Journal of Biosciences and Medicines最新文献_第6页

A 365-Day Record of Maternal Admissions in Intensive Care Unit at the University of Port Harcourt Teaching Hospital in Nigeria 尼日利亚哈科特港大学教学医院重症监护病房365天产妇入院记录

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.114021

J. Otokwala, O. John

引用次数: 2

Role of Genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil 遗传祖先在口咽鳞状细胞癌中的作用:巴西的横断面研究

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.111015

Chrystiano Campos Ferreira, R. R. Gama, A. C. de Carvalho, I. Santana, R. Carvalho, Debora S. De A. e Silva, L. M. de Jesus, R. Reis, R. Dufloth

引用次数: 1

Syphilis and HIV Infection among Pregnant Women Previously Screened Negative during Their First Antenetal Care Visit (ANC) at Some Selected Health Facilities in the Buea Health District, Cameroon 在喀麦隆布埃亚卫生区一些选定的卫生机构进行第一次产前检查(ANC)时筛查呈阴性的孕妇中的梅毒和艾滋病毒感染情况

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.117006

Mbanya Gladice Mbanya, N. A. Longdoh, H. Ngouakam, S. Ako

引用次数: 0

Physical Activity Alters Superoxide Dismutase Activity and Intercellular Adhesion Molecule 1 Levels in Diabetes Mellitus Type 2 Patients 运动改变2型糖尿病患者超氧化物歧化酶活性和细胞间粘附分子1水平

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.117012

Anderson Martins Tavares, Leonardo Matta, Jaslana Hainfellner da Silva, Christiane de Oliveira Bensusan, C. Nascimento, G. F. Taboada, R. Fortunato, L. C. Cardoso-Weide

引用次数: 0

Calpain-1 Mediated Mitochondria ROS/NLRP3 Inflammasome in Atherosclerosis 动脉粥样硬化中Calpain-1介导的线粒体ROS/NLRP3炎性体

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.114005

Futian Tang, Mohamed Ali Awad

引用次数: 0

Research Hotspot and Application Status of Immune Evasion Mechanism in Ovarian Cancer 卵巢癌免疫逃避机制的研究热点及应用现状

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.114032

Yuchun Zhang, Hui Wang

引用次数: 0

Effect of Purified Paper Wasp Ropalidia marginata Venom Toxins on Different Biomolecules in Mice Serum 纯化纸胡蜂毒毒素对小鼠血清中不同生物分子的影响

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.115005

Simran Sharma, R. Upadhyay

引用次数: 0

The Main and Interactive Effects of Fat and Salt Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats 饮食中脂肪和盐含量对雄性Wistar大鼠代谢综合征特征的主要和交互作用

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.116016

A. Jahan-mihan, K. Schwarz, Leila Ninya, Tatyana Kimble

{"title":"The Main and Interactive Effects of Fat and Salt Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats","authors":"A. Jahan-mihan, K. Schwarz, Leila Ninya, Tatyana Kimble","doi":"10.4236/jbm.2023.116016","DOIUrl":"https://doi.org/10.4236/jbm.2023.116016","url":null,"abstract":"The current Western diet contains high amounts of salt and fat. High salt and fat diets are known to have negative impacts on food intake (FI), body weight (BW), body composition (BC), glucose metabolism, and blood pressure. These factors have been studied as separate entities, but the main and interactive effects of dietary salt and fat received little study. The objective of this study was to examine the effect of sodium and fat content of the diet on FI, BW, and BC in male Wistar rats. Male Wistar Rats (n = 48) were allocated into 4 groups (n = 12) and received the following diets: 1. Normal sodium normal fat, 2. Normal sodium high fat, 3. High sodium normal fat, and 4. High sodium high-fat diet for 12 weeks. BW and FI were measured weekly. BC and organs’ weight were recorded post-termination. Regardless of sodium content, a greater FI was observed in normal-fat diet groups compared with high-fat diet groups. However, higher BW and fat (%) were observed in high-fat diet groups. Fasting blood glucose was higher in rats fed normal fat diets compared with those fed high-fat diets. Systolic and diastolic blood pressure was lower in rats fed either high fat, high salt, or normal fat, normal salt diet. In conclusion, fat but not salt content in the diet is a determining factor in the regulation of FI and body weight. Moreover, glucose metabolism can be influenced by both the fat and salt content of the diet.","PeriodicalId":15067,"journal":{"name":"Journal of Biosciences and Medicines","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88579287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Pulmonary Tuberculosis and Associated Factors among Patients Admitted to the Amissa Bongo University Hospital Center in Franceville, Gabon 加蓬弗朗斯维尔Amissa Bongo大学医院中心住院患者肺结核患病率及相关因素

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.117014

Thiéry Ndong Mba, C. Obiang, H. Kenguele, A. B. Pambo-Pambo, Iris Kévin Ivala Zogo Mba, Ulrich Lowens Onkassa Sah, Louis Clément Obame Engonga, C. Bisseye, P. Mickala

引用次数: 0

Patient Recruitment in Clinical Trials: Areas of Challenges and Success, a Practical Aspect at the Private Research Site 临床试验中的患者招募:挑战与成功的领域，私人研究站点的实际方面

Journal of Biosciences and Medicines Pub Date : 2023-01-01 DOI: 10.4236/jbm.2023.1110010

Pranali M. Wandile

{"title":"Patient Recruitment in Clinical Trials: Areas of Challenges and Success, a Practical Aspect at the Private Research Site","authors":"Pranali M. Wandile","doi":"10.4236/jbm.2023.1110010","DOIUrl":"https://doi.org/10.4236/jbm.2023.1110010","url":null,"abstract":"Enrolling in clinical trials could be time-sensitive and time-demanding tasks for the research site, especially if it is a private research organization compared to the research conducted at an academic or medical center. Every study differs in various aspects, such as phases, study indication, eligibility criteria, etc. In terms of meeting the enrollment deadline, typically, the study indication and availability of the patient’s population at the geographical area of the research site would decide if the trial could be time-consuming. Patient recruitment and retention are critical for the success of every clinical trial; however, worldwide, this area is facing tremendous pressure and challenges. Globally 55% of clinical trials terminated due to low recruitment, with an average enrollment success rate of 40% for Phase III and IV trials. Over 80% of clinical trial attempts fail to enroll, extending the study and adding new study sites. In the United States, more than 80% of clinical trials fail to achieve targeted patient enrollment, and 30% of study participants discontinue participation. This article reviewed various factors hindering clinical trial recruitment and retention and suggested strategies to make the research site successful.","PeriodicalId":15067,"journal":{"name":"Journal of Biosciences and Medicines","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135007028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0