Journal of Aerosol Science最新文献

{"title":"Technical Note: Lifetime of evaporating droplets in a closed volume","authors":"N.M. Kortsenshtein","doi":"10.1016/j.jaerosci.2024.106472","DOIUrl":"10.1016/j.jaerosci.2024.106472","url":null,"abstract":"<div><div>The numerical modeling of heat and mass transfer of droplets within a closed volume containing gas heated in relation to the droplets was conducted. The droplet lifetime at variation of initial values of gas and droplet temperatures and droplet mass fraction has been determined. It was found that droplet lifetime exhibits a weak dependence on the initial droplet temperature and a pronounced dependence on the initial gas temperature. Moreover, it was demonstrated that the droplet lifetime in a closed volume is longer than in infinite space. This is due to the fact that the cooling of the surrounding gas by droplets results in a decrease in the evaporation rate of the droplets. A parameter is proposed which allows for the consideration of the effect of evaporating droplets on the thermal regime of the gas-drop mixture, and which enables the generalization of the results of numerical simulation to obtain an expression for the droplet lifetime in a closed volume. The error in the use of the obtained expression is estimated. It was determined that the margin of error for the calculation results is less than ten percent.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106472"},"PeriodicalIF":3.9,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of pediatric extrathoracic aerosol deposition with air-jet dry powder inhalers","authors":"Morgan L. Thomas ,&nbsp;Karl Bass ,&nbsp;Dale Farkas ,&nbsp;Worth Longest","doi":"10.1016/j.jaerosci.2024.106474","DOIUrl":"10.1016/j.jaerosci.2024.106474","url":null,"abstract":"<div><div>The use of air-jet dry powder inhalers (DPIs) offers a number of advantages for the administration of pharmaceutical aerosols, including the ability to achieve highly efficient and potentially targeted aerosol delivery to the lungs of children using the oral or trans-nasal routes of administration. To better plan targeted lung delivery of pharmaceutical aerosols with these inhalers, more information is needed on the extrathoracic (ET) depositional loss in pediatric subjects when using relatively small (e.g., 0.5–2 μm) particles and including oral or nasal device interfaces. The objective of this study was to implement validated computational fluid dynamics (CFD) models to characterize ET depositional loss during mouth-throat (MT) and nose-throat (NT) aerosol administration to pediatric subjects (2–10 years old) using an air-jet DPI platform across a range of initial small-particle aerosol sizes (0.41–13.65 μm) and inhalation flow rates (8–20 L/min).</div><div>A new CFD model focused on small-particle aerosol depositional loss in existing pediatric airway models was developed and validated with existing <em>in vitro</em> data. The validated CFD model was then used to characterize depositional loss in the MT and NT regions of children using particle sizes, flow rates and interfaces consistent with air-jet DPIs.</div><div>Successful validation of the CFD model for small-particle aerosol deposition was achieved through enhanced resolution of the near-wall transport conditions. Existing non-dimensional parameters were used to produce high quality single-curve deposition efficiency correlations with r² values in the range of 0.95–0.97. A new method for predicting realistic polydisperse aerosol deposition using the developed correlations and an equivalent monodisperse particle diameter was also introduced. In conclusion, the newly developed correlations will be useful in planning the lung delivery of next-generation inhaled medications, where achieving both low ET loss and targeted airway deposition, perhaps with excipient enhanced growth technology, are critical factors.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106474"},"PeriodicalIF":3.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of photochemical aging and interactions with secondary organic aerosols on cellular toxicity of combustion particles","authors":"Reuben Attah ,&nbsp;Kamaljeet Kaur ,&nbsp;Christopher A. Reilly ,&nbsp;Cassandra E. Deering-Rice ,&nbsp;Kerry E. Kelly","doi":"10.1016/j.jaerosci.2024.106473","DOIUrl":"10.1016/j.jaerosci.2024.106473","url":null,"abstract":"<div><div>Fine particulate matter (PM_2.5) is associated with numerous adverse health effects, including pulmonary and cardiovascular diseases and premature death. Significant contributors to ambient PM_2.5 include combustion particles and secondary organic aerosols (SOA). Combustion particles enter the atmosphere and undergo an aging process that changes their shape and composition, but there is limited study on the health effects of combustion particle aging and interactions with SOA. This study aimed to understand how biological responses to combustion particles would be affected by atmospheric aging and interaction with anthropogenic SOA. Fresh combustion particles underwent photochemical aging in a potential aerosol mass (PAM) oxidation flow reactor and interacted with SOA produced by the oxidation of toluene vapor in the PAM reactor. Photochemical aging and SOA interactions lead to significant changes in the PAH content and oxidative potential of the particle. Photochemical aging and SOA interactions also affected the biological responses, such as the inflammatory response and CYP1A1 induction of the particles in monoculture and coculture cells. These findings highlight the significance of photochemical aging and SOA interactions on the composition and cellular responses of combustion particles.