{"title":"Profile and Outcomes of Patients Presenting With Sympathetic Crashing Acute Pulmonary Edema (SCAPE) to a Tertiary Care Emergency Department in North India: A Prospective Observational Study.","authors":"Ankit Sharma, Bharat Bhushan Bhardwaj, Poonam Arora, Roshan Mathew, Naman Agrawal","doi":"10.6705/j.jacme.202609_16(3).0003","DOIUrl":"10.6705/j.jacme.202609_16(3).0003","url":null,"abstract":"<p><strong>Background: </strong>Sympathetic crashing acute pulmonary edema (SCAPE) is a severe manifestation of acute heart failure, characterized by sudden pulmonary edema due to elevated sympathetic activity.</p><p><strong>Objective: </strong>This study aimed to describe the clinical profile, management, and short-term outcomes of patients with SCAPE presenting to a tertiary care hospital in North India.</p><p><strong>Methods: </strong>This prospective observational study described the clinical profile of patients with SCAPE who were managed with high-dose nitroglycerin (NTG).</p><p><strong>Results: </strong>Sixty-two patients with a mean age of 49.4 years were enrolled, and 90.3% had one or more comorbidities. All patients exhibited signs of sympathetic excess and pulmonary edema on point-of-care ultrasound (POCUS). The treatment protocol included high-dose NTG and non-invasive ventilation (NIV). Male sex, chronic kidney disease, longer symptom duration, plethoric inferior vena cava on POCUS, higher initial lactate, and the need for hemodialysis were identified as predictors of poor outcomes in the univariate analysis.</p><p><strong>Conclusions: </strong>This study highlights that a protocol-based approach using high-dose NTG and NIV in managing SCAPE patients shows a favorable outcome, resulting in low rates of mechanical ventilation and mortality despite high comorbidity burden and ICU admission rates.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"114-121"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intermittent Bundle Branch Block on Alternate Beats During Sinus Tachycardia.","authors":"Fang-Yu Lin, Kuan-Ting Liu","doi":"10.6705/j.jacme.202609_16(3).0005","DOIUrl":"10.6705/j.jacme.202609_16(3).0005","url":null,"abstract":"<p><p>Regular alternation of wide and narrow QRS complexes is a rare electrocardiographic finding. This report describes a case of sinus tachycardia with a 2:1 atrioventricular (A/V) conduction ratio, showing alternating narrow QRS complexes and right bundle branch block-patterned beats.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"127-129"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adopting a Hyperlordotic Posture can Prevent the Leakage of Cerebrospinal Fluid (CSF) After Lumbar Puncture and Thus Prevent Post-Dural Puncture Headache.","authors":"Josef Finsterer","doi":"10.6705/j.jacme.202609_16(3).0007","DOIUrl":"10.6705/j.jacme.202609_16(3).0007","url":null,"abstract":"","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"139-140"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epigallocatechin-3-gallate Modulates Hyperglycemia-Triggered Macrophage Autophagy Through miR-204-5p Suppression: Implication for Acute Cardiometabloic Injury.","authors":"Chiu-Mei Lin, Bao-Wei Wang, Wei-Jen Fang, Chun-Ming Pan, Kou-Gi Shyu","doi":"10.6705/j.jacme.202609_16(3).0004","DOIUrl":"10.6705/j.jacme.202609_16(3).0004","url":null,"abstract":"<p><p>Epigallocatechin-3-gallate (EGCG) possess many biological properties. Autophagy and inflammation interact to cause cardiovascular diseases, and diabetic cardiovascular diseases; hyperglycemia- and hyperinsulinemia-induced microRNA reduction in the diabetic heart contribute to poor survival and increased infarct size in diabetic myocardial ischemia/reperfusion. However, whether EGCG affects macrophage autophagy and microRNA 204-5p (miR-204-5p) regulation under hyperglycemic conditions remain unclear. In this report, we investigated the effects of EGCG on the molecular regulatory mechanisms of miR-204-5p in LC3B macrophage autophagy under hyperglycemic stimulation conditions. Reverse transcription and real-time quantitative polymerase chain reaction, western blots, and luciferase activity assay were performed. Macrophages were cultured with 5.5 mM (low glucose) and 25 mM (high glucose) for hyperglycemia stimulation, and hyperglycemia was induced for 1 hour. EGCG attenuated cytoplasmic miR-204-5p levels under hyperglycemia stress in time-course and concentration dependent manners. Hyperglycemic treat-EGCG augmented the macrophage autophagy marker LCB mRNA by under hyperglycemia stress in a time-dependent manner significantly. Treatment with EGCG (10<sup>-5</sup> M) or rapamycin or mutant miR-204-5p significantly augmented the LC3B protein expression through the suppressed miR-204-5p level in mouse macrophage cultures under high glucose (25 mM) stimulation at 6 hours. By luciferase activity assay, EGCG combined mutant miR-204-5p reduced LC3B binding activity under hyperglycemia stress. Taken together, EGCG regulates LC3B presentation under hyperglycemia stress by mediating the miR-204-5p under mimicking cardiometabolic injury. This study demonstrated that EGCG upregulated LC3B to suppress miR-204-5p expression in hyperglycemia-stimulated macrophage cultures. The results imply that EGCG is potentially effective for preventing hyperglycemia related cardiovascular diseases.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"122-126"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuh-Jen Ju, Chin-Hua Su, Lorenzo Porta, Shu-Yu Tsao, Chien-Chang Lee
