JOURNAL OF ADVANCES IN CHEMISTRY最新文献

{"title":"Synthesis , Characterization and Biological activity of new derivatives of Chromen-2-one","authors":"A. Behrami","doi":"10.24297/jac.v15i1.7131","DOIUrl":"https://doi.org/10.24297/jac.v15i1.7131","url":null,"abstract":"We report the organic syntheses of new derivatives  from Chromen-2-one and their  antibacterial activity. Compounds  4-[Acetyl-(2-oxo-2H-chromen-4-yl)-amino]- \u0000benzenesulfonyl chloride 1a, 4-[Acetyl-(2-oxo-3-phenylsulfamoyl-2H-chromen-4-yl)-amino]-benzenesulfonyl chloride 2a , 2-{4-[Acetyl-(4-chlorosulfonyl-phenyl)-amino]-2-oxo-3-phenylsulfamoyl-2H-chromen-7-ylamino}-benzoic acid  3a. \u0000All Structures have been synthesized and characterized using melting points , IR spectra , 1H-NMR, 13C-NMR spectra , and elemental analyses  . The purified synthesized compounds (1a,2a,3a), at contcentrations 2,3,5 mg/ml was tested for their  antibacterial activity against three bacterial cultures ;Staphylococcus aureus, Escherchia coli and Bacillus cereus. The antibacterial activity of synthesized compounds are compared with antibacterial activity of standard antibiotics cephalexine and streptomycine.   \u0000The compounds (1a,2a,3a) shows  different bacteriostatic and bacteriocidal activity.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"11 1","pages":"6130-6135"},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72674744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of Acetyl Acetone with Methyl Acrylate","authors":"K. Asemave, U. J. Ahile","doi":"10.24297/JAC.V15I1.7122","DOIUrl":"https://doi.org/10.24297/JAC.V15I1.7122","url":null,"abstract":"Acetyl acetone was modified by a KF/alumina mediated Michael addition reaction under solventless condition with methyl acrylate. Methyl acrylate formed single and double addition with the acetyl acetone. The optimal temperature for this reaction was 393 K. The modified I²-diketones were confirmed using GC-FID and GC-MS. The products could be tested as metal chelating agents and in related applications.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"22 1","pages":"6116-6121"},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77822097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Parameters Of Effluents From A Lubricating Oil Company And Metal Analysis Of The Sediment Of The Receiving Stream In Osogbo Osun State, Nigeria","authors":"A. O. Adeniji, I. Olabanji, Ayodele Emmanuel Oluyemi","doi":"10.24297/JAC.V15I1.7100","DOIUrl":"https://doi.org/10.24297/JAC.V15I1.7100","url":null,"abstract":"Effluent and its receiving sediment samples were collected on seasonal basis, comprising of three months (August to October, 2014) in the wet season and three months (December 2014 to February 2015) in the dry season. Five sampling points around the lubricating oil company were marked for the study. Physicochemical parameters of the effluent samples such as pH, temperature, conductivity, total dissolve solids were determined in situ. Dissolved oxygen and biochemical oxygen demand were determined by Winkler´s method. Digestion of the sediments was carried out by acid dissolution. The heavy metals (Mn, Ni, Co, Cd and Pb) level was determined using Flame Atomic Absorption Spectrophotometer. The results revealed that the physicochemical parameters ranged between (27.40 to 29.860C) for temperature, pH (6.89 to 7.88), electrical conductivity (92.27 to 292.84µs/cm), total dissolve solids, dissolved oxygen (2.58 to 7.01mg/L), biochemical oxygen demand (5.00 to 14.00mg/L) for the sampling periods. The overall total metal was in similar order: Mn > Ni > Co > Cd > Pb for both seasons. Most of the results were within the recommended limit required except for the levels of biochemical oxygen demand which exceeded the recommended value of 10mg/L in dry season by WHO, (2006). Statistically, no significant difference at p ≤ 0.05 between the parameters obtained in both seasons. The study concluded that the effluents discharged from the lubricating oil company in osogbo was polluted based on the results of biochemical oxygen demand and the Cd concentrations in the sediment samples.