ACS Combinatorial Science最新文献

{"title":"Synthesis of Three Isoelemental MXenes and Their Structure–Property Relationships","authors":"Marley Downes,&nbsp;Christopher E. Shuck,&nbsp;Ruocun John Wang,&nbsp;Paweł Piotr Michałowski,&nbsp;Jonathan Shochat,&nbsp;Danzhen Zhang,&nbsp;Mikhail Shekhirev,&nbsp;Yizhou Yang,&nbsp;Nestor J. Zaluzec,&nbsp;Raul Arenal,&nbsp;Steven J. May and Yury Gogotsi*,&nbsp;","doi":"10.1021/jacs.4c1111110.1021/jacs.4c11111","DOIUrl":"https://doi.org/10.1021/jacs.4c11111https://doi.org/10.1021/jacs.4c11111","url":null,"abstract":"<p >The MXene family has rapidly expanded since its discovery in 2011 to include nearly 50 unique MXenes, not accounting for solid solutions and diverse surface terminations. However, a question raised since their discovery has been: What is the effect of <i>n</i>? In other words, how does the number of layers affect the MXene properties? To date, no direct study of the impact of <i>n</i> has been conducted due to the lack of isoelemental MXene compositions spanning more than two <i>n</i> values. Herein, we report on a system of three MXenes with identical M-site chemistries, (Mo_2/3V_1/3)_<i>n</i>+1C_<i>n</i>T_<i>x</i> (<i>n</i> = 1, 2, and 3), allowing for the study of MXene structure–property relationships across <i>n</i>, for the first time. Chemical analysis of the samples shows complete and partial ordering of the M-elements in the <i>n</i> = 2 and 3 samples, respectively. We show that sample stability gradually evolves as <i>n</i> is increased from 1 to 3, while electronic and electrochemical properties exhibit more significant changes in going from <i>n</i> = 1 to 2 than from <i>n</i> = 2 to 3.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31159–31168 31159–31168"},"PeriodicalIF":14.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacs.4c11111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Cavity Quantum Electrodynamics via Self-Aligned Nanoring Doublets: QED-SANDs","authors":"Kyungwha Chung,&nbsp;Soohyun Lee,&nbsp;Nathan Grain,&nbsp;Kyeongdeuk Moon,&nbsp;Seungyeon Han,&nbsp;Subin Yu,&nbsp;Haeun Kang,&nbsp;Dong Ha Kim,&nbsp;Inhee Choi,&nbsp;Sungho Park*,&nbsp;Seokhyoung Kim* and Luke P. Lee*,&nbsp;","doi":"10.1021/jacs.4c1108310.1021/jacs.4c11083","DOIUrl":"https://doi.org/10.1021/jacs.4c11083https://doi.org/10.1021/jacs.4c11083","url":null,"abstract":"<p >Quantum mechanics is applied to create numerous electronic devices, including lasers, electron microscopes, magnetic resonance imaging, and quantum information technology. However, the practical realization of cavity quantum electrodynamics (QED) in various applications is limited due to the demanding conditions required for achieving strong coupling between an optical cavity and excitonic matter. Here, we present biological cavity QED with self-aligned nanoring doublets: QED-SANDs, which exhibit robust room-temperature strong coupling with a biomolecular emitter, chlorophyll-<i>a</i>. We observe the emergence of plasmon-exciton polaritons, which manifest as a bifurcation of the plasmonic scattering peak of biological QED-SANDs into two distinct polariton states with Rabi splitting up to ∼200 meV. We elucidate the mechanistic origin of strong coupling using finite-element modeling and quantify the coupling strength by employing temporal coupled-mode theory to obtain the coupling strength up to approximately 3.6 times the magnitude of the intrinsic decay rate of QED-SANDs. Furthermore, the robust presence of the polaritons is verified through photoluminescence measurements at room temperature, from which strong light emission from the lower polariton state is observed, while emission from the upper polariton state is quenched. QED-SANDs present significant potential for groundbreaking insights into biomolecular behavior in nanocavities, especially in the context of quantum biology.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31150–31158 31150–31158"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Design and Synthetic Approaches for the Realization of Multichannel Radiative Decay Pathways in Gold(III) Complexes and Their Applications in Organic Light-Emitting Devices","authors":"Ming-Yi Leung,&nbsp;Man-Chung Tang,&nbsp;Shun-Cheung Cheng,&nbsp;Ziyong Chen,&nbsp;Shiu-Lun Lai,&nbsp;Wai Kit Tang,&nbsp;Mei-Yee Chan,&nbsp;Chi-Chiu Ko* and Vivian Wing-Wah Yam*,&nbsp;","doi":"10.1021/jacs.4c0920710.1021/jacs.4c09207","DOIUrl":"https://doi.org/10.1021/jacs.4c09207https://doi.org/10.1021/jacs.4c09207","url":null,"abstract":"<p >A unique class of tridentate diaryltriazine ligand-containing gold(III) complexes with thermally activated delayed fluorescence (TADF) and/or thermally stimulated delayed phosphorescence (TSDP) properties has