Journal of Antivirals & Antiretrovirals最新文献_第4页

Concordance of andquot;Rapidandquot; Serological Tests and IgG and IgM Chemiluminescence for SARS-COV-2 “和”的一致性;SARS-COV-2血清学检测及IgG和IgM化学发光

Journal of Antivirals & Antiretrovirals Pub Date : 2021-01-01 DOI: 10.35248/1948-5964.21.13.226

K. Sáenz-Flor, M. SantafeLorena

{"title":"Concordance of andquot;Rapidandquot; Serological Tests and IgG and IgM Chemiluminescence for SARS-COV-2","authors":"K. Sáenz-Flor, M. SantafeLorena","doi":"10.35248/1948-5964.21.13.226","DOIUrl":"https://doi.org/10.35248/1948-5964.21.13.226","url":null,"abstract":"Objectives: To evaluate a sample of immunofluorescent and immunochromatographic rapid tests used in Ecuador to show their agreement in relation to Chemiluminescence. Setting: Primary care limitations for a sample of “rapid test” assays used for serological diagnosis of SARS-CoV-2 in Ecuador, South-America. Participants: A diagnostic test evaluation assay was performed to establish the performance of five “rapid” tests for IgG and IgM serology for SARS-CoV-2 using a panel of 30 serum samples from routine patients. Interventions: For the evaluation of clinical performance, the qualitative results of the \"rapid\" tests were compared against those obtained by chemiluminescence, dichotomized as positives (>10 AU/mL) or negative (<10 UA/mL). Primary and secondary outcome measures: Demonstration of agreement in defining the subjects with the dichotomous criterion (positive or negative for SARS-CoV-2 antibodies), calculating complex repeatability, positive agreements and negative agreements, with their corresponding 95% confidence interval and Cohen's Kappa test. Results: The best agreement is seen in the immunofluorescent assay, for the IgG contrast, with a particularly good kappa index (0.85), without positive disagreements and a negative disagreement of about 15%. In the immunochromatographic methods Kappa index was 0.61 at best, with disagreements in negative findings of ≈35% and in positive cases of up to ≈70%. Conclusions: Given the high demand and supply in the market of \"rapid serological tests\", its evaluation against panels of serologically positive or negative samples established by Chemiluminescence or Electro chemiluminescence is essential to authorize its extensive use in populations.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"126 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81815906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Antiviral Drugs in the Case-Management of Respiratory Syncytial Virus, Influenza and COVID-19 抗病毒药物在呼吸道合胞病毒、流感和COVID-19病例管理中的作用

Journal of Antivirals & Antiretrovirals Pub Date : 2021-01-01 DOI: 10.35248/1948-5964.13.S16.002

T. Ibekwe, V. Kwaghe, Habib Zayad Garba, P. Ibekwe

{"title":"The Role of Antiviral Drugs in the Case-Management of Respiratory Syncytial Virus, Influenza and COVID-19","authors":"T. Ibekwe, V. Kwaghe, Habib Zayad Garba, P. Ibekwe","doi":"10.35248/1948-5964.13.S16.002","DOIUrl":"https://doi.org/10.35248/1948-5964.13.S16.002","url":null,"abstract":"Background: The Respiratory Syncytial, Influenza and the SARS-CoV-2 viruses have a lot in common and are intertwined as leading causes of respiratory infections (flu) and flu-like infections in humans. The morbidity, mortality and disease burden posed by these diseases across the globe is humongous. The epidemiology, pathophysiology, clinical presentations and sequalae of these respiratory illnesses are also very similar and could be safely described as a spectrum of a disease process ‘syncytial respiratory disease’. There is justification in simultaneously studying, investigating and researching on these diseases given their close similarities and thin differences. Methods: This is a review of the literature on Case-Management for RSV, Influenza, COVID-19 and the role of Antiviral drugs. A comprehensive search of MEDLINE (from Jan 2019 to January 2021), EMBASE (from Jan 2019 to January 2021), Publics Ovidius Naso (Ovoid), Database of Abstracts of Reviews of Effects and the Cochrane Central Register of Controlled Trials in Issue 1 of 12, January 2021 of the Cochrane Library was performed. Short-listing of titles and abstracts on the basis of their relevance to the review and subsequent data extraction were undertaken independently by two out of the four authors (TSI and PUI). Differences were resolved by mutual consensus. Results: The Respirtory Syncitial Virus (RSV), Influenza and SARS-CoV2 (COVID-19) virus were all examined in detail. The similarities and differences were x-rayed, including the mechanism of transmission, pathophysiology and pathogenesis of each. The methods of treatment especially susceptibility on antiviral agents were discussed. Conclusion: The similarity indices between RSV, Influenza and SARS-CoV2 are strong. Non-pharmaceutical and pharmaceutical measures are required for holistic cure and total eradication of these diseases. Effective and efficient antiviral agent(s) are needed for active management of these groups of viruses and science is challenged to this effect.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"11 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88621682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Teleconsultation in the Context of the COVID-19 Pandemic COVID-19大流行背景下的儿科远程会诊

