发布求助
文献互助 智能选刊 最新文献

Journal of Amino Acids最新文献

筛选
英文 中文
Pharmacokinetics of oral taurine in healthy volunteers. 健康志愿者口服牛磺酸的药代动力学。
Journal of Amino Acids Pub Date : 2010-01-01 Epub Date: 2010-06-29 DOI: 10.4061/2010/346237
Mohammadreza Ghandforoush-Sattari, Siminozar Mashayekhi, Channarayapatna V Krishna, John P Thompson, Philipp A Routledge
{"title":"Pharmacokinetics of oral taurine in healthy volunteers.","authors":"Mohammadreza Ghandforoush-Sattari,&nbsp;Siminozar Mashayekhi,&nbsp;Channarayapatna V Krishna,&nbsp;John P Thompson,&nbsp;Philipp A Routledge","doi":"10.4061/2010/346237","DOIUrl":"https://doi.org/10.4061/2010/346237","url":null,"abstract":"<p><p>Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22-45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method. Data were subjected to noncompartmental analysis. Maximum plasma taurine concentration (C(max)) was measured at 1.5 ± 0.6 hr after administration as 86.1 ± 19.0 mg/L (0.69 ± 0.15 mmol). Plasma elimination half-life (T(1/2)) and the ratio of clearance/bioavailability (Cl/F) were 1.0 ± 0.3 hr and 21.1 ± 7.8 L/hr, respectively. Since taurine is occasionally used in therapeutics as a medicine, the pharmacokinetics and effects of oral taurine in healthy volunteers would be useful in the future studies of taurine in pharmacology and nutrition.</p>","PeriodicalId":14901,"journal":{"name":"Journal of Amino Acids","volume":"2010 ","pages":"346237"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/346237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30458093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 77
Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase. 三种主要形式苯丙酰- trna合成酶的苯丙酰化结构及质量控制。
Journal of Amino Acids Pub Date : 2010-01-01 Epub Date: 2010-06-27 DOI: 10.4061/2010/983503
Liron Klipcan, Igal Finarov, Nina Moor, Mark G Safro
{"title":"Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase.","authors":"Liron Klipcan,&nbsp;Igal Finarov,&nbsp;Nina Moor,&nbsp;Mark G Safro","doi":"10.4061/2010/983503","DOIUrl":"https://doi.org/10.4061/2010/983503","url":null,"abstract":"<p><p>Aminoacyl-tRNA synthetases (aaRSs) are a canonical set of enzymes that specifically attach corresponding amino acids to their cognate transfer RNAs in the cytoplasm, mitochondria, and nucleus. The aaRSs display great differences in primary sequence, subunit size, and quaternary structure. Existence of three types of phenylalanyl-tRNA synthetase (PheRS)-bacterial (αβ)(2), eukaryotic/archaeal cytosolic (αβ)(2), and mitochondrial α-is a prominent example of structural diversity within the aaRSs family. Although archaeal/eukaryotic and bacterial PheRSs share common topology of the core domains and the B3/B4 interface, where editing activity of heterotetrameric PheRSs is localized, the detailed investigation of the three-dimensional structures from three kingdoms revealed significant variations in the local design of their synthetic and editing sites. Moreover, as might be expected from structural data eubacterial, Thermus thermophilus and human cytoplasmic PheRSs acquire different patterns of tRNA(Phe) anticodon recognition.</p>","PeriodicalId":14901,"journal":{"name":"Journal of Amino Acids","volume":"2010 ","pages":"983503"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4061/2010/983503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30458576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书