been designed and synthesized. With a simple structural modification on the coordination of carbazole moiety in the monodentate ligand, a large spectral shift of ∼160 nm (ca. 4900 cm^–1) spanning from sky blue to red emissions has been demonstrated in solid-state thin films. Three-state or four-state models have been employed in fitting the emission lifetimes of the gold(III) complexes at various temperatures. The findings clearly indicate the presence of three emitting states, S₁, T₁, and T₁′, suggesting the coexistence of TADF, phosphorescence, and TSDP. Notably, a minor structural change in the donor moiety between phenylcarbazolyl and diphenylaminoaryl has been demonstrated to turn on/off the TSDP, resulting in TADF-TSDP-phosphorescence or TADF-phosphorescence emitters. The TADF and/or TSDP properties have also been supported by temperature-dependent ultrafast transient absorption studies, with the direct observation of reverse intersystem crossing (RISC) and reverse internal conversion (RIC) and the determination of the activation parameters and excited state dynamics. Solution-processed and vacuum-deposited organic light-emitting devices (OLEDs) have been prepared, in which sky blue emitting devices based on <b>5</b> exhibit an operational lifetime LT₇₀ ∼ 5 times longer than the previously reported sky blue emitting analogue that shows only TSDP property. These results have provided valuable insights into the manipulation of the excited states via rational molecular design toward the realization of gold(III)-based TSDP and/or TADF materials with multiple radiative decay pathways that show enhanced radiative decay rate constants (<i>k</i>_r) for practical OLED applications.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"30901–30912 30901–30912"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C–H Activation of Pyridines by Boryl Pincer Complexes: Elucidation of Boryl-Directed C–H Oxidative Addition to Ir and Discovery of Transition Metal-Assisted Reductive Elimination from Boron at Rh","authors":"Vinh T. Nguyen,&nbsp;R. Noah Sladek,&nbsp;Yihan Cao,&nbsp;Nattamai Bhuvanesh,&nbsp;Jia Zhou* and Oleg V. Ozerov*,&nbsp;","doi":"10.1021/jacs.4c1214310.1021/jacs.4c12143","DOIUrl":"https://doi.org/10.1021/jacs.4c12143https://doi.org/10.1021/jacs.4c12143","url":null,"abstract":"<p >Experimental and theoretical techniques were used to investigate the mechanism of pyridine C–H activation by diarylboryl/bis(phosphine) PBP pincer complexes of Ir. The critical intermediate (PBP)IrCO (<b>4</b>) contains a three-coordinate, Ir-bound boron that retains Lewis acidity in the perpendicular direction. Coordination of pyridine to this boron center in <b>4</b> leads to fast insertion of Ir into the 2-CH bond of pyridine, providing a different topology of direction than the conventional directed C–H activation where both the directing group coordination and C–H activation happen at the same metal center. Beyond this critical sequence, the system possesses significant complexity in terms of possible isomers and pathways, which have been thoroughly explored. Kinetic and thermodynamic preferences for the activation of differently substituted pyridines were also investigated. In experimental work, the key intermediate <b>4</b> is accessed via elimination of benzene from a phenyl/hydride containing precursor (PB^PhP)IrHCO (<b>3</b>). Density functional theory (DFT) investigations of the mechanism of benzene loss from <b>3</b> revealed the possibility of a genuinely new type of mechanism, whereby the Ph–H bond is made in a concerted process that is best described as C–H reductive elimination from boron, assisted by the transition metal (TMARE). For Ir, this pathway was predicted to be competitive with the more conventional pathways involving C–H reductive elimination from Ir, but still higher in energy barrier. However, for the Rh analog <b>3-Rh</b>, TMARE was calculated to be the preferred pathway for benzene loss and this prediction was experimentally corroborated through the study of reaction rates and the kinetic isotope effect.