Journal of Basic and Clinical Pharmacy最新文献_第2页

Effects of Rosuvastatin Alone or in Combination with Omega-3 Fatty Acid on Adiponectin Levels and Cardiometabolic Profile 瑞舒伐他汀单独或联合Omega-3脂肪酸对脂联素水平和心脏代谢谱的影响

Journal of Basic and Clinical Pharmacy Pub Date : 2016-12-01 DOI: 10.4103/0976-0105.195080

H. Al-kuraishy, Ali I. Al-Gareeb

{"title":"Effects of Rosuvastatin Alone or in Combination with Omega-3 Fatty Acid on Adiponectin Levels and Cardiometabolic Profile","authors":"H. Al-kuraishy, Ali I. Al-Gareeb","doi":"10.4103/0976-0105.195080","DOIUrl":"https://doi.org/10.4103/0976-0105.195080","url":null,"abstract":"Background: Adiponectin is an important adipocyte-related protein that has been postulated to participate in prevention of the development of metabolic syndrome. The relationship between adiponectin serum levels and risk of coronary artery disease (CAD) has been widely investigated and remains controversial. The aim of the present study was to evaluate the effects of rosuvastatin and/or omega-3 fatty acid on adiponectin serum levels in patients with insulin resistance (IR) and CAD. Patients and Methods: This study involved 87 patients with CADs and IR of different etiology, the patients were divided into three groups; 24 patients on treatment with rosuvastatin, 22 patients on treatment with omega-3 fatty acid, 23 patients on treatment with omega-3 fatty acid and rosuvastatin, 18 patients were not previously or currently treated with either rosuvastatin or omega-3 fatty acid, those regarded as control patients. Anthropometric measures, adiponectin serum levels, and other biochemical parameters were assessed in each treated group. Results: Rosuvastatin therapy leads to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 6.76 ± 1.03 ng/mL compared to control P < 0.01. Omega-3 fatty acid therapy leads to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 6.11 ± 1.29 ng/mL compared to control P < 0.01. Rosuvastatin plus omega-3 fatty acid therapy lead to a significant elevation in adiponectin serum levels from 4.1 ± 0.99 ng/mL to 7.99 ± 1.76 ng/mL compared to control P < 0.01. Conclusions: Rosuvastatin and/or omega-3 fatty acid lead to significant cardiometabolic protection through an increment in adiponectin serum levels.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"20 1","pages":"8 - 14"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87348994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Antiepileptic Drugs-induced Stevens–Johnson syndrome: A case Series 抗癫痫药物诱导的史蒂文斯-约翰逊综合征:一个病例系列

Journal of Basic and Clinical Pharmacy Pub Date : 2016-12-01 DOI: 10.4103/0976-0105.195130

B. Trivedi, N. Darji, S. Malhotra, Pankaj R. Patel

引用次数: 11

Rare Manifestation of Digoxin Toxicity: Right Bundle Branch Block 地高辛毒性的罕见表现:右束支阻滞

Journal of Basic and Clinical Pharmacy Pub Date : 2016-12-01 DOI: 10.4103/0976-0105.195128

D. Gill, S. Zaidi

引用次数: 2

Prevalence of potentially inappropriate medications and prescription cost analysis among older cardiac patients in an outpatient department of a tertiary care hospital in India 印度某三级医院门诊部老年心脏病患者中潜在不适当药物的流行程度和处方成本分析

Journal of Basic and Clinical Pharmacy Pub Date : 2016-07-01 DOI: 10.4103/0976-0105.189434

