Journal of applied biomedicine最新文献

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Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell 嗅觉事件相关电位(OERPs)和三叉神经事件相关电位(TERPs)--对嗅觉正常的捷克参与者进行的试点研究
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-07 DOI: 10.32725/jab.2023.020
Richard Holý, K. Janoušková, L. Vašina, Eva Maute, David Kalfeřt, Kristýna Mamiňák, Eva Augste, Jiří Hložek, Helene Schulz, David Funda, Jaromír Astl
{"title":"Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell","authors":"Richard Holý, K. Janoušková, L. Vašina, Eva Maute, David Kalfeřt, Kristýna Mamiňák, Eva Augste, Jiří Hložek, Helene Schulz, David Funda, Jaromír Astl","doi":"10.32725/jab.2023.020","DOIUrl":"https://doi.org/10.32725/jab.2023.020","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"55 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats 长叶乌贼碱乙酸乙酯提取物对金黄色葡萄球菌感染大鼠肺部急性氧化和炎症损伤的影响
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-07 DOI: 10.32725/jab.2023.022
B. Dabanlioglu, B. Suleyman, R. Mammadov, Bulent Yavuzer, Sumeyye Akyuz, Onder Akkas, Behzad Mokhtare, E. A. Turumtay, D. Altuner, Taha Abdulkadir Coban, H. Suleyman
{"title":"Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats","authors":"B. Dabanlioglu, B. Suleyman, R. Mammadov, Bulent Yavuzer, Sumeyye Akyuz, Onder Akkas, Behzad Mokhtare, E. A. Turumtay, D. Altuner, Taha Abdulkadir Coban, H. Suleyman","doi":"10.32725/jab.2023.022","DOIUrl":"https://doi.org/10.32725/jab.2023.022","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"22 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138591337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion 柚皮素抑制新生大鼠背根神经节卫星神经胶质细胞上 P2X4 受体的表达
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-04 DOI: 10.32725/jab.2023.021
Hongji Wang, Lisha Chen, Juping Xing, Xiangchao Shi, Changshui Xu
{"title":"Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion","authors":"Hongji Wang, Lisha Chen, Juping Xing, Xiangchao Shi, Changshui Xu","doi":"10.32725/jab.2023.021","DOIUrl":"https://doi.org/10.32725/jab.2023.021","url":null,"abstract":"","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"61 15","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginsenoside Rb2 improves heart failure by down-regulating miR-216a-5p to promote autophagy and inhibit apoptosis and oxidative stress. 人参皂苷Rb2通过下调miR-216a-5p来促进自噬、抑制细胞凋亡和氧化应激,从而改善心力衰竭。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-12-14 DOI: 10.32725/jab.2023.024
You Peng, Bin Liao, Yan Zhou, Wei Zeng
{"title":"Ginsenoside Rb2 improves heart failure by down-regulating miR-216a-5p to promote autophagy and inhibit apoptosis and oxidative stress.","authors":"You Peng, Bin Liao, Yan Zhou, Wei Zeng","doi":"10.32725/jab.2023.024","DOIUrl":"10.32725/jab.2023.024","url":null,"abstract":"<p><strong>Background: </strong>Ginsenoside Rb2 is beneficial in cardiovascular disease treatment, yet its role in heart failure (HF) is obscure. This study aimed to investigate the effect and mechanism of ginsenoside Rb2 on HF.</p><p><strong>Methods: </strong>The left anterior descending branch-ligated HF rat model and oxygen-glucose deprivation/reoxygenation (OGD/R) H9c2 cell model were constructed. Ginsenoside Rb2 were applied for intervention. Heart function indexes, miR-216a-5p expression, autophagy, oxidative stress, apoptosis, cell morphology, and proliferation were detected to explore the effect of ginsenoside Rb2 on HF. Overexpression of miR-216a-5p was employed to explore the specific mechanism of ginsenoside Rb2 on HF.</p><p><strong>Results: </strong>Ginsenoside Rb2 improved the heart function of HF rats, including the reduction of heart rate, LVEDP, and heart weight/body weight ratio, and the increase of LVSP, +dP/dtmax, -dP/dtmax, LVEF, and LVFS. It also down-regulated miR-216a-5p expression and enhanced OGD/R-induced cardiomyocyte viability. Ginsenoside Rb2 up-regulated Bcl2, LC3B II/I, and Beclin1, and down-regulated Bax, Caspase-3, and p62 in the myocardium of HF rats and OGD/R-induced H9c2 cells. Moreover, ginsenoside Rb2 increased the levels of SOD and CAT, but decreased the levels of MDA and ROS in the myocardium of HF rats and OGD/R-induced H9c2 cells. However, overexpression of miR-216a-5p promoted the apoptosis and oxidative stress of cardiomyocytes and inhibited autophagy, thus reversing the therapeutic effect of ginsenoside Rb2 on HF in vivo and in vitro.