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31281–31294 31281–31294"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacs.4c12143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Engineering Fe–N Doped Graphene to Mimic Biological Functions of NADPH Oxidase in Cells”","authors":"Di Wu,&nbsp;Jingkun Li,&nbsp;Shujuan Xu,&nbsp;Qianqian Xie,&nbsp;Yanxia Pan,&nbsp;Xi Liu,&nbsp;Ronglin Ma,&nbsp;Huizhen Zheng,&nbsp;Meng Gao,&nbsp;Weili Wang,&nbsp;Jia Li,&nbsp;Xiaoming Cai,&nbsp;Frédéric Jaouen* and Ruibin Li*,&nbsp;","doi":"10.1021/jacs.4c1403010.1021/jacs.4c14030","DOIUrl":"https://doi.org/10.1021/jacs.4c14030https://doi.org/10.1021/jacs.4c14030","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31356 31356"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Site Pd Regulated by π−π Stacking for High-Selectivity Cyclopropanation Reaction","authors":"Yuan Yao,&nbsp;Xinyue Zhang,&nbsp;Yingying Cao*,&nbsp;Long Liu,&nbsp;Yanqiang Zhang* and Suojiang Zhang*,&nbsp;","doi":"10.1021/jacs.4c1086010.1021/jacs.4c10860","DOIUrl":"https://doi.org/10.1021/jacs.4c10860https://doi.org/10.1021/jacs.4c10860","url":null,"abstract":"<p >Cyclopropane-based high-energy fuels possess high intramolecular energy and density, and their precise synthesis is a critical challenge. However, owing to the highest strain in the cyclopropane structure (compared to other four- or five-membered rings, etc.), metal-carbene intermediates form with difficulty, resulting in poor catalytic selectivity for its synthesis. Herein, through rational design of π−π stacking between the Pd organic complex and graphene, we report a single-site Pd catalyst for precise synthesis of multicyclopropane-based high-energy fuels. It is discovered that π−π stacking enhanced the electrophilicity of Pd through a weak metal−support interaction, thus promoting the formation of Pd═C carbene active intermediates. Meanwhile, the adsorption between the active centers and intermediates was enhanced via π−π stacking. These two respects led to almost twice selectivity for cyclopropanation reaction up to 80.5% as that without π−π stacking. This work provides an effective strategy of π−π noncovalent interactions for regulating C−C coupling reaction selectivity.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31053–31061 31053–31061"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Behavior of Pt Multimetallic Alloys for Active and Stable Propane Dehydrogenation Catalysts","authors":"Baraa Werghi,&nbsp;Shikha Saini,&nbsp;Pin-Hung Chung,&nbsp;Abinash Kumar,&nbsp;Amani M. Ebrahim,&nbsp;Kristen Abels,&nbsp;Miaofang Chi,&nbsp;Frank Abild-Pedersen,&nbsp;Simon R. Bare* and Matteo Cargnello*,&nbsp;","doi":"10.1021/jacs.4c0942410.1021/jacs.4c09424","DOIUrl":"https://doi.org/10.1021/jacs.4c09424https://doi.org/10.1021/jacs.4c09424","url":null,"abstract":"<p >Improving the use of platinum in propane dehydrogenation catalysts is a crucial aspect to increasing the efficiency and sustainability of propylene production. A known and practiced strategy involves incorporating more abundant metals in supported platinum catalysts, increasing its activity and stability while decreasing the overall loading. Here, using colloidal techniques to control the size and composition of the active phase, we show that Pt/Cu alloy nanoparticles supported on alumina (Pt/Cu/Al₂O₃) displayed elevated rates for propane dehydrogenation at low temperature compared to a monometallic Pt/Al₂O₃ catalyst. We demonstrate that the enhanced catalytic activity is correlated with a higher surface Cu content and formation of a Pt-rich core and Cu-rich shell that isolates Pt sites and increases their intrinsic activity. However, rates declined on stream because of dynamic metal diffusion processes that led to a more uniform alloy structure. This transformation was only partially inhibited by adding excess hydrogen to the feed stream. Instead, cobalt was introduced to provide trimetallic Pt/Cu/Co catalysts with stabilized surface structure and stable activity and higher rates than the original Pt/Cu system. The structure–activity relationship insights in this work offer improved knowledge of propane dehydrogenation catalyst development featuring reduced Pt loadings and notable thermal stability for propylene production.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"30966–30975 30966–30975"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating Substrate Preferences of Promiscuous F420H2-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display","authors":"Alexander A. Vinogradov*,&nbsp;Ghader Bashiri and Hiroaki Suga*,&nbsp;","doi":"10.1021/jacs.4c1101310.1021/jacs.4c11013","DOIUrl":"https://doi.org/10.1021/jacs.4c11013https://doi.org/10.1021/jacs.4c11013","url":null,"abstract":"<p >Stereoselective reduction of dehydroamino acids is a common biosynthetic strategy to introduce <span>d</span>-amino acids into peptidic natural products. The reduction, often observed during the biosynthesis of lanthipeptides, is performed by dedicated dehydroamino acid reductases (dhAARs). Enzymes from the three known dhAAR families utilize nicotinamide, flavin, or F₄₂₀H₂ coenzymes as hydride donors, and little is known about the catalysis performed by the latter family proteins. Here, we perform a bioinformatics-guided identification and large-scale in vitro characterization of five F₄₂₀H₂-dependent