Journal of Biomedical and Clinical Research最新文献_第2页

A study of tumor budding and the factors, affecting interpretability of peritumoral budding, based on endoscopic colorectal biopsies from the left and right sided colorectal carcinoma 基于左右侧结直肠癌的内镜下结直肠活检，研究肿瘤萌芽及影响瘤周萌芽可解释性的因素

Journal of Biomedical and Clinical Research Pub Date : 2024-06-10 DOI: 10.3897/jbcr.e126655

Krasimir T. Petrov, Ivan Ivanov, T. Betova, Reni Tsvetkova, Radoslav G. Trifonov, S. Popovska

{"title":"A study of tumor budding and the factors, affecting interpretability of peritumoral budding, based on endoscopic colorectal biopsies from the left and right sided colorectal carcinoma","authors":"Krasimir T. Petrov, Ivan Ivanov, T. Betova, Reni Tsvetkova, Radoslav G. Trifonov, S. Popovska","doi":"10.3897/jbcr.e126655","DOIUrl":"https://doi.org/10.3897/jbcr.e126655","url":null,"abstract":"In this paper we summarize the results of a retrospective investigation of tumor budding in endoscopic preoperative biopsies in patients with colorectal adenocarcinoma (CRC). The aim of this study was to assess the peritumoral budding evaluation interpretability, based on endoscopic colorectal biopsies in left and right sided colorectal carcinoma and some of the factors that influence it. A group of 100 patients, with preoperative endoscopic biopsies was selected and the tumor buds were counted on H&E stained slides, according to contemporary clinical recommendations. In the studied patient group, budding was identified in a total of 13 patients (13% of the studied cases). The primary localization of the tumor in the left or right colon was not associated with the reporting of budding in endoscopic biopsies of colorectal carcinoma. No budding was observed in highly differentiated tumors, and the presence of budding was reported less frequently in poorly differentiated tumors compared to moderately differentiated ones. Budding was accessible for evaluation in nearly 1/10 of the small biopsies from CRC. Artifacts from the sample management as well as factors related to the tumor characteristics predetermined the possibility for evaluation of tumor budding on small biopsies.","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"116 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of primers and optimization of PCR conditions for the detection of alternatively spliced isoforms of mouse ChAT mRNA 设计引物并优化 PCR 条件以检测小鼠 ChAT mRNA 的替代剪接异构体

Journal of Biomedical and Clinical Research Pub Date : 2024-06-10 DOI: 10.3897/jbcr.e121803

Desislava Marinova, Stefan V. Trifonov

引用次数: 0

Thromboprophylaxis during pregnancy for prevention of adverse complications in patients with inherited thrombophilia: a literature review 为预防遗传性血栓性疾病患者的不良并发症而进行的孕期血栓预防：文献综述

Journal of Biomedical and Clinical Research Pub Date : 2024-06-10 DOI: 10.3897/jbcr.e123690

Zlatko Kirovakov, Elitsa H Gyokova, Nadezdha H. Hinkova, Emiliana Konova

引用次数: 0

Weaknesses of the existing organization of emergency medical care in European countries 欧洲国家现有急救医疗组织的弱点

Journal of Biomedical and Clinical Research Pub Date : 2024-06-10 DOI: 10.3897/jbcr.e125939

