Journal de pharmacologie最新文献_第4页

Direct versus reflex activation of cardiac beta-adrenoceptors in the chronotropic and inotropic effects of isoprenaline and prenalterol in the conscious dog. 异丙肾上腺素和丙戊醇在清醒犬的变时和变肌力作用中心脏β -肾上腺素受体的直接与反射激活。

Journal de pharmacologie Pub Date : 1986-07-01

A Berdeaux, A Edouard, J F Giudicelli

{"title":"Direct versus reflex activation of cardiac beta-adrenoceptors in the chronotropic and inotropic effects of isoprenaline and prenalterol in the conscious dog.","authors":"A Berdeaux, A Edouard, J F Giudicelli","doi":"","DOIUrl":"","url":null,"abstract":"The mechanisms by which isoprenaline and prenalterol increase heart rate and myocardial contractile force were investigated in conscious instrumented dogs. Isoprenaline (0.1 micrograms/kg/min/10 min) increased both heart rate (+98 +/- 14%) and contractility (+36 +/- 5%) and decreased diastolic blood pressure. beta 1-Adrenoceptor blockade abolished the isoprenaline induced increase in contractility whereas the induced tachycardia was reduced by approximately 50%. Either beta 2-blockade, which abolished the hypotensive effect of isoprenaline or ganglionic blockade, which abolished the isoprenaline-induced activation of sino aortic baroreflexes, strongly reduced (-67 +/- 8%) the isoprenaline-induced tachycardia but did not markedly alter the increase in contractility. However, the isoprenaline-induced increase in contractility was potentiated by methylatropine (+83 +/- 12%) whereas the simultaneous tachycardia was less marked than before methylatropine. In the same dogs, prenalterol (2 micrograms/kg/min/5 min) increased contractility (+38 +/- 5%) to the same extent as isoprenaline but induced a lesser increase in heart rate (+23 +/- 3%) and had no effect on aortic pressure. These effects were not significantly modified by pretreatments with either ganglionic or beta 2-blockades but were abolished by beta 1-blockade. After methylatropine the prenalterol-induced increase in heart rate was not modified but the increase in contractility was potentiated (+63 +/- 11%). We conclude that whereas indirect activation of arterial baroreflexes through hypotension markedly contributes to the isoprenaline-induced increase in heart rate, the simultaneous increase in cardiac inotropism is only dependent upon direct beta 1-adrenoceptor activation by isoprenaline.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"17 3","pages":"266-74"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14014245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Measurement of specific airway conductance in the unanesthetized guinea pig]. [未麻醉豚鼠特定气道电导的测量]。

Journal de pharmacologie Pub Date : 1986-07-01

I Macquin-Mavier, A Harf, A M Lorino

引用次数: 0

[Determination of protein binding of drugs using equilibrium dialysis. Influence of volume displacement caused by osmotic pressure]. 用平衡透析法测定药物的蛋白质结合。渗透压对体积位移的影响[j]。

Journal de pharmacologie Pub Date : 1986-07-01

F Lapicque, P Netter, C Monot, B Bannwarth, M S Maknassi, R J Royer

引用次数: 0

Antihypertensive and vasodilating effects of acute medroxalol, a new beta-blocker with beta-2-adrenergic receptor stimulation. 新型β -2-肾上腺素能受体阻滞剂甲羟安的抗高血压和血管舒张作用。

Journal de pharmacologie Pub Date : 1986-07-01

A Simon, J Levenson, J Bouthier, I Merli

{"title":"Antihypertensive and vasodilating effects of acute medroxalol, a new beta-blocker with beta-2-adrenergic receptor stimulation.","authors":"A Simon, J Levenson, J Bouthier, I Merli","doi":"","DOIUrl":"","url":null,"abstract":"The effects of medroxalol, a new beta-blocking drug, were simultaneously studied on the brachial artery, the arterioles and the veins of the forearm in 15 patients with mild to moderate essential hypertension after administration of a single oral dose of 200 mg, by means of pulsed Doppler velocimetry of the brachial artery and strain gauge mercury-in silastic plethysmography of the forearm. In addition the systolic time intervals including preejection period (PEP) and left ventricular time (LVET) were also measured after drug administration. Acute oral medroxalol produced a rapid and significant decrease in systolic and diastolic blood pressure and in heart rate. Concomitantly a significant increase was observed in brachial artery diameter (p less than 0.05), blood velocity and flow (p less than 0.01); forearm vascular resistance decreased (p less than 0.001) but forearm venous tone was unchanged. Lastly medroxalol prolonged PEP but shortened LVET corrected for heart rate. These results demonstrate a rapid antihypertensive action of a single dose of medroxalol with a dilation of the arteries but not of the veins of the forearm and a discrepant effect on the systolic time intervals.","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"17 3","pages":"331-7"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14914022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of chronic chloroquine poisoning on the cardiac binding sites of calcium inhibitors in the rat]. 慢性氯喹中毒对大鼠心脏钙抑制剂结合位点的影响。

Journal de pharmacologie Pub Date : 1986-07-01

A Diouf, G F Alberici, J M Bidart, C Bohuon

引用次数: 0

Adaptation of the tail suspension test to the rat. 悬尾试验对大鼠的适应性。

Journal de pharmacologie Pub Date : 1986-07-01

R Chermat, B Thierry, J A Mico, L Steru, P Simon

引用次数: 0

[Test of delayed hypersensitivity to dinitrochlorobenzene in the guinea pig]. [豚鼠对二硝基氯苯迟发性超敏反应试验]。

Journal de pharmacologie Pub Date : 1986-07-01

J Descotes, R Tedone