{"title":"The Epidemiological Trends of Hospitalized Pneumonia Patients in Taiwan in 2019 and 2020: A Population-based Nationwide Study.","authors":"Yuh-Jen Ju, Chin-Hua Su, Lorenzo Porta, Shu-Yu Tsao, Chien-Chang Lee","doi":"10.6705/j.jacme.202609_16(3).0002","DOIUrl":"10.6705/j.jacme.202609_16(3).0002","url":null,"abstract":"<p><strong>Background: </strong>Pneumonia remains a leading cause of hospitalization and mortality worldwide, particularly among children and older adults. Disease outcomes may vary based on the causative pathogens, disease severity, and comorbidities; furthermore, the emergence of SARS-CoV-2 might have altered pneumonia-related hospitalization trends.</p><p><strong>Methods: </strong>We conducted a population-based study using Taiwan's National Health Insurance Database to analyze pneumonia hospitalizations, length of stay (LOS), and mortality in 2019 and 2020, focusing on pneumonia type, age, comorbidities, and severity. Hospitalizations were classified into four categories: all pneumonia, viral, bacterial, and \"other\" (including atypical and unidentified). We identified comorbidities and defined severity by general ward or ICU admission.</p><p><strong>Results: </strong>Pneumonia hospitalizations decreased from 335,806 in 2019 to 264,672 in 2020. \"Other\" pneumonia was the most common type. Viral pneumonia was more prevalent in pediatric patients, while bacterial pneumonia dominated in those ≥ 65 years. LOS increased across all types, especially for bacterial pneumonia. Mortality increased with age and was higher in 2020 across all types. Among comorbidities, diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) were the most common, while end-stage renal disease (ESRD) had the highest in-hospital mortality. ICU patients had the longest LOS. Bacterial pneumonia had the highest mortality in general wards, while \"other\" pneumonia in the ICU.</p><p><strong>Conclusions: </strong>We examined pneumonia hospitalizations in Taiwan in 2019 and 2020, providing hospitalization proportion, LOS and mortality rate by pathogen types, age group, comorbidities, and severity level. Enhancing vaccination programs, strengthening rapid diagnostics, and managing comorbidities are essential to reduce severe cases, improve outcomes, and lessen healthcare burdens.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"99-113"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adult Acute Flaccid Paralysis Associated With Food Consumption: A Tetrodotoxin Poisoning Case Report and Differential Diagnosis.","authors":"Yen-Hsiang Wei, Yin-Cheng Wu, Chien-An Ko, Chen-Chang Yang, Yan-Chiao Mao, Cheng-Hsuan Ho","doi":"10.6705/j.jacme.202609_16(3).0006","DOIUrl":"10.6705/j.jacme.202609_16(3).0006","url":null,"abstract":"<p><p>Acute flaccid paralysis (AFP) in adults is a clinical emergency with multiple causes, including hypokalemic periodic paralysis (hypoPP), Guillain-Barré syndrome (GBS), myasthenia gravis (MG), and botulinum neurotoxin (BoNT) poisoning. Herein, we present the case of a 64-year-old Asian man who ingested an unidentified fish. Within 30 minutes of ingestion, he developed flaccid paralysis along with gastrointestinal symptoms and perioral tingling. After 3 hours, his condition deteriorated to worsening respiratory distress and unconsciousness, requiring mechanical ventilation for one week. Blood and urine samples tested positive for 11-norTTX-6-ol, a tetrodotoxin (TTX) analog. Cytochrome b (Cytb) gene analysis of the remaining consumed fish revealed that the fish was Lagocephalus lunaris. Although TTX poisoning is rare, some countries have relatively high rates due to regional factors. When immediate laboratory confirmation is not possible, analysis of patient clinical history is crucial for diagnosis. Because this condition progresses rapidly, prompt stabilization of vital signs by clinicians increases the likelihood of survival and reduces the risk of death.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"130-138"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hsiao-Yuan Su, Zong-Shian Tsai, Yu-Chun Chen, Ding-Jun Huang, Chung-Hsun Lee
