Journal of applied biomedicine最新文献_第4页

In vitro study of Nigella sativa and thymoquinone activity on endothelial activation and monocyte adhesion. 黑草和百里醌对内皮细胞活化和单核细胞粘附的体外研究。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-06-01 DOI: 10.32725/jab.2023.006

Al'Aina Yuhainis Firus Khan, Fahmi Mohtar, Thuhairah Abdul Rahman, Suhaila Abdul Muid, Gabriele Ruth Anisah Froemming, Hapizah Nawawi

{"title":"In vitro study of Nigella sativa and thymoquinone activity on endothelial activation and monocyte adhesion.","authors":"Al'Aina Yuhainis Firus Khan, Fahmi Mohtar, Thuhairah Abdul Rahman, Suhaila Abdul Muid, Gabriele Ruth Anisah Froemming, Hapizah Nawawi","doi":"10.32725/jab.2023.006","DOIUrl":"https://doi.org/10.32725/jab.2023.006","url":null,"abstract":"INTRODUCTION Thymoquinone (TQ) is one of the bioactive compounds in Nigella sativa (NS). Also known as black seeds/cumin, it has been postulated to possess anti-atherogenic properties. However, research on the effects of NS oil (NSO) and TQ on atherogenesis remain scarce. The aim of this study is to determine gene and protein expression of Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Endothelial-eukocyte adhesion molecule (E-selectin) in Human Coronary Artery Endothelial Cells (HCAECs). METHODS HCAECs were stimulated for 24 hours (h) with 200 µg/ml of Lipopolysaccharides (LPS) and different concentrations of NSO (55, 110, 220, 440 µg/ml) or TQ (4.5, 9.0, 18.0, 36.0 µm). The effects of NSO and TQ on gene and protein expressions were measured using multiplex gene assay and ELISA assay, respectively. Rose Bengal assay was used to analyse monocyte binding activity. RESULTS NSO and TQ significantly reduced ICAM-1 and VCAM-1 gene and protein expressions. TQ showed significant reduction activity of the biomarkers in dose dependent manner. HCAECs pre-treated with NSO and TQ for 24 h significantly lowered monocytes adherence compared to non-treated HCAECs. CONCLUSIONS NSO and TQ supplementation have anti-atherogenic properties and inhibit monocytes' adherence to HCAECs via down-regulation of ICAM-1 expression. NSO could potentially be incorporated in standard treatment regimens to prevent atherosclerosis and its related complications.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 2","pages":"73-79"},"PeriodicalIF":1.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice. 苦参果提取物对对乙酰氨基酚所致小鼠肝损伤的保护作用。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-06-01 DOI: 10.32725/jab.2023.008

Shanshan Qi, Beibei Lin, Sanqiao Wu, Hao Hao, Hongxin Zheng, Xiang Liu, Xiaoying Zhang, Lijuan Yue, Chen Chen

引用次数: 0

Experimental study on clinical and morphological determination of the optimal cannula diameter for lipoaspirate harvest from rabbit inguinal fat pad. 兔腹股沟脂肪垫吸脂器最佳插管直径的临床及形态学确定实验研究。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-06-01 DOI: 10.32725/jab.2023.011

Ilona Pak, Meirambek Askarov, Nurlan Kissamedenov, Dmitriy Klyuyev, Yevgeniy Kamyshanskiy

{"title":"Experimental study on clinical and morphological determination of the optimal cannula diameter for lipoaspirate harvest from rabbit inguinal fat pad.","authors":"Ilona Pak, Meirambek Askarov, Nurlan Kissamedenov, Dmitriy Klyuyev, Yevgeniy Kamyshanskiy","doi":"10.32725/jab.2023.011","DOIUrl":"https://doi.org/10.32725/jab.2023.011","url":null,"abstract":"Determining the most appropriate cannula diameter for lipoaspirate harvesting is important, both in terms of the quality and composition of the material obtained, and the ease of practical use of the cannula. The size of the cannula is one of the main factors affecting the qualitative characteristics of the obtained lipoaspirate sample for further use of adipose tissue. The purpose of the investigation was to clinically and histomorphometrically determine the optimal cannula diameter for lipoaspirate samples collection from rabbit inguinal fat pad in an experimental study. The methods of Animal models, Surgical procedures, Macroscopic examination, Histological examination, and Morphometric study were applied. There is a direct correlation between the percentage of connective tissue fibres in the lipoaspirate and the diameter of the cannula. The lack of clear criteria for selecting a lipoaspiration cannula is one of the limitations to obtaining generally accepted lipoaspiration protocols with subsequent use of adipose tissue. In this study, the animal experiment determined the most ideal cannula diameter suitable for collecting the largest amount of lipoaspirate for subsequent use.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 2","pages":"99-105"},"PeriodicalIF":1.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10070108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cardiocerebrovascular disease incidence between angiotensin converting enzyme inhibitor and angiotensin receptor blocker users in a real-world cohort. 现实世界队列中血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂使用者心脑血管病发病率的比较

