Journal of Advanced Scientific Research最新文献_第7页

ASSESSMENT OF FLUID INTAKE IN UROLITHIASIS PATIENTS ATTENDING UROLOGY CLINIC AT A TERTIARY CARE CENTERIN NORTH KARNATAKA 北卡纳塔克邦三级护理中心泌尿科门诊尿石症患者液体摄入量评估

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131108

Akshata . Sangolli, R. Nerli, S. Ghagane

{"title":"ASSESSMENT OF FLUID INTAKE IN UROLITHIASIS PATIENTS ATTENDING UROLOGY CLINIC AT A TERTIARY CARE CENTERIN NORTH KARNATAKA","authors":"Akshata . Sangolli, R. Nerli, S. Ghagane","doi":"10.55218/jasr.2022131108","DOIUrl":"https://doi.org/10.55218/jasr.2022131108","url":null,"abstract":"Urolithiasis is a highly prevalent disease all over the world. The prevalence of kidney stone disease in India is around 12%. Fluid intake is one of the important modifiable risk factors in kidney stone disease which can be considered for preventive measures. Nevertheless, various kinds of fluids cannot have the same effect on stone formation. North Karnataka region is more prone to stone formation due to a lack of fluid intake in several parts. We aim to assess the intake of various fluids and beverages along with water in urolithiasis patients attending the urology clinic at the tertiary care centre. A total of 240 kidney stone patients attending a urology clinic at a tertiary care centre were enrolled for the study between the period of 2020 to 2021. Structured and validated questionnaires comprising detailed information about brief medical history, lifestyle habits and fluid intake habits were provided to the subjects. Kidney stones were collected from all 240 patients to analyse the chemical composition and spectral studies. Out of 240 patients, 152 were male patients and 88 were females. The overall male-to-female ratio was 1.72: 1. The mean Body Mass Index (BMI) of all the patients was 25.83. The highest numbers of cases (43.3%) were seen in the age group above 50. Around 65.8% of cases used to consume less than an adequate amount of water. In stone analysis, 58.3% were calcium oxalates and 16.6% were uric acid stones which was the second-highest among cases. Fluids like milk, tea, and fruit juices are shown to reduce the risk of stone formation to some extent whereas less water intake was a major risk factor. Alcohol and aerated beverages are still having controversial results in stone formation. So, more studies have to be conducted in different geographic regions which may help to prevent the reoccurrence and may reduce the burden of urolithiasis.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73502229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND IN-VITRO EVALUATION OF NICARDIPINE HYDROCHLORIDE BILAYERED TABLET FOR CONTROLLED RELEASE 盐酸尼卡地平双层控释片的处方及体外评价

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131109

Jyoti Bhusan Singh, P. Mourya, G. Rai, R. Shukla

{"title":"FORMULATION AND IN-VITRO EVALUATION OF NICARDIPINE HYDROCHLORIDE BILAYERED TABLET FOR CONTROLLED RELEASE","authors":"Jyoti Bhusan Singh, P. Mourya, G. Rai, R. Shukla","doi":"10.55218/jasr.2022131109","DOIUrl":"https://doi.org/10.55218/jasr.2022131109","url":null,"abstract":"The aim of present research work was to prepare and evaluate the controlled release bilayered tablet of Nicardipine HCL to improve its bioavailability for the treatment of hypertension. To minimize critical process parameters, two layer compression method was used for the formulation of Bilayered tablets. The appropriate formulation was achieved successfully with the combination of Polymers MCC, Carbopol 71G and HPMC K100M produced desired release profile for Metoprolol succinate extended release layer. The combination of disintegrating agents that is Sodium starch glycolate and Dicalcium phosphate produced desired release rate for Nicardipine immediate release layer. The results reveal that formulation F7 has met the objective of controlled drug release for over a period of 12 hrs. The formulation F7 ascertained the efficacy of the controlled released Bilayered tablet of Nicardipine and Metoprolol ER tablet in hypertension. This sustained release Bilayered tablet with the combination of Nicardipine and metoprolol can be used in the management of different types of hypertension. The formulation F7 of combination of Nicardipine and metoprolol showed controlled release profile among the other, Hence it was considered as an optimized formulation.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86541296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MODE OF ACTION OF BIOPESTICIDES AGAINST PESTS AND FUTURE PROSPECTS OF BIOPESTICIDES AND NANOBIOPESTICIDES 生物农药对害虫的作用方式及生物农药和纳米农药的发展前景

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131101

N. ., Sabah Mushtaq, G. Saji, Vinod Kumar Gupta

{"title":"MODE OF ACTION OF BIOPESTICIDES AGAINST PESTS AND FUTURE PROSPECTS OF BIOPESTICIDES AND NANOBIOPESTICIDES","authors":"N. ., Sabah Mushtaq, G. Saji, Vinod Kumar Gupta","doi":"10.55218/jasr.2022131101","DOIUrl":"https://doi.org/10.55218/jasr.2022131101","url":null,"abstract":"Biopesticides, and nano-biopesticides such as viruses, bacteria, fungi, algae, and nematodes are currently being used in a huge amount and their importance is increasing day by day because pesticides are already created a harmful effects on our health and environment. Due to the chemicals pesticides, diseases are increased in a high rate and food quality is decreased because toxicity level is increased. Biopesticides are best alternative to chemicals pesticides and best results to control pest control programs. The virulence of many biopesticides such as bacteria, fungus, and plant product were tested in laboratory and evaluated under field conditions and successfully approval by government. Biopesticide products are now sold in market for the control of pest and diseases. The aim of biopesticide research is to make these biopesticide products available at field level at a reasonable price and this would become a possible step in the integrated pest management strategy. Moreover, biopesticide research is still going on and in future more products are needed in aspects of bioformulation and areas such as commercialization. This review paper has the important and basic mode of action of major biopesticides in the past. The future prospects for the development of new biopesticides are also discussed such as nano- biopesticides.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83367167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC- MS SCREENING AND IN-SILICO PREDICTION OF PILA GLOBOSA EXTRACT AGAINST THE BONE DISEASES IN CALCITONIN RECEPTOR 球毛提取物降钙素受体抗骨病的Gc - ms筛选及计算机预测