{"title":"Under-Reporting of Drug Use in Douliu, Taiwan: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Screening Identifies Cases Beyond Education and Tattoo Markers in an Emergency Department Cohort.","authors":"Hsiao-Yuan Su, Zong-Shian Tsai, Yu-Chun Chen, Ding-Jun Huang, Chung-Hsun Lee","doi":"10.6705/j.jacme.202609_16(3).0001","DOIUrl":"10.6705/j.jacme.202609_16(3).0001","url":null,"abstract":"<p><strong>Background: </strong>Substance abuse drives considerable emergency department (ED) demand and remains a major public-health issue. Although low educational attainment and tattoos are linked to high-risk behaviors, their relevance to drug-positive ED visits in Taiwan is unknown. Self-reported drug histories are also unreliable, with many patients denying use despite positive toxicology. We therefore examined these sociocultural markers in confirmed drug-positive cases to assess their value for ED risk stratification.</p><p><strong>Methods: </strong>This single-center descriptive cohort of ED patients with urine-confirmed illicit drug positivity summarized demographic/social characteristics, toxicology findings, and clinical presentations, with prespecified within-cohort contrasts (Fisher's exact and Mann-Whitney U; two-sided α = 0.05) across traffic injury, self-harm, and other presentations; no drug-negative control group was enrolled.</p><p><strong>Results: </strong>The cohort was predominantly male (83.3%) with a median age of 39 years (range, 17-74). Lower educational attainment (≤ upper secondary [senior/vocational high school; ISCED 0-3]) was observed in 40/54 (74.1%; 95% CI, 61.1-83.9), and visible tattoos in 32/54 (59.3%; 95% CI, 46.0-71.3) among drug-positive ED patients. Overall, 92.6% (95% CI, 82.4-97.1) of toxicology-confirmed drug-positive patients denied recent drug use, indicating approximately 13-fold under-detection by history alone. Methamphetamine was the leading substance (42.6%), and 85.0% had ≥ 2 psychoactive substances detected. These estimates are descriptive of the drug-positive cohort; no drug-negative comparator was enrolled.</p><p><strong>Conclusion: </strong>In this mixed urban-rural ED cohort with toxicology-confirmed illicit drug use, lower educational attainment and tattoo presence were commonly observed. Because the study lacked a drug-negative control group, these findings should be interpreted as descriptive rather than evidence of association. The very high prevalence of under-reporting indicates that history alone has limited sensitivity for detecting recent drug use and supports a low threshold for comprehensive toxicology testing, particularly in high-risk presentations and injured drivers. Methamphetamine predominance, frequent polysubstance exposure, and approximately one-in-five drug-positive presentations following traffic injuries highlight the need for clinical vigilance. These descriptive patterns warrant evaluation in multicenter prospective studies with quantitative toxicology capable of assessing impairment and causal relationships.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 3","pages":"91-98"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zachary Robinson, Jessica Queen, Jessica Krizo, Erin L Simon
{"title":"Beyond the Usual: Diagnosing Ruptured Retroperitoneal Ectopic Pregnancy in a Patient With Negative Point-of-Care Ultrasound.","authors":"Zachary Robinson, Jessica Queen, Jessica Krizo, Erin L Simon","doi":"10.6705/j.jacme.202606_16(2).0007","DOIUrl":"10.6705/j.jacme.202606_16(2).0007","url":null,"abstract":"<p><p>Ectopic pregnancy (EP) is a commonly seen, potentially life-threatening condition that can be challenging to diagnose in the emergency department (ED) setting. A retroperitoneal EP is an extremely rare condition, with a limited number of reported cases. Because of this, many emergency medicine physicians may not be familiar with presenting symptoms of a retroperitoneal EP. Rupture of an EP is a life-threatening complication that must be diagnosed quickly to reduce the risk of mortality. We present a 27-year-old female who presented with a two-day history of progressive right lower quadrant abdominal pain, nausea, and vomiting. ED evaluation revealed tachycardia of 140 beats per minute, and laboratory assessment was positive for leukocytosis of 27,030 k/uL and a positive qualitative human chorionic gonadotropin. The initial concern was for appendicitis versus ruptured ectopic pregnancy. Point-of-care ultrasound was negative for both intrauterine pregnancy and intraperitoneal fluid. However, there were heterogeneous contents within the pelvis of unclear etiology. Obstetrics was consulted, admitted the patient, and obtained a formal abdominal ultrasound to evaluate her appendix. The radiologist reported a 12 cm pelvic mass for which the differential diagnosis included a uterine fibroid, ectopic pregnancy, or appendicitis. The patient was taken to the operating room for a diagnostic laparoscopy and laparotomy and was diagnosed with a ruptured retroperitoneal EP. She underwent evacuation of the retroperitoneal hematoma and right salpingo-oophorectomy. She was discharged home on postoperative day four.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 2","pages":"85-88"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shang-Chiao Yang, Yu-Hsiang Chen, Yung-Hsiang Chang, Yih-Jin Hu