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106473"},"PeriodicalIF":3.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedimentation and photophoretic levitation of aerosol clusters in the free molecular regime","authors":"A.A. Cheremisin ,&nbsp;A.V. Kushnarenko","doi":"10.1016/j.jaerosci.2024.106470","DOIUrl":"10.1016/j.jaerosci.2024.106470","url":null,"abstract":"<div><div>Sedimentation of fractal aerosol clusters in rarefied gas medium in the dark and under external illumination similar to sunlight is studied in a numerical experiment taking into account orientation effects, depending on fractal dimension varying within a broad range. The calculation of forces and their moments, including friction forces and photophoretic forces, was carried out on the basis of approximation of free molecular gas kinetic regime and previously developed Monte-Carlo algorithms. Calculation involved 10<!--> <!-->000 clusters, each of them containing 160 primary spherical particles and efficiently absorbing sunlight and IR radiation, similarly to the particles of soot aggregates.</div><div>The velocity of multi-particle cluster settling in the absence of illumination, when particle temperatures are equal to the temperature of the gaseous environment, is a distinct function of fractal dimension and is rather close to the velocity of settling of single spherical particles. The settling velocity approximation depending on fractal dimension has been obtained.</div><div>Illumination brings dramatic changes into sedimentation pattern. The range of cluster sedimentation rate variations broadens substantially, which is a manifestation of gravito-photophoretic effect, so that some clusters even start to levitate. The proportion of levitating clusters is essentially dependent on fractal dimension. For soot-like clusters under irradiation similar to sunlight and pressure equal to atmospheric at the altitude of 30 km, the proportion of levitating aggregates is approximately 7%, which is in good agreement with the experimental data. In the dark and under irradiation, the aggregates rotate, and their trajectories are shaped as spirals.</div><div>In the context of photophoretic phenomena, a result of principle has been obtained: under irradiation with sunlight, gravito-photophoretic levitation of aerosol soot-like aggregates composed of identical primary particles is possible at a pressure corresponding to the stratospheric altitudes. This result points to the possibility of substantial influence of gravito-photophoretic effect on transport and localization of soot aerosol in the Earth’s stratosphere and mesosphere.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106470"},"PeriodicalIF":3.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject-specific multi-scale modeling of the fate of inhaled aerosols","authors":"A.P. Kuprat ,&nbsp;Y. Feng ,&nbsp;R.A. Corley ,&nbsp;C. Darquenne","doi":"10.1016/j.jaerosci.2024.106471","DOIUrl":"10.1016/j.jaerosci.2024.106471","url":null,"abstract":"<div><div>Determining the fate of inhaled aerosols in the respiratory system is essential in assessing the potential toxicity of inhaled airborne materials, responses to airborne pathogens, or in improving inhaled drug delivery. The availability of high-resolution clinical lung imaging and advances in the reconstruction of lung airways from CT images have led to the development of subject-specific in-silico 3D models of aerosol dosimetry, often referred to as computational fluid-particle-dynamics (CFPD) models. As CFPD models require extensive computing resources, they are typically confined to the upper and large airways. These models can be combined with lower-dimensional models to form multiscale models that predict the transport and deposition of inhaled aerosols in the entire respiratory tract. Understanding where aerosols deposit is only the first of potentially several key events necessary to predict an outcome, being a detrimental health effect or a therapeutic response. To that end, multiscale approaches that combine CFPD with physiologically-based pharmacokinetics (PBPK) models have been developed to evaluate the absorption, distribution, metabolism, and excretion (ADME) of toxic or medicinal chemicals in one or more compartments of the human body. CFPD models can also be combined with host cell dynamics (HCD) models to assess regional immune system responses. This paper reviews the state of the art of these different multiscale approaches and discusses the potential role of personalized or subject-specific modeling in respiratory health.