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131111

Shanmugam . Pandirajan, S. Samuel, V. Iswaran, Ramaswamy Venkatachalam

{"title":"GC- MS SCREENING AND IN-SILICO PREDICTION OF PILA GLOBOSA EXTRACT AGAINST THE BONE DISEASES IN CALCITONIN RECEPTOR","authors":"Shanmugam . Pandirajan, S. Samuel, V. Iswaran, Ramaswamy Venkatachalam","doi":"10.55218/jasr.2022131111","DOIUrl":"https://doi.org/10.55218/jasr.2022131111","url":null,"abstract":"India’s flora and fauna has diverse medicinal properties and constitutes the major portion of our traditional medicine system. One among them is snails. Snails have a long history of being used for treating diseases in traditional medicinal systems around the world including India and China. Pila globosa is one of the largest land snails, mainly used as food. Here in this study, the gas chromatography and mass spectrometry discovered the presence of thirteen bio active constituents with various medicinal applications. The constituent Stigmasta-4, 22-dien-3-beta-ol had the highest retention time and exhibited a efficient binding with the human protein calcitonin receptor ectodomain. The calcitonin receptor types is expressed widely in various tissues and cells but most importantly in the osteoclates and hence a very important receptor in the treatment for bone disorders. The binding of the Pila globosa snail constituent with the human calcitonin receptor proved that a novel drug can be developed from the snail for the treatment of bone disorders such as osteoporosis, hypercalcemia of malignancy and paget’s disease. In addition to that, the snail extract exhibited no cytotoxicity and an efficient antioxidant property against DPPH and H2O2 free radicals. The FTIR analysis revealed the snail contained biologically significant functional groups with properties suitable for a drug and prevalent in most of the pharmaceutical drugs. Thus, these results imply the safety and efficacy of the snail Pila globosa for a novel drug development.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"251 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78373447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

FABRICATION OF NANO-STRUCTURED SURFACES BY FINE TUNING OF DEPOSITION PARAMETERS IN CHITOSAN/PSS POLYELECTROLYTE MULTILAYERS 精细调整壳聚糖/ pss聚电解质多层膜沉积参数制备纳米结构表面

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131110

Jissy Mathew

引用次数: 0

CASE REVIEW ON EFFECTS OF AZITHROMYCIN AND ERYTHROMYCIN ON LOWER RESPIRATORY INFECTION 阿奇霉素与红霉素治疗下呼吸道感染的病例回顾

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131107

E. M. V. Goud, Roshanara Ali, V. V. Rajesham, T. Rao

引用次数: 0

A REVIEW ON SECONDARY MANIFESTATIONS OF STRESS 应激的继发性表现综述

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131106

M. P. Mudagal, Arsha . Kv, Vincy Joseph, M. N, Nandadevi . ., S. Janadri, U. Sharma

引用次数: 0

ZEBRAFISH AS AN EMERGING ALTERNATIVE TOOL FOR STUDYING ANXIETY DISORDERS 斑马鱼作为研究焦虑症的新工具

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131103

Radami War, Surendra V, Sukanya Paul, U. Sharma, Suresh J, Manjunath Pm

引用次数: 1

ENHANCING HEALTH CARE MANAGEMENT ON HFMD 加强手足口病的医护管理

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131102

Paidigummal Uday Kumar, P. Pavithra, Sheri Sowmya, P. Deepika, P. Priya

引用次数: 0

MICROPROPAGATION OF PHARMACEUTICAL CROP RUBIA CORDIFOLIA 药用作物茜草的微繁研究

Journal of Advanced Scientific Research Pub Date : 2022-12-31 DOI: 10.55218/jasr.2022131112

D. M., E. Siril

{"title":"MICROPROPAGATION OF PHARMACEUTICAL CROP RUBIA CORDIFOLIA","authors":"D. M., E. Siril","doi":"10.55218/jasr.2022131112","DOIUrl":"https://doi.org/10.55218/jasr.2022131112","url":null,"abstract":"Plants are cherished as the chief resource for healthcare products attributed to synthesizing diverse array of bio-molecules through various metabolic alterations. Over exploitation of such resources can intimidate its existence. Developing medicinal plants into crops and the use of micropropagation as technique to mass produce high-demand biomass can make a continuous supply of natural therapeutic products. Rubia cordifolia is one such plant, so an improved, efficient, reproducible and reliable in vitro clonal propagation protocol is to be adopted for the conservation of germplasm. MS medium fortified with phytohormons viz., BA, Kin, 2-iP, TDZ, mT, IAA, IBA and NAA singly or in combinations were used for the study. After one month of inoculation, 2.5 μM of BA and TDZ (9.37) endorsed the instigation of multiple shoots through axillary bud proliferation in a short span of time. In vitro produced microshoots were subjected to ex vitro rooting by treating 2.5 mM IBA for 5 min and planting in plastic pots containing potting mixture, to produce maximum rooting (79.17%) response. It was found to be an efficient and effective mode of rooting, since it combines both hardening and rooting. Under green house condition, all the rooted plantlets showed more than 90% survival. So direct regeneration protocol from nodal explants without the intervention of callus and thus ensure production of clonally uniform plants of R. cordifolia.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79106644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0