Journal of Antivirals & Antiretrovirals Pub Date : 2021-01-01 DOI: 10.35248/1948-5964.21.S18.003

F. Bennaoui, S. Moussaoui, N. Slitine, F. Maoulainine

{"title":"Pediatric Teleconsultation in the Context of the COVID-19 Pandemic","authors":"F. Bennaoui, S. Moussaoui, N. Slitine, F. Maoulainine","doi":"10.35248/1948-5964.21.S18.003","DOIUrl":"https://doi.org/10.35248/1948-5964.21.S18.003","url":null,"abstract":"Three billion individuals worldwide are currently confined to fight the COVID-19 pandemic. In this context, since physical examinations are less present. Teleconsultation is the delivery of health care services using the phone, information or communication technology. In the current pandemic scenario, teleconsultation can supplement health-care delivery in the absence of in-person visit. Our study aimed to assess the efficiency and security of teleconsultation with only a smartphone to manage the flow of pediatric emergencies in Morocco. This prospective observational cohort study was conducted on the first 500 patients, who received a teleconsultation by contacting pediatricians by smartphone, using audio, videos or photos, during two months April and May 2020, the patients were calling from all Morocco. The average of age was 2 years and 4 months with extremes ranging from 4 days to 15 years. Gender: male-60.7% and female-39.3%. The communication type was written message-100%; Photos-15%; Voice mail-8%. Our attitude was give as Prescription-69%; Tips-43%; Specialist advice-15%; Emergencies-6%; Diet- 5%; Balance-5%; Consultation-4%; Radiological assessment-3%; Family treatment-1%. This study is the first to assess the utility of emergency pediatric teleconsultation with a simple smartphone application to manage emergency in a population with suddenly restrained access to pediatricians. This approach permitted us to preserve social distancing.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"53 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84464141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BNT162b2 Vaccine: possible codons misreading, errors in protein synthesis and alternative splicing's anomalies BNT162b2疫苗:可能的密码子误读，蛋白质合成错误和选择性剪接异常

Journal of Antivirals & Antiretrovirals Pub Date : 2020-12-31 DOI: 10.35248/1948-5964.21.13.210

Kira Smith

{"title":"BNT162b2 Vaccine: possible codons misreading, errors in protein synthesis and alternative splicing's anomalies","authors":"Kira Smith","doi":"10.35248/1948-5964.21.13.210","DOIUrl":"https://doi.org/10.35248/1948-5964.21.13.210","url":null,"abstract":"BNT162b2 vaccine against Covid-19 is composed of\u0000an RNA having 4284 nucleotides, divided into 6\u0000sections, which bring the information to create\u0000a factory of S Spike proteins, the ones used\u0000by Sars-CoV-2 (Covid-19) to infect the host. After\u0000that, these proteins are directed outside the cell,\u0000triggering the immune\u0000reaction and antibody production.\u0000 The problem is the heavy alteration of the\u0000mRNA: Uracil is replaced to fool the immune system\u0000with Ψ (Pseudouridine); the letters of all\u0000codon triplets are replaced by a C or a G,\u0000to extremely increase the speed of protein\u0000synthesis; replacement of some amino\u0000acids with Proline; addition of a sequence\u0000(3’-UTR) with unknown alteration.\u0000 These impairments could cause strong doubts about the\u0000presence of codon usage errors. An\u0000eventual mistranslation has consequences on\u0000the pathophysiology of a variety of diseases.In\u0000addition, mRNA injected is a pre-mRNA, which\u0000can lead to the multiple mature mRNAs; these\u0000are alternative splicing anomalies,\u0000direct source of serious long-term harm on the human\u0000health.\u0000 In essence, what will be created may not be\u0000identical with protein S Spike: just an error in\u0000translational decoding, codons misreading, production\u0000of different amino acids, then proteins, to cause\u0000serious long-term damage to human health, despite\u0000the DNA is not modified, being instead in the cell\u0000nucleus and not in the cytoplasm, where the modified mRNA\u0000arrives.\u0000 However, in this case, the correlation between speed of\u0000synthesis and protein expression with synthesis\u0000errors, as well as the mechanism that could affect\u0000the translation of the sequence remain obscure,\u0000many trials have not yet been performed.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"103 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80423050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19 and Lockdown in India: Evaluation using Analysis of Covariance COVID-19和印度的封锁:使用协方差分析进行评估

Journal of Antivirals & Antiretrovirals Pub Date : 2020-12-30 DOI: 10.21203/rs.3.rs-136260/v1