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2023.002

Suehyun Lee, Hyunah Kim, Hyeon Woo Yim, Kim Hun-Sung, Ju Han Kim

{"title":"Comparison of cardiocerebrovascular disease incidence between angiotensin converting enzyme inhibitor and angiotensin receptor blocker users in a real-world cohort.","authors":"Suehyun Lee, Hyunah Kim, Hyeon Woo Yim, Kim Hun-Sung, Ju Han Kim","doi":"10.32725/jab.2023.002","DOIUrl":"https://doi.org/10.32725/jab.2023.002","url":null,"abstract":"Background: Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are known to be effective in managing cardiovascular diseases, but more evidence supports the use of an ACEI. This study investigated the difference in cardiovascular disease incidence between relatively low-compliance ACEIs and high-compliance ARBs in the clinical setting.Methods: Patients who were first prescribed ACEIs or ARBs at two tertiary university hospitals in Korea were observed in this retrospective cohort study for the incidence of heart failure, angina, acute myocardial infarction, cerebrovascular disease, ischemic heart disease, and major adverse cardiovascular events for 5 years after the first prescription. Additionally, 5-year Kaplan-Meier survival curves were used based on the presence or absence of statins.Results: Overall, 2,945 and 9,189 patients were prescribed ACEIs and ARBs, respectively. When compared to ACEIs, the incidence of heart failure decreased by 52% in those taking ARBs (HR [95% CI] = 0.48 [0.39-0.60], P < 0.001), and the incidence of cerebrovascular disease increased by 62% (HR [95% CI] = 1.62 [1.26-2.07], P < 0.001). The incidence of ischemic heart disease (P = 0.223) and major adverse cardiovascular events (P = 0.374) did not differ significantly between the two groups.Conclusions: ARBs were not inferior to ACEIs in relation to reducing the incidence of cardiocerebrovascular disease in the clinical setting; however, there were slight differences for each disease. The greatest strength of real-world evidence is that it allows the follow-up of specific drug use, including drug compliance. Large-scale studies on the effects of relatively low-compliance ACEIs and high-compliance ARBs on cardiocerebrovascular disease are warranted in the future.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"7-14"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

hKLK alleviates myocardial fibrosis in mice with viral myocarditis. hKLK减轻病毒性心肌炎小鼠心肌纤维化。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2023.005

Youfa Qin, Xiaomei Ye, Ye Luo, Luting Peng, Guanghui Zhou, Yongkun Zhu, Chunyu Pan

{"title":"hKLK alleviates myocardial fibrosis in mice with viral myocarditis.","authors":"Youfa Qin, Xiaomei Ye, Ye Luo, Luting Peng, Guanghui Zhou, Yongkun Zhu, Chunyu Pan","doi":"10.32725/jab.2023.005","DOIUrl":"https://doi.org/10.32725/jab.2023.005","url":null,"abstract":"Myocardial fibrosis is the most serious complication of viral myocarditis (VMC). This study aimed to investigate the therapeutic benefits and underlying mechanisms of lentivirus-mediated human tissue kallikrein gene transfer in myocardial fibrosis in VMC mice. We established VMC mouse model via intraperitoneal injection with Coxsackie B3 virus. The effect was then assessed after treatment with vehicle, the empty lentiviral vectors (EZ.null), and the vectors expressing hKLK1 (EZ.hKLK1) via tail vein injection for 30 days, respectively. The results showed that administering EZ.hKLK1 successfully induced hKLK1 overexpression in mouse heart. Compared with EZ.null treatment, EZ.hKLK1 administration significantly reduced the heart/weight ratio, improved cardiac function, and ameliorated myocardial inflammation in VMC mice, suggesting that hKLK1 overexpression alleviates VMC in mice. EZ.hKLK1 administration also significantly abrogated the increased myocardial collagen content, type I/III collagen ratio, TGF-β1 mRNA and protein expression in VMC mice, suggesting that hKLK1 overexpression reduces collagen accumulation and blunts TGF-β1 signaling in the hearts of VMC mice. In conclusion, our results suggest that hKLK1 alleviates myocardial fibrosis in VMC mice, possibly by downregulating TGF-β1 expression.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"15-22"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amaryllidaceae alkaloids in skin cancer management: Photoprotective effect on human keratinocytes and anti-proliferative activity in melanoma cells. 紫丁香科生物碱在皮肤癌管理中的作用:对人角质形成细胞的光保护作用和黑色素瘤细胞的抗增殖活性。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2023.004

