Journal of Basic Research in Medical Sciences最新文献_第6页

Investigation of UV/TiO2-N photocatalytic degradation of AR 40 using response surface methodology (RSM) 响应面法研究UV/TiO2-N光催化降解AR40

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-15 DOI: 10.18869/ACADPUB.JBRMS.4.2.29

M. Nademi, M. Moraveji, M. Mansouri

引用次数: 5

The impact of fatigue on balancing in creating re-injuries in mountaineers with chronic ankle sprain 疲劳对慢性踝关节扭伤登山运动员再损伤平衡的影响

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-15 DOI: 10.18869/ACADPUB.JBRMS.4.2.41

H. Ebrahimi, M. Shahrokhi, Zahra Toktam Barmar, R. Balouchi

{"title":"The impact of fatigue on balancing in creating re-injuries in mountaineers with chronic ankle sprain","authors":"H. Ebrahimi, M. Shahrokhi, Zahra Toktam Barmar, R. Balouchi","doi":"10.18869/ACADPUB.JBRMS.4.2.41","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.2.41","url":null,"abstract":"Introduction: Sensory-motor control and in general gaining balance will be impaired after an ankle injury and in fatigue situations. The aim of this research was to study the effect of exercise-based fatigue on static and dynamic balance in mountaineering athletes who were successful in returning to a suitable level of physical activity after an ankle sprain injury. Materials and methods: 25 active mountaineering athletes between 20 and 40 years were recruited on a voluntary basis. 12 persons with severe ankle sprain in the past were selected as experimental group and 13 healthy mountaineering athletes were selected as control group. Because balance test measuring was under the influence of evaluation time; fatigue test measurement running on the treadmill was performed in 2 sessions. Changes or fluctuations in the pressure Center or static balance were evaluated by Sharpened Romberg balance test and dynamic balance was evaluated by stability time after side jumping (the first session) and the maximum distance in the balance test Y (second session) were evaluated in the pre-test and post-test immediately after fatigue resulted by running on a treadmill. Data were analyzed using covariance test. Results: before fatigue condition, there were a few differences between the two groups in stability time while doing side jump test (P<0.014). After the fatigue and in balance test Y and stability time while doing side jump test; there were more differences (P<0.001). In this case, there was a similar increase on static swing in both groups. Fatigue was considerably reduced the static and dynamic postural control of the athletes who had a history of injury. Changes related to fatigue was significant in dynamic postural control in athletes with previous ankle sprain history. Conclusion: Even after the successful return to sport for athletes with previous damages, abnormalities in sensory-motor control and balance may lead to an increase the risk of ankle","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44737477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The short-term survival following acute myocardial infarction: A prospective observational study 急性心肌梗死后的短期生存:一项前瞻性观察研究

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-01 DOI: 10.18869/ACADPUB.JBRMS.4.2.9

M. Aryaie, F. Bakhsha, Seyyed Yaghub Jafari, Z. Yousefi, A. Heidari, Z. Esmaeili, S. Sobhani, Shima Aghili

{"title":"The short-term survival following acute myocardial infarction: A prospective observational study","authors":"M. Aryaie, F. Bakhsha, Seyyed Yaghub Jafari, Z. Yousefi, A. Heidari, Z. Esmaeili, S. Sobhani, Shima Aghili","doi":"10.18869/ACADPUB.JBRMS.4.2.9","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.2.9","url":null,"abstract":"Introduction: To investigate 28 days survival rate following first acute myocardial infarction (AMI) associated with the presence of classical risk factors and treatment modalities in Gorgan, north of Iran. Materials and methods: Our cohort including all patients hospitalized due to AMI from 2010 to 2013. Data were collected on demographic, prophylactic drugs and classical coronary risk factors. Data were analyzed using Kaplan-Meier and log rank tests. Cox proportional hazard model was built to estimate relative risk by taking into account other variables. Results: Median age of subjects was 58 and 64 for men and women, respectively; moreover, the occurrence of diabetes was 52.5 and 24.5 for them. A poorer outcome was detected in survival rate for women in the final model. Excess death occurrence in Fars or nonPersian ethnicity, and those who were not prescribed statin was detected in the adjusted model. Conclusion: A better survival rate for those who were prescribed statin suggest that it could be beneficial in treatment modality and non-Persian ethnicities needed to be considered as a group of at risk for earlier screening programs. In spite of some other studies a poorer outcome following AMI for women was found even after taking into account age and comorbidity.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43926392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells as a reference cell for HLA-typing 间充质干细胞作为hla分型的参比细胞