Miroslava T. Hristova, Tsvetelina V. Miteva

{"title":"Weaknesses of the existing organization of emergency medical care in European countries","authors":"Miroslava T. Hristova, Tsvetelina V. Miteva","doi":"10.3897/jbcr.e125939","DOIUrl":"https://doi.org/10.3897/jbcr.e125939","url":null,"abstract":"The importance of an emergency medical care system for ensuring affordable and quality healthcare in any country is indisputable. Studying and analyzing existing problems in organizing this system is the first step to solving them. The present study aimed to investigate and outline the possible scope of the problems of emergency medical care, their recurrence, and similarity in 17 European countries. Content analysis of documents was used. The most characteristic organizational problems in providing emergency medical care for each of the countries are identified and grouped into five categories: Direct patient access to hospital emergency departments; Overloading of emergency departments by non-urgent, self-referral patients; Telephone triage by dispatchers - nurses or assistants; Existing and/or impending shortage of doctors in Emergency Medical Services (EMS); Regional and social inequalities in access to emergency medical care.\u0000 A quantitative measurement of the categories and their relative weight were reported. Based on the analysis, the conclusions of the study were drawn. The identified problems, grouped into categories of weaknesses of the existing emergency medical care organization in European countries, may serve as a basis for undertaking health care reforms.","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression in Parkinson’s Disease – Profile and Assessment 帕金森病患者的抑郁 - 概述与评估

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0012

Desislava Е. Marinova, Maya P. Danovska, Yoanna Todorova, Trayana Obreshkova

引用次数: 0

Serum Erythropoietin in Patients with Chronic Renal Failure in the Predialysis Stage 透析前慢性肾衰竭患者血清中的促红细胞生成素

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0018

Gergana V. Todorova, A. Akisheva, Diana I. Pendicheva-Duhlenska, Vasil V. Todorov, Milena Y. Stoimenova, Adelaida Ruseva

{"title":"Serum Erythropoietin in Patients with Chronic Renal Failure in the Predialysis Stage","authors":"Gergana V. Todorova, A. Akisheva, Diana I. Pendicheva-Duhlenska, Vasil V. Todorov, Milena Y. Stoimenova, Adelaida Ruseva","doi":"10.2478/jbcr-2023-0018","DOIUrl":"https://doi.org/10.2478/jbcr-2023-0018","url":null,"abstract":"Summary A prospective study was carried out of serum erythropoietin levels in patients with chronic renal failure/chronic kidney disease in the predialysis period. The study is part of scientific project № 2/2022, financed by Medical University-Pleven. Fifty patients were tested – 22 males and 28 females (average age 63.7±13.0), with average serum creatinine 253±127 mcmol/l and average glomerular filtration rate of 22.6±11.8 ml/min/1,72 m2. The results showed that the serum erythropoietin level varied from 1.86 to 48.50 U/l and was below the borderline in only three patients. There were no significant differences between serum erythropoietin and haemoglobin values in both genders. No differences were found between the average haemoglobin values of patients with different values of serum erythropoietin. Non-significant differences were found in the values of serum erythropoietin in patients with different haemoglobin values. A statistically significant difference between the average value of serum erythropoietin was seen in the group of patients who were not undergoing treatment for anaemia with recombinant erythropoietin (8.5±5.9 U/l) and the groups treated with a dose above 3000 UI/weakly (from 18.6±11.3 to 19.7±8.8 U/l).","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"6 1","pages":"136 - 141"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of Stereotactic Vacuum-Assisted Breast Biopsy in Bulgaria 保加利亚引进立体定向真空辅助乳腺活检术

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0022

Ivelina Y. Petrova-Burdzheva, M. Karamanliev, Daniela P. Simova, Dobromir Dimitrov

引用次数: 0

Squamous Cell Carcinoma of the Skin: Epidemiology, Diagnosis, Management, Recurrence and Mortality Rates for the Bulgarian Population 皮肤鳞状细胞癌：保加利亚人口的流行病学、诊断、管理、复发和死亡率

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0024

Preslav Vasilev, Milen Karaivanov, M. Karamanliev, Dobromir Dimitrov, Petranka Troyanova, I. Yordanova

引用次数: 0

Ocular and Visual Discomfort Epidemic Amid COVID-19 Pandemic: A Sample of Medical Students in Bulgaria 在 COVID-19 大流行中眼部和视力不适的流行：保加利亚医科学生样本