</div></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106471"},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new procedure to validate and optimize 210Po measurements in atmospheric aerosols","authors":"A. Barba-Lobo ,&nbsp;E.G. San Miguel ,&nbsp;J.P. Bolívar","doi":"10.1016/j.jaerosci.2024.106469","DOIUrl":"10.1016/j.jaerosci.2024.106469","url":null,"abstract":"<div><p>The exposure to air fine aerosols can cause health effects due to inhalations of alpha emitters such as ²²²Rn daughters. Lead-210 and ²¹⁰Po are mainly associated to aerosols with median aerodynamic diameter lower than 1 μm. The ²¹⁰Po is characterized by having a high radiotoxicity. The precise measurement of ²¹⁰Po in surface air aerosols is usually quite complex due to the significant contribution of the ²¹⁰Pb on their concentrations. Additionally, there is no possible means to manufacture a certified material to validate the measurements of ²¹⁰Pb and ²¹⁰Po concentrations in surface air aerosols. For these reasons, this study aims to develop a novel and comprehensive methodology to validate ²¹⁰Po measurements in surface air aerosols by preparing in our laboratory “standard samples” with known activities of both ²¹⁰Pb and ²¹⁰Po. A detailed sensitivity analysis on the precision of ²¹⁰Po concentration measurements has been carried out as a function of the involved variables such as sampling time, time elapsed between the sampling start and ²¹⁰Po self-deposition and the ²¹⁰Po/²¹⁰Pb activity ratio in surface air aerosols. This study is necessary to find the optimum conditions for a precise measurement of ²¹⁰Po in surface air aerosols. In addition, this methodology has been applied for the determination of ²¹⁰Po concentrations in 30 samplings campaigns of atmospheric aerosols carried out at the El Carmen campus (Huelva province) from March 25th to July 15th, 2022. The results obtained for ²¹⁰Pb and ²¹⁰Po concentrations and atmospheric aerosol residence times (via ²¹⁰Po/²¹⁰Pb activity ratio) were consistent with other previous works.</p></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106469"},"PeriodicalIF":3.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021850224001368/pdfft?md5=d3f23dfe804d18dc3a2f8073405f7bba&pid=1-s2.0-S0021850224001368-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaerosol sampling and bioanalysis: Applicability of the next generation impactor for quantifying Legionella pneumophila in droplet aerosols by flow cytometry","authors":"Lena Heining ,&nbsp;Laura Welp ,&nbsp;Achim Hugo ,&nbsp;Martin Elsner ,&nbsp;Michael Seidel","doi":"10.1016/j.jaerosci.2024.106460","DOIUrl":"10.1016/j.jaerosci.2024.106460","url":null,"abstract":"<div><p>Bioaerosol generation, sampling, and cultivation-independent quantification of pathogenic bacteria play a crucial role in studying dose-response effects of <em>Legionella pneumophila</em>. Here, the Next Generation Impactor (NGI), initially created for pharmaceutical inhaling studies, was assessed for its potential to sample airborne bioaerosols and to separate size-dependent wet droplets by incrementally increasing the airflow speed. This stainless-steel sampler was shown in this study to be suitable for sampling prior to cultivation-independent analysis of pathogen-containing bioaerosols using washable cups. The applicability was studied by quantifying the total and intact cell count of <em>L. pneumophila</em> by flow cytometry after being dispersed into a droplet aerosol. Our results demonstrate a high total sampling efficiency of 95.5% ± 11.8% despite a lower biological sampling efficiency of 59.7% ± 16.5% for dry aerosols. However, by elevating the relative humidity (RH) to 100% in a liquid aerosolization unit, the biological sampling efficiency increased to over 90% for <em>L. pneumophila.</em> More than 50% of the cells were found in stage 1 using the liquid aerosolization unit. In comparison, 80% of the cells were sampled in stages 4–6 at 30% RH. Specifically, while at 100% RH, the droplet size mattered, at 30% RH, the size distribution of dry particles, in this case <em>L. pneumophila</em>, was relevant due to evaporation processes, which explains the size differences. These findings indicate the potential of the NGI for further exploration and application in studying other aerosol-borne pathogens, especially concerning the size distribution of wet droplets, viability, or effect-based bioanalysis.</p></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"183 ","pages":"Article 106460"},"PeriodicalIF":3.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021850224001277/pdfft?md5=953240a91f2134ba9b3fbe98ff5ee60f&pid=1-s2.0-S0021850224001277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of air-borne and feces-borne ARGs and microbial community in different livestock farms in China","authors":"Khamsay Keovilayphone ,&nbsp;Ran Cao ,&nbsp;Can Wang ,&nbsp;Lu Song ,&nbsp;Min Gao","doi":"10.1016/j.jaerosci.2024.106459","DOIUrl":"10.1016/j.jaerosci.2024.106459","url":null,"abstract":"<div><p>Livestock farms are hotspots of antibiotic resistance due to the intensive use of antibiotics, in which the characteristics of air-borne and feces-borne antibiotic resistance genes (ARGs) and microbial communities are of great significance. This study delves into the distribution of ARGs and microbial communities across various livestock farms in China, and the correlation