K. Shah, Harshdeep Joshi, R. P. Christian, K. Patel, S. Malhotra

{"title":"Prevalence of potentially inappropriate medications and prescription cost analysis among older cardiac patients in an outpatient department of a tertiary care hospital in India","authors":"K. Shah, Harshdeep Joshi, R. P. Christian, K. Patel, S. Malhotra","doi":"10.4103/0976-0105.189434","DOIUrl":"https://doi.org/10.4103/0976-0105.189434","url":null,"abstract":"Aims: The aim of this study is to evaluate potentially inappropriate medications (PIMs) in the elderly at cardiology outpatient department (OPD) of a tertiary care teaching hospital using Beers criteria and to find the direct cost burden of PIMs. Materials and Methods: The present study was an observational cross-sectional study. Prescriptions of the patients′ aged ≥65 years were collected from the cardiology OPD and were analyzed. PIMs were identified with the help of Beers 2012 criteria. Direct costs of prescribed drugs were calculated. Predictors (comorbid conditions, number of drugs prescribed) associated with PIM use were identified using bivariate analysis. Multivariate logistic regression was then applied to study the influence of these variables on PIM use. A P < 0.05 was considered statistically significant. Results: A total of 236 patients received 1443 drugs. According to Beers 2012 criteria, 29.3% patients received at least one PIM followed by two and three PIMs in 10 and 23 patients, respectively. The most commonly prescribed PIM was spironolactone in 15.7% patients followed by benzodiazepines in 15 patients. The total cost of therapy for 1 day was Indian Rupee (INR) 10,029.2 while total cost of all prescribed medications in per day was INR 42.5. Conclusions: This study showed higher use of PIMs among the elderly in cardiac OPD. It is important to improve the situation of older cardiac patients who have higher use of PIMs. In older patients, high prevalence of PIMs was associated with increased cost. The use of regular continuing medical education program by the hospital and educating and training doctors on rational prescribing will help alleviate this issue.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"54 1","pages":"110 - 115"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72795601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Carbamazepine-induced angioedema Carbamazepine-induced血管性水肿

Journal of Basic and Clinical Pharmacy Pub Date : 2016-07-01 DOI: 10.4103/0976-0105.189436

Ansha Subramanian, M. Adhimoolam, S. Gopalakrishnan, Meher Ali Rajamohammed

引用次数: 1

Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice 阿立哌唑与羟嗪联用对小鼠抗焦虑作用的评价

Journal of Basic and Clinical Pharmacy Pub Date : 2016-07-01 DOI: 10.4103/0976-0105.189429

Nikita Shekhar Sawantdesai, P. Kale, J. Savai

{"title":"Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice","authors":"Nikita Shekhar Sawantdesai, P. Kale, J. Savai","doi":"10.4103/0976-0105.189429","DOIUrl":"https://doi.org/10.4103/0976-0105.189429","url":null,"abstract":"Context: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. Aim: The objective of the present study was to evaluate the anxiolytic effect of aripiprazole and hydroxyzine in combination. Materials and Methods: Swiss albino mice (male) received treatment of 5% of Tween 80 in 0.9% saline (10 ml/kg; control group), \"aripiprazole alone\" (1 mg/kg), \"hydroxyzine alone\" (3 mg/kg), and aripiprazole (0.5 mg/kg) + hydroxyzine (1.5 mg/kg) through the intraperitoneal route. Statistical Analysis Used: One-way ANOVA followed by Tukey′s honest significant difference was employed for statistical analysis. Results: The in vivo outcomes (elevated plus maze, light/dark transition, and marble burying tests) of hydroxyzine monotherapy-treated group showed a significant anxiolytic activity. The combination-treated group was found to be better than control and aripiprazole-treated groups. The combination-treated group showed a significant increase in the level of serotonin in different brain regions as compared to aripiprazole-treated group but not better than the hydroxyzine group. The in vitro results were in compliance with the in vivo results. The combinational approach was found to be beneficial in anxiolytic treatment as compared to aripiprazole monotherapy. However, hydroxyzine showed better anxiolytic activity when compared to control, aripiprazole monotherapy, and combination groups. Conclusions: The anxiolytic effect of combination-treated group was found to be better than aripiprazole monotherapy and lesser than hydroxyzine monotherapy.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"27 1","pages":"97 - 104"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88715093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Use of simulated patient approach to assess the community pharmacists’ knowledge of appropriate use of metered dose inhaler 采用模拟病人方法评估社区药师对正确使用计量吸入器的知识

