Journal of biological regulators and homeostatic agents最新文献

{"title":"Expression of NLR and IL-1β and their predictive efficacy value in acute myocardial infarction patients treated with aspirin combined with clopidogrel.","authors":"Q Ma, W N Li, H Y Liu, H Y Zhang, J Y Dong, X L Tian","doi":"10.23812/21-88-L","DOIUrl":"https://doi.org/10.23812/21-88-L","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39345270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodropropizine in children: over thirty years of clinical experience.","authors":"G Ciprandi, A Licari, M A Tosca, G L Marseglia","doi":"10.23812/21-176-L","DOIUrl":"https://doi.org/10.23812/21-176-L","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39281203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted regulation of BBOX1-AS1 on miR-361-3p and its effect on the biological function of non-small cell lung cancer cell.","authors":"Y F Lian, X M Jiang, L H Sui, X J Shi","doi":"10.23812/21-143-L","DOIUrl":"https://doi.org/10.23812/21-143-L","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39199070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of long non-coding RNA expression profiles in disuse osteoporosis using microarray and bioinformatics.","authors":"W Z Wei,&nbsp;B Li,&nbsp;J X Lin,&nbsp;J Zhao,&nbsp;X F Zhang,&nbsp;X Q Wang,&nbsp;Z Lv,&nbsp;J Liu","doi":"10.23812/21-246-A","DOIUrl":"https://doi.org/10.23812/21-246-A","url":null,"abstract":"<p><p>Disuse osteoporosis (DOP) is one of the major consequences of long space flights. DOP also occurs in patients with spinal cord injuries and prolonged bedridden states that can have a severe impact on human health. Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal cells that play an important role in bone homeostasis. Long non-coding RNAs (lncRNAs) are involved in regulating osteogenic differentiation of BMSCs, and their abnormal expression might lead to the formation of orthopedic diseases. However, the specific mechanism of DOP has not yet been elucidated. All sequencing data were obtained from Gene Expression Omnibus (GEO) datasets. The limma package of R was applied to identify DEmRNAs and DElncRNAs. Pearson correlation coefficients (PCC) between DElncRNADEmRNA expression levels were calculated. Functional annotation was performed for DEmRNAs coexpressed with DElncRNAs. In addition, the Cytohubba plug-in in Cytoscape was applied to determine the top 10 hub genes. Finally, connectivity map (CMap) analysis was used to identify potential therapeutic drugs for DOP. The gene expression data, GSE100930 and GSE17696, were retrieved from the GEO database. A total of 2,212 differentially expressed mRNAs (DEmRNAs) and 22 differentially expressed lncRNAs (DElncRNAs) were obtained. Gene ontology (GO) functional terms, Kyoto Encyclopedia of Genes, and Genomes (KEGG) pathway enrichment analysis reveal 30 significant GO terms and 13 significant pathways. A coding-non-coding gene co-expression (CNC) network was constructed to study the potential role of hub-DElncRNAs and their co-expressed DEmRNAs in DOP. The lncRNAs, GSNAS1, SNHG12, and EPB41LA4A-AS1, were significant in the CNC network and potential regulators of DOP development. Three bioactive compounds (scoulerine, kinetin riboside, dexanabinol) with potential therapeutic significance for DOP were obtained through the Connectivity Map (CMAP) analysis. Our study revealed a new mechanism for a lineage shift of bone marrow mesenchymal stem cells under microgravity, and linked the function of protein-coding mRNAs with ncRNAs, which may contribute to the development of new therapies for DOP.