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Journal for Immunotherapy of Cancer最新文献

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HER2 CAR-expressing iPSC-derived iNKT cells exhibit multifaceted immunomodulatory functions beyond direct tumor killing. 表达HER2 car的ipsc衍生iNKT细胞除了直接杀伤肿瘤外，还表现出多方面的免疫调节功能。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-20 DOI: 10.1136/jitc-2026-016268
Koichiro Shioya, Tomio Matsumura, Akane Urakami, Tomokuni Shigeura, Yu-Ching Lin, Mio Fujimaki, Yuji Mishima, Takahiro Aoki, Momoko Okoshi, Kiwamu Motoyoshi, Shinichiro Motohashi, Haruhiko Koseki, Lilin Zhang
{"title":"HER2 CAR-expressing iPSC-derived iNKT cells exhibit multifaceted immunomodulatory functions beyond direct tumor killing.","authors":"Koichiro Shioya, Tomio Matsumura, Akane Urakami, Tomokuni Shigeura, Yu-Ching Lin, Mio Fujimaki, Yuji Mishima, Takahiro Aoki, Momoko Okoshi, Kiwamu Motoyoshi, Shinichiro Motohashi, Haruhiko Koseki, Lilin Zhang","doi":"10.1136/jitc-2026-016268","DOIUrl":"https://doi.org/10.1136/jitc-2026-016268","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil-epithelial niches arrest B-cell maturation in dysfunctional tertiary lymphoid structures of gastric cancer neoadjuvant immunochemotherapy. 中性粒细胞-上皮小龛在胃癌新辅助免疫化疗功能失调的三级淋巴样结构中阻止b细胞成熟。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-20 DOI: 10.1136/jitc-2026-016301
Chen Wei, Qiang Fu, Hejia Wei, Hao Zhai, Shuailei Dong, Xiaoqing Ma, Liangyu Bie, Yijie Ma, Yuanyuan Wang, Qingxin Xia, Suxia Luo, Ning Li
{"title":"Neutrophil-epithelial niches arrest B-cell maturation in dysfunctional tertiary lymphoid structures of gastric cancer neoadjuvant immunochemotherapy.","authors":"Chen Wei, Qiang Fu, Hejia Wei, Hao Zhai, Shuailei Dong, Xiaoqing Ma, Liangyu Bie, Yijie Ma, Yuanyuan Wang, Qingxin Xia, Suxia Luo, Ning Li","doi":"10.1136/jitc-2026-016301","DOIUrl":"https://doi.org/10.1136/jitc-2026-016301","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCSK9 drives acquired resistance to anti-PD-1 immunotherapy through cystine metabolic reprogramming in lung cancer. 肺癌中PCSK9通过胱氨酸代谢重编程驱动抗pd -1免疫治疗获得性耐药
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-20 DOI: 10.1136/jitc-2026-015974
Guangling Jie, Zhengqi Cao, Jingze Wang, Wenqing Lu, Xiaokuan Zhu, Ziming Li, Ying Wang, Shun Lu, Liliang Xia
{"title":"PCSK9 drives acquired resistance to anti-PD-1 immunotherapy through cystine metabolic reprogramming in lung cancer.","authors":"Guangling Jie, Zhengqi Cao, Jingze Wang, Wenqing Lu, Xiaokuan Zhu, Ziming Li, Ying Wang, Shun Lu, Liliang Xia","doi":"10.1136/jitc-2026-015974","DOIUrl":"https://doi.org/10.1136/jitc-2026-015974","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observation versus maintenance immunotherapy after PD-1-induced clinical complete response in dMMR/MSI-H colorectal cancer managed non-operatively: a multicenter cohort study. dMMR/MSI-H结直肠癌非手术治疗pd -1诱导临床完全缓解后的观察与维持免疫治疗：一项多中心队列研究
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-20 DOI: 10.1136/jitc-2026-016538
Xiaohang Gao, Qiaoxuan Wang, Zitong Zhang, Fang He, Yi Ding, Liping Zhang, Duoduo Pei, Shaoqing Niu, Hailan Chen, Rui Sun, Ye Yao, Weiming Han, Yanjun Chen, Hui Chang, Weiwei Xiao, Liren Li, Rong Zhang, Yuanhong Gao