Carol Castaneda, Karent Bravo, Natalie Cortes, Janeth Bedoya, Warley S de Borges, Jaume Bastida, Edison Osorio

{"title":"Amaryllidaceae alkaloids in skin cancer management: Photoprotective effect on human keratinocytes and anti-proliferative activity in melanoma cells.","authors":"Carol Castaneda, Karent Bravo, Natalie Cortes, Janeth Bedoya, Warley S de Borges, Jaume Bastida, Edison Osorio","doi":"10.32725/jab.2023.004","DOIUrl":"https://doi.org/10.32725/jab.2023.004","url":null,"abstract":"Skin cancer has high rates of mortality and therapeutic failure. In this study, to develop a multi-agent strategy for skin cancer management, the selective cytotoxicity of several alkaloid fractions and pure alkaloids isolated from Amaryllidaceae species was evaluated in melanoma cells. In addition, UVB-stimulated keratinocytes (HaCaT) were exposed to seven alkaloid fractions characterized by GC-MS, and the production of intracellular reactive oxygen species (ROS) and IL-6, were measured to evaluate their photoprotection effects. The Eucharis caucana (bulb) alkaloid fraction (20 μg/ml) had a clear effect on the viability of melanoma cells, reducing it by 45.7% without affecting healthy keratinocytes. This alkaloid fraction and tazettine (both at 2.5 μg/ml) suppressed UVB-induced ROS production by 31.6% and 29.4%, respectively. The highest anti-inflammatory potential was shown by the Zephyranthes carinata (bulb) alkaloid fraction (10 μg/ml), which reduced IL-6 production by 90.8%. According to the chemometric analysis, lycoramine and tazettine had a photoprotective effect on the UVB-exposed HaCaT cells, attenuating the production of ROS and IL-6. These results suggest that Amaryllidaceae alkaloids have photoprotective and therapeutic potential in skin cancer management, especially at low concentrations.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"36-47"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

As a novel anticancer candidate, ether extract of Dendrobium nobile overstimulates cellular protein biosynthesis to induce cell stress and autophagy. 石斛醚提取物是一种新型的抗肿瘤药物，可过度刺激细胞蛋白合成，诱导细胞应激和自噬。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2022.019

Ruoxi Zhao, Shigang Zheng, Ying Li, Xueqin Zhang, Dan Rao, Ze Chun, Yadong Hu

{"title":"As a novel anticancer candidate, ether extract of Dendrobium nobile overstimulates cellular protein biosynthesis to induce cell stress and autophagy.","authors":"Ruoxi Zhao, Shigang Zheng, Ying Li, Xueqin Zhang, Dan Rao, Ze Chun, Yadong Hu","doi":"10.32725/jab.2022.019","DOIUrl":"https://doi.org/10.32725/jab.2022.019","url":null,"abstract":"Increasing data has confirmed the potential anticancer properties of Dendrobium, a traditional Chinese herb. However, most anticancer compositions from the plant of Dendrobium were usually extracted by high polar solvent, while weak polar compositions with excellent anticancer activity remained largely unexplored. In this study, the differences between ether extract and ethanol extract of Dendrobium nobile Lindl. on chemical components and anticancer activities were investigated, as well as the anticancer mechanisms among different extracts. The results demonstrated that the ether extract exhibited a stronger anticancer effect than ethanol extract, and its anticancer effect was mainly due to weak polar compounds rather than polysaccharides and alkaloids. Quantitative proteomics suggested that the ether extract significantly stimulated the over-expression of immature proteins, the endoplasmic reticulum stress and unfolded protein response were subsequently induced, the intracellular reactive oxygen species level was seriously elevated, and oxidative stress occurred in the meanwhile. Eventually, autophagy and apoptosis were activated to cause cell death. Our findings demonstrate that the ether extract of D. nobile is a potential candidate for anticancer drug development, and that future research on anticancer drugs derived from medicinal plants should also concentrate on weak polar compounds.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"23-35"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Closed reduction and minimally invasive screw osteosynthesis of Pipkin femoral head fractures. Pipkin股骨头骨折闭合复位微创螺钉固定术。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2023.001