</p><p><strong>Conclusion: </strong>Ginsenoside Rb2 demonstrated potential as a therapeutic intervention for HF by enhancing autophagy and reducing apoptosis and oxidative stress through miR-216a-5p downregulation. Further research could explore its application in clinical trials and investigate the complex mechanism networks underlying its effects.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 4","pages":"180-192"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways. 神黄膏药通过激活 TGF-β 和 Hippo/YAP 信号通路促进家兔肠吻合口愈合
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI: 10.32725/jab.2023.018
Fengchun Xiao, Chenchen Zhu, Xing Wei, Guiping Chen, Xiaohong Xu
{"title":"Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways.","authors":"Fengchun Xiao, Chenchen Zhu, Xing Wei, Guiping Chen, Xiaohong Xu","doi":"10.32725/jab.2023.018","DOIUrl":"10.32725/jab.2023.018","url":null,"abstract":"<p><p>Although many efforts have been made to improve management strategies and diagnostic methods in the past several decades, the prevention of anastomotic complications, such as anastomotic leaks and strictures, remain a major clinical challenge. Therefore, new molecular pathways need to be identified that regulate anastomotic healing, and to design new treatments for patients after anastomosis to reduce the occurrence of complications. Rabbits were treated with a MST1/2 inhibitor XMU-XP-1, a Chinese medicine formula Shenhuang plaster (SHP) or a control vehicle immediately after surgery. The anastomotic burst pressure, collagen deposition, and hydroxyproline concentration were evaluated at 3 and 7 days after the surgery, and qRT-PCR and western-blot analyses were used to characterize mRNA and protein expression levels. Both XMU-XP-1 and SHP significantly increased anastomotic burst pressure, collagen deposition, and the concentration of hydroxyproline in intestinal anastomotic tissue at postoperative day 7 (POD 7). Importantly, SHP could induce TGF-β1 expression, which activated its downstream target Smad-2 to activate the TGF-β1 signaling pathway. Moreover, SHP reduced the phosphorylation level of YAP and increased its active form, and treatment with verteporfin, a YAP-TEAD complex inhibitor, significantly suppressed the effects induced by SHP during anastomotic tissue healing. This study demonstrated that activation of the Hippo-YAP pathway enhances anastomotic healing, and that SHP enhances both the TGF-β1/Smad and YAP signaling pathways to promote rabbit anastomotic healing after surgery. These results suggest that SHP could be used to treat patients who underwent anastomosis to prevent the occurrence of anastomotic complications.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 4","pages":"208-217"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
False aneurysms of the thoracic aorta: anastomosis investigation using the inflation-extension test. 胸主动脉假性动脉瘤:利用充气-拉伸试验进行吻合术研究。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-12-13 DOI: 10.32725/jab.2023.023
Sandra Recicarova, Hynek Chlup, Michael Jonak, Ivan Netuka