Journal of Basic and Clinical Pharmacy Pub Date : 2016-07-01 DOI: 10.4103/0976-0105.189435

S. Nduka, M. Anetoh, K. Amorha, Okechukwu O. Henry, M. Okonta

{"title":"Use of simulated patient approach to assess the community pharmacists’ knowledge of appropriate use of metered dose inhaler","authors":"S. Nduka, M. Anetoh, K. Amorha, Okechukwu O. Henry, M. Okonta","doi":"10.4103/0976-0105.189435","DOIUrl":"https://doi.org/10.4103/0976-0105.189435","url":null,"abstract":"Rationale: The pharmacist charged with the responsibility of drug administration and counseling should have the basic knowledge and skills necessary to demonstrate the use of metered dose inhalers (MDIs) to asthma patients for the maximization of treatment outcomes. Objective: This study was designed to evaluate the community pharmacists′ knowledge of the appropriate use of MDIs in Anambra State, Nigeria. Methods: The study was carried out in two major cities in Anambra State, Nigeria, using 41 registered community pharmacists. A simulated patient approach utilizing two adequately trained pharmacy students were used. Obtained data were analyzed using independent t-test and one-way ANOVA through SPSS version 18. Results: The pharmacists had a mean demonstration score of 45.45%. Step number seven of the correct use of MDI, which involves breathing in and depressing the canister was the most demonstrated step (90.2%) while step 4 which involves tilting the head back slightly was the least demonstrated (14.6%) by the pharmacists. Among five identified critical steps in asthma guideline used, two were well demonstrated (75.6% and 90.2%): one averagely demonstrated (51.2%) and two poorly demonstrated (39% and 31.7%). Sociodemographic characteristics did not influence the demonstration ability of the pharmacists in this study. Conclusion: The study indicated that community pharmacists lacked the adequate knowledge of appropriate use of MDI. Training programs for pharmacists focusing on the use of such devices will enable them to educate patients on the effective use of MDIs in patients with asthma.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"1 1","pages":"116 - 119"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88131364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave. 印度桑德班红树榄叶的抗氧化和保肝作用。

Journal of Basic and Clinical Pharmacy Pub Date : 2016-06-01 DOI: 10.4103/0976-0105.183262

Tapas Kumar Sur, Avijit Hazra, Alok Kumar Hazra, Dipankar Bhattacharyya

{"title":"Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave.","authors":"Tapas Kumar Sur, Avijit Hazra, Alok Kumar Hazra, Dipankar Bhattacharyya","doi":"10.4103/0976-0105.183262","DOIUrl":"https://doi.org/10.4103/0976-0105.183262","url":null,"abstract":"Background: Bruguiera gymnorrhiza L. (family Rhizophoraceae) is a true mangrove habitat in Indian Sunderban and traditionally uses for liver disorders.Objectives: The aim was to evaluate antioxidant and hepatoprotective actions of leave extract of B. gymnorrhiza L.Materials and methods: Hydro-methanolic extract of mangrove leaves (BR) was standardized using spectrophotometric and high-performance thin layer chromatography methods. Radical scavenging activities were assessed in different in vitro methods, like 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid (+), superoxides, nitric oxides and hydroxyl radicals. Hepatoprotective efficacy of BR (125 mg/kg and 250 mg/kg, p.o) was measured in D-galactosamine (GalN) induced (200 mg/kg, i.p) hepatitis in Wistar rats. Silymarin (25 mg/kg, p.o) was used as known hepatoprotective agent.Results: Polyphenols such as gallic acid, quercetin, and coumarin obtained from BR exhibited powerful antioxidant properties. Moreover, it produced dose-dependent protection against GalN induced hepatitis in rats. It significantly reduced GalN induced elevation of enzymes (alanine transaminase, aspartate aminotransferase, and alkaline phosphatase) in serum and resist oxidative stress marked by lipid peroxides, glutathione, and catalase in hepatic parenchyma.Conclusions: Polyphenols rich B. gymnorrhiza L. leaves ameliorate hepatic tissue injury through its antioxidant effects.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"7 3","pages":"75-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4103/0976-0105.183262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34501950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates. 姜黄素与抗生素对产生生物膜的临床细菌分离株的抗菌协同作用。