{"title":"Observation versus maintenance immunotherapy after PD-1-induced clinical complete response in dMMR/MSI-H colorectal cancer managed non-operatively: a multicenter cohort study.","authors":"Xiaohang Gao, Qiaoxuan Wang, Zitong Zhang, Fang He, Yi Ding, Liping Zhang, Duoduo Pei, Shaoqing Niu, Hailan Chen, Rui Sun, Ye Yao, Weiming Han, Yanjun Chen, Hui Chang, Weiwei Xiao, Liren Li, Rong Zhang, Yuanhong Gao","doi":"10.1136/jitc-2026-016538","DOIUrl":"https://doi.org/10.1136/jitc-2026-016538","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering T cell-engaging bispecific antibodies targeting KRAS G12V neoantigen across HLA-A*11:01 and HLA-A*03:01. HLA-A*11:01和HLA-A*03:01靶向KRAS G12V新抗原的工程T细胞结合双特异性抗体
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-18 DOI: 10.1136/jitc-2026-016411
Xiaojing Wu, Clara Effenberger, Yosuke Matsushita, Hiroki Tanaka, Yu Ishii, Suyong Re, Saki Matsumoto, Satoshi Nagayama, Yusuke Nakamura, Kazuma Kiyotani
{"title":"Engineering T cell-engaging bispecific antibodies targeting KRAS G12V neoantigen across HLA-A*11:01 and HLA-A*03:01.","authors":"Xiaojing Wu, Clara Effenberger, Yosuke Matsushita, Hiroki Tanaka, Yu Ishii, Suyong Re, Saki Matsumoto, Satoshi Nagayama, Yusuke Nakamura, Kazuma Kiyotani","doi":"10.1136/jitc-2026-016411","DOIUrl":"https://doi.org/10.1136/jitc-2026-016411","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels. 错配修复缺陷(dMMR)/微卫星不稳定性高（MSI-H）胃肠道（GI）癌症的不同基因组景观取决于肿瘤突变负担（TMB）水平。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-15 DOI: 10.1136/jitc-2026-015933
Jingyuan Wang, Joanne Xiu, Alex P Farrell, Francesca Battaglin, Hiroyuki Arai, Yan Yang, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F Shields, Axel Grothey, Benjamin A Weinberg, John Marshall, Emil Lou, Moh'd Khushman, Davendra P S Sohal, Michael J Hall, Tianshu Liu, Matthew James Oberley, David Spetzler, Heinz-Josef Lenz
{"title":"Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.","authors":"Jingyuan Wang, Joanne Xiu, Alex P Farrell, Francesca Battaglin, Hiroyuki Arai, Yan Yang, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F Shields, Axel Grothey, Benjamin A Weinberg, John Marshall, Emil Lou, Moh'd Khushman, Davendra P S Sohal, Michael J Hall, Tianshu Liu, Matthew James Oberley, David Spetzler, Heinz-Josef Lenz","doi":"10.1136/jitc-2026-015933","DOIUrl":"https://doi.org/10.1136/jitc-2026-015933","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal and therapeutic confounders in predicting efficacy of immunotherapy rechallenge via baseline intratumoral tertiary lymphoid structures. 通过基线肿瘤内三级淋巴组织预测免疫治疗再挑战疗效的时间和治疗混杂因素。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-15 DOI: 10.1136/jitc-2026-016391
Anran Sun, Hongkai Chen, Anyang Wei
{"title":"Temporal and therapeutic confounders in predicting efficacy of immunotherapy rechallenge via baseline intratumoral tertiary lymphoid structures.","authors":"Anran Sun, Hongkai Chen, Anyang Wei","doi":"10.1136/jitc-2026-016391","DOIUrl":"https://doi.org/10.1136/jitc-2026-016391","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective expansion of neoantigen-specific peripheral blood lymphocytes through antigen-presenting cell-T cell conjugate isolation. 通过抗原呈递细胞- t细胞偶联分离选择性扩增新抗原特异性外周血淋巴细胞。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-15 DOI: 10.1136/jitc-2026-014996