{"title":"False aneurysms of the thoracic aorta: anastomosis investigation using the inflation-extension test.","authors":"Sandra Recicarova, Hynek Chlup, Michael Jonak, Ivan Netuka","doi":"10.32725/jab.2023.023","DOIUrl":"10.32725/jab.2023.023","url":null,"abstract":"<p><strong>Introduction: </strong>False aneurysms in the thoracic aorta are dangerous complications that can occur after cardiac surgery. They often result in high mortality rates. These aneurysms are caused by damage to all layers of the aortic wall. This study aimed to pinpoint the area of the experimental specimen (native vessel, anastomosis, or prosthetic graft) with the greatest deformation, to determine whether a false aneurysm is likely to develop in the anastomotic portion.</p><p><strong>Methods: </strong>We conducted the inflation-extension test by performing eight cycles ranging from 0 to 20. The pressure sampling frequency was 100 Hz, and each cycle lasted approximately 34 seconds, resulting in a loading frequency of 0.03 Hz. During the experiment, each camera captured 3,000 frames. Based on the data collected, we evaluated and compared the loading stages of cycle 1 and cycle 8.</p><p><strong>Results and discussion: </strong>During loading, the native vessel experienced a dominant deformation of approximately 7% in the circumferential direction. The prosthetic graft, which had a longitudinal construction, deformed by approximately 8% in the axial direction. The prosthetic graft, on the other hand, only experienced a deformation of up to 1.5% in the circumferential direction, which was about 5 times smaller than the deformation of the native vessel. The anastomosis area was very stiff and showed minimal deformation. Additionally, there was little difference in the mechanical response between the first C1 and the eighth C8 cycle.</p><p><strong>Conclusion: </strong>Based on the available evidence, it can be inferred that aortic false aneurysms are more likely to form just behind the suture lines in the native aorta, which is more elastic compared to stiff sections of anastomosis and prosthetic graft. Numerous pulsations of the native vessel will likely cause the impairment of the aorta at the margin of the anastomosis. This will lead to disruption of the aortic wall and false aneurysm formation in the native vessel near the area of anastomosis.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 4","pages":"174-179"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homospisulosine induced apoptosis in cervical carcinoma cells is associated with phosphorylation of Bcl-2 and up-regulation of p27/Kip1. 高磷肌苷诱导宫颈癌细胞凋亡与 Bcl-2 磷酸化和 p27/Kip1 上调有关。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI: 10.32725/jab.2023.019
Martina Bago Pilatova, Natalia Nosalova, Gabriela Ockajakova, Martin Kello, Klaudia Kotorova, Peter Takac, Peter Petik, Peter Bohus, Kvetoslava Stankova, Miroslava Martinkova, Roman Mezencev
{"title":"Homospisulosine induced apoptosis in cervical carcinoma cells is associated with phosphorylation of Bcl-2 and up-regulation of p27/Kip1.","authors":"Martina Bago Pilatova, Natalia Nosalova, Gabriela Ockajakova, Martin Kello, Klaudia Kotorova, Peter Takac, Peter Petik, Peter Bohus, Kvetoslava Stankova, Miroslava Martinkova, Roman Mezencev","doi":"10.32725/jab.2023.019","DOIUrl":"10.32725/jab.2023.019","url":null,"abstract":"<p><p>Spisulosine (1-deoxysphinganine) is a sphingoid amino alcohol isolated from the sea clams that showed potent antiproliferative activity against a broad spectrum of solid tumors but failed in clinical trials due to neurotoxicity. However, its structural similarity to other bioactive sphingoids, interesting mode of action, and appreciable potency against cancer cells make it a suitable lead for future anticancer drug development. The present study was conducted to elucidate mechanisms of the antiproliferative/cytotoxic effects of newly synthesized spisulosine analog homospisulosine (KP7). The evaluation was performed on cervical carcinoma cells, representing an in vitro model of one of the most common cancer types and a significant worldwide cause of women's cancer mortality. Treatment with homospisulosine (2.0 μM) for 24, 48, and 72 h significantly inhibited the growth of HeLa cells in vitro and induced apoptosis detectable by DNA fragmentation, externalization of phosphatidylserine, dissipation of mitochondrial membrane potential, activation of caspase-3 and cleavage of PARP. In addition, treating HeLa cells with spisulosine increased p27 and Bcl-2 on protein levels and phosphorylation of Bcl-2 on Ser70 residue. These results support the potential for spisulosine analogs represented here by homospisulosine for future therapeutic development.