{"title":"The Impact of Establishing Prehospital Drug Administration Routes on Emergency Department Resuscitation Efficiency and Patient Survival Rates.","authors":"Shang-Chiao Yang, Yu-Hsiang Chen, Yung-Hsiang Chang, Yih-Jin Hu","doi":"10.6705/j.jacme.202606_16(2).0003","DOIUrl":"10.6705/j.jacme.202606_16(2).0003","url":null,"abstract":"<p><strong>Background: </strong>Prehospital drug administration is crucial for improving resuscitation efforts in emergency departments (EDs) and enhancing survival rates for out-of-hospital cardiac arrest (OHCA) patients. While evidence supports the prehospital use of life-saving medications like epinephrine, the effects of prehospital vascular access routes remain under-researched. This study collects two years of data on adult patients with non-traumatic OHCA transported by Taoyuan Emergency Medical Services (EMS), aiming to evaluate how prehospital vascular access impacts resuscitation success and survival outcomes.</p><p><strong>Methods: </strong>This was a retrospective study conducted by the Taoyuan Fire Department and Taoyuan General Hospital. Data were collected from January 1, 2023 to September 30, 2024. The inclusion criteria consisted of adult patients experiencing non-traumatic OHCA who had established vascular access at the scene. Exclusion criteria were those with missing data and EMS-witnessed OHCA enroute. The outcome measurements aimed to assess whether establishing vascular access from prehospital improves the efficiency of epinephrine administration in the ED and enhances survival rates among OHCA patients. Data were collected using the Electronic Patient Care Report.</p><p><strong>Results: </strong>A total of 185 cases were included in the analysis, consisting of 97 males (52.4%) and 88 females (47.6%), with an average age of 71 years. When comparing the 95 cases with vascular access to the 90 cases without vascular access, the overall time from arrival in the emergency room to the administration of epinephrine was significantly shorter for those with vascular access, averaging 2 minutes compared to 4 minutes for those without (p < 0.001). Additionally, the cumulative time-event analysis using the Kaplan-Meier method showed a significant reduction in the time to epinephrine administration (p < 0.001).</p><p><strong>Conclusion: </strong>Establishing prehospital vascular access significantly enhances ED resuscitation efficiency in non-traumatic OHCA. These findings support integrating vascular access protocols into prehospital care practices to improve outcomes for cardiac arrest.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 2","pages":"67-75"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cartap Hydrochloride Poisoning: Rarely Seen, Rarely Heard.","authors":"Samata Chororia, Satyabrata Guru, Upendra Hansda, Sadananda Brink","doi":"10.6705/j.jacme.202606_16(2).0006","DOIUrl":"10.6705/j.jacme.202606_16(2).0006","url":null,"abstract":"<p><p>Cartap hydrochloride (CH) is a Class II hazardous pesticide that causes toxicity by inhibiting post-synaptic nicotinic acetylcholine receptors and affecting calcium release in the sarcoplasmic reticulum. While mortality is generally low, severe cases can lead to respiratory failure. A 25-year-old male presented to the emergency department six hours after intentionally consuming approximately 12 g of 50% CH. He exhibited vomiting, drowsiness (Glasgow Coma Score [GCS]: 13/15), and bradycardia (HR: 52/min). Initial arterial blood gas (ABG) analysis revealed mixed acidosis (pH: 7.296, pCO<sub>2</sub>: 60.8, pO<sub>2</sub>: 102.8, Lactate: 4.2, and HCO<sub>3</sub>: 20.3). Notably, serum pseudo-cholinesterase levels and other laboratory findings were within normal limits. The patient was treated with non-invasive ventilation (NIV) for respiratory acidosis and administered a loading dose of N-acetylcysteine (NAC) (150 mg/kg) along with symptomatic management. His sensorium and ABG parameters normalized within six hours of treatment. He remained asymptomatic and was discharged after three days. Human toxicity from CH is rarely reported, and cases involving mixed acidosis are particularly sparse in literature. This case highlights the importance of recognizing CH poisoning, which can mimic organophosphate toxicity. Vigilant monitoring for acidosis via ABG and early intervention with NAC and supportive care, such as NIV, are crucial for successful clinical outcomes.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"16 2","pages":"82-84"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}