{"title":"From bile acids to melancholia","authors":"Alexandra S. Klein, M. Kheirbek","doi":"10.1016/j.neuron.2024.05.007","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.05.007","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"12 33","pages":"1725-1727"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Turning down the body heat: A novel mechanism for TRPV1 antagonist-induced hyperthermia","authors":"Kali Esancy, Ajay K Dhaka","doi":"10.1016/j.neuron.2024.04.031","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.04.031","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"1 10","pages":"1727-1729"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seq-ing mechanisms behind types of Alzheimer’s disease","authors":"Yun Chen, Jason D. Ulrich","doi":"10.1016/j.neuron.2024.04.030","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.04.030","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"6 9","pages":"1723-1724"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mass spectrometry-based methods for characterizing transient protein–protein interactions","authors":"Clinton G. L. Veale, David J Clarke","doi":"10.1016/j.trechm.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.002","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"140 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Cui, Xiang Chen, F. Lan, Bohang An, Xiao Zhang
{"title":"Photocatalysis as a tool for upcycling of polymers","authors":"Hao Cui, Xiang Chen, F. Lan, Bohang An, Xiao Zhang","doi":"10.1016/j.trechm.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.003","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"313 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Landry, Meera Mehta, Dan Preston, Timothy Su, Clinton Veale, Xiao Zhang
{"title":"Meet our emerging leaders in chemistry – part I","authors":"Matthew Landry, Meera Mehta, Dan Preston, Timothy Su, Clinton Veale, Xiao Zhang","doi":"10.1016/j.trechm.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.004","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"51 14","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High five to the future of chemistry!","authors":"Jessica Pancholi","doi":"10.1016/j.trechm.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.06.002","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"7 16","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karen T Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, R. D. De Maeyer, John Ferguson, Matthias Mack, Jeremy S Brown, G. Ercoli, Connar M Mawer, Arne N. Akbar, James R W Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, A. Kendall, Michelle Sugimoto, Derek W. Gilroy
{"title":"Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia","authors":"Karen T Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, R. D. De Maeyer, John Ferguson, Matthias Mack, Jeremy S Brown, G. Ercoli, Connar M Mawer, Arne N. Akbar, James R W Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, A. Kendall, Michelle Sugimoto, Derek W. Gilroy","doi":"10.1001/jama.294.5.626","DOIUrl":"https://doi.org/10.1001/jama.294.5.626","url":null,"abstract":"Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolution of Streptococcus pneumoniae-triggered lung inflammation, there is an influx of antigen specific lymphocytes with a memory and tissue-resident phenotype as well as macrophages bearing alveolar or interstitial phenotype. The transcriptome of these macrophages shows enrichment of genes associated with prostaglandin biosynthesis and genes that drive T cell chemotaxis and differentiation. Therapeutic depletion of post-resolution macrophages, inhibition of prostaglandin E2 (PGE2) synthesis or treatment with an EP4 antagonist, MF498, reduce numbers of lung CD4+/CD44+/CD62L+ and CD4+/CD44+/CD62L-/CD27+ T cells as well as their expression of the α-integrin, CD103. The T cells fail to reappear and reactivate upon secondary challenge for up to six weeks following primary infection. Concomitantly, EP4 antagonism through MF498 causes accumulation of lung macrophages and marked tissue fibrosis. Our study thus shows that PGE2 signalling, predominantly via EP4, plays an important role during the second wave of immune activity following resolution of inflammation. This secondary immune activation drives local tissue-resident T cell development while limiting tissue injury","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"63 4","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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