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-01 DOI: 10.18869/acadpub.jbrms.4.2.50

R. M. Khalilabadi, F. Yari, N. Amirizadeh, M. Nikougoftar, A. Oodi

{"title":"Mesenchymal stem cells as a reference cell for HLA-typing","authors":"R. M. Khalilabadi, F. Yari, N. Amirizadeh, M. Nikougoftar, A. Oodi","doi":"10.18869/acadpub.jbrms.4.2.50","DOIUrl":"https://doi.org/10.18869/acadpub.jbrms.4.2.50","url":null,"abstract":"Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high expenses. On the other hand, transferring of these cells is problematic and in some instances is not practical. In this study, we introduced umbilical cord-derived mesenchymal stem cells (MSCs) as reference cells for HLA genotyping. These cells are national and can be prepared locally. Materials and methods: We isolated MSCs from three umbilical cord and after their growth and proliferation, these cells were characterized by flow cytometry technique using antibodies to CD29, CD34, CD44, CD45, CD73, CD90 and CD105. HLA-typing was then carried out by PCR-SSP kits for HLA-A, -B and -DRB allele’s identification. Results: Isolated MSCs were positive for MSCs markers; CD29, CD44, CD73, CD90, and CD105 and negative for hematopoietic stem cell markers; CD34 and CD45. HLA alleles were determined. One of the samples was homologous for HLA alleles and the others were heterologous. Conclusion: We can develop a reference panel for HLA-typing by obtaining MSCs from available sources like umbilical cord.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"50-57"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46834904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The effect of lansoprazole administration during pregnancy on the placenta 妊娠期兰索拉唑对胎盘的影响

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-01 DOI: 10.18869/ACADPUB.JBRMS.4.2.24

A. Monfared, M. Shamsi

{"title":"The effect of lansoprazole administration during pregnancy on the placenta","authors":"A. Monfared, M. Shamsi","doi":"10.18869/ACADPUB.JBRMS.4.2.24","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.2.24","url":null,"abstract":"Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administration. Materials and methods: A total of 24 pregnant Balb/C mice were randomly divided into one control and three experiment groups (n=6).The experimental animals were given 25, 50 and 100 mg/kg of lansoprazole intraperitoneally on days 6-16 of pregnancy. At the end point and on the day 17 of gestation all animals were sacrificed. Then, the placentas specimens were taken and processed for histological examinations. Histological sections were stained with hematoxylin-eosin and were examined under light microscopy. Results: The histological examinations showed remarkable cellular changes in the placenta after treatment with lansoprazole. The placentas from drug administrated mice exhibited conspicuous decrease in the spongy layers size when compared with controls. Also, both polymorph and mononuclear cell infiltration into placental parenchyma were seen in the animals treated with 100 mg/kg lansoprazole. In addition, dilation of the intervillous space, massive vasculature congestion, increased giant cell population and fibroblastic proliferation were seen in the placental tissues from experimental groups. Conclusion: The findings of the present study led us to investigate the effect of the lansoprazole administration on the mouse placenta. Taken together, this drug should not be prescribed during pregnancy.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45648118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions 未经治疗干预的雄性大鼠脊髓挫伤模型的功能恢复评估

Journal of Basic Research in Medical Sciences Pub Date : 2017-03-01 DOI: 10.18869/acadpub.jbrms.4.2.17