dhAARs. We construct an mRNA display-based pipeline for ultrahigh throughput substrate specificity profiling of the enzymes. The pipeline relies on a 4-track selection strategy to deliver large quantities of clean data, which were leveraged to build accurate substrate fitness models. Our results identify a remarkably promiscuous enzyme, referred to as MaeJ_C, that is capable of installing <span>d</span>-Ala residues into arbitrary substrates with minimal recognition requirements. We integrate MaeJ_C into a thiopeptide biosynthetic pathway to produce <span>d</span>-amino acids-containing thiopeptides, demonstrating the utility of MaeJ_C for the programmable installation of <span>d</span>-amino acids in ribosomal peptides.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31124–31136 31124–31136"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Electrochemical Indicators upon Sarcoplasmic Meat Discoloration","authors":"Sandun Bogahawaththa Kasthuri Dias,&nbsp;Silan Bhandari,&nbsp;Sachinthani A. Devage,&nbsp;Jennifer A. Avery,&nbsp;Rishav Kumar,&nbsp;Ranjith Ramanathan* and Sadagopan Krishnan*,&nbsp;","doi":"10.1021/jacs.4c0937510.1021/jacs.4c09375","DOIUrl":"https://doi.org/10.1021/jacs.4c09375https://doi.org/10.1021/jacs.4c09375","url":null,"abstract":"<p >Meat discoloration is one of the challenges facing the food industry, which affects both quality and shelf life. In this report, we present our groundbreaking discovery of electrochemically probing specific redox peaks associated with meat discoloration and successfully monitor its delay when controlled biochemically with added antioxidants. We have validated the redox features by spectrophotometry measurements of the relative levels of oxymyoglobin, which gives meat its cherry red color, and metmyoglobin, which causes the meat to turn brown in relation to discoloration. The insights from this research open up new avenues for the development of innovative electroanalytical tools for studying meat color and quality. These new tools could potentially minimize nutritious beef waste, lessen the environmental burden associated with waste disposal, and reduce CO₂ emissions linked to discoloration issues.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"30728–30732 30728–30732"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/jacs.4c09375","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Button-Push On-Demand Synthesis for Rapid Optimization of Antiviral Peptidomimetics","authors":"Duanshuai Tian,&nbsp;Ting Wei Tan,&nbsp;Ronald Toh Kuan Hai,&nbsp;Gan Wang,&nbsp;Fadhil Peer Mohamed,&nbsp;Zhenyang Yu,&nbsp;Hwee Ting Ang,&nbsp;Weijun Xu,&nbsp;Qian Wen Tan,&nbsp;Pearly Shuyi Ng,&nbsp;Choon Heng Low,&nbsp;Boping Liu,&nbsp;Perlyn Quek Zekui,&nbsp;Joma Kanikadu Joy,&nbsp;Joseph Cherian,&nbsp;Frankie S Mak* and Jie Wu*,&nbsp;","doi":"10.1021/jacs.4c1283410.1021/jacs.4c12834","DOIUrl":"https://doi.org/10.1021/jacs.4c12834https://doi.org/10.1021/jacs.4c12834","url":null,"abstract":"<p >The optimization of hit compounds into drug candidates is a pivotal phase in drug discovery but often hampered by cumbersome manual synthesis of derivatives. While automated organic molecule synthesis has enhanced efficiency, safety, and cost-effectiveness, achieving fully automated multistep synthesis remains a formidable challenge due to issues such as solvent and reagent incompatibilities and the accumulation of side-products. We herein demonstrate an automated solid-phase flow platform for synthesizing α-keto-amides and nitrile peptidomimetics, guided by docking simulations, to identify potent broad-spectrum antiviral leads. A compact parallel synthesizer was built in-house, capable of producing 5 distinct molecules per cycle; 525 reactions could be finished within three months to generate 42 derivatives for a structure–activity relationship (SAR) investigation. Among these, ten derivatives exhibited promising target inhibitory activity (IC₅₀ &lt; 100 nM) including two with antiviral activity (EC₅₀ &lt; 250 nM). The platform, coupled with digital chemical recipe files, offers rapid access to a wide range of peptidomimetics, serving as a valuable reservoir for broad-spectrum antiviral candidates. This automated solid-phase flow synthesis approach expedites the generation of previously difficult complex molecular scaffolds. By integration of SPS-flow synthesis with medicinal chemistry campaign, &gt;10-fold target inhibitory activity was achieved from a small set of derivatives, which indicates the potential to shift the paradigm of drug discovery.</p>","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"146 45","pages":"31321–31329 31321–31329"},"PeriodicalIF":14.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}