Journal of Basic and Clinical Pharmacy Pub Date : 2016-06-01 DOI: 10.4103/0976-0105.183265

Arunava Kali, Devaraj Bhuvaneshwar, Pravin M V Charles, Kunigal Srinivasaiah Seetha

{"title":"Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates.","authors":"Arunava Kali, Devaraj Bhuvaneshwar, Pravin M V Charles, Kunigal Srinivasaiah Seetha","doi":"10.4103/0976-0105.183265","DOIUrl":"https://doi.org/10.4103/0976-0105.183265","url":null,"abstract":"Introduction: The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect as an antibacterial agent is currently under focus.Materials and methods: We have evaluated the in vitro synergy of curcumin with antibiotics against sixty biofilm producing bacterial isolates. Congo red agar method was used to identify the biofilm producing isolates. Curcumin minimum inhibitory concentration (MIC) was determined by agar dilution method. Its antibiotic synergy was identified by the increase in disc diffusion zone size on Mueller-Hinton agar with 32 mg/L curcumin.Results: The mean MICs of curcumin against Gram-positive and Gram-negative isolates were 126.9 mg/L and 117.4 mg/L, respectively. Maximum synergy was observed with ciprofloxacin among Gram-positive and amikacin, gentamicin, and cefepime among Gram-negative isolates.Conclusions: Curcumin per se as well as in combination with other antibiotics has a demonstrable antibacterial action against biofilm producing bacterial isolates. It may have a beneficial role in supplementing antibiotic therapy.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"7 3","pages":"93-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4103/0976-0105.183265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34501953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 79

Knowledge of healthcare professionals about medication errors in hospitals. 医疗保健专业人员对医院用药错误的了解。

Journal of Basic and Clinical Pharmacy Pub Date : 2016-06-01 DOI: 10.4103/0976-0105.183264

Mohamed M M Abdel-Latif

{"title":"Knowledge of healthcare professionals about medication errors in hospitals.","authors":"Mohamed M M Abdel-Latif","doi":"10.4103/0976-0105.183264","DOIUrl":"https://doi.org/10.4103/0976-0105.183264","url":null,"abstract":"Context: Medication errors are the most common types of medical errors in hospitals and leading cause of morbidity and mortality among patients.Aims: The aim of the present study was to assess the knowledge of healthcare professionals about medication errors in hospitals.Settings and design: A self-administered questionnaire was distributed to randomly selected healthcare professionals in eight hospitals in Madinah, Saudi Arabia.Subjects and methods: An 18-item survey was designed and comprised questions on demographic data, knowledge of medication errors, availability of reporting systems in hospitals, attitudes toward error reporting, causes of medication errors.Statistical analysis used: Data were analyzed with Statistical Package for the Social Sciences software Version 17.Results: A total of 323 of healthcare professionals completed the questionnaire with 64.6% response rate of 138 (42.72%) physicians, 34 (10.53%) pharmacists, and 151 (46.75%) nurses. A majority of the participants had a good knowledge about medication errors concept and their dangers on patients. Only 68.7% of them were aware of reporting systems in hospitals. Healthcare professionals revealed that there was no clear mechanism available for reporting of errors in most hospitals. Prescribing (46.5%) and administration (29%) errors were the main causes of errors. The most frequently encountered medication errors were anti-hypertensives, antidiabetics, antibiotics, digoxin, and insulin.Conclusions: This study revealed differences in the awareness among healthcare professionals toward medication errors in hospitals. The poor knowledge about medication errors emphasized the urgent necessity to adopt appropriate measures to raise awareness about medication errors in Saudi hospitals.","PeriodicalId":15046,"journal":{"name":"Journal of Basic and Clinical Pharmacy","volume":"7 3","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4103/0976-0105.183264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34501952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44