of microorganisms between livestock farms and other global environments was investigated. The concentrations of ARGs and mobile genetic elements (MGEs) in air samples were basically at the same level, but those in fecal samples collected from chicken farms were universally higher than those in pig and cattle farms. There was significant ability of ARGs to spread easily among different bacteria in all samples in livestock farms. Additionally, there may be more possible host bacteria of airborne ARGs in chicken farms. In the global-scale analysis of highly similar microbial communities, the database matching with the highest number of similarities to microbial communities collected from livestock farms is genes related to human sources (54.8%). This study advances our understanding of ARG dynamics in different livestock farms and contributes to the development of sustainable livestock management practices.</p></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"182 ","pages":"Article 106459"},"PeriodicalIF":3.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between beverage consumption and droplet production during respiratory activity using interferometric Mie imaging experiment","authors":"Wonseok Oh ,&nbsp;Yunchen Bu ,&nbsp;Hideki Kikumoto ,&nbsp;Ryozo Ooka","doi":"10.1016/j.jaerosci.2024.106458","DOIUrl":"10.1016/j.jaerosci.2024.106458","url":null,"abstract":"<div><p>This study investigates the effects of beverage consumption on droplet production during coughing and speaking. Interferometric Mie imaging (IMI) measures particle size using the diffraction characteristics of light and was used to examine the particle size distribution and particle count concentration of exhaled droplets without water (WW), with still water (SW), and with carbonated water (CW). The parameters of the IMI technique were calibrated using glass beads and respiratory droplets were measured for 16 subjects, which showed that drinking beverages had a significant impact on the particle size distribution during coughing and speaking. Another important aspect of this study was the variability in particle emissions among individuals. The results showed that the consumption of SW and CW led to a significant increase in total particle count concentrations in the coughing condition when compared with WW, with no significant difference among beverage type. Individuals with relatively high particle emissions WW showed more particle generation when consuming SW and CW. When speaking, SW ingestion significantly increased the total particle count concentrations when compared with the WW condition, whereas CW consumption did not increase the total particle count concentrations to the same extent as that in the SW condition. These results emphasize that the consumption of beverages such as SW and CW have the potential to significantly increase particle production during respiratory activities, amplifying the potential risks associated with infection transmission.</p></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"182 ","pages":"Article 106458"},"PeriodicalIF":3.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple-charging effects on the CCN activity and hygroscopicity of surrogate black carbon particles","authors":"Ogochukwu Y. Enekwizu ,&nbsp;Jezrielle Annis-Mildon ,&nbsp;Ernie R. Lewis ,&nbsp;Arthur J. Sedlacek III","doi":"10.1016/j.jaerosci.2024.106457","DOIUrl":"10.1016/j.jaerosci.2024.106457","url":null,"abstract":"<div><p>Accurate measurements of cloud condensation nuclei (CCN) activity and hygroscopicity of black carbon (BC)-containing particles are particularly important because of the positive climate forcing from these particles. Such measurements are typically conducted on particles selected by a Differential Mobility Analyzer (DMA), which in addition to singly charged particles transmits multiply charged larger particles that have the same electrical mobility. These larger particles activate at lower supersaturations than the singly charged particles, biasing measurements and resulting in overestimation of CCN activity and hygroscopicity parameter (<em>κ</em>). Here, we measure the CCN activity and determine <em>κ</em> for different BC surrogates with electrical mobility diameters from 100 to 200 nm selected 1) only by electrical mobility with a DMA, and 2) by both electrical mobility and mass using a DMA and a Centrifugal Particle Mass Analyzer (CPMA), thus allowing selection of only singly charged particles. We demonstrate the use of the DMA-CPMA system in resolving biases caused by multiply charged particles, and we show that the effect of multiple charging on the CCN activity of the BC particles is strongly influenced by morphology dispersion, i.e., the variability due to the range of morphologies of particles that have the same electrical mobility and mass. Our findings show that electrical mobility-based methods alone are unlikely to lead to accurate results in measurements of CCN activation and hygroscopicity of BC particles, even for those with a more compact morphology.</p></div>","PeriodicalId":14880,"journal":{"name":"Journal of Aerosol Science","volume":"182 ","pages":"Article 106457"},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}