A. Tak, B. Das, Saurabh Gahlot

{"title":"COVID-19 and Lockdown in India: Evaluation using Analysis of Covariance","authors":"A. Tak, B. Das, Saurabh Gahlot","doi":"10.21203/rs.3.rs-136260/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-136260/v1","url":null,"abstract":"\u0000 Background: The lockdown in India has entered into its ninth month to curb the Coronavirus disease-19 (COVID-19) pandemic. The objective of the present study is to evaluate impact of different phases of lockdown on evolution of new cases of infection and deaths due to COVID-19.Methods: In this retrospective longitudinal study, the Indian data on new cases of infection and deaths due to COVID-19 were retrieved from John Hopkins University dashboard. The cases from 25 March to 31 October 2020 were analyzed using analysis of covariance for four phases of lockdown and five phases of unlockdown.Results: The coefficients of regression for new cases did not differ significantly for initial four phases of lockdown and unlock-1, while from unlock-2 the coefficients showed significant decrease till unlock-5. While death cases showed no significant differences between coefficients of regression for initial four phases of lockdown and unlock, but coefficient of unlock-5 was significantly lower than unlock-4. Conclusion: The trends of coefficients of regression of new cases and deaths reveals positive effects of lockdown in flattening the epidemic curve. Though the pandemic is on downslope, till the availability of vaccines, non-pharmaceutical measures such as social distancing, wearing of masks need to be implemented.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"PP 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84318695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Delay of Detection Of COVID-19 Patients In Bangladesh; An Application To Cox Proportional Hazard Model 孟加拉国COVID-19患者发现延迟Cox比例风险模型的应用

Journal of Antivirals & Antiretrovirals Pub Date : 2020-12-08 DOI: 10.21203/rs.3.rs-117305/v1

Sujan Rudra, Shuva Das, Md. Ehsanul Hoque, A. Kalam, Mohammad Arifur Rahman

{"title":"Delay of Detection Of COVID-19 Patients In Bangladesh; An Application To Cox Proportional Hazard Model","authors":"Sujan Rudra, Shuva Das, Md. Ehsanul Hoque, A. Kalam, Mohammad Arifur Rahman","doi":"10.21203/rs.3.rs-117305/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-117305/v1","url":null,"abstract":"\u0000 Objective: To delineate the survival rate of the patients with coronavirus disease 2019 (COVID-19) who did the diagnostic tests lately after the development of symptoms. The aim is to determine the socio-demographic risk factors associated with the delay of the detection of COVID-19 patients. Methods: For this cross-sectional study, 300 patients were selected who were diagnosed as COVID-19 patients in the Molecular Biology Laboratory of Chittagong Medical College, Chattogram, Bangladesh. Data were collected from May to July 2020. Clinical characteristics were obtained from over phone interviews and laboratory diagnosis by Real-time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR). Cox proportional hazard model is applied to estimate risk factors affecting the delay of detection of COVID-19 patients.Result: Female mortality rate was 44.9% higher compared to males, graduates died 32% more than undergraduates, unmarried peoples’ death rate were 56% more than married and those who were in traveling irregularly and in contact with symptomatic patients, were 86% more died than non-travelers.Conclusion: Early diagnosis of COVID-19 can save a huge amount of lives and special attention should be emphasized on the significant explanatory variable.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"2003 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86541815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A review on the SARS-CoV-2 mediated global pandemic: proximal origin, pathogenicity and therapeutic approaches SARS-CoV-2介导的全球大流行:近端起源、致病性和治疗方法综述

Journal of Antivirals & Antiretrovirals Pub Date : 2020-10-29 DOI: 10.31219/osf.io/fpqsw

S. Chatterjee, B. Dhara, Dattatreya Mukherjee, Debraj Mukhopadhyay, A. Mitra

{"title":"A review on the SARS-CoV-2 mediated global pandemic: proximal origin, pathogenicity and therapeutic approaches","authors":"S. Chatterjee, B. Dhara, Dattatreya Mukherjee, Debraj Mukhopadhyay, A. Mitra","doi":"10.31219/osf.io/fpqsw","DOIUrl":"https://doi.org/10.31219/osf.io/fpqsw","url":null,"abstract":"The world is amidst a public health crisis as the pandemic has shook us to the core. The COVID-19 caused by the novel SARS-CoV-2 is of zoonotic origin and this tries to explain what could have been the possible proximal origins for the disease in humans. Our review aims at addressing the question like what structural or genomic vicissitude enabled the viral outbreak across genera and so efficiently infect the human populace across the globe. We also try to discuss the prospect of drug repurposing and scope for vaccine development considering the rapid genome modification of the virus. Another finding lies into the action of pre-existing drugs when they are applied in combination and probably that shades some light on the therapeutic approaches. Several investigation have been performed but we are still in search of a novel antiviral drug. With that vision, our focus shifted on the evaluation of existing drugs with positive response against the novel corona virus. We also try discussing certain trends including increased immunity to the disease in the population from a particular geographical area.","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"41 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79093483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Note for Antivirals: New Drug Delivery Systems 抗病毒药物:新的给药系统

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S7.E002

Ramya Derai

引用次数: 0

Covid-19 and Nutrients Covid-19和营养素

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.12.205

M. Phadke, U. Bodhankar, Y. Patil, P. Menon

引用次数: 0

Drugomics of Human Immuno Deficiency Virus 人类免疫缺陷病毒的药物组学

Journal of Antivirals & Antiretrovirals Pub Date : 2020-01-01 DOI: 10.35248/1948-5964.20.S10.E001

D. Kaul

引用次数: 0