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0019

Vesela I. Lubenova, Zehra B. Gay, S. Murgova

{"title":"Ocular and Visual Discomfort Epidemic Amid COVID-19 Pandemic: A Sample of Medical Students in Bulgaria","authors":"Vesela I. Lubenova, Zehra B. Gay, S. Murgova","doi":"10.2478/jbcr-2023-0019","DOIUrl":"https://doi.org/10.2478/jbcr-2023-0019","url":null,"abstract":"Summary The purpose of оur research was to evaluate the effect of remote education on ocular health among medical students during the current COVID-19 pandemic. The students included in the study were 219 in total, all from Medical Universities in Bulgaria. They were asked about their eye health and comfort during the distance-learning semester. They were interviewed anonymously, with an online questionnaire, between April 1-30, 2021. The findings of the study highlighted that digital learning increases screen time, at potentially dangerous for eye health levels. The most common presenting complaints were eye fatigue (83.1%), tearing (epiphora) (58.9%), dry eyes (58.4%), blurred vision (40.2%), photophobia (37.4%), itchiness (34.7%) etc. Regarding the longest uninterrupted time spent working on a computer, 32% of the students reported 1-2 hours without a break, 57.1% - more than 2 hours, and only 3.7% spent less than 20 min before taking a break. As the conclusion of this study, it was observed that distance learning during the pandemic and social isolation adversely affected eye health and eye fatigue among medical students. Increased screen time during online semester causes digital eye strain, which interferes with the quality of life and is an emerging public health issue.","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"190 1","pages":"142 - 145"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats 日本榅桲果汁对饮食诱发代谢综合征模型大鼠的心脏保护作用

Journal of Biomedical and Clinical Research Pub Date : 2023-11-01 DOI: 10.2478/jbcr-2023-0015

Klementina M. Moneva-Marinova, M. Tzaneva, Elis R. Gasanzadeeva, Mehmed Abtulov, Milena T. Salbashqn, M. Eftimov, Silvia G. Marinova, Maria D. Zhelyazkova‐Savova, S. Valcheva-Kuzmanova

{"title":"Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats","authors":"Klementina M. Moneva-Marinova, M. Tzaneva, Elis R. Gasanzadeeva, Mehmed Abtulov, Milena T. Salbashqn, M. Eftimov, Silvia G. Marinova, Maria D. Zhelyazkova‐Savova, S. Valcheva-Kuzmanova","doi":"10.2478/jbcr-2023-0015","DOIUrl":"https://doi.org/10.2478/jbcr-2023-0015","url":null,"abstract":"Summary The current study aimed to evaluate the influence of Japanese quince (Chaenomeles japonica) fruit juice (JQFJ) on the myocardium and on the coronary arteries of rats with diet-induced metabolic syndrome (MS). Male Wistar rats (n=50) were divided into 5 groups: Control, MS, MS+JQFJ2.5, MS+JQFJ5 and MS+JQFJ10. MS was induced with a high-fat high-fructose diet for 10 weeks. During that period, all animals were daily orally treated with distilled water (Control and MS groups) or with JQFJ at doses of 2.5 ml/kg, 5 ml/kg and 10 ml/kg (the other three groups, respectively). At the end of the experiment, the myocardium and coronary arteries were examined histopathologically. In group MS, necrotic endothelial cells and exposed basal membrane were observed. JQFJ at 2.5 ml/kg reduced the impairment but activated endothelial cells were still found. JQFJ at 5 ml/kg and 10 ml/kg prevented coronary artery endothelium damage, preserving the normal morphology. The myocardium in MS group presented with cardiomyocyte degeneration and increased distance between the cells. In group MS+JQFJ2.5, the degeneration was decreased. In groups MS+JQFJ5 and MS+JQFJ10, the histology of the myocardium resembled that of the control group. In the current histopathological evaluation, JQFJ prevented the MS-induced impairment of myocardium and coronary arteries.","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"594 1","pages":"118 - 123"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139302463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0