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Investigative ophthalmology最新文献

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Comparison of ocular prostaglandin synthesis inhibitors. 眼部前列腺素合成抑制剂的比较。
Investigative ophthalmology Pub Date : 1976-10-01
S M Podos, B Becker
{"title":"Comparison of ocular prostaglandin synthesis inhibitors.","authors":"S M Podos,&nbsp;B Becker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparative study was carried out of the inhibitory effect of 14 nonsteroidal anti-inflammatory compounds, administered topically, on the intraocular pressure and aqueous humor protein elevation induced by arachidonic acid in rabbits. The most effective agents were flurbiprofen solution and suspensions of indoxole (polysorbate-dispersed), meclofenamic acid, indomethacin, and clonixin.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 10","pages":"841-4"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12160023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photosensitive pigments formed with rat opsin. 由大鼠视蛋白形成的光敏色素。
Investigative ophthalmology Pub Date : 1976-10-01
R Crouch
{"title":"Photosensitive pigments formed with rat opsin.","authors":"R Crouch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Photosensitive pigments are formed in vitro from rat opsin with the rods in suspension or as digitonin solutions. Rhodopsin, isorhodopsin I, and isorhodopsin II were generated with 11-cis, 9-cis and 9, 13-dicis retinal, respectively. An isorhodopsin I analogue was formed on combination with 9-cis 13-desmethyl-14-methylretinal. The absorption spectra and photosensitivities of these pigments were found to be similar to the corresponding bovine pigments although the rates of formation are several fold slower.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 10","pages":"872-5"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12160029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An improved model of experimentally induced ocular hypertension in the rabbit. 兔实验性高眼压模型的改进。
Investigative ophthalmology Pub Date : 1976-09-01
L Bonomi, L Tomazzoli, D Jaria
{"title":"An improved model of experimentally induced ocular hypertension in the rabbit.","authors":"L Bonomi,&nbsp;L Tomazzoli,&nbsp;D Jaria","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A model of experimentally induced ocular hypertension for the evaluation of antiglaucoma drugs in the unanesthetized rabbit is described. It is based on the intravenous infusion of suitable amounts of 5 per cent glucose solution, and advantageously substitutes the oral water load. The method is sensitive to drugs acting both on the outflow facility (2 per cent pilocarpine) and an aqueous humor formation (10 per cent guanethidine).</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 9","pages":"781-4"},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12144145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of mechanical agitation on endothelial function of preserved corneas. 机械搅拌对保存角膜内皮功能的影响。
Investigative ophthalmology Pub Date : 1976-09-01
M I Perlmutter, K Green, J A Stanley
{"title":"Effects of mechanical agitation on endothelial function of preserved corneas.","authors":"M I Perlmutter,&nbsp;K Green,&nbsp;J A Stanley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Corneas from adult albino New Zealand rabbits were stored in either MK medium or moist chambers at 4 degrees C. for 18 to 24 hours. During that time, half the corneas from each group were agitated for 8 hours to simulate the motion that might occur during long-distance shipment. The corneas were then placed in specular microscopes and perfused for 4 hours with a modified Krebs-Ringer solution at 34 degrees C. Serial measurements of corneal thickness made during temperature reversal showed that agitation had no effect on endothelial viability of corneas stored in either solution. Electron microscopy of selected corneas confirmed this finding.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 9","pages":"774-7"},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12144143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corneal water and electrolyte content following storage in moist chamber and MK medium. 在湿润室和MK培养基中储存后的角膜水分和电解质含量。
Investigative ophthalmology Pub Date : 1976-09-01
D S Hull, K Green, K Bowman
{"title":"Corneal water and electrolyte content following storage in moist chamber and MK medium.","authors":"D S Hull,&nbsp;K Green,&nbsp;K Bowman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rabbit corneas were subjected to MK-medium or moist-chamber storage for periods up to 7 days. Sodium, potassium, and chloride concentrations and hydration were measured. The hydration of corneas stored in MK medium was less than that of those stored in moist chambers. The sodium concentration of MK corneas remained stable for up to 7 days; the potassium concentration, however, decreased with increasingly longer periods of storage. Chloride concentrations quickly equilibrated with the high chloride level of MK medium. The concentration of sodium and chloride in moist chamber-stored corneas fell with progressively longer storage periods. Potassium showed an initial decrease in concentration followed by an increase in concentration that paralleled, and equilibrated with, the increasing acqueous humor concentration.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 9","pages":"778-80"},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12144144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of pilocarpine drops on the diurnal intraocular pressure variation in patients with glaucoma. 匹罗卡品滴剂对青光眼患者日眼压变化的影响。