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"18 776 1","pages":"6087-6098"},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73184459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Analytical Study For The Charge-Transfer Reactions Of Omeprazole With 2,3-Dichloro-Naphthoquinone And 2,3,5,6-Tetrabromo- 1,4-Benzoquinone: Application For The Development Of Microwell Assay Of Omeprazole","authors":"Saad A Alkahtania, A. Mahmoud, Samer S. Abu Al-Rubb","doi":"10.24297/JAC.V15I1.7003","DOIUrl":"https://doi.org/10.24297/JAC.V15I1.7003","url":null,"abstract":"Novel analytical study was performed in order to develop and validate new high-throughput microwell-based spectrophotometric assays for determination of omeprazole (OMZ) in its pharmaceutical formulations. The proposed assays were based on the charge-transfer (CT) reaction of OMZ with 2,3-dichloronaphthoquinone (DCNQ) and 2,3,5,6-tetrabromo-1,4-benzo-quinone (BROM). In the present study, the CT reactions was carried out in microwell plates as reaction vessels in order to increase the automation of the assays and the efficiency of its use in quality control laboratories (QCLs). All factors affecting the CT reactions were carefully studied, and the conditions were optimized. Kinetics and stoichiometry of the CT reactions were investigated, and the mechanism was postulated. Activation energy of the CT reactions was determined and found to be 13.87 and 16.27 Kcal mol−1 for the reaction of OMZ with DCNQ and BROM, respectively. The initial rate and fixed time methods were applied for generating the calibration graphs for determination of OMZ concentrations. Under the optimum conditions, the linear range was 0.145 – 1.45 x 10-4 and 1.45 – 7.25 x 10-4 M with LOD of 0.6 and 6.0 microgram ml-1 for DCNQ and BROM, respectively. Analytical performance of the proposed methods, in terms of accuracy and precision, was statistically validated and the results were satisfactory; RSD was <2.8% for both repeatability and reproducibility. The proposed methods were successfully applied to the analysis of OMZ in its dosage forms and the recovery results (98.64 – 100.6 ± 0.25 -2.74 %) were comparable with those of the reported method. The developed method may provide a safer and economic tool for the analysis of OMZ in QCLs.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"21 1","pages":"6099-6115"},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91101038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metallo - Bioactive Compounds as Potential Novel Anticancer Therapy","authors":"A. El-Tabl, M. Wahed, Mohammed H. H. Abu-Setta","doi":"10.5121/IJAC.2018.4102","DOIUrl":"https://doi.org/10.5121/IJAC.2018.4102","url":null,"abstract":"Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry. Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective treatment. the indicate the of water molecules, thermal analyses (DTA and were carried out to certain their nature. The thermal curves in the temperature 27-600°range for complexes ( 2 ), ( 3 ), ( 4 ), ( 5 ) and ( 6 are thermally stable up to 45 °C. Broken of hydrogen bonding occurs as endothermic peak within the temperature 45-50 °C as shown in (Table Dehydration is characterized by endothermic peak at the temperature 85 °C, corresponding to the loss of hydrated water molecules as in complex ( 5 ). The elimination of coordinated water molecules occur in 130-150°C range accompanied by endothermic peaks as in complexes ( 2 ), ( 3 ), ( 4 ), ( 5 ) and ( 6 ) [60,61]. The TG and DTA thermogramof Cu(II) complex ( 2 ) showed that, the complexes decomposed in five steps. The first occurred at 50°C with no weight loss as endothermic peak, may be due to break of hydrogen bonding. The second step occurred at 150°C with 5.50% weight loss (Calc. 5.65%) could be due to the elimination of two coordinated H 2 O. The TG curve displays another thermal decomposition at 265°C with 9.99% weight loss (Calc. 10.16%), which could be due to the loss of acetate group. The complex shows an exothermic peak observed at 320°C is due its melting point. Finally, exothermic peaks appear at 455, 504, 559, 580 and 595 °C corresponding to oxidative thermal decomposition which