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 4","pages":"218-227"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular targets of Kangai injection in gastric cancer by in silico network pharmacology approach and experiment confirmation. 通过计算机网络药理学方法和实验证实了抗癌注射液在癌症中的分子靶点。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-09-01 Epub Date: 2023-09-22 DOI: 10.32725/jab.2023.017
Yongjun Qiu, Sujun Huang, Minfang Zhu
{"title":"The molecular targets of Kangai injection in gastric cancer by in silico network pharmacology approach and experiment confirmation.","authors":"Yongjun Qiu,&nbsp;Sujun Huang,&nbsp;Minfang Zhu","doi":"10.32725/jab.2023.017","DOIUrl":"https://doi.org/10.32725/jab.2023.017","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to identify the phytochemical constituents that could target gastric cancer in Kangai injection using a network pharmacology-based approach.</p><p><strong>Methods: </strong>Protein-protein interactions (PPI), Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted utilizing String and OmicShare tools. In the in vitro experiments, the related mRNA and protein levels were assessed via real-time quantitative polymerase chain reaction and Western blotting, respectively. Cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay.</p><p><strong>Results: </strong>Kangai injection comprises several compounds, which target multiple substrates and pathways related to gastric cancer. The PPI and Gene Ontology analyses revealed that tumor necrosis factor (TNF) was a hub gene. KEGG pathway enrichment analysis indicated that the the TNF pathway was significantly enriched. Kangai injection decreased the mRNA levels of TNFR2, TRAF2, PI3K, AKT, and IκBα and inhibited the phosphorylation of PI3K, AKT, and IκBα phosphorylations. Kangai injection inhibited cell proliferation, while TNFR2 overexpression or treatment with the PI3K activator 740 Y-P partially restored it.</p><p><strong>Conclusion: </strong>Kangai injection operates through multiple targets and pathways in gastric cancer, with the TNFR2/PI3K/AKT/NF-κB pathway playing a crucial role in its mechanism against gastric cancer.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 3","pages":"150-159"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resting-state EEG alpha rhythm spectral power in children with specific language impairment: a cross-sectional study. 特定语言障碍儿童静息状态脑电图α节律频谱功率的横断面研究。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-09-01 Epub Date: 2023-09-18 DOI: 10.32725/jab.2023.013
Nina Stanojevic, Saska Fatic, Ljiljana Jelicic, Vanja Nenadovic, Miodrag Stokic, Ruzica Bilibajkic, Misko Subotic, Tatjana Boskovic Matic, Ljubica Konstantinovic, Dragana Cirovic
{"title":"Resting-state EEG alpha rhythm spectral power in children with specific language impairment: a cross-sectional study.","authors":"Nina Stanojevic,&nbsp;Saska Fatic,&nbsp;Ljiljana Jelicic,&nbsp;Vanja Nenadovic,&nbsp;Miodrag Stokic,&nbsp;Ruzica Bilibajkic,&nbsp;Misko Subotic,&nbsp;Tatjana Boskovic Matic,&nbsp;Ljubica Konstantinovic,&nbsp;Dragana Cirovic","doi":"10.32725/jab.2023.013","DOIUrl":"10.32725/jab.2023.013","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated EEG alpha rhythm spectral power in children with Specific Language Impairment (SLI) and compared it to typically developing children to better understand the electrophysiological characteristics of this disorder. Specifically, we explored resting-state EEG, because there are studies that point to it being linked to speech and language development.