</p>","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39211883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of miRNAs, mRNAs, lncRNAs, and circRNAs associated with hepatocellular carcinoma recurrence after interferon treatment.","authors":"W P Zhu,&nbsp;X G He,&nbsp;H X Zhu,&nbsp;L R Wang,&nbsp;Z H Lin,&nbsp;M Wang,&nbsp;L Wang","doi":"10.23812/21-173-A","DOIUrl":"https://doi.org/10.23812/21-173-A","url":null,"abstract":"<p><p>To study the molecular mechanism of interferon-alpha (IFN-α) in the treatment of hepatocellular carcinoma (HCC) and the molecular markers that can predict the therapeutic effect, differentially expressed (DE)-miRNAs, -mRNAs, -lncRNAs, and -circRNAs were screened between 12 samples collected from 4 patients who had not received treatment (control), 4 patients who had received recombinant human interferon a-2b treatment (case1), and 4 patients who had relapsed after receiving recombinant human interferon a-2b treatment (case2). Enrichment analyses were performed to determine the principal functions of the DE-RNAs. We also constructed protein-protein interactions (PPI) and competing endogenous RNA (ceRNA) networks. In addition, a series-cluster analysis was performed to analyze changes in gene expression across different groups of HCC. Furthermore, the expression of the genes were verified in the Cancer Genome Atlas (TCGA) database. A total of 36 union DE-miRNAs, 175 union DE-mRNAs, 65 union DE-lncRNAs, and 52 union DE-circRNAs were obtained between the control vs case1, and case2 vs case1 groups. DE-mRNAs were mainly involved in the mitochondrial inner membrane. DE-circRNAs were mainly enriched in the Golgi apparatus. ceRNA network contained 68 DE-mRNAs, 26 DE-miRNAs, 45 DE-lncRNAs, and 23 DE-circRNAs. A total of 24 DE-miRNAs, 175 DE-mRNAs, 65 DE-lncRNAs, and 52 DE-circRNAs were classified into eight profiles, respectively. A total of 26 genes showed a significant correlation with prognosis of HCC (p < 0.05). Some genes may be used to predict the efficacy of IFN-α in the treatment of HCC. The results may lay a foundation for investigating the different sensitivities of IFN-α in the treatment of HCC.</p>","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39212757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of early oral and perioral physiotherapy on feeding autonomy in preterm infants: results of randomized controlled trials.","authors":"M S Cori,&nbsp;P E Ferrara,&nbsp;P Papacci,&nbsp;F Serrao,&nbsp;A Di Polito,&nbsp;A Del Vecchio,&nbsp;I Bastoni,&nbsp;C Di Paola,&nbsp;U Moscato,&nbsp;S Codazza,&nbsp;G Ferriero,&nbsp;G Vento,&nbsp;G Ronconi","doi":"10.23812/21-199-L","DOIUrl":"https://doi.org/10.23812/21-199-L","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39341764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of circRNA-mediated competing endogenous RNA network in the development of bladder urothelial carcinoma.","authors":"S P Shao,&nbsp;R J Zhao,&nbsp;S Lu,&nbsp;L P Wen,&nbsp;J J Ni,&nbsp;K M Zhu,&nbsp;W D Han","doi":"10.23812/21-117-L","DOIUrl":"https://doi.org/10.23812/21-117-L","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39355543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level changes of serum high-sensitivity C-reactive protein and vascular endothelial growth factor in patients with St-segment elevation myocardial infarction after percutaneous coronary intervention.","authors":"H G Wang,&nbsp;X H Ji,&nbsp;C C Wang,&nbsp;X L Tian","doi":"10.23812/21-SI1-4","DOIUrl":"https://doi.org/10.23812/21-SI1-4","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39273732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"microRNA-486-5p functions as a tumor suppressor in gastric carcinoma via directly targeting KDM5B.","authors":"Y B Li,&nbsp;X Y Fan,&nbsp;L Ning,&nbsp;S K Li,&nbsp;Z P Yu","doi":"10.23812/21-SI1-2","DOIUrl":"https://doi.org/10.23812/21-SI1-2","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39259071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of lutein in cerebral ischemia-reperfusion injury in rats and its mechanism.","authors":"A X Yang,&nbsp;C Y Liu,&nbsp;H Y Liu,&nbsp;T T Li,&nbsp;B F Ren,&nbsp;P P Qiao","doi":"10.23812/21-SI1-3","DOIUrl":"https://doi.org/10.23812/21-SI1-3","url":null,"abstract":"","PeriodicalId":15084,"journal":{"name":"Journal of biological regulators and homeostatic agents","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39273731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}