Advancements in Case Studies最新文献_第3页

Multi-Particulate High Intensity of Brain MRI in 30’s Male Heavy Smoker Suicidal Attempt Case following Mild COVID-19 Pneumonia 30岁男性重度吸烟者新冠肺炎轻度肺炎后自杀未遂病例的多颗粒高强度脑MRI分析

Advancements in Case Studies Pub Date : 2021-09-15 DOI: 10.31031/aics.2021.03.000558

K. Ikemoto

引用次数: 1

Case Report: Hyperglycemia-an Ominous Symptom of Disease Course of Covid-19 in Full-term Newborn 病例报告:高血糖——足月新生儿Covid-19病程的一个不祥症状

Advancements in Case Studies Pub Date : 2021-07-26 DOI: 10.31031/aics.2021.03.000556

R. Lauterbach

引用次数: 0

Mucormycosis and Aspergillosis have been Linked to Covid-19-Related Fungal Infections in India 在印度，毛霉病和曲霉病与covid -19相关的真菌感染有关

Advancements in Case Studies Pub Date : 2021-06-04 DOI: 10.31031/aics.2021.03.000555

C. Baruah

引用次数: 4

Toxic Epidermal Necrolysis Following Dabrafenib and Trametinib for Stage 3c Locally Advanced Inoperable Melanoma: A Case Report 达非尼和曲美替尼治疗局部晚期不能手术的3c期黑色素瘤后毒性表皮坏死松解一例报告

Advancements in Case Studies Pub Date : 2021-05-17 DOI: 10.31031/aics.2021.03.000554

C. Yeoh

{"title":"Toxic Epidermal Necrolysis Following Dabrafenib and Trametinib for Stage 3c Locally Advanced Inoperable Melanoma: A Case Report","authors":"C. Yeoh","doi":"10.31031/aics.2021.03.000554","DOIUrl":"https://doi.org/10.31031/aics.2021.03.000554","url":null,"abstract":"Severe cutaneous manifestations are commonly seen in drug hypersensitivity reactions which can present as pustular and bullous skin eruption. This can further progress and deteriorate into Steven-Johnsons syndrome or Toxic Epidermal Necrolysis syndrome (TENs) which require hospitalization. We report the case of a woman in her early fifties with metastatic melanoma who developed SJS and TENs 11 days following administration of Dabrafenib and Trametinib. Interestingly our patient had previously undergone 4 cycles of dual immunotherapy followed by single infusion of Nivolumab prior to this. Nivolumab had to be stopped due to grade 3 toxicity (hepatitis and hypoadrenalism). We believe this primed her immune system for potentially any hypersensitive reaction, in addition to attacking cancerous cells. Dabrafenib and Trametinib was commenced 18 days after discontinuation of immunotherapy. Our patient developed symptoms consistent with SJS and TEN, which was later confirmed on skin biopsy. She recovered well and following ITU admission and step down to oncology inpatient ward was discharged home. To our knowledge there are no links between Dabrafenib and SJS and TEN, although this has been reported in other BRAF inhibitors such as Vemurafenib. We changed her treatment to a third type of BRAF inhibitor, Encorafenib and Binimetinib (MEKtovi) which resulted in good Complete response control of her Melanoma for 6 months, to date. Epidermal Syndrome; (BRAF/MEKi): BRAF and inhibitor biologic","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"67 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116656017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Inducing RNAs (CIRs) from Human Fetal Heart Promote the Differentiation of Non-Muscle Cells to Form into Cardiomyocytes in vitro 心脏诱导rna (CIRs)在体外促进非肌肉细胞向心肌细胞的分化

Advancements in Case Studies Pub Date : 2021-04-01 DOI: 10.31031/aics.2021.03.000553