proceeds slowly with leaving CuO with 14.71% weight loss (Calc. 14.75%) 62 . The TG and DTA thermogramof Cu(II) Complex ( 5 ) shows endothermic peak at 85 °C, with 5.03% weight loss (Calc. 5.07%) due to The biological activity of the ligand (1) and its metal complexes (2) , (3) , (4) , (5) , (9) and (10) were evaluated aga","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"88 1","pages":"17-37"},"PeriodicalIF":0.0,"publicationDate":"2018-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80498943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Toxic Chemicals and Biological Pollutants from Groundwater Wells Using Modified Downflow Hanging Sponge Reactor","authors":"A. El-Tabl, Mahmoud Sayed Ahmed Shahin","doi":"10.5121/IJAC.2018.4101","DOIUrl":"https://doi.org/10.5121/IJAC.2018.4101","url":null,"abstract":"Water pollution is one of the most important environmental problems in the world. In developing countries, contaminated water has frequently caused water diseases. Today, water borne toxic chemicals (anions and heavy metal ions) and biological pollutants pose a great threat to the safety of water supplies. Currently, the quality of groundwater with respect to pollutants is of great concern. Modified Downflow Hanging Sponge (DHS) reactor will be a good groundwater treatment technology in the near future, it is used for excellent removal of heavy metals, anions, organic pollutants and harmful microbes, and also the reactor has advantages like low cost, easy to apply and satisfaction level. In order to achieve these objectives, treatment scheme has been investigated. It consists of mixing organic chelator with impure groundwater in different concentrations followed by a downflow hanging sponge (DHS) reactor. In the presence of 0.5 g/L of the chelator, the average removal of total NO3 and NO2 and (total dissolved solids) TDS are respectively 72%, 62% and 75%. The results show that, when Cd treated with chelator, the amount decreases from 0.0063 to 0.0 mgL -1 (100%) after 1 h, Cu decreases from 0.0023 to 0.0 mgL -1 (100%) after 1 h, Fe decreases from 0.4 to 0.0 mgL -1 (100%) after 1 h, Mn decreases from 0.3 to 0.0 mgL -1 (100%) after 1 h and Zn decreases from 0.012 to 0.0 mgL -1 (100%) after 1 h. Also, the results show removal of fecal coliform . Decreased from 50 to 0 and the overall removal efficiency of fecal coliform is (100%).","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"16 1","pages":"01-15"},"PeriodicalIF":0.0,"publicationDate":"2018-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79859963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorption of Ni(II) and Cr(III) ions by the Chironomus yoshimatsui larvae from wastewater","authors":"K. Ryoo","doi":"10.24297/JAC.V15I1.6725","DOIUrl":"https://doi.org/10.24297/JAC.V15I1.6725","url":null,"abstract":"In this study, Chironomus yoshimatsui larvae were applied to remove Ni(II) and Cr(III) ions from wastewater. The sorption studies were carried out using laboratory-reared C. y. larvae. It was found that C. y. larvae are very susceptible to Cr(III) as compared to Ni(II). The survival capacity of C. y. larvae was sharply reduced when exposed to even low Cr(III) concentration. Sorption isotherm and kinetics of C. y. larvae for Ni(II) were determined by means of controlled experiments in a batch system. It was observed that sorpyion efficiency of Ni(II) was largely concentration dependent and more effective at lower concentration. At each equilibrium, Ni(II) was removed up to roughly 44∼80 %. Sorption data were better fitted to the Langmuir isotherm model because of its correlation coefficient R2 value greater than that of the Freundlich isotherm model. The sorption kinetics by C. y. larvae for Ni(II) was well described a pseudo-first-order rate expression. C. y. larvae have enormous potential for application in wastewater treatment technologies because they are widespread and abundant all around the world and can be easily kept in culture.