smooth muscle cells (VSMC) and induce calcification through ERK1/2 and [Ca<sup>2+</sup>]<sub>i</sub> signaling. We hypothesized that these changes were mediated by increased reactive oxygen species (ROS) production.</p><p><strong>Methods: </strong>MV were co-cultured with recipient VSMC in the presence of high phosphorus and ROS production and cell signaling assessed.</p><p><strong>Results: </strong>The results demonstrated MV endocytosis led to increased ROS production in recipient VSMC with no increase in mitochondrial oxygen consumption or oxidative phosphorylation (OXPHOS), indicating the ROS was not from the mitochondria. The use of inhibitors demonstrated that endocytosis of these MV by VSMC led to a signaling cascade in the cytoplasm beginning with ERK1/2 signaling, then increased [Ca<sup>2+</sup>]<sub>i</sub> and stimulation of ROS production, mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)1/4. Media-derived MV did not induce this cascade, indicating endocytosis itself was not a factor. Furthermore, inhibition of either ERK1/2 activation or [Ca<sup>2+</sup>]<sub>i</sub> reduced vascular calcification.</p><p><strong>Conclusion: </strong>We conclude that endocytosis of pro-mineralizing MV can induce a series of signaling events in normal VSMC that culminate in generation of ROS via activation of NOX1/4. Understanding these pathways will allow the development of future targeted therapeutics.</p>","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"585-594"},"PeriodicalIF":3.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1358863X211024721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
First-in-human experience of the Bashir Endovascular Catheter in the treatment of iliocaval deep vein thrombosis. 人类首次使用Bashir血管内导管治疗髂腔深静脉血栓。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-08-16 DOI: 10.1177/1358863X211028287
Mohamad Al-Otaibi, Neal B Shah, Omer Iftikhar, Prateek Sharma, Koneti Rao, Riyaz Bashir, Vladimir Lakhter
{"title":"First-in-human experience of the Bashir Endovascular Catheter in the treatment of iliocaval deep vein thrombosis.","authors":"Mohamad Al-Otaibi,&nbsp;Neal B Shah,&nbsp;Omer Iftikhar,&nbsp;Prateek Sharma,&nbsp;Koneti Rao,&nbsp;Riyaz Bashir,&nbsp;Vladimir Lakhter","doi":"10.1177/1358863X211028287","DOIUrl":"https://doi.org/10.1177/1358863X211028287","url":null,"abstract":"<p><p>Deep vein thrombosis (DVT) is a common disorder affecting approximately 900,000 new patients in the United States each year. Although the mainstay of treatment of DVT patients is therapeutic anticoagulation, some patients remain significantly symptomatic and therefore require more advanced interventions such as catheter-directed thrombolysis (CDT). We describe a case series of 13 patients with acute symptomatic inferior vena cava (IVC) and iliofemoral DVT that were treated with CDT using the Bashir Endovascular Catheter (BEC). We report the first-in-human use of BEC, which is a novel pharmacomechanical thrombolysis device. All the treated patients had complete and rapid resolution of their symptoms with excellent venous outflow. Despite initial promising results, larger studies using this catheter design will be needed to assess the role of BEC-directed therapy on rates of post-thrombotic syndrome and bleeding complications.</p>","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"648-653"},"PeriodicalIF":3.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39311145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diagnostic accuracy of postexercise toe-brachial index for identifying peripheral artery disease (PAD): A pilot study. 运动后脚趾肱指数诊断外周动脉疾病(PAD)的准确性:一项初步研究
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-09-06 DOI: 10.1177/1358863X211039548
Peta Ellen Tehan, Richard Rounsley, Mathew Sebastian, Vivienne Helaine Chuter
{"title":"Diagnostic accuracy of postexercise toe-brachial index for identifying peripheral artery disease (PAD): A pilot study.","authors":"Peta Ellen Tehan,&nbsp;Richard Rounsley,&nbsp;Mathew Sebastian,&nbsp;Vivienne Helaine Chuter","doi":"10.1177/1358863X211039548","DOIUrl":"https://doi.org/10.1177/1358863X211039548","url":null,"abstract":"Toe–brachial indices (TBI) are being integrated into international guidelines1,2 due to their utility as an adjunct test for peripheral artery disease (PAD), particularly in diabetes populations.3,4 The addition of an exercise protocol has been demonstrated to improve diagnostic accuracy of the traditional ankle–brachial index (ABI).5 However, there has been limited investigation of the effect of exercise on the accuracy of TBI. Therefore, this pilot study aimed to determine the diagnostic test accuracy of the TBI for PAD following an exercise protocol in participants with suspected PAD. This prospective cross-sectional study ran between 2019 and 2020 in a private vascular laboratory in Newcastle, Australia. Adults exhibiting signs or symptoms consistent with PAD were recruited. Exclusion criteria included inability to adhere to testing protocol (e.g., treadmill walking), conditions preventing toe or brachial pressure measurement (e.g., vasoneural disorders, connective tissue disorders, hallux wound or bilateral mastectomy). Informed written consent was obtained, and ethics approval was in place (H-2010-1230). One limb per participant was included in the study – the symptomatic limb, or where both limbs were symptomatic, the right limb. One vascular sonographer conducted all assessments, with inter-rater reliability previously determined to be acceptable.6 All measurements were taken in a temperature-controlled clinical room (23–25°C). Pretesting participant protocols and the measurement procedure for pressure measurements for the vascular laboratory are consistent with current guidelines and as previously described.1,4 A Hadeco Smartdop 45 (Hadeco, Kawasaki, Japan) with a photoplethysmography probe was used to measure systolic toe pressure (TP). Participants walked on a treadmill at a maximum of 3 km/ hour and a 10° incline for up to 5 minutes. If the participant experienced excessive lower extremity discomfort, angina, or dyspnoea, exercise was ceased. Toe, ankle, and brachial pressures were then immediately recorded in a supine position. Subsequently, visualisation of arteries and peak systolic velocities were obtained from the distal aorta to the foot via colour duplex ultrasound (reference standard) and were completed in the same session. Velocity ratios for grading of stenoses have previously been reported.6 Descriptive statistics and measures of sensitivity, specificity, and positive and negative likelihood ratios with 95% CIs were calculated for TBI for detecting PAD – defined as one or more lower limb arteries with stenosis of ⩾ 50%.7 The diagnostic threshold for PAD using TBI was considered to be &lt; 0.70. Interpretation of postexercise TBI was evaluated firstly by using the diagnostic threshold of &lt; 0.70 for PAD, and secondly, if the postexercise value was &gt; 20% lower than the resting TBI. A receiver operating characteristic (ROC) curve was performed for TBI and postexercise TBI (online Supplementary file) and the area under the curve (A","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"657-659"},"PeriodicalIF":3.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral deep vein thrombosis: Time to screen for occult cancer? 双侧深静脉血栓:是时候筛查隐匿性癌症了?