Mamduh Khateb, Raina Jung, Patrick Hadley, Stav Leibou, Zhiya Yu, Aaron J Dinerman, Victoria Dulemba, Billel Gasmi, Noam Levin, Sanghyun Peter Kim, Aarushi Bhasin, Deepali Bhat, Sivasish Sindiri, Jared J Gartner, Todd D Prickett, Tiffany Benzine, Shahram Farid, Maria Parkhurst, Hyunmi Halas, Guangzhe Ge, Yaqiang Cao, Keji Zhao, James C Yang, Paul Robbins, Frank J Lowery, Sri Krishna, Theo Heller, Daniel Mcvicar, Steven A Rosenberg, Nicholas D Klemen
{"title":"Selective expansion of neoantigen-specific peripheral blood lymphocytes through antigen-presenting cell-T cell conjugate isolation.","authors":"Mamduh Khateb, Raina Jung, Patrick Hadley, Stav Leibou, Zhiya Yu, Aaron J Dinerman, Victoria Dulemba, Billel Gasmi, Noam Levin, Sanghyun Peter Kim, Aarushi Bhasin, Deepali Bhat, Sivasish Sindiri, Jared J Gartner, Todd D Prickett, Tiffany Benzine, Shahram Farid, Maria Parkhurst, Hyunmi Halas, Guangzhe Ge, Yaqiang Cao, Keji Zhao, James C Yang, Paul Robbins, Frank J Lowery, Sri Krishna, Theo Heller, Daniel Mcvicar, Steven A Rosenberg, Nicholas D Klemen","doi":"10.1136/jitc-2026-014996","DOIUrl":"https://doi.org/10.1136/jitc-2026-014996","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma cell-free RNA ITGB3 is associated with long-term clinical benefit in patients with non-small cell lung cancer receiving immunochemotherapy. 血浆无细胞RNA ITGB3与接受免疫化疗的非小细胞肺癌患者的长期临床获益相关。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-14 DOI: 10.1136/jitc-2026-015873
Yunbo Yu, Yuheng Liu, Xin Zhang, Wenyue Yang, Sencong Hou, Wenqian Yu, Feifei Zhang, Bo Yu, Zhihuang Hu, Zhenhua Wu, Shenglin Huang, Jialei Wang
{"title":"Plasma cell-free RNA ITGB3 is associated with long-term clinical benefit in patients with non-small cell lung cancer receiving immunochemotherapy.","authors":"Yunbo Yu, Yuheng Liu, Xin Zhang, Wenyue Yang, Sencong Hou, Wenqian Yu, Feifei Zhang, Bo Yu, Zhihuang Hu, Zhenhua Wu, Shenglin Huang, Jialei Wang","doi":"10.1136/jitc-2026-015873","DOIUrl":"https://doi.org/10.1136/jitc-2026-015873","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCNE1 overexpression drives a cGAS-STING-dependent interferon response and sensitizes HRD-positive ovarian cancer to immune checkpoint blockade. CCNE1过表达驱动cgas - sting依赖的干扰素反应，并使hrd阳性卵巢癌对免疫检查点阻断敏感。
IF 11.7 1区 医学
Journal for Immunotherapy of Cancer Pub Date : 2026-10-14 DOI: 10.1136/jitc-2026-015326
Xueling Wang, Tian Chen, Zehua Wang, Chenyang Wang, Xuyao Xu, Moran Yang, Guodong Zhang, Yan Huang, Haiou Liu
{"title":"CCNE1 overexpression drives a cGAS-STING-dependent interferon response and sensitizes HRD-positive ovarian cancer to immune checkpoint blockade.","authors":"Xueling Wang, Tian Chen, Zehua Wang, Chenyang Wang, Xuyao Xu, Moran Yang, Guodong Zhang, Yan Huang, Haiou Liu","doi":"10.1136/jitc-2026-015326","DOIUrl":"https://doi.org/10.1136/jitc-2026-015326","url":null,"abstract":"","PeriodicalId":14820,"journal":{"name":"Journal for Immunotherapy of Cancer","volume":"14 10","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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