Journal of Biosciences and Medicines最新文献_第6页

Codiaeum Variegatum Hydro Alcoholic Leaf Extracts and Their Fractions Inhibit Pro-Inflammatory Mediators in Vitro 黄菖蒲醇提取物及其组分对促炎介质的体外抑制作用

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.115004

S. Nsangou, Charifa Ngbetnkom Mandou, Carine Matsingang Fondjou, Vigny Sayal Ngohoba, Edie Brice Enang II, Ibrahim Njingou, E. Njoya, F. N. Njayou, P. M. Fewou

引用次数: 1

The Main and Interactive Effects of Fat and Salt Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats 饮食中脂肪和盐含量对雄性Wistar大鼠代谢综合征特征的主要和交互作用

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.116016

A. Jahan-mihan, K. Schwarz, Leila Ninya, Tatyana Kimble

{"title":"The Main and Interactive Effects of Fat and Salt Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats","authors":"A. Jahan-mihan, K. Schwarz, Leila Ninya, Tatyana Kimble","doi":"10.4236/jbm.2023.116016","DOIUrl":"https://doi.org/10.4236/jbm.2023.116016","url":null,"abstract":"The current Western diet contains high amounts of salt and fat. High salt and fat diets are known to have negative impacts on food intake (FI), body weight (BW), body composition (BC), glucose metabolism, and blood pressure. These factors have been studied as separate entities, but the main and interactive effects of dietary salt and fat received little study. The objective of this study was to examine the effect of sodium and fat content of the diet on FI, BW, and BC in male Wistar rats. Male Wistar Rats (n = 48) were allocated into 4 groups (n = 12) and received the following diets: 1. Normal sodium normal fat, 2. Normal sodium high fat, 3. High sodium normal fat, and 4. High sodium high-fat diet for 12 weeks. BW and FI were measured weekly. BC and organs’ weight were recorded post-termination. Regardless of sodium content, a greater FI was observed in normal-fat diet groups compared with high-fat diet groups. However, higher BW and fat (%) were observed in high-fat diet groups. Fasting blood glucose was higher in rats fed normal fat diets compared with those fed high-fat diets. Systolic and diastolic blood pressure was lower in rats fed either high fat, high salt, or normal fat, normal salt diet. In conclusion, fat but not salt content in the diet is a determining factor in the regulation of FI and body weight. Moreover, glucose metabolism can be influenced by both the fat and salt content of the diet.","PeriodicalId":15067,"journal":{"name":"Journal of Biosciences and Medicines","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88579287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Pulmonary Tuberculosis and Associated Factors among Patients Admitted to the Amissa Bongo University Hospital Center in Franceville, Gabon 加蓬弗朗斯维尔Amissa Bongo大学医院中心住院患者肺结核患病率及相关因素

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.117014

Thiéry Ndong Mba, C. Obiang, H. Kenguele, A. B. Pambo-Pambo, Iris Kévin Ivala Zogo Mba, Ulrich Lowens Onkassa Sah, Louis Clément Obame Engonga, C. Bisseye, P. Mickala

引用次数: 0

A 365-Day Record of Maternal Admissions in Intensive Care Unit at the University of Port Harcourt Teaching Hospital in Nigeria 尼日利亚哈科特港大学教学医院重症监护病房365天产妇入院记录

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.114021

J. Otokwala, O. John

引用次数: 2

Patient Recruitment in Clinical Trials: Areas of Challenges and Success, a Practical Aspect at the Private Research Site 临床试验中的患者招募:挑战与成功的领域，私人研究站点的实际方面

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.1110010

Pranali M. Wandile

{"title":"Patient Recruitment in Clinical Trials: Areas of Challenges and Success, a Practical Aspect at the Private Research Site","authors":"Pranali M. Wandile","doi":"10.4236/jbm.2023.1110010","DOIUrl":"https://doi.org/10.4236/jbm.2023.1110010","url":null,"abstract":"Enrolling in clinical trials could be time-sensitive and time-demanding tasks for the research site, especially if it is a private research organization compared to the research conducted at an academic or medical center. Every study differs in various aspects, such as phases, study indication, eligibility criteria, etc. In terms of meeting the enrollment deadline, typically, the study indication and availability of the patient’s population at the geographical area of the research site would decide if the trial could be time-consuming. Patient recruitment and retention are critical for the success of every clinical trial; however, worldwide, this area is facing tremendous pressure and challenges. Globally 55% of clinical trials terminated due to low recruitment, with an average enrollment success rate of 40% for Phase III and IV trials. Over 80% of clinical trial attempts fail to enroll, extending the study and adding new study sites. In the United States, more than 80% of clinical trials fail to achieve targeted patient enrollment, and 30% of study participants discontinue participation. This article reviewed various factors hindering clinical trial recruitment and retention and suggested strategies to make the research site successful.","PeriodicalId":15067,"journal":{"name":"Journal of Biosciences and Medicines","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135007028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Lactobacillus and Bifidobacterium 16S rRNA Gene in Breast Milk of Some Healthy Women in Kinshasa (DR Congo) 金沙萨部分健康妇女母乳中乳酸菌和双歧杆菌16S rRNA基因的鉴定

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.112022

O. Nzingula, Junior Disashi, J. Mulwahali, P. Kabututu, Paola Biakas, J. Masumu

引用次数: 0

Exploring Chemovar-Specific Cannabis Extracts Quantification and Evaluation of Cytotoxic Compounds for Targeting Glioblastoma Multiforme 探索化疗特异性大麻提取物对多形性胶质母细胞瘤细胞毒性化合物的定量和评价

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.118015

Ashraf Duzan, M. Basti, Travis Cesarone, W. Debinski, Daniel Todd

引用次数: 0

Information Needs and Self-Care Practices of Diabetic Patients in Mbala, Northern Province, Zambia 赞比亚北部省姆巴拉市糖尿病患者的信息需求和自我保健实践

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.113014

Chisha Jones Simuyemba, Patricia Katowa-Mukwato Patricia, K. Chitundu, Michael Mumba Kanyanta

引用次数: 0

Clinical Observation of Hemodynamic and Cerebral Protective Effects of Different Doses of Dexmedetomidine in Patients with Traumatic Brain Injury 不同剂量右美托咪定对颅脑外伤患者血流动力学及脑保护作用的临床观察

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.112010

Jiacai Dong, Lei Liu, Jingwei Liu, Yan-bo Peng

引用次数: 0

Iron Status of a People Living with HIV in Sub-Saharan Africa Using a Multi-Criteria Approach Based on the Determination of Blood Ferritin, sTfR, CRP and sTfR-F Index 使用基于血液铁蛋白、sTfR、CRP和sTfR- f指数测定的多标准方法检测撒哈拉以南非洲HIV感染者的铁状况

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.115017

Joelle Akissi Koffi, H. Ahiboh, Philémond By, D. Gabillard, Affi Roseline, Francisk Kouakou, Inwoley André

引用次数: 0