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-09-17 DOI: 10.1177/1358863X211034919
Salma Adham, Guillaume Armengol, Nicole Cailleux-Talbot, Hervé Levesque, Ygal Benhamou, Sébastien Miranda
{"title":"Bilateral deep vein thrombosis: Time to screen for occult cancer?","authors":"Salma Adham,&nbsp;Guillaume Armengol,&nbsp;Nicole Cailleux-Talbot,&nbsp;Hervé Levesque,&nbsp;Ygal Benhamou,&nbsp;Sébastien Miranda","doi":"10.1177/1358863X211034919","DOIUrl":"https://doi.org/10.1177/1358863X211034919","url":null,"abstract":"Among patients with unprovoked venous thromboembolism (VTE), the benefit of advanced cancer screening with abdomino-pelvic computed tomography (AP-CT) scan1 or 18-fluorodeoxyglucose positron emission tomography (18FDG PET) scan2 was low. Thus, guidelines do not support the use of CT or PET in routine cancer screening.3 However, the issue of cancer screening according to the clinical presentation of VTE is still debated, especially for bilateral deep vein thrombosis (DVT). This subgroup was outside the scope of the main studies that support current recommendations and previous reports have suggested that bilateral DVT was significantly associated with cancer.4 In this study, we aimed to report the prevalence of occult cancer diagnosed with systematic CT scan in patients admitted for unprovoked VTE according to the presence of bilateral DVT. We retrospectively reviewed the records of patients admitted to Rouen University Hospital, France, between 2007 and 2016, with a new diagnosis of symptomatic VTE (lower limb DVT, pulmonary embolism [PE], or both). Patients who underwent AP-CT (with thorax if CT pulmonary angiography [CTPA] was not initially performed) for cancer screening were included in the analysis. All patients admitted for PE and/or DVT were routinely investigated with bilateral whole leg colour-Doppler ultrasound (CDUS). A cancer was retrospectively adjudicated as occult if the patient with newly diagnosed cancer within 1 year after the thrombotic event was asymptomatic with normal physical examination and normal first-line test results (blood test, mammography, prostate-specific antigen [PSA]) at the time of VTE. A total of 891 patients were identified with lower limb DVT or PE. Of these, 435 (48.8%) events were provoked by transient, persistent risk factors or did not have AP-CT. Of the remaining 456 patients, mean age was 67.7 ± 16.3 years and 216 (47.3%) were male. PE was identified in 315 (69.1%) patients and DVT in 303 (66.44%), including bilateral DVT in 47 (10.3%) cases. A cancer was diagnosed in 83 (18.4%, 95% CI: 15.1–22.2%) patients at the time of the thrombotic event or within the 1-year follow-up. Out of the 83 patients, 31 had a malignancy suspected on the AP-CT scan performed for the diagnosis of PE. Multivariate analysis demonstrated a significant association between malignancy and age over 60 years (odds ratio [OR] = 3.4, 95% CI: 1.5–7.6; p &lt; 0.004), active smoking (OR = 3.0, 95% CI: 1.3–6.8; p = 0.01), and bilateral DVT (OR = 3.3, 95% CI: 1.6–6.5; p &lt; 0.001). Incidence of cancer diagnosis over time was more frequent in patients with bilateral DVT at presentation (hazard rate [HR] = 2.8, 95% CI: 1.64– 4.85; p &lt; 0.001). This association was previously reported in the large MASTER cohort, with a significantly higher incidence of bilateral DVT in patients with cancer than in patients without cancer (8.5% vs 4.6%; p &lt; 0.01).4 Another study reported an association between cancer and bilateral DVT, with an OR = 2.5 (95% CI: 1.3","PeriodicalId":151049,"journal":{"name":"Vascular Medicine (London, England)","volume":" ","pages":"660-661"},"PeriodicalIF":3.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39425077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presidential Address: Action is better than inaction. 总统演讲:行动总比不作为好。
IF 3.5
Vascular Medicine (London, England) Pub Date : 2021-12-01 Epub Date: 2021-10-19 DOI: 10.1177/1358863X211051778
Raghu Kolluri
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