S. Rezaei, S. Bakhtiari, K. Asadollahi, Somayeh Heidarizadi, A. Moayeri, M. Azizi

{"title":"Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions","authors":"S. Rezaei, S. Bakhtiari, K. Asadollahi, Somayeh Heidarizadi, A. Moayeri, M. Azizi","doi":"10.18869/acadpub.jbrms.4.2.17","DOIUrl":"https://doi.org/10.18869/acadpub.jbrms.4.2.17","url":null,"abstract":"Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to regeneration of axons in the spinal cord. However, the studies have found that over time, a spontaneous partial motor recovery is observed in animals with injury without intervention. Thus, in this study, the recovery of animals with spinal cord injury was assessed after 12 weeks. Materials and methods: In this study, 12 adult male Wistar rats weighing approximately 265±15gr were used to assess spinal cord injury and randomly divided into 3 groups: normal control (n = 3), sham (n = 3), injury (n = 6). Healthy animals in the normal control group received no laminectomy or injury, and laminectomy with or without contusion model using weight drop in segment T10 of spinal cord were carried out in injury and sham groups, respectively. Locomotor function of animals in all groups were evaluated by BBB test at the first 48 hours per day and then weekly for 12 weeks. Results: Comparison of the results of motor evaluation from the second week to the twelfth week of the group with injury without treatment showed a relative functional recovery as the BBB score of animals from 1.4 in the second week after the injury reached to 6.5 in the twelfth week. Conclusion: The results indicate a spontaneous partial recovery in injured animals without intervention.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48392389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality assessment of care provided to patients with type 2 diabetes based on Clinical Practice Guidelines 基于临床实践指南的2型糖尿病患者护理质量评估

Journal of Basic Research in Medical Sciences Pub Date : 2017-01-15 DOI: 10.18869/ACADPUB.JBRMS.4.1.1

J. Tabrizi, Y. Partovi, A. Bahrami, M. Asghari

{"title":"Quality assessment of care provided to patients with type 2 diabetes based on Clinical Practice Guidelines","authors":"J. Tabrizi, Y. Partovi, A. Bahrami, M. Asghari","doi":"10.18869/ACADPUB.JBRMS.4.1.1","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.1.1","url":null,"abstract":"Introduction: Diabetes is one of the usual medical problems that had an important negative effect on patient’s health. Researches demonstrate that there is a wide gap between recommended medical actions and received care by patients with diabetes. The aim of study was to assess the quality of care provided to patients with type 2 diabetes. Materials and methods: A cross-sectional study was carried out among 180 people with type 2 diabetes in diabetic’s clinics using convenience sampling method in Tabriz, Iran in 2011. Using a questionnaire we assessed the reported adherence to minimum recommended annual care for 23 processes indicators based on Iranian Diabetes Guidelines. Results: The proportions of the participants who received recommended annual care for all three top clinical and all six top lifestyle indicators were 82.26% and 43.96%, respectively. For lifestyle and management indicators, reported adherence rates to guidelines were low (38.9% for medication review, 67.7% for self-management evaluation, 55% for physical activity review, and 58.3% for nutrition consultation). From the participants' perspective, most of the participants (87%) had well-controlled diabetes. Conclusion: A substantial proportion of people with type 2 diabetes indicated receiving suboptimal care and there is a notable gap between their expectations and what they have actually received in most aspects of the provided care.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43607974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the prevalence rate of hypertension in Iranian men and women: A study of systematic review and meta-analysis 伊朗男性和女性高血压患病率调查：系统综述和荟萃分析研究

Journal of Basic Research in Medical Sciences Pub Date : 2017-01-15 DOI: 10.18869/ACADPUB.JBRMS.4.1.53

Yousof Mohsenzadeh, Morteza Motedayen, F. Hemmati, K. Sayehmiri, M. Sarokhani, Diana Sarokhani