L. Lemanski

{"title":"Cardiac Inducing RNAs (CIRs) from Human Fetal Heart Promote the Differentiation of Non-Muscle Cells to Form into Cardiomyocytes in vitro","authors":"L. Lemanski","doi":"10.31031/aics.2021.03.000553","DOIUrl":"https://doi.org/10.31031/aics.2021.03.000553","url":null,"abstract":"We have discovered a cardiac-inducing RNA (CIR) in the axolotl, Ambystoma mexicanum , (a salamander) and two cardiac inducing RNAs (CIR-6 and CIR-30) in human heart that have the ability to induce the differentiation of non-muscle cells, including induced pluripotent stem cells from human skin, mouse embryonic stem cells, and mouse fibroblasts into cardiomyocytes in vitro . Although the primary sequences of salamander and human RNAs are not homologous, their secondary structures are very similar and we believe account for their shared unique abilities to promote differentiation of non-muscle cells into definitive cardiomyocytes. We are beginning to explore the potential for repair/regeneration of cardiac muscle in vivo using mouse and rat models with induced acute myocardial infarctions (AMI) to determine if pluripotent stem cells or fibroblasts transfected with the human CIRs or CIRs alone injected into the damaged areas of the hearts can affect repair of the damaged cardiac muscle tissue and return the infarcted hearts and the AMI animal models to pre-heart-attack function again. If cardiac cells damaged in heart attacks can be replaced with living, functioning cardiomyocytes, patients with heart disease would be able to have normal heart function restored and could return to normal pre-heart-attack activity levels. Understanding how CIR transforms non-muscle cells into vigorously contracting, functional cardiac muscle and effectively replacing damaged heart cells with newly-formed cardiac muscle tissue would represent a major breakthrough in modern biology and medicine with the potential to have a significant impact on the survival rate and quality of life of millions of individuals worldwide who suffer heart attacks each year.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127166187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docetaxel-Induced Supravenous Serpentine Dermatitis: A Case Report 多西他赛致静脉蛇形皮炎1例

Advancements in Case Studies Pub Date : 2020-12-10 DOI: 10.31031/aics.2020.02.000550

Nazia Hossain

引用次数: 0

The Relationship Between Type 2 Diabetes Mellitus and Osteoporosis in Elderly Patients: A Retrospective Study 老年患者2型糖尿病与骨质疏松关系的回顾性研究

Advancements in Case Studies Pub Date : 2020-12-03 DOI: 10.31031/aics.2020.02.000549

A. Alshaali

引用次数: 0

The Role of Blood Microbiome and Microbial Product Translocation in Disease Pathogenesis 血液微生物组和微生物产物易位在疾病发病中的作用

Advancements in Case Studies Pub Date : 2020-11-20 DOI: 10.31031/aics.2020.02.000548

Lei Huang

引用次数: 0

The Report of 20 Missed Real COVID-19 Cases 20例新冠肺炎真实漏诊病例报告

Advancements in Case Studies Pub Date : 2020-09-28 DOI: 10.31031/aics.2020.02.000546

Iraj Salehi Abari

{"title":"The Report of 20 Missed Real COVID-19 Cases","authors":"Iraj Salehi Abari","doi":"10.31031/aics.2020.02.000546","DOIUrl":"https://doi.org/10.31031/aics.2020.02.000546","url":null,"abstract":"The COVID-19 is a new contagious viral/immunological systemic disorder with predominantly respiratory features caused by human infection with SARS-CoV-2. From the time the virus enters the body to the time of initial symptoms of the disease, it is called the incubation period which ranges from one day to fourteen days. Initial presentation in the patients with mild COVID-19 is including mild fever, dry cough, fatigue and then body ache, anosmia, and lack of taste. About 40% of patients with COVID-19 are asymptomatic and, 40%; mild, 15%; severe, and 5% are critical COVID-19. A negative SARS-CoV-2 test does not rule out the diagnosis of COVID-19 and that a positive test does not necessarily indicate a COVID-19 diagnosis. The normal lungs in HRCT scan with a negative SARS-CoV-2 test does not preclude that the person has COVID-19. Patients may contract COVID-19 without any risk factors and have no symptoms. The authors conclude that to reject or confirm the diagnosis of COVID-19 by performing a SARS-CoV-2 kit test and the HRCT scanning of lungs may not be the gold standard for diagnosis of COVID-19. In other words, history is the key to COVID-19 diagnosis. Therefore, in this article, twenty cases of COVID-19 are presented, in most of which the diagnostic test of SARS-CoV-2 and HRCT scan of the lungs are negative.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130907747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Follow Up of a Patient with De Novo Mutation at Kcna2 Gene Leading to Ataxia and Epileptic Encephalopathy 病例报告:1例Kcna2基因从头突变导致共济失调和癫痫性脑病的随访

Advancements in Case Studies Pub Date : 2020-06-04 DOI: 10.31031/aics.2020.02.000545

Zanluchi Vbs

引用次数: 0