</p><p><strong>Methods: </strong>EEG recordings of 30 children diagnosed with specific language impairment and 30 typically developing children, aged 4.0-6.11 years, were carried out under eyes closed and eyes open conditions. Differences in alpha rhythm spectral power in relation to brain topography and experimental conditions were calculated.</p><p><strong>Results: </strong>In the eyes closed condition, alpha rhythm spectral power was statistically significantly lower in children with specific language impairment in the left temporal (T5) and occipital electrodes (O1, O2) than in typically developing children. In the eyes open condition, children with SLI showed significantly lower alpha rhythm spectral power in the left temporal (T3, T5), parietal (P3, Pz), and occipital electrodes (O1, O2). There were no statistically significant differences between the groups in relation to the relative change (the difference between average alpha rhythm spectral power during eyes closed condition and average alpha rhythm spectral power during eyes open condition divided by average alpha rhythm spectral power during eyes closed condition) in the alpha rhythm spectral power between the conditions.</p><p><strong>Conclusion: </strong>Lower alpha rhythm spectral power in the left temporal, left, midline parietal, and occipital brain regions could be a valuable electrophysiological marker in children with SLI. Further investigation is needed to examine the connection between EEG alpha spectral power and general processing and memory deficits in patients with SLI.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 3","pages":"113-120"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41114998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guanxinning tablets improve myocardial hypertrophy by inhibiting the activation of MEK-ERK1/2 signaling pathway. 冠心宁片通过抑制MEK-ERK1/2信号通路的激活来改善心肌肥大。
IF 1.3 4区 医学
Journal of applied biomedicine Pub Date : 2023-09-01 Epub Date: 2023-09-18 DOI: 10.32725/jab.2023.014
Yan Zhang, Yu Huang, Quan-Xin Ma, Song-Tao Xu, Liye Shen, Yan-Yun Xu, Tu Hai-Ye, Min-Li Chen, Yi-Li Rong
{"title":"Guanxinning tablets improve myocardial hypertrophy by inhibiting the activation of MEK-ERK1/2 signaling pathway.","authors":"Yan Zhang,&nbsp;Yu Huang,&nbsp;Quan-Xin Ma,&nbsp;Song-Tao Xu,&nbsp;Liye Shen,&nbsp;Yan-Yun Xu,&nbsp;Tu Hai-Ye,&nbsp;Min-Li Chen,&nbsp;Yi-Li Rong","doi":"10.32725/jab.2023.014","DOIUrl":"https://doi.org/10.32725/jab.2023.014","url":null,"abstract":"<p><p>Myocardial hypertrophy may lead to heart failure and sudden death. As traditional Chinese medicine, Guanxinning tablets (GXN) have significant pharmacological effects in the prevention and treatment of cardiovascular diseases. However, the anti-cardiac hypertrophy efficacy of GXN and its mechanism of action are still unclear. Therefore, we established a heart failure rat model and isolated primary cardiomyocytes of neonatal rat to observe the protective effect of GXN on heart failure rat model and the intervention effect on myocardial cell hypertrophy, and to explore the possible mechanism of GXN preventing and treating myocardial hypertrophy. The results of in vivo experiments showed that GXN could significantly reduce the degree of cardiac hypertrophy, reduce the size of cardiomyocytes, inhibit the degree of myocardial remodeling and fibrosis, and improve cardiac function in rats with early heart failure. The results of in vitro experiments showed that GXN was safe for primary cardiomyocytes and could improve cardiomyocyte hypertrophy and reduce the apoptosis of cardiomyocytes in pathological state, which may be related to the inhibition of the over-activation of MEK-ERK1/2 signaling pathway. In conclusion, GXN may inhibit cardiac hypertrophy and improve early heart failure by inhibiting the over-activation of MEK-ERK1/2 signaling pathway.</p>","PeriodicalId":14912,"journal":{"name":"Journal of applied biomedicine","volume":"21 3","pages":"137-149"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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