{"title":"Investigating the prevalence rate of hypertension in Iranian men and women: A study of systematic review and meta-analysis","authors":"Yousof Mohsenzadeh, Morteza Motedayen, F. Hemmati, K. Sayehmiri, M. Sarokhani, Diana Sarokhani","doi":"10.18869/ACADPUB.JBRMS.4.1.53","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.1.53","url":null,"abstract":"Introduction: Based on the serious complications which are followed, hypertension is a common and asymptomatic health problem. This study aims to present a general statistics of the rate of the prevalence of systolic and diastolic hypertension in Iranian men and women based on the age range through the systematic review and meta-analysis method. Materials and methods: In this study of systematic review and meta-analysis, some databases such as Google Scholar, Scope.com, Magiran, Iran Medex, Medlib, Sid, and Pubmed were searched by using keywords such as hypertension, men and women, Iran, and prevalence. The first and the last published articles in this field were in 1999 and 2012, respectively. Data were combined by random effects meta-analysis model and they were analyzed by STATA11. Results: From 100 articles which were found in the searched references, 22 of them were finally analyzed. Among the selected final articles from 1999 to 2012, 96689 subjects were used in this study. The mean prevalence of hypertension was 17% (confidence coefficient of 95%, 17-17%). The prevalence rate of hypertension among the people above 20 was between 10-32% and its mean was 24% (confidence coefficient of 95%, 23-24%). The mean prevalence of hypertension among the people below 20 was 5% (confidence coefficient of 95%, 4-5%). Conclusion: In the studies done in Iran, the prevalence rate of hypertension was high. Noticing that hypertension is an important and dangerous factor for cardiovascular diseases, it is a worrying issue in Iran and it is necessary to be programmed in order to control and prevent this disease.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2017-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45459110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effects of Flaxseed oil supplementation on renal dysfunction due to ischemia/reperfusion in rat 补充亚麻籽油对大鼠缺血再灌注肾功能的影响

Journal of Basic Research in Medical Sciences Pub Date : 2017-01-01 DOI: 10.18869/ACADPUB.JBRMS.4.1.22

Tahmineh Mokhtari, Hedyeh Faghir Ghanesefat, G. Hassanzadeh, A. Moayeri, Seyed Mohammad Jafar Haeri, A. R. Kanavee, Seyyed Majid Mousavi Movahed

引用次数: 6

Effect of olfactory ensheathing cells (OECs) transplantation on functional recovery in acute phase of spinal contused rats 嗅鞘细胞移植对脊髓挫伤大鼠急性期功能恢复的影响

Journal of Basic Research in Medical Sciences Pub Date : 2017-01-01 DOI: 10.18869/ACADPUB.JBRMS.4.1.30

Somayeh Heidarizadi, N. Abbasi, K. Asadollahi, S. Rezaei, A. Moayeri, M. Azizi

{"title":"Effect of olfactory ensheathing cells (OECs) transplantation on functional recovery in acute phase of spinal contused rats","authors":"Somayeh Heidarizadi, N. Abbasi, K. Asadollahi, S. Rezaei, A. Moayeri, M. Azizi","doi":"10.18869/ACADPUB.JBRMS.4.1.30","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBRMS.4.1.30","url":null,"abstract":"Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits. Poor prognosis of patients is the motivation of searching a treatment for the chronic injury. Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results. This study aims at evaluating the effect of transplanted OECs on functional recovery of acute SCI in rats. Materials and methods: In this study, eighteen adult male Wistar rats weighting approximately 210 ± 10 gr were used to study spinal cord injury. They were randomly divided into four groups: Sham (n = 3), Control (n = 6), Vehicle (n=3) and Treatment (n=6). In the Sham Group, only laminectomy was performed in the area of T9 spinal cord. In three groups of Control, vehicle and Treatment, after laminectomy, spinal cord contusion model was performed using the Weight drop technique. Immediately after the injury, 10μl Dulbecco's Modified Eagle Medium (DMEM) alone or with 10 cells were injected to vehicle and Treatment Group animals. For culturing cells, the olfactory mucosa of 7-day-old male Wistar rats was used. Motor function of animals in all groups, was evaluated in the first 48 hours daily and then weekly for eight weeks. Results: Comparing the results of the second to eighth week of the study showed significant differences in the group receiving the OECs with the control group (P<0.05). Conclusion: The results indicate a positive influence of the olfactory ensheathing cells in functional improvement of spinal cord injury in the acute phase of injury.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67673166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3