Martin Kloub, Karel Holub, Marek Peml, Jiri Urban, Pavel Latal

{"title":"Closed reduction and minimally invasive screw osteosynthesis of Pipkin femoral head fractures.","authors":"Martin Kloub, Karel Holub, Marek Peml, Jiri Urban, Pavel Latal","doi":"10.32725/jab.2023.001","DOIUrl":"https://doi.org/10.32725/jab.2023.001","url":null,"abstract":"Background: Femoral posterior hip dislocation with associated femoral head fractures (Pipkin fractures) are rare high-energy injuries. Published treatment modalities involve conservative treatment, head fragment resection, open reduction and internal fixation, and total hip replacement. The experience with mini-invasive screw osteosynthesis of these fractures is the main focus of our study.Methods: Seven Pipkin fractures (five Pipkin II and two Pipkin I) in six patients were treated by closed reduction of hip dislocation, followed by minimal invasive lag screw osteosynthesis. Cancellous screw(s) were inserted from the incision on the lateral hip through the femoral neck to the reduced fracture fragment. In all patients, postoperative CT was performed to check the quality of surgery. Active physiotherapy with immediate toe-touch weight bearing was the routine postoperative protocol. In all patients, radiological and clinical results were evaluated with the Thompson Epstein, Merle d'Aubigne and Postel score, and Harris hip score.Results: All fractures united, and all femoral heads survived. Infectious complications were not observed, and no secondary surgery was needed. After an average follow-up of 18.4 months, the average Merle d'Aubigne and Postel score was 17.7 points, while the mean Harris hip score reached 98.1 points. The majority of patients achieved an excellent Thompson-Epstein clinical and radiological outcome. All patients returned to their original occupation.Conclusions: Mini-invasive screw osteosynthesis can be used for the treatment of Pipkin type I-II femoral head fractures. Successful reduction of hip dislocation and head fracture is necessary for using this technique. Long-term follow-up is necessary to confirm this technique.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines. 齐墩果酸通过调节炎症细胞因子对小鼠背侧皮肤毛发生长的影响。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2023-04-01 DOI: 10.32725/jab.2023.003

Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He

{"title":"Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines.","authors":"Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He","doi":"10.32725/jab.2023.003","DOIUrl":"https://doi.org/10.32725/jab.2023.003","url":null,"abstract":"Oleanolic acid (OA) is a pentacyclic triterpenoid with favourable physiological activity. It is widely distributed in more than 200 species of plants. OA has garnered significant interest because of its potential biological activities, such as antioxidant, bacteriostatic, and hair growth-promoting effects. To study the effect of OA on hair growth and related mechanisms, we investigated hair growth in mice with testosterone-induced androgenetic alopecia (AGA) that were treated with three diﬀerent concentrations of OA. The antioxidant, bacteriostatic, and cytotoxic effects of OA were evaluated. We found that mice with testosterone-induced AGA treated with 1% or 0.5% OA showed significantly enhanced hair growth and increased vascular endothelial growth factor/glyceraldehyde-3-phosphate dehydrogenase ratio and levels of fibroblast growth factor receptor and insulin-like growth factor 1. Using an immunofluorescence staining assay, we demonstrated that β-catenin, a key Wnt signalling transducer, was highly expressed in the OA-treated groups. These results suggest that OA may promote hair growth by stimulating hair matrix cell proliferation via the Wnt/β-catenin pathway and lowering the levels of tumour necrosis factor-alpha, and transforming growth factor-beta 1, dihydrotestosterone, and 5α-reductase.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 1","pages":"48-57"},"PeriodicalIF":1.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of periodontal membranes in the field of periodontology: spotlight on collagen membranes. 牙周膜在牙周病学领域的应用:聚焦于胶原膜。

IF 1.3 4区医学

Journal of applied biomedicine Pub Date : 2022-12-01 DOI: 10.32725/jab.2022.020

Hanene Ayari

{"title":"The use of periodontal membranes in the field of periodontology: spotlight on collagen membranes.","authors":"Hanene Ayari","doi":"10.32725/jab.2022.020","DOIUrl":"https://doi.org/10.32725/jab.2022.020","url":null,"abstract":"Periodontal regenerative techniques are performed to accomplish the restitution of soft and hard teeth-supporting tissues that have been lost due to trauma or inflammatory disease. Periodontal membranes are used for these techniques to provide support and a framework for cell growth and tissue regeneration. They act as a temporary and selective barrier to cell proliferation. Easy clinical handling, biomechanical specifications, high biocompatibility, cell-occlusivity, and satisfactory bioresorption rate are essential properties a membrane needs to be effective. The creation and maintenance of a secluded space is also a fundamental rule in periodontal regenerative techniques. The use of barrier membranes in the field of restorative dentistry has progressed toward the use of minimally invasive approaches optimizing wound closure and limiting patient morbidity. This review intends to provide an overview of the major cellular events in the surgical wound and membrane surface. It was also performed to assess, from literature data, the pertinence of using non-resorbable and resorbable membranes for this regenerative purpose. Special attention will be given to collagen membranes.","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"20 4","pages":"154-162"},"PeriodicalIF":1.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9119639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1