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"15 1","pages":"6062-6069"},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82142811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on Biodiesel Synthesis Using Nanosilica Immobilised Lipase in Inverse Fluidized Bed Bioreactors","authors":"C. Narayanan, A. Pandey","doi":"10.24297/JAC.V15I1.7108","DOIUrl":"https://doi.org/10.24297/JAC.V15I1.7108","url":null,"abstract":"Biodiesel synthesis from neem oil and methyl acetate using lipase catalyst immobilised in nanosilica particles in a continuous inverse fluidised bed bioreactor of modified design has been analysed. The process has been simulated mathematically by developing a multiparameter software package and subsequently verified through pilot plant tests(experiments).The improved performance characteristics of the bioreactor of proposed design have been highlighted. Graphical data have been presented to illustrate the dependence of reactor performance on system/operating parameters such as substrate flow rate, catalyst loading and molar ratio of oil to acetate in the blend(substrate solution).The downflow mode of operation is an added advantage of these bioreactors which tends to reduce their operating cost. Due to the use of nanoparticles, the effectiveness factor is close to unity and consequently, the global rate of transesterification is more or less equal to the intrinsic rate. This enhances the performance efficiency of the bioreactor.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"1 1","pages":"6072-6086"},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88129185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrode Processes in Electrochromic Anodic Oxide Films on Niobium","authors":"L. Skatkov, V. Gomozov, G. Tulskiy, S. Deribo, A. Tulskaya","doi":"10.24297/jac.v15i1.6828","DOIUrl":"https://doi.org/10.24297/jac.v15i1.6828","url":null,"abstract":"We review the following issues: peculiarities of polycrystalline AOP development at niobium in nitrate salt melt at temperatures of Nb2O5 recrystallization, the mechanisms of change in structure and properties of niobium pentoxide in the result of electrode processes under cathodic polarization (at the model structure of polycrystalline film), as well as the methods of amorphous electrochromic AOP development and ways of electrochromic processes optimization at such films.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"6 1","pages":"6070-6071"},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87485526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Of Fe(II) And Fe(III)-Hydralazine Complexes, A Potentiometric And Spectrophotometric Studa","authors":"S. Imad, M. Iqbal, S. Nisar, Shazia Ghaffar","doi":"10.24297/JAC.V14I1.6620","DOIUrl":"https://doi.org/10.24297/JAC.V14I1.6620","url":null,"abstract":"Iron in oxidation states (+2 and +3) is very essential element for human body, and its concentration significantly altered in cardio vascular disease. So the aim of the present work is to study the interaction of Fe(II) and Fe(III) with very commonly used antihypertensive drug hydralazine through potentiometric and spectrophotometric methods. The objectives of the work is to study the stoichiometry, behavior of the complexes in aqueous solution, effect of pH and behavior of this drugs towards both oxidation states of Iron. Both methods show that hydralazine forms a stable complex with both oxidation states of the metal, but the nature of complex changes with change in pH, ligand concentration and with time span. Both methods confirms 1:2 stoichiometry for Fe(II)-Hydralazine while 1:3 for Fe(III)-Hydralazine. Stabilities of both complexes were also calculated. For Fe(II)-Hydralazine complex values of log β1 and log β2 were found to be 4.99 and  7.58 respectively. For Fe(III)-Hydralazine complex log β1, log β2 and log β3 values were found to be 2.74, 7.39 and 11.32 respectively. At high ligand concentration hydralazine also show reducing properties. The study suggests a strong interaction of hydralazine with iron; however the nature of interaction is different with both oxidation states of iron.","PeriodicalId":14904,"journal":{"name":"JOURNAL OF ADVANCES IN CHEMISTRY","volume":"67 1","pages":"6046-6056"},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83460431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}