Investigative ophthalmology Pub Date : 1976-09-01
D M Worthen
{"title":"Effect of pilocarpine drops on the diurnal intraocular pressure variation in patients with glaucoma.","authors":"D M Worthen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The diurnal intraocular pressure was measured in 14 eyes of patients with glaucoma while they were using no medication and compared to the diurnal pressures while they were using pilocarpine drops. During the 48 hour control period, the pressures measured every 3 hours by the non-contact tonometer had a mean value of 26 mm. Hg and a mean maximum diurnal variation of 18.5 mm. Hg. During the pilocarpine treatment period, the mean pressure and maximum diurnal variation dropped to 17 and 8.5 mm. Hg, respectively. The greatest pressure-lowering effect occurred between 9 A.M. and 6 P.M.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 9","pages":"784-7"},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12167293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of trigeminal nerve and ganglion manipulation on recurrence of ocular herpes simplex in rabbits. 三叉神经及神经节手法对兔眼部单纯疱疹复发的影响。
Investigative ophthalmology Pub Date : 1976-09-01
A B Nesburn, R Dickinson, M Radnoti
{"title":"The effect of trigeminal nerve and ganglion manipulation on recurrence of ocular herpes simplex in rabbits.","authors":"A B Nesburn,&nbsp;R Dickinson,&nbsp;M Radnoti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Latent herpes simplex virus (HSV) has been demonstrated in the trigeminal ganglia of experimentally infected rabbits between episodes of spontaneous ocular recurrence. In three experiments reported here, the normal pattern of recurrence was modified by manipulation of the trigeminal nerve and ganglion. Temporary retrobulbar disruption of trigeminal nerve function in chronically infected animals significantly decreased the number of ocular HSV isolations obtained during the 20 weeks immediately following surgery. Stereotaxic interruption of intracranial trigeminal nerve function prior to initial HSV infection dramatically reduced the incidence of peripheral recurrence of HSV. In chronically infected animals, stereotaxic stimulation of the trigeminal ganglion caused a marked increase in positive cultures within 2 days. These studies provide additional evidence for the theory that the reservoir for latent ocular HSV in rabbits is the trigeminal ganglion. Moreover, the studies suggest that the transmission of latent HSV from the trigeminal ganglion to its infectious form in the peripheral tissues involves the trigeminal nerve. We have shown that mechanical and stereotaxic stimulation of the trigeminal ganglion is a reliable and rapid means of precipitating peripheral ocular shedding of HSV on command, a finding which should prove most productive in future research.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 9","pages":"726-31"},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11400464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Keratoprosthesis. 编辑:Keratoprosthesis。
Investigative ophthalmology Pub Date : 1976-08-01
F M Polack
{"title":"Editorial: Keratoprosthesis.","authors":"F M Polack","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 8","pages":"593-5"},"PeriodicalIF":0.0,"publicationDate":"1976-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12137515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rabbit corneal epithelial cells grown in vitro without serum. 体外无血清培养兔角膜上皮细胞。
Investigative ophthalmology Pub Date : 1976-08-01
M I Allman, R A Harper, M Yanoff, L J Curfman, J D Cameron, B A Flaxman
{"title":"Rabbit corneal epithelial cells grown in vitro without serum.","authors":"M I Allman,&nbsp;R A Harper,&nbsp;M Yanoff,&nbsp;L J Curfman,&nbsp;J D Cameron,&nbsp;B A Flaxman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary outgrowth cultures of normal rabbit corneal epithelium can be initiated and propagated in vitro up to 6 days in serum-free medium. By the eighth day the majority of cells have ceased to divide. Epithelial cells grown without serum show DNA synthetic activity at a level comparable to control cultures grown with added serum.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 8","pages":"666-8"},"PeriodicalIF":0.0,"publicationDate":"1976-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12137523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dextran uptake into, and loss from, corneas stored in intermediate-term preservative. 右旋糖酐进入角膜和从角膜中流失，储存在中期防腐剂中。
Investigative ophthalmology Pub Date : 1976-08-01
D S Hull, K Green, K Bowman
{"title":"Dextran uptake into, and loss from, corneas stored in intermediate-term preservative.","authors":"D S Hull,&nbsp;K Green,&nbsp;K Bowman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This investigation demonstrates that dextran passes into rabbit corneas stored in M-K medium prior to corneal transplantation. An equilibrium between dextran in the cornea and in the M-K medium is reached at about 24 hours. Post-keratoplasty dextran efflux is rapid with about 70 to 75 per cent being lost within one to three hours and 99 per cent being lost in 12 hours.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 8","pages":"663-6"},"PeriodicalIF":0.0,"publicationDate":"1976-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11976452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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